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AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates

Research ArticleBrain

Differentiation of Typical and Atypical Parkinson Syndromes by Quantitative MR Imaging

N.K. Focke, G. Helms, P.M. Pantel, S. Scheewe, M. Knauth, C.G. Bachmann, J. Ebentheuer, P. Dechent, W. Paulus and C. Trenkwalder
American Journal of Neuroradiology December 2011, 32 (11) 2087-2092; DOI: https://doi.org/10.3174/ajnr.A2865
N.K. Focke
aFrom the Department of Clinical Neurophysiology (N.K.F., P.M.P., S.S., C.G.B., W.P.)
dParacelsus Elena Klinik (N.K.F., J.E., C.T.), Specialized Movement Disorders Hospital, Kassel, Germany.
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G. Helms
bMR-Research in Neurology and Psychiatry (G.H., P.D.)
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P.M. Pantel
aFrom the Department of Clinical Neurophysiology (N.K.F., P.M.P., S.S., C.G.B., W.P.)
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S. Scheewe
aFrom the Department of Clinical Neurophysiology (N.K.F., P.M.P., S.S., C.G.B., W.P.)
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M. Knauth
cDepartment of Neuroradiology (M.K.), Georg-August University Göttingen, Göttingen, Germany
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C.G. Bachmann
aFrom the Department of Clinical Neurophysiology (N.K.F., P.M.P., S.S., C.G.B., W.P.)
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J. Ebentheuer
dParacelsus Elena Klinik (N.K.F., J.E., C.T.), Specialized Movement Disorders Hospital, Kassel, Germany.
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P. Dechent
bMR-Research in Neurology and Psychiatry (G.H., P.D.)
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W. Paulus
aFrom the Department of Clinical Neurophysiology (N.K.F., P.M.P., S.S., C.G.B., W.P.)
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C. Trenkwalder
dParacelsus Elena Klinik (N.K.F., J.E., C.T.), Specialized Movement Disorders Hospital, Kassel, Germany.
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    Fig 1.

    3D rendering of the regions of interest in a control subject: CN (red), PU (green), PA (blue), and SN (yellow). Regions of interest overlaid on the 3D T1-weighted image. A, Axial cut plane at the level of the striatum. B, Axial cut plane through the mesencephalon. C, Coronal oblique cut plane along the main axis of the SN region of interest.

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    Fig 2.

    Regions of interest overlaid on the quantitative maps: CN (red), PU (green), and PA (blue). Regions of interest overlaid on axial sections of a 3D T1-weighted image (A), an R2 map (B), an R2* map (C), a magnetization transfer map (D), a 3D T2-weighted image (E), MD (F), FA (G), and R1 map (H).

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    Fig 3.

    Group differences of R2* measurements. Error bars (95% confidence intervals) of R2* measurements (right side only) are shown clustered by diagnosis group.

Tables

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  • Demographic details of controls and patient groups

    No.Age (mean)Sex (female/male)
    Controls1367.6 ± 10.58:5
    IPS1266.3 ± 7.82:10
    MSA-P1062.5 ± 8.55:5
    PSP967.0 ± 4.32:7
    Total4466.0 ± 8.317:27
    • Note:—MSA-P indicates multiple systems atrophy–type Parkinson.

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American Journal of Neuroradiology: 32 (11)
American Journal of Neuroradiology
Vol. 32, Issue 11
1 Dec 2011
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Cite this article
N.K. Focke, G. Helms, P.M. Pantel, S. Scheewe, M. Knauth, C.G. Bachmann, J. Ebentheuer, P. Dechent, W. Paulus, C. Trenkwalder
Differentiation of Typical and Atypical Parkinson Syndromes by Quantitative MR Imaging
American Journal of Neuroradiology Dec 2011, 32 (11) 2087-2092; DOI: 10.3174/ajnr.A2865

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Differentiation of Typical and Atypical Parkinson Syndromes by Quantitative MR Imaging
N.K. Focke, G. Helms, P.M. Pantel, S. Scheewe, M. Knauth, C.G. Bachmann, J. Ebentheuer, P. Dechent, W. Paulus, C. Trenkwalder
American Journal of Neuroradiology Dec 2011, 32 (11) 2087-2092; DOI: 10.3174/ajnr.A2865
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Cited By...

  • Automated classification of neurodegenerative parkinsonian syndromes using multimodal magnetic resonance imaging in a clinical setting
  • Combined Diffusion Tensor Imaging and Apparent Transverse Relaxation Rate Differentiate Parkinson Disease and Atypical Parkinsonism
  • Diffusion tensor imaging in parkinsonian syndromes: A systematic review and meta-analysis
  • Individual Detection of Patients with Parkinson Disease using Support Vector Machine Analysis of Diffusion Tensor Imaging Data: Initial Results
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