Article Figures & Data
Figures
- Fig 1.
A 16-year-old male patient with brain abscess. A, T2-weighted image shows bilobed centrally hyperintense lesions with a peripheral hypointense rim and surrounding edema in the left tempoparietal region causing mass effect. B and C, The lesion shows central hypointensity with a peripheral isointense rim on the T1-weighted image (B) and rim enhancement on the postcontrast T1-weighted image (C). D−F, DWI at b-values of 1000 (D), 2000 (E), and 3000 s/mm2 (F), respectively, show intense hyperintensity inside the lesions with maximal suppression of free water at 3000 s/mm2 (F). G−I, ADC maps generated from DWI at different b-values (1000, 2000, and 3000 s/mm2) show a decrease in signal intensity inside the lesions with increasing b-values, suggestive of maximal suppression of extracellular water. J and K, The fast (J) and slow (K) component ADC maps derived from the biexponential fit in the abscess cavity have values of (1.11 ± 0.06) × 10−3 s/mm2 and (0.15 ± 0.23) × 10−3 s/mm2, respectively. Pus culture showed S aureus.
- Fig 2.
Scatterplot shows correlation between VCD with mean ADC values measured from different b-values (b = 1000, 2000, and 3000 s/mm2) within the abscess cavity of patients with brain abscess.
- Fig 3.
Graph shows biexponential fitting in the WM (A), GM (B), and abscess cavity (C) of patients with brain abscess. On increasing the b-value, there is a reduction in the signal intensity of combined ADC values and the fast ADC component in WM, GM, and the abscess cavity, but slow ADC component show gradual reduction from GM to WM with not much change in the abscess cavity.
Tables
- Table 1:
ADC values quantified from the abscess cavity, CNWM, and GM of patients with brain abscess and the WM and GM of healthy controls at different b-values
Regions ADCa P Value A (b = 1000) B (b = 2000) C (b = 3000) Patients (n = 30) Abscess cavity 0.59 ± 0.20 0.48 ± 0.13 0.39 ± 0.11 A vs B = .05; A vs C = .01, B vs C = .05 CNWM 0.64 ± 0.04 0.63 ± 0.11 0.62 ± 0.14 A vs B = .86, A vs C = .80, B vs C = .93 GM 0.74 ± 0.04 0.71 ± 0.12 0.71 ± 0.02 A vs B = .37, A vs C = .01, B vs C = .97 Healthy controls (n = 10) WM 0.82 ± 0.02 0.68 ± 0.02 0.58 ± 0.02 A vs B = .01, A vs C = .01, B vs C = .01 GM 0.78 ± 0.03 0.71 ± 0.01 0.64 ± 0.02 A vs B = .01, A vs C = .01, B vs C = .01 -
↵a (Mean ± SD) × 10−3 s/mm2.
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- Table 2:
Mean values of fast and slow components of ADC quantified from the abscess cavity, CNWM, and GM at different b-values of patients with brain abscess
Group ADCa P Value Abscess Cavity (A) CNWM (B) GM (C) Fast 1.11 ± 0.06 1.03 ± 0.13 1.12 ± 0.12 A vs B = .62, A vs C = .95, B vs C = .06 Slow 0.15 ± 0.23 0.26 ± 0.10 0.30 ± 0.02 A vs B = .09, A vs C = .01, B vs C = .1 -
↵a (Mean ± SD) × 10−3 s/mm2.
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