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AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates

Research ArticleSpine Imaging and Spine Image-Guided Interventions

Diffusion Tensor Imaging of the Pediatric Spinal Cord at 1.5T: Preliminary Results

F.B. Mohamed, L.N. Hunter, N. Barakat, C.-S.J. Liu, H. Sair, A.F. Samdani, R.R. Betz, S.H. Faro, J. Gaughan and M.J. Mulcahey
American Journal of Neuroradiology February 2011, 32 (2) 339-345; DOI: https://doi.org/10.3174/ajnr.A2334
F.B. Mohamed
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L.N. Hunter
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N. Barakat
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C.-S.J. Liu
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H. Sair
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A.F. Samdani
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R.R. Betz
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S.H. Faro
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J. Gaughan
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M.J. Mulcahey
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    Fig 1.

    Region-of-interest placement on an axial B0 image of the cervical spine used in this study.

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    Fig 2.

    Average FA values for controls compared with FA values for each individual subject, with SCI as a function of section number.

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    Fig 3.

    Average D values for controls compared with D values for each individual subject, with SCI as a function of section number.

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    Fig 4.

    Average radial D values for controls compared with radial D values for each individual subject, with SCI as a function section number.

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    Fig 5.

    Average axial D values for controls compared with D values for each individual subject, with SCI as a function of section number.

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    Fig 6.

    A, MR tractography images of the cervical spinal cord of a child with IS derived from FA values in the white matter tracts, a measure of degree of myelination of the white matter tracts along the spinal cord. B, Conventional midline sagittal T2-weighted image of a child with SCI (complete injury, ASIA A). C, An MR tractography image based on the FACT algorithm of the cervical spinal cord of the child in B. This algorithm failed, however, to track the rest of the cervical cord well below the injury (arrow) level, even though the FA measurements for this subject 4 showed recovery of FA values as seen in Fig 2.

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    Table 1:

    ISNCSCI scores for the subjects with SCI

    Subject No.Age (yr)AISNLMLSLSeverityTotal LT ScoreaTotal PP ScoreaTotal MSbASAC
    SCI18BC1C1C1Incomplete363234YesNo
    SCI214DC2C2C2Incomplete729372YesYes
    SCI315AC4C7C4Complete201629NoNo
    SCI49AC5C6C5Complete333126NoNo
    SCI512AC5C5C7Complete292443NoNo
    • a Maximum score, 112 points.

    • b Maximum score, 100 points.

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    Table 2:

    rs of DTI values obtained using ISNCSCI scores

    FA rs (P value < .0001)aD rs (P value < .0001)a
    PP score left0.28
    Manual muscle test score, upper extremities−0.290.16
    Manual muscle test score, lower extremities0.47−0.32
    Total MS0.28
    AC0.50−0.33
    Highest NL−0.26
    LT score, right S4–50.50−0.24
    LT score, left S4–50.50−0.26
    LT total score, S4–50.50−0.25
    PP score, right S4–50.50−0.27
    PP score, left S4–50.50−0.29
    Total PP, score S4–50.50−0.28
    • a P < .05 is significant.

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American Journal of Neuroradiology: 32 (2)
American Journal of Neuroradiology
Vol. 32, Issue 2
1 Feb 2011
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Cite this article
F.B. Mohamed, L.N. Hunter, N. Barakat, C.-S.J. Liu, H. Sair, A.F. Samdani, R.R. Betz, S.H. Faro, J. Gaughan, M.J. Mulcahey
Diffusion Tensor Imaging of the Pediatric Spinal Cord at 1.5T: Preliminary Results
American Journal of Neuroradiology Feb 2011, 32 (2) 339-345; DOI: 10.3174/ajnr.A2334

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Diffusion Tensor Imaging of the Pediatric Spinal Cord at 1.5T: Preliminary Results
F.B. Mohamed, L.N. Hunter, N. Barakat, C.-S.J. Liu, H. Sair, A.F. Samdani, R.R. Betz, S.H. Faro, J. Gaughan, M.J. Mulcahey
American Journal of Neuroradiology Feb 2011, 32 (2) 339-345; DOI: 10.3174/ajnr.A2334
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