MR Imaging of Brain Volumes: Evaluation of a Fully Automatic Software

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Fig 1.
Manual segmentation of brain volumes.
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Fig 2.
Comparison between manual and automatic volumes. A1 and B1, Plots of automatic versus manual for VV and ICV. The oblique dashed line represents the equality line. A2 and B2, The corresponding Bland-Altman plots for VV and ICV. The horizontal dashed lines are the confidence intervals of the difference between manual and automatic volumes.
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Fig 3.
Comparison between manual and automatic volumes. A1 and B1, The plots of automatic versus manual for BTV and WMHV. The oblique dashed line represents the equality line. A2 and B2, The corresponding Bland-Altman plots for BTV and WMHV. The horizontal dashed lines are the confidence intervals of the difference between manual and automatic volumes.

Table 1:

Brain volumes using the manual and the automatic tool Q_Brain^a

	VV^b (mL)		BTV^b (mL)		ICV^b (mL)		WMHV^b (mL)
	M	A	M	A	M	A	M	A
Mean ± SD	75 ± 60	81 ± 64	1183 ± 97	1172 ± 96	1513 ± 131	1465 ± 124	13 ± 16	10 ± 14
Median	49	51	1178	1158	1503	1459	5	4
Range	14–257	17–272	953–1385	928–1409	1188–1854	1146–1783	0–74	0–68

a N= 61.
b Statistically different between the mean manual and the mean automatic (P < .05).

Table 2:

Brain volume variability

Comparison	MD_VV (2SD, mL) MRD_VV (2SD, %)	MD_BTV (2SD, mL) MRD_BTV(2SD, %)	MD_ICV(2SD, mL) MRD_ICV (2SD, %)	MD_WMHV (2SD, mL) MRD_WMHV (2SD, %)
Obs1 vs Obs2	−1 (8)	−11 (34)	−10 (45)	−1 (6)
(n = 10)	−0.21 (14.45)	−0.78 (3.59)	−0.71 (3.12)	−8.47 (47.54)
Obs1 vs Obs1	1 (1)	4 (19)	6 (31)	−1 (3)
(n = 10)	0.75 (2.78)	1.00 (1.29)	0.37 (2.04)	−6.10 (11.09)
Obs1 vs Auto^a	−9 (8)	24 (65)	28 (90)	8 (10)
(n= 10)	−2.75 (9.66)	2.28 (5.62)	1.89 (6.08)	46.42 (11.88)
Obs1 vs Auto^a	−6 (10)	11 (70)	49 (93)	2 (9)
(n = 61)	−9.14 (10.78)	1.00 (6.00)	3.20 (5.94)	15.99 (80.66)