Multimodal Imaging Does Not Delay Intravenous Thrombolytic Therapy in Acute Stroke

American Journal of Neuroradiology

Table 1:

Patient characteristics by multimodal CT imaging status

Characteristic	Multimodal Imaging (n = 108)	Unenhanced CT Alone (n = 15)	P Value
Age ≥65	65.7 (71)	80.0 (12)	0.38
Female sex	59.3 (64)	60.0 (9)	0.96
Prehospital stroke notification	83.3 (90)	73.3 (11)	0.47
Peak arrival time (12pm to 12 am)	39.8 (43)	40.0 (6)	0.99
Weekday arrival (Monday–Friday)	70.4 (76)	66.7 (10)	0.77
Initial NIHSS Score ≥8	63.8 (67)	46.7 (7)	0.20
Onset-to-arrival time^a	48 (35–75)	50 (30–70)	0.99
Arrival to CT start time^a	11 (7–17)	15 (10–30)	0.11
Door-to-needle time^a	55 (41–75)	78 (53–114)	0.02
Year^b			0.56
2006	30.6 (33)	40.0 (6)
2007	32.4 (35)	26.7 (4)
2008	37.0 (40)	33.3 (5)

Table 2:

Patient characteristics by time to IV tPA initiation

Characteristic	≤60 Minutes to tPA (n = 67)	>60 Minutes to tPA (n = 56)	P Value
Multimodal CT imaging	92.5 (62)	82.1 (46)	.08
Age ≥65	68.7 (46)	66.1 (37)	.76
Female sex	59.7 (40)	58.9 (33)	.93
Prehospital stroke notification	89.6 (60)	73.2 (41)	.02^a
Peak arrival time (12pm to 12 am)	43.3 (29)	35.7 (20)	.39
Weekday arrival (Monday–Friday)	67.2 (45)	73.2 (41)	.47
Initial NIHSS score ≥ 8	68.2 (45)	53.7 (29)	.10
Onset-to-arrival time^a	50 (35–83)	44 (35–63)	.10
Arrival to CT start time^a	10 (6–15)	14 (9–26)	.01
Door-to-needle time^b	43 (37–50)	83.5 (70–95)	<.001
Year^b			.25
2006	34.3 (23)	28.6 (16)
2007	34.3 (23)	28.6 (16)
2008	31.4 (21)	42.9 (24)

Table 3:

Independent predictors of receiving IV tPA within 60 minutes from hospital arrival

Variable	OR	95% CI	P Value
Multimodal CT	3.99	0.91–17.49	.07
Alerted by EMS/transfer	3.47	1.11–10.88	.03
NIHSS score ≥ 8 (vs 0–7)	1.10	0.46–2.63	.83
Time from onset (min)	1.02	1.00–1.03	.04
Time from admit to CT (min)	0.94	0.90–0.99	.01