Skip to main content
Advertisement

Main menu

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • Video Articles
    • AJNR Case Collection
    • Case of the Week Archive
    • Case of the Month Archive
    • Classic Case Archive
  • Special Collections
    • AJNR Awards
    • Low-Field MRI
    • Alzheimer Disease
    • ASNR Foundation Special Collection
    • Photon-Counting CT
    • View All
  • Multimedia
    • AJNR Podcasts
    • AJNR SCANtastic
    • Trainee Corner
    • MRI Safety Corner
    • Imaging Protocols
  • For Authors
    • Submit a Manuscript
    • Submit a Video Article
    • Submit an eLetter to the Editor/Response
    • Manuscript Submission Guidelines
    • Statistical Tips
    • Fast Publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Imaging Protocol Submission
    • Author Policies
  • About Us
    • About AJNR
    • Editorial Board
    • Editorial Board Alumni
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home

User menu

  • Alerts
  • Log in

Search

  • Advanced search
American Journal of Neuroradiology
American Journal of Neuroradiology

American Journal of Neuroradiology

ASHNR American Society of Functional Neuroradiology ASHNR American Society of Pediatric Neuroradiology ASSR
  • Alerts
  • Log in

Advanced Search

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • Video Articles
    • AJNR Case Collection
    • Case of the Week Archive
    • Case of the Month Archive
    • Classic Case Archive
  • Special Collections
    • AJNR Awards
    • Low-Field MRI
    • Alzheimer Disease
    • ASNR Foundation Special Collection
    • Photon-Counting CT
    • View All
  • Multimedia
    • AJNR Podcasts
    • AJNR SCANtastic
    • Trainee Corner
    • MRI Safety Corner
    • Imaging Protocols
  • For Authors
    • Submit a Manuscript
    • Submit a Video Article
    • Submit an eLetter to the Editor/Response
    • Manuscript Submission Guidelines
    • Statistical Tips
    • Fast Publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Imaging Protocol Submission
    • Author Policies
  • About Us
    • About AJNR
    • Editorial Board
    • Editorial Board Alumni
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home
  • Follow AJNR on Twitter
  • Visit AJNR on Facebook
  • Follow AJNR on Instagram
  • Join AJNR on LinkedIn
  • RSS Feeds

AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates

Research ArticlePatient SafetyF
Open Access

Safety of High Doses of Urokinase and Reteplase for Acute Ischemic Stroke

V. Misra, R. El Khoury, R. Arora, P.R. Chen, S. Suzuki, N. Harun, N.R. Gonzales, A.D. Barreto, J.C. Grotta and S.I. Savitz
American Journal of Neuroradiology June 2011, 32 (6) 998-1001; DOI: https://doi.org/10.3174/ajnr.A2427
V. Misra
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
R. El Khoury
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
R. Arora
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
P.R. Chen
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
S. Suzuki
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
N. Harun
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
N.R. Gonzales
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
A.D. Barreto
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
J.C. Grotta
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
S.I. Savitz
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • Info & Metrics
  • Responses
  • References
  • PDF
Loading

References

  1. 1.↵
    1. Nogueira RG,
    2. Liebeskind DS,
    3. Sung G,
    4. et al
    . Predictors of good clinical outcomes, mortality, and successful revascularization in patients with acute ischemic stroke undergoing thrombectomy: pooled analysis of the Mechanical Embolus Removal in Cerebral Ischemia (MERCI) and Multi MERCI trials. Stroke 2009; 40: 3777– 83
    Abstract/FREE Full Text
  2. 2.↵
    1. Saqqur M,
    2. Molina CA,
    3. Salam A,
    4. et al
    . Clinical deterioration after intravenous tissue plasminogen activator treatment: a multicenter transcranial Doppler study. Stroke 2007; 38: 69– 74
    Abstract/FREE Full Text
  3. 3.↵
    1. Adams HP,
    2. del Zoppo G,
    3. Alberts MJ,
    4. et al
    . Guidelines for the early management of adults with ischemic stroke: a guideline from the American Heart Association/American Stroke Association Stroke Council, Clinical Cardiology Council, Cardiovascular Radiology and Intervention Council, and the Atherosclerotic Peripheral Vascular Disease and Quality of Care Outcomes in Research Interdisciplinary Working Groups: the American Academy of Neurology affirms the value of this guideline as an educational tool for neurologists. Stroke 2007; 38: 1655– 711
    Abstract/FREE Full Text
  4. 4.↵
    1. Shaltoni HM,
    2. Albright KC,
    3. Gonzales NR,
    4. et al
    . Is intra-arterial thrombolysis safe after full-dose intravenous recombinant tissue plasminogen activator for acute ischemic stroke? Stroke 2007; 38: 80– 84
    Abstract/FREE Full Text
  5. 5.↵
    1. Lee KY,
    2. Kim DI,
    3. Kim SH,
    4. et al
    . Sequential combination of intravenous recombinant tissue plasminogen activator and intra-arterial urokinase in acute ischemic stroke. AJNR Am J Neuroradiol 2004; 25: 1470– 75
    Abstract/FREE Full Text
  6. 6.↵
    1. Noser EA,
    2. Shaltoni HM,
    3. Hall CA,
    4. et al
    . Aggressive mechanical clot disruption: a safe adjunct to thrombolytic therapy in acute stroke? Stroke 2005; 36: 292– 96
    Abstract/FREE Full Text
  7. 7.↵
    1. Yoon W,
    2. Park MS,
    3. Cho KH.
    . Low-dose intra-arterial urokinase and aggressive mechanical clot disruption for acute ischemic stroke after failure of intravenous thrombolysis. AJNR Am J Neuroradiol 2010; 31: 161– 64
    Abstract/FREE Full Text
  8. 8.↵
    1. Qureshi AI,
    2. Siddiqui AM,
    3. Suri MF,
    4. et al
    . Aggressive mechanical clot disruption and low dose intra-arterial third-generation thrombolytic agent for ischemic stroke: a prospective study. Neurosurgery 2002; 51: 1319– 27
    PubMedWeb of Science
  9. 9.↵
    1. Georgiadis AL,
    2. Memon MZ,
    3. Shah QA,
    4. et al
    . Comparison of partial (.6 mg/kg) versus full-dose (.9 mg/kg) intravenous recombinant tissue plasminogen activator followed by endovascular treatment for acute ischemic stroke: a meta-analysis. J Neuroimaging 2009; Epub ahead of print
  10. 10.↵
    1. Sugg RM,
    2. Noser EA,
    3. Shaltoni HM,
    4. et al
    . Intra-arterial reteplase compared to urokinase for thrombolytic recanalization in acute ischemic stroke. AJNR Am J Neuroradiol 2006; 27: 769– 73
    Abstract/FREE Full Text
  11. 11.↵
    1. Lin R,
    2. Vora N,
    3. Zaidi S,
    4. et al
    . Mechanical approaches combined with intra-arterial pharmacologic therapy are associated with higher recanalization rates than either intervention alone in revascularization of acute carotid terminus occlusion. Stroke 2009; 40: 2092– 97
    Abstract/FREE Full Text
  12. 12.↵
    1. Tirschwell DL,
    2. Coplin WM,
    3. Becker KJ,
    4. et al
    . Intra-arterial urokinase for acute ischemic stroke: factors associated with complications. Neurology 2001; 57: 1100– 03
    Abstract/FREE Full Text
  13. 13.↵
    1. Qureshi AI,
    2. Suri MF,
    3. Shatla AA,
    4. et al
    . Intraarterial recombinant tissue plasminogen activator for acute ischemic stroke: an accelerating dose regimen. Neurosurgery 2000; 47: 473– 76
    PubMed
  14. 14.↵
    1. Vora NA,
    2. Gupta R,
    3. Thomas AJ,
    4. et al
    . Factors predicting hemorrhagic complications after multimodal reperfusion therapy for acute ischemic stroke. AJNR Am J Neuroradiol 2007; 28: 1391– 94
    Abstract/FREE Full Text
  15. 15.↵
    1. Soares BP,
    2. Chien JD,
    3. Wintermark M
    . MR and CT monitoring of recanalization, reperfusion, and penumbra salvage: everything that recanalizes does not necessarily reperfuse! Stroke 2009; 40: S24– 27
    Abstract/FREE Full Text
  16. 16.↵
    1. Grunwald MR,
    2. Hofmann LV
    . Comparison of urokinase, alteplase, and reteplase for catheter-directed thrombolysis of deep venous thrombosis. J Vasc Interv Radiol 2004; 15: 347– 52
    PubMedWeb of Science
  17. 17.↵
    1. Robertson I,
    2. Kessel DO,
    3. Berridge DC
    . Fibrinolytic agents for peripheral artery occlusion. Cochrane Database Syst Rev 2010; 3: CD001099
    PubMed
  18. 18.↵
    1. Ogawa A,
    2. Mori E,
    3. Minematsu K,
    4. et al
    . Randomized trial of intraarterial infusion of urokinase within 6 hours of middle cerebral artery stroke: the middle cerebral artery embolism local fibrinolytic intervention trial (MELT) Japan. Stroke 2007; 38: 2633– 39
    Abstract/FREE Full Text
  19. 19.↵
    1. Mori E,
    2. Tabuchi M,
    3. Yoshida T,
    4. et al
    . Intracarotid urokinase with thromboembolic occlusion of the middle cerebral artery. Stroke 1988; 19: 802– 12
    Abstract/FREE Full Text
  20. 20.↵
    1. Khatri P,
    2. Hill MD,
    3. Palesch YY,
    4. et al
    . Methodology of the Interventional Management of Stroke III trial. Int J Stroke 2008; 3: 130– 37
    CrossRefPubMedWeb of Science
  21. 21.↵
    MR and recanalization of stroke clots using embolectomy (MR RESCUE). http://www.clinicaltrials.gov/ct2/show/NCT00389467?term=MR+RESCUE+TRIAL&rank=1. Accessed July 1, 2009
PreviousNext
Back to top

In this issue

American Journal of Neuroradiology: 32 (6)
American Journal of Neuroradiology
Vol. 32, Issue 6
1 Jun 2011
  • Table of Contents
  • Index by author
Advertisement
Print
Download PDF
Email Article

Thank you for your interest in spreading the word on American Journal of Neuroradiology.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Safety of High Doses of Urokinase and Reteplase for Acute Ischemic Stroke
(Your Name) has sent you a message from American Journal of Neuroradiology
(Your Name) thought you would like to see the American Journal of Neuroradiology web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Cite this article
V. Misra, R. El Khoury, R. Arora, P.R. Chen, S. Suzuki, N. Harun, N.R. Gonzales, A.D. Barreto, J.C. Grotta, S.I. Savitz
Safety of High Doses of Urokinase and Reteplase for Acute Ischemic Stroke
American Journal of Neuroradiology Jun 2011, 32 (6) 998-1001; DOI: 10.3174/ajnr.A2427

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
0 Responses
Respond to this article
Share
Bookmark this article
Safety of High Doses of Urokinase and Reteplase for Acute Ischemic Stroke
V. Misra, R. El Khoury, R. Arora, P.R. Chen, S. Suzuki, N. Harun, N.R. Gonzales, A.D. Barreto, J.C. Grotta, S.I. Savitz
American Journal of Neuroradiology Jun 2011, 32 (6) 998-1001; DOI: 10.3174/ajnr.A2427
del.icio.us logo Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One
Purchase

Jump to section

  • Article
    • Abstract
    • Abbreviations
    • Materials and Methods
    • Results
    • Discussion
    • Conclusions
    • Footnotes
    • References
  • Figures & Data
  • Info & Metrics
  • Responses
  • References
  • PDF

Related Articles

  • No related articles found.
  • PubMed
  • Google Scholar

Cited By...

  • Reteplase versus alteplase for acute ischaemic stroke within 4.5 hours (RAISE): rationale and design of a multicentre, prospective, randomised, open-label, blinded-endpoint, controlled phase 3 non-inferiority trial
  • Crossref
  • Google Scholar

This article has not yet been cited by articles in journals that are participating in Crossref Cited-by Linking.

More in this TOC Section

  • Safety of Intrathecal Gadobutrol in Various Doses
  • Impact of Kidney Function on CNS Gadolinium Deposition in Patients Receiving Repeated Doses of Gadobutrol
  • Contrast-Induced Acute Kidney Injury in Radiologic Management of Acute Ischemic Stroke in the Emergency Setting
Show more Patient Safety

Similar Articles

Advertisement

Indexed Content

  • Current Issue
  • Accepted Manuscripts
  • Article Preview
  • Past Issues
  • Editorials
  • Editor's Choice
  • Fellows' Journal Club
  • Letters to the Editor
  • Video Articles

Cases

  • Case Collection
  • Archive - Case of the Week
  • Archive - Case of the Month
  • Archive - Classic Case

More from AJNR

  • Trainee Corner
  • Imaging Protocols
  • MRI Safety Corner
  • Book Reviews

Multimedia

  • AJNR Podcasts
  • AJNR Scantastics

Resources

  • Turnaround Time
  • Submit a Manuscript
  • Submit a Video Article
  • Submit an eLetter to the Editor/Response
  • Manuscript Submission Guidelines
  • Statistical Tips
  • Fast Publishing of Accepted Manuscripts
  • Graphical Abstract Preparation
  • Imaging Protocol Submission
  • Evidence-Based Medicine Level Guide
  • Publishing Checklists
  • Author Policies
  • Become a Reviewer/Academy of Reviewers
  • News and Updates

About Us

  • About AJNR
  • Editorial Board
  • Editorial Board Alumni
  • Alerts
  • Permissions
  • Not an AJNR Subscriber? Join Now
  • Advertise with Us
  • Librarian Resources
  • Feedback
  • Terms and Conditions
  • AJNR Editorial Board Alumni

American Society of Neuroradiology

  • Not an ASNR Member? Join Now

© 2025 by the American Society of Neuroradiology All rights, including for text and data mining, AI training, and similar technologies, are reserved.
Print ISSN: 0195-6108 Online ISSN: 1936-959X

Powered by HighWire