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References

1. 1.↵
   1. Hom J,
   2. Dankbaar JW,
   3. Soares BP,
   4. et al

   . Blood-brain barrier permeability assessed by perfusion CT predicts symptomatic hemorrhagic transformation and malignant edema in acute ischemic stroke. AJNR Am J Neuroradiol 2011;32:41–48

   Abstract/FREE Full Text
2. 2.↵
   1. Hacke W,
   2. Kaste M,
   3. Bluhmki E,
   4. et al

   . Thrombolysis with alteplase 3 to 4.5 hours after acute ischemic stroke. N Engl J Med 2008;359:1317–29

   CrossRefPubMed
3. 3.↵
   1. Wahlgren N,
   2. Ahmed N,
   3. Dávalos A,
   4. et al

   . Thrombolysis with alteplase for acute ischaemic stroke in the Safe Implementation of Thrombolysis in Stroke-Monitoring Study (SITS-MOST): an observational study. Lancet 2007;369:275–82

   CrossRefPubMed
4. 4.↵
   1. Hacke W,
   2. Donnan G,
   3. Fieschi C,
   4. et al.

   for the ATLANTIS Trials Investigators; ECASS Trials Investigators; NINDS rt-PA Study Group Investigators. Association of outcome with early stroke treatment: pooled analysis of ATLANTIS, ECASS, and NINDS rt-PA stroke trials. Lancet 2004;363:768–74

   CrossRefPubMedWeb of Science
5. 5.↵
   1. Hoffmann A,
   2. Bredno J,
   3. Wendland MF,
   4. et al

   . Validation of in vivo MRI blood-brain barrier permeability measurements by comparison with gold standard histology. Stroke. In press