Article Figures & Data
Figures
- Fig 1.
Diffusion parameters in relation to cognitive outcome. Mean FA skeleton (green) overlaid on the mean FA map in the axial, coronal, and sagittal planes. Regions of the mean FA skeleton in green voxels in which there is no correlation between FA and cognitive score. A, Voxels showing a significant correlation between FA and cognitive scores are shown in red-yellow. The graphs demonstrate the relationship between FA (R2 = 0.31, B), AD (R2 = 0.04, C), and RD (R2 = 0.13, D) and cognitive scaled scores from voxels in the CC (170 voxels), which showed a significant correlation between FA and cognitive score.
- Fig 2.
Diffusion parameters in relation to fine-motor scores. Mean FA skeleton (green) overlaid on the mean FA map in the axial, coronal, and sagittal planes. Regions of the mean FA skeleton in green represent voxels in which there is no correlation between FA and fine-motor score. A, Voxels showing a significant correlation between FA and fine-motor scores are in red-yellow. The graphs demonstrate the relationship between FA (R2 = 0.26, B), AD (R2 = 0.04, C), and RD (R2 = 0.28, D) and fine-motor scaled scores from voxels in the left PLIC (45 voxels), which showed a significant correlation between FA and fine-motor score.
- Fig 3.
Diffusion parameters in relation to gross-motor scores. Mean FA skeleton (green) overlaid on the mean FA map in the axial, coronal, and sagittal planes. Regions of the mean FA skeleton in green represent voxels where there was no correlation between FA and gross-motor score. A, Voxels showing a significant correlation between RD and gross-motor scores are in red-yellow. The graphs demonstrate the relationship between FA (R2 = 0.26, B), AD (R2 = 0.02, C), and RD (R2 = 0.22, D) and gross-motor scaled scores from voxels in the left PLIC (52 voxels), which showed a significant correlation between FA and gross-motor score.
Tables
Characteristics Total (n = 63) Gestational age, mean in weeks (range) 28.7 ± 1.7 (25.1–30.9) Birth weight, mean in grams (range) 1146 ± 335 (650–1910) Male, No. (%) 36 (57.1) Birthset: singleton/twins, No. (%) 51 (81.0)/12 (19.0) PPROM, no (%)a 13 (20.6) Antenatal steroids, No. (%)b 47 (74.6) Race, No. (%) Caucasian 50 (79.4) Other 12 (9.0) Mixed 1 (1.6) Apgar at 5 minutes, median (range) 9 (5–10) Late-onset sepsis positive blood culture, No. (%) 23 (36.5) Days of ventilation, median (range) 5 (0–23) IVH, No. (%) No IVH 46 (73.0) IVH I 5 (7.9) IVH II 7 (11.1) IVH III 4 (6.3) IVH IV 1 (1.6) Educational level of mother, No. (%)c Low 14 (22.2) Middle 21 (33.3) High 26 (41.3) Postmenstrual age, mean in weeks (range)d 41.6 ± 1.0 (39.6–44.7) -
↵a PPROM indicates preterm prolonged rupture of membranes.
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↵b Two doses of steroids administered 24 hours before labor.
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↵c Education level according to the CBS (Statistics Netherlands, The Hague, The Netherlands; http://www.cbs.nl/en-GB/menu/home/default.htm).
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↵d Postmenstrual age at the time of the scanning.
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Median Range Infants with Scores ≤1 SD (No.) Cognition Scaled score corrected agea 11 6–19 5 Composite score corrected ageb,c 105 80–145 5 Composite score chronologic agec,d 95 75–130 13 Fine motor: scaled score corrected agea,b 13 7–19 1 Gross motor: scaled score corrected agea,b 9 6–15 6 Total motor Composite score corrected ageb,c 107 88–133 0 Composite score chronologic agec,d 97 82–121 4
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