Article Figures & Data
Figures
- Fig 1.
A flow diagram of voxelwise analysis performed by TBSS. After spatial normalization to a stereotactic space using a default FMRIB58_FA template, tracts are traced in FA, AD, and RD maps. Voxels surviving P < .05 (corrected for multiple comparisons) are overlaid onto a group averaged FA map and their anatomic correspondence is defined by ICBM-DTI-81 white matter and Harvard-Oxford subcortical structural atlases.
- Fig 2.
Pattern of reduced fractional anisotropy (green) in patients with CJD compared with healthy normal controls. Results are overlaid onto a representative anatomic scan in Montreal Neurological Institute standard brain (MNI152) stereotactic space. Arrows indicate corresponding anatomic regions. Voxels are considered significant at a threshold of P < .05 (corrected for multiple comparisons).
- Fig 3.
Group averaged DTI indices of the significant voxels shown in Fig 1. Group averaged values of (A) FA, (B) MD, (C) AD, and (D) RD are plotted by diagnosis. The error bars represent standard deviations.
- Fig 4.
Pearson product-moment correlation between duration of illness and averaged FA over the significant voxels. Open circles represent mean FA values of each patient. The filled circles and error bar represent the mean and standard deviations of FA in controls.
Tables
Total number 21 Age (years) 59.4 ± 7.4 Male/Female 13/8 MMSE 20.9 ± 6.7 Clinical Neurological Scale 12.1 ± 5.8 Duration of illness (months) 2.8 ± 2.0 Survival after MRI (months) 4.3 ± 4.7 Symptoms (%) Brain stem dysfunction 57% Frontal release signs 86 Cerebellar signs 90 Extrapyramidal signs 86 Pyramidal signs 76 Cognitive impairment (MMSE<24) 60
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