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Research ArticleBrain
Open Access

Different Iron-Deposition Patterns of Multiple System Atrophy with Predominant Parkinsonism and Idiopathetic Parkinson Diseases Demonstrated by Phase-Corrected Susceptibility-Weighted Imaging

Y. Wang, S.R. Butros, X. Shuai, Y. Dai, C. Chen, M. Liu, E.M. Haacke, J. Hu and H. Xu
American Journal of Neuroradiology February 2012, 33 (2) 266-273; DOI: https://doi.org/10.3174/ajnr.A2765
Y. Wang
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S.R. Butros
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X. Shuai
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Y. Dai
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C. Chen
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M. Liu
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E.M. Haacke
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J. Hu
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H. Xu
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References

  1. 1.↵
    1. Stankiewicz J,
    2. Panter SS,
    3. Neema M,
    4. et al
    . Iron in chronic brain disorders: imaging and neurotherapeutic implications. Neurotherapeutics 2007; 4: 371– 86
    CrossRefPubMedWeb of Science
  2. 2.↵
    1. Thomas M,
    2. Jankovic J
    . Neurodegenerative disease and iron storage in the brain. Curr Opin Neurol 2004; 17: 437– 42
    CrossRefPubMedWeb of Science
  3. 3.↵
    1. Zhu WZ,
    2. Zhong WD,
    3. Wang W,
    4. et al
    . Quantitative MR phase-corrected imaging to investigate increased brain iron deposition of patients with Alzheimer disease. Radiology 2009; 253: 497– 504
    CrossRefPubMedWeb of Science
  4. 4.↵
    1. Haacke EM,
    2. Makki M,
    3. Ge Y,
    4. et al
    . Characterizing iron deposition in multiple sclerosis lesions using susceptibility weighted imaging. J Magn Reson Imaging 2009; 29: 537– 44
    CrossRefPubMed
  5. 5.↵
    1. Berg D,
    2. Hochstrasser H
    . Iron metabolism in Parkinsonian syndromes. Mov Disord 2006; 21: 1299– 310
    CrossRefPubMedWeb of Science
  6. 6.↵
    1. van Royen E,
    2. Verhoeff NF,
    3. Speelman JD,
    4. et al
    . Multiple system atrophy and progressive supranuclear palsy: diminished striatal D2 dopamine receptor activity demonstrated by 123I-IBZM single photon emission computed tomography. Arch Neurol 1993; 50: 513– 16
    CrossRefPubMedWeb of Science
  7. 7.↵
    1. Schulz JB,
    2. Klockgether T,
    3. Petersen D,
    4. et al
    . Multiple system atrophy: natural history, MRI morphology, and dopamine receptor imaging with 123IBZM-SPECT. J Neurol Neurosurg Psychiatry 1994; 57: 1047– 56
    Abstract/FREE Full Text
  8. 8.↵
    1. Poewe W,
    2. Wenning G
    . The differential diagnosis of Parkinson's disease. Eur J Neurol 2002; 9 (suppl 3): 23– 30
    PubMedWeb of Science
  9. 9.↵
    1. Wenning GK,
    2. Colosimo C
    . Diagnostic criteria for multiple system atrophy and progressive supranuclear palsy. Rev Neurol (Paris) 2010; 166: 829– 33. Epub 2010 Sep 1
    CrossRefPubMed
  10. 10.↵
    1. Ordidge RJ,
    2. Gorell JM,
    3. Deniau JC,
    4. et al
    . Assessment of relative brain iron concentrations using T2-weighted and T2*-weighted MRI at 3 Tesla. Magn Reson Med 1994; 32: 335– 41
    CrossRefPubMedWeb of Science
  11. 11.↵
    1. Gelman N,
    2. Gorell JM,
    3. Barker PB,
    4. et al
    . MR imaging of human brain at 3.0 T: preliminary report on transverse relaxation rates and relation to estimated iron content. Radiology 1999; 210: 759– 67
    PubMedWeb of Science
  12. 12.↵
    1. Bartzokis G,
    2. Tishler TA,
    3. Lu PH,
    4. et al
    . Brain ferritin iron may influence age- and gender-related risks of neurodegeneration. Neurobiol Aging 2007; 28: 414– 23
    CrossRefPubMedWeb of Science
  13. 13.↵
    1. Pfefferbaum A,
    2. Adalsteinsson E,
    3. Rohlfing T,
    4. et al
    . MRI estimates of brain iron concentration in normal aging: comparison of field-dependent (FDRI) and phase (SWI) methods. Neuroimage 2009; 47: 493– 500
    CrossRefPubMedWeb of Science
  14. 14.↵
    1. Jensen JH,
    2. Szulc K,
    3. Hu C,
    4. et al
    . Magnetic field correlation as a measure of iron-generated magnetic field inhomogeneities in the brain. Magn Reson Med 2009; 61: 481– 85
    CrossRefPubMed
  15. 15.↵
    1. Bartzokis G,
    2. Cummings JL,
    3. Markham CH,
    4. et al
    . MRI evaluation of brain iron in earlier- and later-onset Parkinson's disease and normal subjects. Magn Reson Imaging 1999; 17: 213– 22
    CrossRefPubMedWeb of Science
  16. 16.↵
    1. Bartzokis G,
    2. Cummings J,
    3. Perlman S,
    4. et al
    . Increased basal ganglia iron levels in Huntington disease. Arch Neurol 1999; 56: 569– 74
    CrossRefPubMedWeb of Science
  17. 17.↵
    1. Bartzokis G,
    2. Tishler TA
    . MRI evaluation of basal ganglia ferritin iron and neurotoxicity in Alzheimer's and Huntington's disease. Cell Mol Biol (Noisy-le-grand) 2000; 46: 821– 33
    PubMedWeb of Science
  18. 18.↵
    1. Bartzokis G,
    2. Tishler TA,
    3. Shin IS,
    4. et al
    . Brain ferritin iron as a risk factor for age at onset in neurodegenerative diseases. Ann N Y Acad Sci 2004; 1012: 224– 36
    CrossRefPubMedWeb of Science
  19. 19.↵
    1. Bishop GM,
    2. Robinson SR,
    3. Liu Q,
    4. et al
    . Iron: a pathological mediator of Alzheimer disease? Dev Neurosci 2002; 24: 184– 87
    CrossRefPubMedWeb of Science
  20. 20.↵
    1. Martin WR,
    2. Roberts TE,
    3. Ye FQ,
    4. et al
    . Increased basal ganglia iron in striatonigral degeneration: in vivo estimation with magnetic resonance. Can J Neurol Sci 1998; 25: 44– 47
    PubMedWeb of Science
  21. 21.↵
    1. Sipe JC,
    2. Lee P,
    3. Beutler E
    . Brain iron metabolism and neurodegenerative disorders. Dev Neurosci 2002; 24: 188– 96
    CrossRefPubMed
  22. 22.↵
    1. Schrag A,
    2. Good CD,
    3. Miszkiel K,
    4. et al
    . Differentiation of atypical parkinsonian syndromes with routine MRI. Neurology 2000; 54: 697– 702
    Abstract/FREE Full Text
  23. 23.↵
    1. Yekhlef F,
    2. Ballan G,
    3. Macia F,
    4. et al
    . Routine MRI for the differential diagnosis of Parkinson's disease, MSA, PSP, and CBD. J Neural Transm 2003; 110: 151– 69
    CrossRefPubMedWeb of Science
  24. 24.↵
    1. Reichenbach JR,
    2. Venkatesan R,
    3. Yablonskiy DA,
    4. et al
    . Theory and application of static field inhomogeneity effects in gradient-echo imaging. J Magn Reson Imaging 1997; 7: 266– 79
    CrossRefPubMedWeb of Science
  25. 25.↵
    1. Haacke EM,
    2. Cheng NY,
    3. House MJ,
    4. et al
    . Imaging iron stores in the brain using magnetic resonance imaging. Magn Reson Imaging 2005; 23: 1– 25
    CrossRefPubMedWeb of Science
  26. 26.↵
    1. Haacke EM,
    2. Xu Y,
    3. Cheng YC,
    4. et al
    . Susceptibility weighted imaging (SWI). Magn Reson Med 2004; 52: 612– 18
    CrossRefPubMedWeb of Science
  27. 27.↵
    1. Ogg RJ,
    2. Langston JW,
    3. Haacke EM,
    4. et al
    . The correlation between phase shifts in gradient-echo MR images and regional brain iron concentration. Magn Reson Imaging 1999; 17: 1141– 48
    CrossRefPubMedWeb of Science
  28. 28.↵
    1. Hughes AJ,
    2. Daniel SE,
    3. Kilford L,
    4. et al
    . Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinico-pathological study of 100 cases. J Neurol Neurosurg Psychiatry 1992; 55: 181– 84
    Abstract/FREE Full Text
  29. 29.↵
    1. Gilman S,
    2. Low PA,
    3. Quinn N,
    4. et al
    . Consensus statement on the diagnosis of multiple system atrophy. J Neurol Sci 1999; 163: 94– 98
    CrossRefPubMedWeb of Science
  30. 30.↵
    1. Haacke EM,
    2. Ayaz M,
    3. Khan A,
    4. et al
    . Establishing a baseline phase behavior in magnetic resonance imaging to determine normal vs. abnormal iron content in the brain. J Magn Reson Imaging 2007; 26: 256– 64
    CrossRefPubMedWeb of Science
  31. 31.↵
    1. Haacke EM,
    2. Miao Y,
    3. Liu M,
    4. et al
    . Correlation of putative iron content as represented by changes in R2* and phase with age in deep gray matter of healthy adults. J Magn Reson Imaging 2010; 32: 561– 76
    CrossRefPubMed
  32. 32.↵
    1. Hallgren B,
    2. Sourander P
    . The effect of age on the non-haemin iron in the human brain. J Neurochem 1958; 3: 41– 51
    CrossRefPubMedWeb of Science
  33. 33.↵
    1. Bartzokis G,
    2. Mintz J,
    3. Sultzer D,
    4. et al
    . In vivo MR evaluation of age-related increases in brain iron. AJNR Am J Neuroradiol 1994; 15: 1129– 38
    Abstract/FREE Full Text
  34. 34.↵
    1. Kurisaki H,
    2. Yomono H,
    3. Murayama S,
    4. et al
    . Multiple system atrophy with a-/hypo-ceruloplasminemia: distribution of iron in brains of 2 autopsy cases [in Japanese]. Rinsho Shinkeigaku 2002; 42: 293– 98
    PubMed
  35. 35.↵
    1. Spokes EG,
    2. Bannister R,
    3. Oppenheimer DR
    . Multiple system atrophy with autonomic failure: clinical, histological and neurochemical observations on four cases. J Neurol Sci 1979; 43: 59– 82
    CrossRefPubMedWeb of Science
  36. 36.↵
    1. Fearnley JM,
    2. Lees AJ
    . Striatonigral degeneration: a clinicopathological study. Brain 1990; 113 (pt 6): 1823– 42
    Abstract/FREE Full Text
  37. 37.↵
    1. Vymazal J,
    2. Righini A,
    3. Brooks RA,
    4. et al
    . T1 and T2 in the brain of healthy subjects, patients with Parkinson disease, and patients with multiple system atrophy: relation to iron content. Radiology 1999; 211: 489– 95
    PubMedWeb of Science
  38. 38.↵
    1. Kraft E,
    2. Trenkwalder C,
    3. Auer DP
    . T2*-weighted MRI differentiates multiple system atrophy from Parkinson's disease. Neurology 2002; 59: 1265– 67
    Abstract/FREE Full Text
  39. 39.↵
    1. von Lewinski F,
    2. Werner C,
    3. Jorn T,
    4. et al
    . T2*-weighted MRI in diagnosis of multiple system atrophy: a practical approach for clinicians. J Neurol 2007; 254: 1184– 88
    CrossRefPubMedWeb of Science
  40. 40.↵
    1. Lantos PL,
    2. Papp MI
    . Cellular pathology of multiple system atrophy: a review. J Neurol Neurosurg Psychiatry 1994; 57: 129– 33
    FREE Full Text
  41. 41.↵
    1. Kraft E,
    2. Schwarz J,
    3. Trenkwalder C,
    4. et al
    . The combination of hypointense and hyperintense signal changes on T2-weighted magnetic resonance imaging sequences: a specific marker of multiple system atrophy? Arch Neurol 1999; 56: 225– 28
    CrossRefPubMedWeb of Science
  42. 42.↵
    1. Brass SD,
    2. Chen NK,
    3. Mulkern RV,
    4. et al
    . Magnetic resonance imaging of iron deposition in neurological disorders. Top Magn Reson Imaging 2006; 17: 31– 40
    CrossRefPubMed
  43. 43.↵
    1. Atasoy HT,
    2. Nuyan O,
    3. Tunc T,
    4. et al
    . T2-weighted MRI in Parkinson's disease; substantia nigra pars compacta hypointensity correlates with the clinical scores. Neurol India 2004; 52: 332– 37
    PubMed
  44. 44.↵
    1. Kosta P,
    2. Argyropoulou MI,
    3. Markoula S,
    4. et al
    . MRI evaluation of the basal ganglia size and iron content in patients with Parkinson's disease. J Neurol 2006; 253: 26– 32
    CrossRefPubMedWeb of Science
  45. 45.↵
    1. Gorell JM,
    2. Ordidge RJ,
    3. Brown GG,
    4. et al
    . Increased iron-related MRI contrast in the substantia nigra in Parkinson's disease. Neurology 1995; 45: 1138– 43
    Abstract/FREE Full Text
  46. 46.↵
    1. Graham JM,
    2. Paley MN,
    3. Grunewald RA,
    4. et al
    . Brain iron deposition in Parkinson's disease imaged using the PRIME magnetic resonance sequence. Brain 2000; 123 (pt 12): 2423– 31
    Abstract/FREE Full Text
  47. 47.↵
    1. Michaeli S,
    2. Oz G,
    3. Sorce DJ,
    4. et al
    . Assessment of brain iron and neuronal integrity in patients with Parkinson's disease using novel MRI contrasts. Mov Disord 2007; 22: 334– 40
    CrossRefPubMed
  48. 48.↵
    1. Feng F,
    2. You H,
    3. Wang H,
    4. et al
    . Phase-weighted imaging in differentiating multiple system atrophy from idiopathic Parkinson disease [in Chinese]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao 2009; 31: 129– 33
    PubMed
  49. 49.↵
    1. Gupta D,
    2. Saini J,
    3. Kesavadas C,
    4. et al
    . Utility of susceptibility-weighted MRI in differentiating Parkinson's disease and atypical parkinsonism. Neuroradiology 2010; 52: 1087– 94
    CrossRefPubMedWeb of Science
  50. 50.↵
    1. Wang YH,
    2. Dai YM,
    3. Xu HB
    . High iron percentage in human brain-idiopathic Parkinsons, Parkinsonism and healthy cases. DOI: 10.1594/ecr2010/C-2511. 2010
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Y. Wang, S.R. Butros, X. Shuai, Y. Dai, C. Chen, M. Liu, E.M. Haacke, J. Hu, H. Xu
Different Iron-Deposition Patterns of Multiple System Atrophy with Predominant Parkinsonism and Idiopathetic Parkinson Diseases Demonstrated by Phase-Corrected Susceptibility-Weighted Imaging
American Journal of Neuroradiology Feb 2012, 33 (2) 266-273; DOI: 10.3174/ajnr.A2765

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Different Iron-Deposition Patterns of Multiple System Atrophy with Predominant Parkinsonism and Idiopathetic Parkinson Diseases Demonstrated by Phase-Corrected Susceptibility-Weighted Imaging
Y. Wang, S.R. Butros, X. Shuai, Y. Dai, C. Chen, M. Liu, E.M. Haacke, J. Hu, H. Xu
American Journal of Neuroradiology Feb 2012, 33 (2) 266-273; DOI: 10.3174/ajnr.A2765
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  • Comparison of 3T and 7T Susceptibility-Weighted Angiography of the Substantia Nigra in Diagnosing Parkinson Disease
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