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Research ArticlePharmacology Vignette

Dabigatran (Pradaxa)

J. Comin and D.F. Kallmes
American Journal of Neuroradiology March 2012, 33 (3) 426-428; DOI: https://doi.org/10.3174/ajnr.A3000
J. Comin
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D.F. Kallmes
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References

  1. 1.↵
    1. Ammollo C,
    2. Semeraro F,
    3. Incampo F,
    4. et al
    . Dabigatran enhances clot susceptibility to fibrinolysis by mechanisms dependent on and independent of thrombin-activatable fibrinolysis inhibitor. J Thromb Haemost 2010; 8: 790– 98
    CrossRefPubMed
  2. 2.↵
    1. Connolly S,
    2. Ezekowitz M,
    3. Yusuf S,
    4. et al
    . Dabigatran versus warfarin in patients with atrial fibrillation. N Engl J Med 2009; 361: 1139– 51
    CrossRefPubMedWeb of Science
  3. 3.↵
    1. Stangier J,
    2. Rathgen K,
    3. Stahle H,
    4. et al
    . The pharmacokinetics, pharmacodynamics and tolerability of dabigatran etexilate, a new oral direct thrombin inhibitor, in healthy male subjects. Br J Clin Pharmacol 2007; 64: 292– 303
    CrossRefPubMedWeb of Science
  4. 4.↵
    1. Stangier J,
    2. Stahle H,
    3. Rathgen K,
    4. et al
    . Pharmacokinetics and pharmacodynamics of the direct oral thrombin inhibitor dabigatran in healthy elderly subjects. Clin Pharmacokinet 2008; 47: 47– 59
    CrossRefPubMedWeb of Science
  5. 5.↵
    1. Stangier J,
    2. Rathgen K,
    3. Stahle H,
    4. et al
    . Influence of renal impairment on the pharmacokinetics and pharmacodynamics of oral dabigatran etexilate: an open-label, parallel-group, single-centre study. Clin Pharmacokinet 2010; 49: 259– 68
    CrossRefPubMedWeb of Science
  6. 6.↵
    1. Lauer A,
    2. Cianchetti F,
    3. Van Cott E,
    4. et al
    . Anticoagulation with the oral direct thrombin inhibitor dabigatran does not enlarge hematoma volume in experimental intracerebral hemorrhage. Circulation 2011; 124: 1654– 62. Epub 2011 Sep 12.
    Abstract/FREE Full Text
  7. 7.↵
    1. Celikel R,
    2. McClintock R,
    3. Roberts J,
    4. et al
    . Modulation of alpha-thrombin function by distinct interactions with platelet glycoprotein Ib alpha. Science 2003; 301: 218– 21
    Abstract/FREE Full Text
  8. 8.↵
    1. Eriksson B,
    2. Quinlan D,
    3. Weitz J
    . Comparative pharmacodynamics and pharmacokinetics of oral direct thrombin and factor xa inhibitors in development. Clin Pharmacokinet 2009; 48: 1– 22
    CrossRefPubMedWeb of Science
  9. 9.↵
    1. Liesenfeld K,
    2. Schafer H,
    3. Troconiz I,
    4. et al
    . Effects of the direct thrombin inhibitor dabigatran on ex vivo coagulation time in orthopedic surgery patients: a population model analysis. Br J Clin Pharmacol 2006; 62: 527– 37
    CrossRefPubMedWeb of Science
  10. 10.↵
    Pradaxa [package insert]. Ridgefield, Connecticut: Boehringer Ingelheim Pharmaceuticals; 2003.
  11. 11.↵
    1. Van Ryn J,
    2. Stangier J,
    3. Naertter S,
    4. et al
    . Dabigatran etexilate: a novel, reversible, oral direct thrombin inhibitor—interpretation of coagulation assays and reversal of anticoagulant activity. Thrombo Haemost 2010; 103: 1116– 27
    CrossRefPubMedWeb of Science
  12. 12.↵
    1. Flaker G,
    2. Weachter R
    . Pharmacologic strategies for the prevention of stroke in patients with atrial fibrillation. Curr Treat Options Cardiovasc Med 2011; 13: 361– 69
    CrossRefPubMed
  13. 13.↵
    1. Freeman J,
    2. Zhu R,
    3. Owens D,
    4. et al
    . Cost-effectiveness of dabigatran compared with warfarin for stroke prevention in atrial fibrillation. Ann Intern Med 2011; 154: 1– 11. Epub 2010 Nov 1
    CrossRefPubMedWeb of Science
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American Journal of Neuroradiology: 33 (3)
American Journal of Neuroradiology
Vol. 33, Issue 3
1 Mar 2012
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J. Comin, D.F. Kallmes
Dabigatran (Pradaxa)
American Journal of Neuroradiology Mar 2012, 33 (3) 426-428; DOI: 10.3174/ajnr.A3000

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Dabigatran (Pradaxa)
J. Comin, D.F. Kallmes
American Journal of Neuroradiology Mar 2012, 33 (3) 426-428; DOI: 10.3174/ajnr.A3000
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