Skip to main content
Advertisement

Main menu

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • AJNR Case Collection
    • Case of the Week Archive
    • Classic Case Archive
    • Case of the Month Archive
  • Special Collections
    • Spinal CSF Leak Articles (Jan 2020-June 2024)
    • 2024 AJNR Journal Awards
    • Most Impactful AJNR Articles
  • Multimedia
    • AJNR Podcast
    • AJNR Scantastics
    • Video Articles
  • For Authors
    • Submit a Manuscript
    • Author Policies
    • Fast publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Manuscript Submission Guidelines
    • Imaging Protocol Submission
    • Submit a Case for the Case Collection
  • About Us
    • About AJNR
    • Editorial Board
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home
  • Other Publications
    • ajnr

User menu

  • Alerts
  • Log in

Search

  • Advanced search
American Journal of Neuroradiology
American Journal of Neuroradiology

American Journal of Neuroradiology

ASHNR American Society of Functional Neuroradiology ASHNR American Society of Pediatric Neuroradiology ASSR
  • Alerts
  • Log in

Advanced Search

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • AJNR Case Collection
    • Case of the Week Archive
    • Classic Case Archive
    • Case of the Month Archive
  • Special Collections
    • Spinal CSF Leak Articles (Jan 2020-June 2024)
    • 2024 AJNR Journal Awards
    • Most Impactful AJNR Articles
  • Multimedia
    • AJNR Podcast
    • AJNR Scantastics
    • Video Articles
  • For Authors
    • Submit a Manuscript
    • Author Policies
    • Fast publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Manuscript Submission Guidelines
    • Imaging Protocol Submission
    • Submit a Case for the Case Collection
  • About Us
    • About AJNR
    • Editorial Board
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home
  • Follow AJNR on Twitter
  • Visit AJNR on Facebook
  • Follow AJNR on Instagram
  • Join AJNR on LinkedIn
  • RSS Feeds

Welcome to the new AJNR, Updated Hall of Fame, and more. Read the full announcements.


AJNR is seeking candidates for the position of Associate Section Editor, AJNR Case Collection. Read the full announcement.

 

Research ArticleBrainE
Open Access

The Added Value of Apparent Diffusion Coefficient to Cerebral Blood Volume in the Preoperative Grading of Diffuse Gliomas

A. Hilario, A. Ramos, A. Perez-Nuñez, E. Salvador, J.M. Millan, A. Lagares, J.M. Sepulveda, P. Gonzalez-Leon, A. Hernandez-Lain and J.R. Ricoy
American Journal of Neuroradiology April 2012, 33 (4) 701-707; DOI: https://doi.org/10.3174/ajnr.A2846
A. Hilario
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
A. Ramos
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
A. Perez-Nuñez
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
E. Salvador
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
J.M. Millan
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
A. Lagares
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
J.M. Sepulveda
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
P. Gonzalez-Leon
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
A. Hernandez-Lain
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
J.R. Ricoy
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • Info & Metrics
  • Responses
  • References
  • PDF
Loading

References

  1. 1.↵
    1. Warmuth C,
    2. Günther M,
    3. Zimmer C
    . Quantification of blood flow in brain tumors: comparison of arterial spin labeling and dynamic susceptibility-weighted contrast-enhanced MR imaging. Radiology 2003;228: 523–32
    CrossRefPubMedWeb of Science
  2. 2.↵
    1. Hakyemez B,
    2. Erdogan C,
    3. Ercan I,
    4. et al
    . High-grade and low-grade gliomas: differentiation by using perfusion MR imaging. Clin Radiol 2005;60: 493–502
    CrossRefPubMed
  3. 3.↵
    1. Hirai T,
    2. Murakami R,
    3. Nakamura H,
    4. et al
    . Prognostic value of perfusion MR imaging of high-grade astrocytomas: long-term follow-up study. AJNR Am J Neuroradiol 2008;29: 1505–10
    Abstract/FREE Full Text
  4. 4.↵
    1. Bulakbasi N,
    2. Kocaoglu M,
    3. Farzaliyev A,
    4. et al
    . Assessment of diagnostic accuracy of perfusion MR imaging in primary and metastatic solitary malignant brain tumors. AJNR Am J Neuroradiol 2005;26: 2187–99
    Abstract/FREE Full Text
  5. 5.↵
    1. Rollin N,
    2. Guyotat J,
    3. Streichenberger N,
    4. et al
    . Clinical relevance of diffusion and perfusion magnetic resonance in assessing intra-axial brain tumors. Neuroradiology 2006;48: 150–59
    CrossRefPubMed
  6. 6.↵
    1. Sadeghi N,
    2. D'Haene N,
    3. Decaestecker C,
    4. et al
    . Apparent diffusion coefficient and cerebral blood volume in brain gliomas: relation to tumor cell density and tumor microvessel density based on stereotactic biopsies. AJNR Am J Neuroradiol 2008;29: 476–82
    Abstract/FREE Full Text
  7. 7.↵
    1. Cha S
    . Update on brain tumor imaging: from anatomy to physiology. AJNR Am J Neuroradiol 2006;27: 475–87
    FREE Full Text
  8. 8.↵
    1. Gupta RK,
    2. Cloughesy TF,
    3. Sinha U,
    4. et al
    . Relationships between choline magnetic resonance spectroscopy, apparent diffusion coefficient and quantitative histopathology in human glioma. J Neurooncol 2000;50: 215–26
    CrossRefPubMed
  9. 9.↵
    1. Cha S,
    2. Knopp EA,
    3. Johnson G,
    4. et al
    . Intracranial mass lesions: dynamic contrast-enhanced susceptibility-weighted echo-planar perfusion MR imaging. Radiology 2002;233: 11–29
  10. 10.↵
    1. Louis DN,
    2. Ohgaki H,
    3. Wiestler OD,
    4. et al.
    , eds. WHO Classification of Tumours of the Central Nervous System. 4th ed. Lyon, France: IARC Press; 2007
  11. 11.↵
    1. Lacerda S,
    2. Law M
    . Magnetic resonance perfusion and permeability imaging in brain tumors. Neuroimaging Clin N Am 2009;19: 527–57
    CrossRefPubMedWeb of Science
  12. 12.↵
    1. Wetzel SG,
    2. Cha S,
    3. Johnson G,
    4. et al
    . Relative cerebral blood volume measurements in intracranial mass lesions: interobserver and intraobserver reproducibility study. Radiology 2002;224: 797–803
    CrossRefPubMedWeb of Science
  13. 13.↵
    1. Lee EJ,
    2. Lee SK,
    3. Agid R,
    4. et al
    . Preoperative grading of presumptive low-grade astrocytomas on MR imaging: diagnostic value of minimum apparent diffusion coefficient. AJNR Am J Neuroradiol 2008;29: 1872–77
    Abstract/FREE Full Text
  14. 14.↵
    1. Knopp EA,
    2. Cha S,
    3. Johnson G,
    4. et al
    . Glial neoplasms: dynamic contrast-enhanced T2*-weighted MR imaging. Radiology 1999;211: 791–98
    CrossRefPubMedWeb of Science
  15. 15.↵
    1. McKnight TR,
    2. Lamborn KR,
    3. Love TD,
    4. et al
    . Correlation of magnetic resonance spectroscopic and growth characteristics within grade II and III gliomas. J Neurosurg 2007;106: 660–66
    CrossRefPubMedWeb of Science
  16. 16.↵
    1. Law M,
    2. Yang S,
    3. Wang H,
    4. et al
    . Glioma grading: sensitivity, specificity, and predictive values of perfusion MR imaging and proton MR spectroscopic imaging compared with conventional MR imaging. AJNR Am J Neuroradiol 2003;24: 1989–98
    Abstract/FREE Full Text
  17. 17.↵
    1. Kim HS,
    2. Kim SY
    . A prospective study on the added value of pulsed arterial spin labeling and apparent diffusion coefficients in the grading of gliomas. AJNR Am J Neuroradiol 2007;28: 1693–99
    Abstract/FREE Full Text
  18. 18.↵
    1. Sugahara T,
    2. Korogi Y,
    3. Kochi M,
    4. et al
    . Usefulness of diffusion-weighted MRI with echo-planar technique in the evaluation of cellularity in gliomas. J Magn Reson Imaging 1999;9: 53–60
    CrossRefPubMedWeb of Science
  19. 19.↵
    1. Aronen HJ,
    2. Gazit IE,
    3. Louis DN,
    4. et al
    . Cerebral blood volume maps of gliomas: comparison with tumor grade and histologic findings. Radiology 1994;191: 41–51
    CrossRefPubMedWeb of Science
  20. 20.↵
    1. Law M,
    2. Yang S,
    3. Babb JS,
    4. et al
    . Comparison of cerebral blood volume and vascular permeability from dynamic susceptibility contrast-enhanced perfusion MR imaging with glioma grade. AJNR Am J Neuroradiol 2004;25: 746–55
    Abstract/FREE Full Text
  21. 21.↵
    1. Boxerman JL,
    2. Schmainda KM,
    3. Weisskoff RM
    . Relative cerebral blood volume maps corrected for contrast agent extravasation significantly correlate with glioma tumor grade, whereas uncorrected maps do not. AJNR Am J Neuroradiol 2006;27: 859–67
    Abstract/FREE Full Text
  22. 22.↵
    1. Lev MH,
    2. Ozsunar Y,
    3. Henson JW,
    4. et al
    . Glial tumor grading and outcome prediction using dynamic spin-echo MR susceptibility mapping compared with conventional contrast-enhanced MR: confounding effect of elevated rCBV of oligodendrogliomas. AJNR Am J Neuroradiol 2004;25: 214–21
    Abstract/FREE Full Text
  23. 23.↵
    1. Lev MH,
    2. Rosen BR
    . Clinical applications of intracranial perfusion MR imaging. Neuroimaging Clin N Am 1999;9: 309–31
    PubMedWeb of Science
  24. 24.↵
    1. Shin JH,
    2. Lee HK,
    3. Kwun BD,
    4. et al
    . Using relative cerebral blood flow and volume to evaluate the histopathologic grade of cerebral gliomas: preliminary results. AJR Am J Roentgenol 2002;179: 783–89
    CrossRefPubMed
  25. 25.↵
    1. Law M,
    2. Young RJ,
    3. Babb JS,
    4. et al
    . Gliomas: predicting time to progression or survival with cerebral blood volume measurements at dynamic susceptibility-weighted contrast-enhanced perfusion MR imaging. Radiology 2008;247: 490–98
    CrossRefPubMedWeb of Science
  26. 26.↵
    1. Kwee TC,
    2. Galban CJ,
    3. Tsien C,
    4. et al
    . Comparison of apparent diffusion coefficients and distributed diffusion coefficients in high-grade gliomas. J Magn Reson Imaging 2010;31: 531–37
    CrossRefPubMed
  27. 27.↵
    1. Kono K,
    2. Inoue Y,
    3. Nakayama K,
    4. et al
    . The role of diffusion-weighted imaging in patients with brain tumors. AJNR Am J Neuroradiol 2001;22: 1081–88
    Abstract/FREE Full Text
  28. 28.↵
    1. Yamasaki F,
    2. Kurisu K,
    3. Satoh K,
    4. et al
    . Apparent diffusion coefficient of human brain tumors at MR imaging. Radiology 2005;235: 985–91
    CrossRefPubMedWeb of Science
  29. 29.↵
    1. Kitis O,
    2. Altay H,
    3. Calli C,
    4. et al
    . Minimum apparent diffusion coefficients in the evaluation of brain tumors. Eur J Radiol 2005;55: 393–400
    CrossRefPubMed
  30. 30.↵
    1. Calli C,
    2. Kitis O,
    3. Yunten N,
    4. et al
    . Perfusion and diffusion MR imaging in enhancing malignant cerebral tumors. Eur J Radiol 2006;58: 393–403
  31. 31.↵
    1. Yang D,
    2. Korogi Y,
    3. Sugahara T,
    4. et al
    . Cerebral gliomas: prospective comparison of multivoxel 2D chemical-shift imaging proton MR spectroscopy, echo-planar perfusion and diffusion-weighted MRI. Neuroradiology 2002;44: 656–66
    CrossRefPubMed
  32. 32.↵
    1. Stadnik TW,
    2. Chaskis C,
    3. Michotte A,
    4. et al
    . Diffusion-weighted MR imaging of intracerebral masses: comparison with conventional MR imaging and histologic findings. AJNR Am J Neuroradiol 2001;22: 969–76
    Abstract/FREE Full Text
PreviousNext
Back to top

In this issue

American Journal of Neuroradiology: 33 (4)
American Journal of Neuroradiology
Vol. 33, Issue 4
1 Apr 2012
  • Table of Contents
  • Index by author
Advertisement
Print
Download PDF
Email Article

Thank you for your interest in spreading the word on American Journal of Neuroradiology.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
The Added Value of Apparent Diffusion Coefficient to Cerebral Blood Volume in the Preoperative Grading of Diffuse Gliomas
(Your Name) has sent you a message from American Journal of Neuroradiology
(Your Name) thought you would like to see the American Journal of Neuroradiology web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Cite this article
A. Hilario, A. Ramos, A. Perez-Nuñez, E. Salvador, J.M. Millan, A. Lagares, J.M. Sepulveda, P. Gonzalez-Leon, A. Hernandez-Lain, J.R. Ricoy
The Added Value of Apparent Diffusion Coefficient to Cerebral Blood Volume in the Preoperative Grading of Diffuse Gliomas
American Journal of Neuroradiology Apr 2012, 33 (4) 701-707; DOI: 10.3174/ajnr.A2846

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
0 Responses
Respond to this article
Share
Bookmark this article
The Added Value of Apparent Diffusion Coefficient to Cerebral Blood Volume in the Preoperative Grading of Diffuse Gliomas
A. Hilario, A. Ramos, A. Perez-Nuñez, E. Salvador, J.M. Millan, A. Lagares, J.M. Sepulveda, P. Gonzalez-Leon, A. Hernandez-Lain, J.R. Ricoy
American Journal of Neuroradiology Apr 2012, 33 (4) 701-707; DOI: 10.3174/ajnr.A2846
del.icio.us logo Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One
Purchase

Jump to section

  • Article
    • Abstract
    • ABBREVIATIONS:
    • Materials and Methods
    • Results
    • Discussion
    • Conclusion
    • Footnotes
    • References
  • Figures & Data
  • Info & Metrics
  • Responses
  • References
  • PDF

Related Articles

  • No related articles found.
  • PubMed
  • Google Scholar

Cited By...

  • Utility of Early Postoperative DWI to Assess the Extent of Resection of Adult-Type World Health Organization Grade 2 and 3 Diffuse Gliomas
  • Differentiating Low-Grade from High-Grade Intracranial Ependymomas: Comparison of Dynamic Contrast-Enhanced MRI and Diffusion-Weighted Imaging
  • Utilizing the Amide Proton Transfer Technique to Characterize Diffuse Gliomas Based on the WHO 2021 Classification of CNS Tumors
  • Regional and Volumetric Parameters for Diffusion-Weighted WHO Grade II and III Glioma Genotyping: A Method Comparison
  • High-Grade Gliomas in Children with Neurofibromatosis Type 1: Literature Review and Illustrative Cases
  • Predicting Genotype and Survival in Glioma Using Standard Clinical MR Imaging Apparent Diffusion Coefficient Images: A Pilot Study from The Cancer Genome Atlas
  • 3D Pseudocontinuous Arterial Spin-Labeling MR Imaging in the Preoperative Evaluation of Gliomas
  • Discrimination between Glioma Grades II and III Using Dynamic Susceptibility Perfusion MRI: A Meta-Analysis
  • Comparison of the Effect of Vessel Size Imaging and Cerebral Blood Volume Derived from Perfusion MR Imaging on Glioma Grading
  • Mean Diffusional Kurtosis in Patients with Glioma: Initial Results with a Fast Imaging Method in a Clinical Setting
  • Diffusion-Weighted Imaging in Cancer: Physical Foundations and Applications of Restriction Spectrum Imaging
  • A Prognostic Model Based on Preoperative MRI Predicts Overall Survival in Patients with Diffuse Gliomas
  • Multimodal MR Imaging (Diffusion, Perfusion, and Spectroscopy): Is It Possible to Distinguish Oligodendroglial Tumor Grade and 1p/19q Codeletion in the Pretherapeutic Diagnosis?
  • Crossref (116)
  • Google Scholar

This article has been cited by the following articles in journals that are participating in Crossref Cited-by Linking.

  • Advances in neuro-oncology imaging
    Karl-Josef Langen, Norbert Galldiks, Elke Hattingen, Nadim Jon Shah
    Nature Reviews Neurology 2017 13 5
  • Diffusion-Weighted Imaging in Cancer: Physical Foundations and Applications of Restriction Spectrum Imaging
    Nathan S. White, Carrie R. McDonald, Niky Farid, Josh Kuperman, David Karow, Natalie M. Schenker-Ahmed, Hauke Bartsch, Rebecca Rakow-Penner, Dominic Holland, Ahmed Shabaik, Atle Bjørnerud, Tuva Hope, Jona Hattangadi-Gluth, Michael Liss, J. Kellogg Parsons, Clark C. Chen, Steve Raman, Daniel Margolis, Robert E. Reiter, Leonard Marks, Santosh Kesari, Arno J. Mundt, Christopher J. Kane, Bob S. Carter, William G. Bradley, Anders M. Dale
    Cancer Research 2014 74 17
  • Glioma: Application of Whole-Tumor Texture Analysis of Diffusion-Weighted Imaging for the Evaluation of Tumor Heterogeneity
    Young Jin Ryu, Seung Hong Choi, Sang Joon Park, Tae Jin Yun, Ji-Hoon Kim, Chul-Ho Sohn, Christopher P. Hess
    PLoS ONE 2014 9 9
  • Diagnostic performance of texture analysis on MRI in grading cerebral gliomas
    Karoline Skogen, Anselm Schulz, Johann Baptist Dormagen, Balaji Ganeshan, Eirik Helseth, Andrès Server
    European Journal of Radiology 2016 85 4
  • Diffusion- and perfusion-weighted MRI radiomics model may predict isocitrate dehydrogenase (IDH) mutation and tumor aggressiveness in diffuse lower grade glioma
    Minjae Kim, So Yeong Jung, Ji Eun Park, Yeongheun Jo, Seo Young Park, Soo Jung Nam, Jeong Hoon Kim, Ho Sung Kim
    European Radiology 2020 30 4
  • Differentiation of high-grade and low-grade diffuse gliomas by intravoxel incoherent motion MR imaging
    Osamu Togao, Akio Hiwatashi, Koji Yamashita, Kazufumi Kikuchi, Masahiro Mizoguchi, Koji Yoshimoto, Satoshi O. Suzuki, Toru Iwaki, Makoto Obara, Marc Van Cauteren, Hiroshi Honda
    Neuro-Oncology 2016 18 1
  • Multimodal MR Imaging (Diffusion, Perfusion, and Spectroscopy): Is It Possible to Distinguish Oligodendroglial Tumor Grade and 1p/19q Codeletion in the Pretherapeutic Diagnosis?
    S. Fellah, D. Caudal, A.M. De Paula, P. Dory-Lautrec, D. Figarella-Branger, O. Chinot, P. Metellus, P.J. Cozzone, S. Confort-Gouny, B. Ghattas, V. Callot, N. Girard
    American Journal of Neuroradiology 2013 34 7
  • Which Combination of MR Imaging Modalities Is Best for Predicting Recurrent Glioblastoma? Study of Diagnostic Accuracy and Reproducibility
    Ho Sung Kim, Myeong Ju Goh, Namkug Kim, Choong Gon Choi, Sang Joon Kim, Jeong Hoon Kim
    Radiology 2014 273 3
  • Data-driven Grading of Brain Gliomas: A Multiparametric MR Imaging Study
    Massimo Caulo, Valentina Panara, Domenico Tortora, Peter A. Mattei, Chiara Briganti, Emanuele Pravatà, Simone Salice, Antonio R. Cotroneo, Armando Tartaro
    Radiology 2014 272 2
  • Mean Diffusional Kurtosis in Patients with Glioma: Initial Results with a Fast Imaging Method in a Clinical Setting
    A. Tietze, M.B. Hansen, L. Østergaard, S.N. Jespersen, R. Sangill, T.E. Lund, M. Geneser, M. Hjelm, B. Hansen
    American Journal of Neuroradiology 2015 36 8

More in this TOC Section

  • Fast Contrast-Enhanced 4D MRA and 4D Flow MRI Using Constrained Reconstruction (HYPRFlow): Potential Applications for Brain Arteriovenous Malformations
  • Quiet PROPELLER MRI Techniques Match the Quality of Conventional PROPELLER Brain Imaging Techniques
  • Predictors of Reperfusion in Patients with Acute Ischemic Stroke
Show more Brain

Similar Articles

Advertisement

Indexed Content

  • Current Issue
  • Accepted Manuscripts
  • Article Preview
  • Past Issues
  • Editorials
  • Editors Choice
  • Fellow Journal Club
  • Letters to the Editor

Cases

  • Case Collection
  • Archive - Case of the Week
  • Archive - Case of the Month
  • Archive - Classic Case

Special Collections

  • Special Collections

Resources

  • News and Updates
  • Turn around Times
  • Submit a Manuscript
  • Author Policies
  • Manuscript Submission Guidelines
  • Evidence-Based Medicine Level Guide
  • Publishing Checklists
  • Graphical Abstract Preparation
  • Imaging Protocol Submission
  • Submit a Case
  • Become a Reviewer/Academy of Reviewers
  • Get Peer Review Credit from Publons

Multimedia

  • AJNR Podcast
  • AJNR SCANtastic
  • Video Articles

About Us

  • About AJNR
  • Editorial Board
  • Not an AJNR Subscriber? Join Now
  • Alerts
  • Feedback
  • Advertise with us
  • Librarian Resources
  • Permissions
  • Terms and Conditions

American Society of Neuroradiology

  • Not an ASNR Member? Join Now

© 2025 by the American Society of Neuroradiology All rights, including for text and data mining, AI training, and similar technologies, are reserved.
Print ISSN: 0195-6108 Online ISSN: 1936-959X

Powered by HighWire