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Research ArticleBrain

Detection of Intratumoral Calcification in Oligodendrogliomas by Susceptibility-Weighted MR Imaging

M. Zulfiqar, N. Dumrongpisutikul, J. Intrapiromkul and D.M. Yousem
American Journal of Neuroradiology May 2012, 33 (5) 858-864; DOI: https://doi.org/10.3174/ajnr.A2862
M. Zulfiqar
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N. Dumrongpisutikul
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J. Intrapiromkul
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D.M. Yousem
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    Fig 1.

    Imaging findings of a 23-year-old woman with a histopathologic diagnosis of OD. A, CT shows a 2.3 × 3.3 cm ill-defined relatively hypoattenuated mass in the left frontal lobe with curvilinear calcification (arrow). There is no hemorrhage. B, T2WI image shows an intermediate-to-hyperintense lesion. The area of calcification by CT is seen on the MR imaging study, but it is hypointense and, therefore, is not suggestive of calcification (arrow). C, SWI image shows curvilinear calcification (hypointense area). D, SWI mIP image shows calcification.

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    Fig 2.

    Value of phase imaging in identifying calcification in OD. Magnitude (A), mIP (B), and SWI (C) images do not help distinguish iron-containing hemorrhage from calcification in this tumor. D, Phase image shows high signal intensity centrally identifying calcification. E, CT image shows faint hyperattenuation, which had persisted for months and represented calcified tumor.

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    Fig 3.

    Calcification on SWI series. Again, the magnitude (A), mIP (B), and SWI (C) images could represent hemorrhage or calcification. D and E, However, the phase image (D) shows hyperintensity of calcification, confirmed on the CT scan (E).

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    Fig 4.

    Postoperative OD with hemorrhage and calcification. Magnitude (A), mIP (B), and SWI (C) images fail to distinguish hemorrhage in the operative bed from calcification. D and E, Phase images show mixed signal intensity, but an area of high signal intensity more medially (arrow) was read as representing calcification. CT confirmed a calcified component (arrow).

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    Table 1:

    Decision matrix data for the detection of calcification in ODs for MRSWI and MRnoSWIa versus CT (criterion standard)

    CT+CT−
    MRSWI +61
    −15
    MRnoSWI +11
    −65
    • Note:—+ indicates test was positive for calcification; −, test was negative for calcification.

    • ↵a n = 13, paired. The same cases but read without SWI sequences.

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    Table 2:

    Sensitivity, specificity, PPV, NPV, and accuracy of MRSWI versus MRnoSWI for detection of calcification in ODs compared with our criterion standard CT

    MRSWI (n = 13)MRnoSWIa (n = 13)P ValuebMRnoSWIc (n = 71)
    Sensitivity (%)86 (6/7)14.3 (1/7).01533 (9/27)
    Specificity (%)83 (5/6)83 (5/6)NS95 (42/44)
    PPV (%)86 (6/7)50 (1/2)NS82 (9/11)
    NPV (%)83 (5/6)83 (5/6)NS70 (42/60)
    Accuracy (%)85 (11/13)46 (6/13).04872 (51/71)
    • Note:—PPV indicates positive predictive value, NPV, negative predictive value; NS, not statistically significant.

    • ↵a Those cases with SWI sequences but read without the SWI sequences.

    • ↵b Significance = P < .05.

    • ↵c All cases read without SWI sequences.

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    Table 3:

    Decision matrix data for the detection of calcification in ODs for MRnoSWIa versus CT (criterion standard)

    CT+CT−
    MRnoSWI reading+92
    MRnoSWI reading−1842
    • Note:—+ indicates test was positive for calcification; −, test was negative for calcification.

    • ↵a n = 71, unpaired.

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American Journal of Neuroradiology: 33 (5)
American Journal of Neuroradiology
Vol. 33, Issue 5
1 May 2012
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M. Zulfiqar, N. Dumrongpisutikul, J. Intrapiromkul, D.M. Yousem
Detection of Intratumoral Calcification in Oligodendrogliomas by Susceptibility-Weighted MR Imaging
American Journal of Neuroradiology May 2012, 33 (5) 858-864; DOI: 10.3174/ajnr.A2862

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Detection of Intratumoral Calcification in Oligodendrogliomas by Susceptibility-Weighted MR Imaging
M. Zulfiqar, N. Dumrongpisutikul, J. Intrapiromkul, D.M. Yousem
American Journal of Neuroradiology May 2012, 33 (5) 858-864; DOI: 10.3174/ajnr.A2862
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