Skip to main content
Advertisement

Main menu

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • Video Articles
    • AJNR Case Collection
    • Case of the Week Archive
    • Case of the Month Archive
    • Classic Case Archive
  • Special Collections
    • AJNR Awards
    • Low-Field MRI
    • Alzheimer Disease
    • ASNR Foundation Special Collection
    • Photon-Counting CT
    • View All
  • Multimedia
    • AJNR Podcasts
    • AJNR SCANtastic
    • Trainee Corner
    • MRI Safety Corner
    • Imaging Protocols
  • For Authors
    • Submit a Manuscript
    • Submit a Video Article
    • Submit an eLetter to the Editor/Response
    • Manuscript Submission Guidelines
    • Statistical Tips
    • Fast Publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Imaging Protocol Submission
    • Author Policies
  • About Us
    • About AJNR
    • Editorial Board
    • Editorial Board Alumni
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home

User menu

  • Alerts
  • Log in

Search

  • Advanced search
American Journal of Neuroradiology
American Journal of Neuroradiology

American Journal of Neuroradiology

ASHNR American Society of Functional Neuroradiology ASHNR American Society of Pediatric Neuroradiology ASSR
  • Alerts
  • Log in

Advanced Search

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • Video Articles
    • AJNR Case Collection
    • Case of the Week Archive
    • Case of the Month Archive
    • Classic Case Archive
  • Special Collections
    • AJNR Awards
    • Low-Field MRI
    • Alzheimer Disease
    • ASNR Foundation Special Collection
    • Photon-Counting CT
    • View All
  • Multimedia
    • AJNR Podcasts
    • AJNR SCANtastic
    • Trainee Corner
    • MRI Safety Corner
    • Imaging Protocols
  • For Authors
    • Submit a Manuscript
    • Submit a Video Article
    • Submit an eLetter to the Editor/Response
    • Manuscript Submission Guidelines
    • Statistical Tips
    • Fast Publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Imaging Protocol Submission
    • Author Policies
  • About Us
    • About AJNR
    • Editorial Board
    • Editorial Board Alumni
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home
  • Follow AJNR on Twitter
  • Visit AJNR on Facebook
  • Follow AJNR on Instagram
  • Join AJNR on LinkedIn
  • RSS Feeds

AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates

EditorialEditorials

Dramatically Reducing Imaging-to-Recanalization Time in Acute Ischemic Stroke: Making Choices

M. Goyal and M.A. Almekhlafi
American Journal of Neuroradiology August 2012, 33 (7) 1201-1203; DOI: https://doi.org/10.3174/ajnr.A3215
M. Goyal
aDepartments of Diagnostic Imaging and Clinical Neurosciences University of Calgary Calgary, Alberta, Canada
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
M.A. Almekhlafi
aDepartments of Diagnostic Imaging and Clinical Neurosciences University of Calgary Calgary, Alberta, Canada
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Info & Metrics
  • Responses
  • References
  • PDF
Loading

References

  1. 1.↵
    1. Heiss WD,
    2. Rosner G
    . Functional recovery of cortical neurons as related to degree and duration of ischemia. Ann Neurol 1983;14:294–301
    CrossRefPubMedWeb of Science
  2. 2.↵
    1. Savitz SI,
    2. Fisher M
    . Future of neuroprotection for acute stroke: in the aftermath of the SAINT trials. Ann Neurol 2007;61:396–402
    CrossRefPubMedWeb of Science
  3. 3.↵
    1. Pierpaoli C,
    2. Righini A,
    3. Linfante I,
    4. et al
    . Histopathologic correlates of abnormal water diffusion in cerebral ischemia: diffusion-weighted MR imaging and light and electron microscopic study. Radiology 1993;189:439–48
    PubMedWeb of Science
  4. 4.↵
    1. Barber PA,
    2. Demchuk AM,
    3. Zhang J,
    4. et al
    . Validity and reliability of a quantitative computed tomography score in predicting outcome of hyperacute stroke before thrombolytic therapy: ASPECTS Study Group Alberta Stroke Programme Early CT Score. Lancet 2000;355:1670–74
    CrossRefPubMedWeb of Science
  5. 5.↵
    1. Dani KA,
    2. Thomas RG,
    3. Chappell FM,
    4. et al
    . Computed tomography and magnetic resonance perfusion imaging in ischemic stroke: definitions and thresholds. Ann Neurol 2011;70:384–401
    CrossRefPubMed
  6. 6.↵
    1. Schellinger PD,
    2. Bryan RN,
    3. Caplan LR,
    4. et al
    . Evidence-based guideline: the role of diffusion and perfusion MRI for the diagnosis of acute ischemic stroke—report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology. Neurology 2010;75:177–85
    Abstract/FREE Full Text
  7. 7.↵
    1. Boysen G,
    2. Christensen H
    . Early stroke: a dynamic process. Stroke 2001;32:2423–25
    FREE Full Text
  8. 8.↵
    1. Verro P,
    2. Chow M
    . Prolonged dependence of ischemic penumbra on induced hypertension. Neurologist 2009;15:296–97
    CrossRefPubMedWeb of Science
  9. 9.↵
    1. Rha JH,
    2. Saver JL
    . The impact of recanalization on ischemic stroke outcome: a meta-analysis. Stroke 2007;38:967–73
    Abstract/FREE Full Text
  10. 10.↵
    1. Hacke W,
    2. Kaste M,
    3. Bluhmki E,
    4. et al
    . Thrombolysis with alteplase 3 to 4.5 hours after acute ischemic stroke. N Engl J Med 2008;359:1317–29
    CrossRefPubMedWeb of Science
  11. 11.↵
    1. del Zoppo GJ,
    2. Higashida RT,
    3. Furlan AJ,
    4. et al
    . PROACT: a phase II randomized trial of recombinant pro-urokinase by direct arterial delivery in acute middle cerebral artery stroke—PROACT Investigators. Prolyse in Acute Cerebral Thromboembolism. Stroke 1998;29:4–11
    Abstract/FREE Full Text
  12. 12.↵
    1. Smith WS,
    2. Sung G,
    3. Saver J,
    4. et al
    . Mechanical thrombectomy for acute ischemic stroke: final results of the Multi MERCI trial. Stroke 2008;39:1205–12
    Abstract/FREE Full Text
  13. 13.↵
    1. Takano K,
    2. Latour LL,
    3. Formato JE,
    4. et al
    . The role of spreading depression in focal ischemia evaluated by diffusion mapping. Ann Neurol 1996;39:308–18
    CrossRefPubMedWeb of Science
  14. 14.↵
    1. Strong AJ,
    2. Anderson PJ,
    3. Watts HR,
    4. et al
    . Peri-infarct depolarizations lead to loss of perfusion in ischaemic gyrencephalic cerebral cortex. Brain 2007;130(pt 4):995–1008
    Abstract/FREE Full Text
  15. 15.↵
    1. Dijkhuizen RM,
    2. Knollema S,
    3. van der Worp HB,
    4. et al
    . Dynamics of cerebral tissue injury and perfusion after temporary hypoxia-ischemia in the rat: evidence for region-specific sensitivity and delayed damage. Stroke 1998;29:695–704
    Abstract/FREE Full Text
  16. 16.↵
    1. Heiss WD
    . The ischemic penumbra: correlates in imaging and implications for treatment of ischemic stroke: the Johann Jacob Wepfer award 2011. Cerebrovasc Dis 2011;32:307–20
    CrossRefPubMed
  17. 17.↵
    1. von Kummer R,
    2. Meyding-Lamade U,
    3. Forsting M,
    4. et al
    . Sensitivity and prognostic value of early CT in occlusion of the middle cerebral artery trunk. AJNR Am J Neuroradiol 1994;15:9–15, discussion 16–18
    Abstract/FREE Full Text
  18. 18.↵
    Tissue plasminogen activator for acute ischemic stroke: the National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group. N Engl J Med 1995;333:1581–87
    CrossRefPubMedWeb of Science
  19. 19.↵
    1. Hacke W,
    2. Kaste M,
    3. Fieschi C,
    4. et al
    . Randomised double-blind placebo-controlled trial of thrombolytic therapy with intravenous alteplase in acute ischaemic stroke (ECASS II): Second European-Australasian Acute Stroke Study Investigators. Lancet 1998;352:1245–51
    CrossRefPubMedWeb of Science
  20. 20.↵
    1. Khatri P,
    2. Hill MD,
    3. Palesch YY,
    4. et al
    . Methodology of the Interventional Management of Stroke III Trial. Int J Stroke 2008;3:130–37
    CrossRefPubMedWeb of Science
  21. 21.↵
    1. Hacke W,
    2. Albers G,
    3. Al-Rawi Y,
    4. et al
    . The Desmoteplase in Acute Ischemic Stroke Trial (DIAS): a phase II MRI-based 9-hour window acute stroke thrombolysis trial with intravenous desmoteplase. Stroke 2005;36:66–73
    Abstract/FREE Full Text
  22. 22.↵
    1. Hacke W,
    2. Furlan AJ,
    3. Al-Rawi Y,
    4. et al
    . Intravenous desmoteplase in patients with acute ischaemic stroke selected by MRI perfusion-diffusion weighted imaging or perfusion CT (DIAS-2): a prospective, randomised, double-blind, placebo-controlled study. Lancet Neurol 2009;8:141–50
    CrossRefPubMedWeb of Science
  23. 23.↵
    1. Davis SM,
    2. Donnan GA,
    3. Parsons MW,
    4. et al
    . Effects of alteplase beyond 3 h after stroke in the Echoplanar Imaging Thrombolytic Evaluation Trial (EPITHET): a placebo-controlled randomised trial. Lancet Neurol 2008;7:299–309
    CrossRefPubMedWeb of Science
  24. 24.↵
    1. Marks MP,
    2. Olivot JM,
    3. Kemp S,
    4. et al
    . Patients with acute stroke treated with intravenous tPA 3–6 hours after stroke onset: correlations between MR angiography findings and perfusion- and diffusion-weighted imaging in the DEFUSE study. Radiology 2008;249:614–23
    CrossRefPubMed
  25. 25.↵
    1. Graves MJ,
    2. U-King-Im J,
    3. Howarth S,
    4. et al
    . Ultrafast magnetic resonance imaging protocols in stroke. Expert Rev Neurother 2006;6:921–30
    CrossRefPubMed
  26. 26.↵
    1. Hand PJ,
    2. Wardlaw JM,
    3. Rowat AM,
    4. et al
    . Magnetic resonance brain imaging in patients with acute stroke: feasibility and patient related difficulties. J Neurol Neurosurg Psychiatry 2005;76:1525–27
    Abstract/FREE Full Text
  27. 27.↵
    1. Baker WL,
    2. Colby JA,
    3. Tongbram V,
    4. et al
    . Neurothrombectomy devices for the treatment of acute ischemic stroke: state of the evidence. Ann Intern Med 2011;154:243–52
    CrossRefPubMedWeb of Science
  28. 28.↵
    1. Costalat V,
    2. Machi P,
    3. Lobotesis K,
    4. et al
    . Rescue, combined, and stand-alone thrombectomy in the management of large vessel occlusion stroke using the Solitaire device: a prospective 50-patient single-center study: timing, safety, and efficacy. Stroke 2011;42:1929–35
    Abstract/FREE Full Text
  29. 29.↵
    1. Lin K,
    2. Rapalino O,
    3. Law M,
    4. et al
    . Accuracy of the Alberta Stroke Program Early CT Score during the first 3 hours of middle cerebral artery stroke: comparison of noncontrast CT, CT angiography source images, and CT perfusion. AJNR Am J Neuroradiol 2008;29:931–36
    Abstract/FREE Full Text
  30. 30.↵
    1. Rapalino O,
    2. Kamalian S,
    3. Payabvash S,
    4. et al
    . Cranial CT with adaptive statistical iterative reconstruction: improved image quality with concomitant radiation dose reduction. AJNR Am J Neuroradiol 2012;33:609–15
    Abstract/FREE Full Text
  31. 31.↵
    1. Krol AL,
    2. Dzialowski I,
    3. Roy J,
    4. et al
    . Incidence of radiocontrast nephropathy in patients undergoing acute stroke computed tomography angiography. Stroke 2007;38:2364–66
    Abstract/FREE Full Text
  32. 32.↵
    1. Schramm P,
    2. Schellinger PD,
    3. Fiebach JB,
    4. et al
    . Comparison of CT and CT angiography source images with diffusion-weighted imaging in patients with acute stroke within 6 hours after onset. Stroke 2002;33:2426–32
    Abstract/FREE Full Text
  33. 33.↵
    1. Menon BK,
    2. Smith EE,
    3. Modi J,
    4. et al
    . Regional leptomeningeal score on CT angiography predicts clinical and imaging outcomes in patients with acute anterior circulation occlusions. AJNR Am J Neuroradiol 2011;32:1640–45
    Abstract/FREE Full Text
  34. 34.↵
    1. Gupta R,
    2. Horev A,
    3. Wisco D,
    4. et al
    . Abstract 207: CT perfusion increases time to reperfusion and may not enhance patient selection for endovascular reperfusion therapies in acute ischemic stroke. Stroke 2012;43:A207
  35. 35.↵
    1. Konstas AA,
    2. Lev MH:
    CT perfusion imaging of acute stroke: the need for arrival time, delay insensitive, and standardized postprocessing algorithms? Radiology 2010;254:22–25
    CrossRefPubMedWeb of Science
  36. 36.↵
    1. Heiss WD,
    2. Kracht LW,
    3. Thiel A,
    4. et al
    . Penumbral probability thresholds of cortical flumazenil binding and blood flow predicting tissue outcome in patients with cerebral ischaemia. Brain 2001;124(pt 1):20–29
    Abstract/FREE Full Text
  37. 37.↵
    1. Eastwood JD,
    2. Lev MH,
    3. Wintermark M,
    4. et al
    . Correlation of early dynamic CT perfusion imaging with whole-brain MR diffusion and perfusion imaging in acute hemispheric stroke. AJNR Am J Neuroradiol 2003;24:1869–75
    Abstract/FREE Full Text
  38. 38.↵
    1. Davis MJ,
    2. Menon BK,
    3. Baghirzada LB,
    4. et al
    . Anesthetic management and outcome in patients during endovascular therapy for acute stroke. Anesthesiology 2012;116:396–405
    CrossRefPubMedWeb of Science
  39. 39.↵
    1. Biros MH,
    2. Lewis RJ,
    3. Olson CM,
    4. et al
    . Informed consent in emergency research: consensus statement from the Coalition Conference of Acute Resuscitation and Critical Care Researchers. JAMA 1995;273:1283–87
    CrossRefPubMedWeb of Science
PreviousNext
Back to top

In this issue

American Journal of Neuroradiology: 33 (7)
American Journal of Neuroradiology
Vol. 33, Issue 7
1 Aug 2012
  • Table of Contents
  • Index by author
Advertisement
Print
Download PDF
Email Article

Thank you for your interest in spreading the word on American Journal of Neuroradiology.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Dramatically Reducing Imaging-to-Recanalization Time in Acute Ischemic Stroke: Making Choices
(Your Name) has sent you a message from American Journal of Neuroradiology
(Your Name) thought you would like to see the American Journal of Neuroradiology web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Cite this article
M. Goyal, M.A. Almekhlafi
Dramatically Reducing Imaging-to-Recanalization Time in Acute Ischemic Stroke: Making Choices
American Journal of Neuroradiology Aug 2012, 33 (7) 1201-1203; DOI: 10.3174/ajnr.A3215

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
0 Responses
Respond to this article
Share
Bookmark this article
Dramatically Reducing Imaging-to-Recanalization Time in Acute Ischemic Stroke: Making Choices
M. Goyal, M.A. Almekhlafi
American Journal of Neuroradiology Aug 2012, 33 (7) 1201-1203; DOI: 10.3174/ajnr.A3215
del.icio.us logo Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One
Purchase

Jump to section

  • Article
    • References
  • Info & Metrics
  • Responses
  • References
  • PDF

Related Articles

  • No related articles found.
  • PubMed
  • Google Scholar

Cited By...

  • Overcoming the evening/weekend effects on time delays and outcomes of endovascular stroke therapy: the Calgary Stroke Program experience
  • Evaluation of Interval Times From Onset to Reperfusion in Patients Undergoing Endovascular Therapy in the Interventional Management of Stroke III Trial
  • Optimal Workflow and Process-Based Performance Measures for Endovascular Therapy in Acute Ischemic Stroke: Analysis of the Solitaire FR Thrombectomy for Acute Revascularization Study
  • Crossref
  • Google Scholar

This article has not yet been cited by articles in journals that are participating in Crossref Cited-by Linking.

More in this TOC Section

  • Comeback Victory
  • Teaching Lessons by MR CLEAN
  • Coffee Houses and Reading Rooms
Show more EDITORIALS

Similar Articles

Advertisement

Indexed Content

  • Current Issue
  • Accepted Manuscripts
  • Article Preview
  • Past Issues
  • Editorials
  • Editor's Choice
  • Fellows' Journal Club
  • Letters to the Editor
  • Video Articles

Cases

  • Case Collection
  • Archive - Case of the Week
  • Archive - Case of the Month
  • Archive - Classic Case

More from AJNR

  • Trainee Corner
  • Imaging Protocols
  • MRI Safety Corner
  • Book Reviews

Multimedia

  • AJNR Podcasts
  • AJNR Scantastics

Resources

  • Turnaround Time
  • Submit a Manuscript
  • Submit a Video Article
  • Submit an eLetter to the Editor/Response
  • Manuscript Submission Guidelines
  • Statistical Tips
  • Fast Publishing of Accepted Manuscripts
  • Graphical Abstract Preparation
  • Imaging Protocol Submission
  • Evidence-Based Medicine Level Guide
  • Publishing Checklists
  • Author Policies
  • Become a Reviewer/Academy of Reviewers
  • News and Updates

About Us

  • About AJNR
  • Editorial Board
  • Editorial Board Alumni
  • Alerts
  • Permissions
  • Not an AJNR Subscriber? Join Now
  • Advertise with Us
  • Librarian Resources
  • Feedback
  • Terms and Conditions
  • AJNR Editorial Board Alumni

American Society of Neuroradiology

  • Not an ASNR Member? Join Now

© 2025 by the American Society of Neuroradiology All rights, including for text and data mining, AI training, and similar technologies, are reserved.
Print ISSN: 0195-6108 Online ISSN: 1936-959X

Powered by HighWire