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Research ArticleBrainE
Open Access

Malignant CTA Collateral Profile Is Highly Specific for Large Admission DWI Infarct Core and Poor Outcome in Acute Stroke

L.C.S. Souza, A.J. Yoo, Z.A. Chaudhry, S. Payabvash, A. Kemmling, P.W. Schaefer, J.A. Hirsch, K.L. Furie, R.G. González, R.G. Nogueira and M.H. Lev
American Journal of Neuroradiology August 2012, 33 (7) 1331-1336; DOI: https://doi.org/10.3174/ajnr.A2985
L.C.S. Souza
aFrom the Departments of Radiology (L.C.S.S., A.J.Y., Z.A.C., S.P., A.K., P.W.S., J.A.H., R.G.G., M.H.L.)
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A.J. Yoo
aFrom the Departments of Radiology (L.C.S.S., A.J.Y., Z.A.C., S.P., A.K., P.W.S., J.A.H., R.G.G., M.H.L.)
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Z.A. Chaudhry
aFrom the Departments of Radiology (L.C.S.S., A.J.Y., Z.A.C., S.P., A.K., P.W.S., J.A.H., R.G.G., M.H.L.)
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S. Payabvash
aFrom the Departments of Radiology (L.C.S.S., A.J.Y., Z.A.C., S.P., A.K., P.W.S., J.A.H., R.G.G., M.H.L.)
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A. Kemmling
aFrom the Departments of Radiology (L.C.S.S., A.J.Y., Z.A.C., S.P., A.K., P.W.S., J.A.H., R.G.G., M.H.L.)
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P.W. Schaefer
aFrom the Departments of Radiology (L.C.S.S., A.J.Y., Z.A.C., S.P., A.K., P.W.S., J.A.H., R.G.G., M.H.L.)
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J.A. Hirsch
aFrom the Departments of Radiology (L.C.S.S., A.J.Y., Z.A.C., S.P., A.K., P.W.S., J.A.H., R.G.G., M.H.L.)
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K.L. Furie
bNeurology (K.L.F., R.G.N.), Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.
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R.G. González
aFrom the Departments of Radiology (L.C.S.S., A.J.Y., Z.A.C., S.P., A.K., P.W.S., J.A.H., R.G.G., M.H.L.)
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R.G. Nogueira
bNeurology (K.L.F., R.G.N.), Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.
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M.H. Lev
aFrom the Departments of Radiology (L.C.S.S., A.J.Y., Z.A.C., S.P., A.K., P.W.S., J.A.H., R.G.G., M.H.L.)
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References

  1. 1.↵
    1. Yoo AJ,
    2. Barak ER,
    3. Copen WA,
    4. et al
    . Combining acute diffusion-weighted imaging and mean transmit time lesion volumes with National Institutes of Health Stroke Scale score improves the prediction of acute stroke outcome. Stroke 2010;41:1728–35
    Abstract/FREE Full Text
  2. 2.↵
    1. Parsons MW,
    2. Christensen S,
    3. McElduff P,
    4. et al
    . Pretreatment diffusion- and perfusion-MR lesion volumes have a crucial influence on clinical response to stroke thrombolysis. J Cereb Blood Flow Metab 2010;30:1214–25
    CrossRefPubMed
  3. 3.↵
    1. Yoo AJ,
    2. Verduzco LA,
    3. Schaefer PW,
    4. et al
    . MRI-based selection for intra-arterial stroke therapy: value of pretreatment diffusion-weighted imaging lesion volume in selecting patients with acute stroke who will benefit from early recanalization. Stroke 2009;40:2046–54
    Abstract/FREE Full Text
  4. 4.↵
    1. Albers GW,
    2. Thijs VN,
    3. Wechsler L,
    4. et al
    . Magnetic resonance imaging profiles predict clinical response to early reperfusion: the diffusion and perfusion imaging evaluation for understanding stroke evolution (DEFUSE) study. Ann Neurol 2006;60:508–17
    CrossRefPubMedWeb of Science
  5. 5.↵
    1. Fiorella D,
    2. Heiserman J,
    3. Prenger E,
    4. et al
    . Assessment of the reproducibility of postprocessing dynamic CT perfusion data. AJNR Am J Neuroradiol 2004;25:97–107
    Abstract/FREE Full Text
  6. 6.↵
    1. Wintermark M,
    2. Flanders AE,
    3. Velthuis B,
    4. et al
    . Perfusion-CT assessment of infarct core and penumbra: receiver operating characteristic curve analysis in 130 patients suspected of acute hemispheric stroke. Stroke 2006;37:979–85
    Abstract/FREE Full Text
  7. 7.↵
    1. Bivard A,
    2. McElduff P,
    3. Spratt N,
    4. et al
    . Defining the extent of irreversible brain ischemia using perfusion computed tomography. Cerebrovasc Dis 2011;31:238–45
    CrossRefPubMed
  8. 8.↵
    1. Wintermark M,
    2. Albers GW,
    3. Alexandrov AV,
    4. et al
    . Acute stroke imaging research roadmap. AJNR Am J Neuroradiol 2008;29:e23–30
    Abstract/FREE Full Text
  9. 9.↵
    1. Kamalian S,
    2. Maas MB,
    3. Goldmacher GV,
    4. et al
    . CT cerebral blood flow maps optimally correlate with admission diffusion-weighted imaging in acute stroke but thresholds vary by postprocessing platform. Stroke 2011;42:1923–28
    Abstract/FREE Full Text
  10. 10.↵
    1. Tan JC,
    2. Dillon WP,
    3. Liu S,
    4. et al
    . Systematic comparison of perfusion-CT and CT-angiography in acute stroke patients. Ann Neurol 2007;61:533–43
    CrossRefPubMedWeb of Science
  11. 11.↵
    1. Lima FO,
    2. Furie KL,
    3. Silva GS,
    4. et al
    . The pattern of leptomeningeal collaterals on CT angiography is a strong predictor of long-term functional outcome in stroke patients with large vessel intracranial occlusion. Stroke 2010;41:2316–22
    Abstract/FREE Full Text
  12. 12.↵
    1. Tan IY,
    2. Demchuk AM,
    3. Hopyan J,
    4. et al
    . CT angiography clot burden score and collateral score: correlation with clinical and radiologic outcomes in acute middle cerebral artery infarct. AJNR Am J Neuroradiol 2009;30:525–31
    Abstract/FREE Full Text
  13. 13.↵
    1. Hacke W,
    2. Albers G,
    3. Al-Rawi Y,
    4. et al
    . The Desmoteplase in Acute Ischemic Stroke Trial (DIAS): a phase II MRI-based 9-hour window acute stroke thrombolysis trial with intravenous desmoteplase. Stroke 2005;36:66–73
    Abstract/FREE Full Text
  14. 14.↵
    1. Sanák D,
    2. Nosal V,
    3. Horak D,
    4. et al
    . Impact of diffusion-weighted MRI-measured initial cerebral infarction volume on clinical outcome in acute stroke patients with middle cerebral artery occlusion treated by thrombolysis. Neuroradiology 2006;48:632–39
    CrossRefPubMedWeb of Science
  15. 15.↵
    1. Thomalla G,
    2. Hartmann F,
    3. Juettler E,
    4. et al
    . Prediction of malignant middle cerebral artery infarction by magnetic resonance imaging within 6 hours of symptom onset: a prospective multicenter observational study. Ann Neurol 2010;68:435–45
    CrossRefPubMed
  16. 16.↵
    1. Higashida RT,
    2. Furlan AJ,
    3. Roberts H,
    4. et al
    . Trial design and reporting standards for intra-arterial cerebral thrombolysis for acute ischemic stroke. Stroke 2003;34:e109–37
    Abstract/FREE Full Text
  17. 17.↵
    1. Puetz V,
    2. Dzialowski I,
    3. Hill MD,
    4. et al
    . Malignant profile detected by CT angiographic information predicts poor prognosis despite thrombolysis within three hours from symptom onset. Cerebrovasc Dis 2010;29:584–91
    CrossRefPubMed
  18. 18.↵
    1. Bang OY,
    2. Saver JL,
    3. Kim SJ,
    4. et al
    . Collateral flow predicts response to endovascular therapy for acute ischemic stroke. Stroke 2011;42:693–99
    Abstract/FREE Full Text
  19. 19.↵
    1. Angermaier A,
    2. Langner S,
    3. Kirsch M,
    4. et al
    . CT-angiographic collateralization predicts final infarct volume after intra-arterial thrombolysis for acute anterior circulation ischemic stroke. Cerebrovasc Dis 2011;31:177–84
    CrossRefPubMed
  20. 20.↵
    1. Rosenthal ES,
    2. Schwamm LH,
    3. Roccatagliata L,
    4. et al
    . Role of recanalization in acute stroke outcome: rationale for a CT angiogram-based “benefit of recanalization” model. AJNR Am J Neuroradiol 2008;29:1471–75
    Abstract/FREE Full Text
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American Journal of Neuroradiology: 33 (7)
American Journal of Neuroradiology
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L.C.S. Souza, A.J. Yoo, Z.A. Chaudhry, S. Payabvash, A. Kemmling, P.W. Schaefer, J.A. Hirsch, K.L. Furie, R.G. González, R.G. Nogueira, M.H. Lev
Malignant CTA Collateral Profile Is Highly Specific for Large Admission DWI Infarct Core and Poor Outcome in Acute Stroke
American Journal of Neuroradiology Aug 2012, 33 (7) 1331-1336; DOI: 10.3174/ajnr.A2985

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Malignant CTA Collateral Profile Is Highly Specific for Large Admission DWI Infarct Core and Poor Outcome in Acute Stroke
L.C.S. Souza, A.J. Yoo, Z.A. Chaudhry, S. Payabvash, A. Kemmling, P.W. Schaefer, J.A. Hirsch, K.L. Furie, R.G. González, R.G. Nogueira, M.H. Lev
American Journal of Neuroradiology Aug 2012, 33 (7) 1331-1336; DOI: 10.3174/ajnr.A2985
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