Skip to main content
Advertisement

Main menu

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • AJNR Case Collection
    • Case of the Week Archive
    • Classic Case Archive
    • Case of the Month Archive
  • Special Collections
    • Spinal CSF Leak Articles (Jan 2020-June 2024)
    • 2024 AJNR Journal Awards
    • Most Impactful AJNR Articles
  • Multimedia
    • AJNR Podcast
    • AJNR Scantastics
    • Video Articles
  • For Authors
    • Submit a Manuscript
    • Author Policies
    • Fast publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Manuscript Submission Guidelines
    • Imaging Protocol Submission
    • Submit a Case for the Case Collection
  • About Us
    • About AJNR
    • Editorial Board
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home
  • Other Publications
    • ajnr

User menu

  • Alerts
  • Log in

Search

  • Advanced search
American Journal of Neuroradiology
American Journal of Neuroradiology

American Journal of Neuroradiology

ASHNR American Society of Functional Neuroradiology ASHNR American Society of Pediatric Neuroradiology ASSR
  • Alerts
  • Log in

Advanced Search

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • AJNR Case Collection
    • Case of the Week Archive
    • Classic Case Archive
    • Case of the Month Archive
  • Special Collections
    • Spinal CSF Leak Articles (Jan 2020-June 2024)
    • 2024 AJNR Journal Awards
    • Most Impactful AJNR Articles
  • Multimedia
    • AJNR Podcast
    • AJNR Scantastics
    • Video Articles
  • For Authors
    • Submit a Manuscript
    • Author Policies
    • Fast publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Manuscript Submission Guidelines
    • Imaging Protocol Submission
    • Submit a Case for the Case Collection
  • About Us
    • About AJNR
    • Editorial Board
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home
  • Follow AJNR on Twitter
  • Visit AJNR on Facebook
  • Follow AJNR on Instagram
  • Join AJNR on LinkedIn
  • RSS Feeds

Welcome to the new AJNR, Updated Hall of Fame, and more. Read the full announcements.


AJNR is seeking candidates for the position of Associate Section Editor, AJNR Case Collection. Read the full announcement.

 

Research ArticleBrain
Open Access

White Matter Alterations in Cognitively Normal apoE ɛ2 Carriers: Insight into Alzheimer Resistance?

G.C. Chiang, W. Zhan, N. Schuff and M.W. Weiner
American Journal of Neuroradiology August 2012, 33 (7) 1392-1397; DOI: https://doi.org/10.3174/ajnr.A2984
G.C. Chiang
aFrom the Center for Imaging of Neurodegenerative Diseases, Department of Veteran Affairs Medical Center, San Francisco, California, and the Department of Radiology, University of California, San Francisco, California.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
W. Zhan
aFrom the Center for Imaging of Neurodegenerative Diseases, Department of Veteran Affairs Medical Center, San Francisco, California, and the Department of Radiology, University of California, San Francisco, California.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
N. Schuff
aFrom the Center for Imaging of Neurodegenerative Diseases, Department of Veteran Affairs Medical Center, San Francisco, California, and the Department of Radiology, University of California, San Francisco, California.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
M.W. Weiner
aFrom the Center for Imaging of Neurodegenerative Diseases, Department of Veteran Affairs Medical Center, San Francisco, California, and the Department of Radiology, University of California, San Francisco, California.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • Info & Metrics
  • Responses
  • References
  • PDF
Loading

Article Information

vol. 33 no. 7 1392-1397
DOI 
https://doi.org/10.3174/ajnr.A2984
PubMed 
22383234

Published By 
American Journal of Neuroradiology
Print ISSN 
0195-6108
Online ISSN 
1936-959X
History 
  • Received September 18, 2011
  • Accepted after revision November 2, 2011
  • Published online August 14, 2012.

Copyright & Usage 
© 2012 by American Journal of Neuroradiology Indicates open access to non-subscribers at www.ajnr.org

Author Information

  1. G.C. Chianga,
  2. W. Zhana,
  3. N. Schuffa and
  4. M.W. Weinera
  1. aFrom the Center for Imaging of Neurodegenerative Diseases, Department of Veteran Affairs Medical Center, San Francisco, California, and the Department of Radiology, University of California, San Francisco, California.
  1. Please address correspondence to Gloria C. Chiang, MD, Department of Radiology, University of California at San Francisco, 505 Parnassus Ave M-391, San Francisco, CA 94143; e-mail: gloria.chiang{at}ucsf.edu
View Full Text

Altmetrics

Cited By...

  • 23 Citations
  • 24 Citations
  • Google Scholar

This article has been cited by the following articles in journals that are participating in Crossref Cited-by Linking.

  • Age, APOE and sex: Triad of risk of Alzheimer’s disease
    Brandalyn C. Riedel, Paul M. Thompson, Roberta Diaz Brinton
    The Journal of Steroid Biochemistry and Molecular Biology 2016 160
  • Thalamic pathology and memory loss in early Alzheimer’s disease: moving the focus from the medial temporal lobe to Papez circuit
    John P. Aggleton, Agathe Pralus, Andrew J. D. Nelson, Michael Hornberger
    Brain 2016 139 7
  • Brain connectivity in neurodegenerative diseases—from phenotype to proteinopathy
    Michela Pievani, Nicola Filippini, Martijn P. van den Heuvel, Stefano F. Cappa, Giovanni B. Frisoni
    Nature Reviews Neurology 2014 10 11
  • The forgotten APOE allele: A review of the evidence and suggested mechanisms for the protective effect of APOE ɛ2
    Sana Suri, Verena Heise, Aaron J. Trachtenberg, Clare E. Mackay
    Neuroscience & Biobehavioral Reviews 2013 37 10
  • Gray matter maturation and cognition in children with different APOE ε genotypes
    Linda Chang, Vanessa Douet, Cinnamon Bloss, Kristin Lee, Alexandra Pritchett, Terry L. Jernigan, Natacha Akshoomoff, Sarah S. Murray, Jean Frazier, David N. Kennedy, David G. Amaral, Jeffrey Gruen, Walter E. Kaufmann, B.J. Casey, Elizabeth Sowell, Thomas Ernst, Terry L. Jernigan, Connor McCabe, Linda Chang, Natacha Akshoomoff, Erik Newman, Anders M. Dale, Thomas Ernst, Anders M. Dale, Peter Van Zijl, Joshua Kuperman, Sarah Murray, Cinnamon Bloss, Mark Appelbaum, Anthony Gamst, Wesley Thompson, Brian Keating, David Amaral, Walter Kaufmann, Peter Van Zijl, Stewart Mostofsky, B.J. Casey, Erika J. Ruberry, Alisa Powers, Bruce Rosen, Tal Kenet, Jean Frazier, David Kennedy, Jeffrey Gruen
    Neurology 2016 87 6
  • White matter abnormalities associated with Alzheimer’s disease and mild cognitive impairment: a critical review of MRI studies
    Marcia Radanovic, Fabrício Ramos Silvestre Pereira, Florindo Stella, Ivan Aprahamian, Luiz Kobuti Ferreira, Orestes Vicente Forlenza, Geraldo F Busatto
    Expert Review of Neurotherapeutics 2013 13 5
  • Relationship betweenAPOEGenotype and Structural MRI Measures throughout Adulthood in the Study of Health in Pomerania Population-Based Cohort
    M. Habes, J.B. Toledo, S.M. Resnick, J. Doshi, S. Van der Auwera, G. Erus, D. Janowitz, K. Hegenscheid, G. Homuth, H. Völzke, W. Hoffmann, H.J. Grabe, C. Davatzikos
    American Journal of Neuroradiology 2016 37 9
  • Imaging markers of structural and functional brain changes that precede cognitive symptoms in risk for Alzheimer’s disease
    Alison Burggren, Jesse Brown
    Brain Imaging and Behavior 2014 8 2
  • Longitudinal white matter and cognitive development in pediatric carriers of the apolipoprotein ε4 allele
    Justin Remer, Douglas C. Dean, Kewei Chen, Rebecca A. Reiman, Matthew J. Huentelman, Eric M. Reiman, Sean C.L. Deoni
    NeuroImage 2020 222
  • Apolipoprotein E Genotype e2: Neuroprotection and Its Limits
    Hyun Kim, Davangere P. Devanand, Scott Carlson, Terry E. Goldberg
    Frontiers in Aging Neuroscience 2022 14
  • Disrupted Thalamus White Matter Anatomy and Posterior Default Mode Network Effective Connectivity in Amnestic Mild Cognitive Impairment
    Thomas Alderson, Elizabeth Kehoe, Liam Maguire, Dervla Farrell, Brian Lawlor, Rose A. Kenny, Declan Lyons, Arun L. W. Bokde, Damien Coyle
    Frontiers in Aging Neuroscience 2017 9
  • Impact of Apolipoprotein E gene polymorphism during normal and pathological conditions of the brain across the lifespan
    Diego Iacono, Gloria C. Feltis
    Aging 2019 11 2
  • Differential associations between apolipoprotein E alleles and cerebral myelin content in normative aging
    Curtis Triebswetter, Matthew Kiely, Nikkita Khattar, Luigi Ferrucci, Susan M. Resnick, Richard G. Spencer, Mustapha Bouhrara
    NeuroImage 2022 251
  • Tract Based Spatial Statistic Reveals No Differences in White Matter Microstructural Organization between Carriers and Non-Carriers of the APOE ɛ4 and ɛ2 Alleles in Young Healthy Adolescents
    Flavio Dell’Acqua, Wasim Khan, Natalie Gottlieb, Vincent Giampietro, Cedric Ginestet, David Bouls, Steven Newhouse, Richard Dobson, Tobias Banaschewski, Gareth J. Barker, Arun L.W. Bokde, Christian Büchel, Patricia Conrod, Herta Flor, Vincent Frouin, Hugh Garavan, Penny Gowland, Anreas Heinz, Hervé Lemaítre, Frauke Nees, Tomas Paus, Zdenka Pausova, Marcella Rietschel, Michael N. Smolka, Andreas Ströhle, Jean Gallinat, Eric Westman, Gunther Schumann, Simon Lovestone, Andrew Simmons, Maheen Adamson
    Journal of Alzheimer's Disease 2015 47 4
  • White matter injury, cholesterol dysmetabolism, and APP/Abeta dysmetabolism interact to produce Alzheimer’s disease (AD) neuropathology: A hypothesis and review
    Frank R. Sharp, Charles S. DeCarli, Lee-Way Jin, Xinhua Zhan
    Frontiers in Aging Neuroscience 2023 15
  • Sex-Specific Protective Effects ofAPOEε2 on Cognitive Performance
    Noemí Lamonja-Vicente, Rosalia Dacosta-Aguayo, Jorge López-Olóriz, Laia Prades-Senovilla, Francesca Roig-Coll, Alba Castells-Sánchez, Juan José Soriano-Raya, Inmaculada Clemente, Júlia Miralbell, Maite Barrios, Elena López-Cancio, Cynthia Cáceres, Juan Francisco Arenillas, Mónica Millán, Pere Torán, Guillem Pera, Rosa Fores, Maria Teresa Alzamora, Maria Mataró, Marc Via, David Le Couteur
    The Journals of Gerontology: Series A 2021 76 1
  • The Specific Impact of Apolipoprotein E Epsilon 2 on Cognition and Brain Function in Cognitively Normal Elders and Mild Cognitive Impairment Patients
    Liang Gong, Ronghua Xu, Duan Liu, Lin Lan, Bei Zhang, Chuantao Zhang
    Frontiers in Aging Neuroscience 2020 11
  • Differential White Matter Connectivity in Early Mild Cognitive Impairment According to CSF Biomarkers
    Jae-Sung Lim, Young Ho Park, Jae-Won Jang, So Yong Park, SangYun Kim, Karl Herholz
    PLoS ONE 2014 9 3
  • Effects of APOE2 and APOE4 on brain microstructure in older adults: modification by age, sex, and cognitive status
    Emilie T. Reas, Curtis Triebswetter, Sarah J. Banks, Linda K. McEvoy
    Alzheimer's Research & Therapy 2024 16 1
  • Cognitively healthy APOE4/4 carriers show white matter impairment associated with serum NfL and amyloid-PET
    Claudia Tato-Fernández, Laura L. Ekblad, Elina Pietilä, Virva Saunavaara, Semi Helin, Riitta Parkkola, Henrik Zetterberg, Kaj Blennow, Juha O. Rinne, Anniina Snellman
    Neurobiology of Disease 2024 192
  • Frequencies of apolipoprotein E alleles in depressed patients undergoing hemodialysis – a case-control study
    Yan-yan Su, Yun-fang Zhang, Shen Yang, Jie-lin Wang, Bao-jun Hua, Jie Luo, Qi Wang, De-wang Zeng, Yan-qun Lin, Hong-yan Li
    Renal Failure 2015 37 5
  • Impact of APOE-ε alleles on brain structure and cognitive function in healthy older adults: A VBM and DTI replication study
    Colleen Lacey, Theone Paterson, Jodie R. Gawryluk, Xiong Jiang
    PLOS ONE 2024 19 4
  • White Matter Dementia
    2016
  • White Matter Dementia
    2016
PreviousNext
Back to top

In this issue

American Journal of Neuroradiology: 33 (7)
American Journal of Neuroradiology
Vol. 33, Issue 7
1 Aug 2012
  • Table of Contents
  • Index by author
Advertisement
Print
Download PDF
Email Article

Thank you for your interest in spreading the word on American Journal of Neuroradiology.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
White Matter Alterations in Cognitively Normal apoE ɛ2 Carriers: Insight into Alzheimer Resistance?
(Your Name) has sent you a message from American Journal of Neuroradiology
(Your Name) thought you would like to see the American Journal of Neuroradiology web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Cite this article
G.C. Chiang, W. Zhan, N. Schuff, M.W. Weiner
White Matter Alterations in Cognitively Normal apoE ɛ2 Carriers: Insight into Alzheimer Resistance?
American Journal of Neuroradiology Aug 2012, 33 (7) 1392-1397; DOI: 10.3174/ajnr.A2984

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
0 Responses
Respond to this article
Share
Bookmark this article
White Matter Alterations in Cognitively Normal apoE ɛ2 Carriers: Insight into Alzheimer Resistance?
G.C. Chiang, W. Zhan, N. Schuff, M.W. Weiner
American Journal of Neuroradiology Aug 2012, 33 (7) 1392-1397; DOI: 10.3174/ajnr.A2984
del.icio.us logo Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One
Purchase

Jump to section

  • Article
    • Abstract
    • ABBREVIATIONS:
    • Materials and Methods
    • Results
    • Discussion
    • Footnotes
    • References
  • Figures & Data
  • Info & Metrics
  • Responses
  • References
  • PDF

Related Articles

  • No related articles found.
  • PubMed
  • Google Scholar

Cited By...

  • White matter integrity and its association with amyloid-PET and serum NfL in healthy APOE4 homozygotes, heterozygotes and non-carries
  • Relationship between APOE Genotype and Structural MRI Measures throughout Adulthood in the Study of Health in Pomerania Population-Based Cohort
  • Gray matter maturation and cognition in children with different APOE {varepsilon} genotypes
  • Crossref (24)
  • Google Scholar

This article has been cited by the following articles in journals that are participating in Crossref Cited-by Linking.

  • Age, APOE and sex: Triad of risk of Alzheimer’s disease
    Brandalyn C. Riedel, Paul M. Thompson, Roberta Diaz Brinton
    The Journal of Steroid Biochemistry and Molecular Biology 2016 160
  • Thalamic pathology and memory loss in early Alzheimer’s disease: moving the focus from the medial temporal lobe to Papez circuit
    John P. Aggleton, Agathe Pralus, Andrew J. D. Nelson, Michael Hornberger
    Brain 2016 139 7
  • Brain connectivity in neurodegenerative diseases—from phenotype to proteinopathy
    Michela Pievani, Nicola Filippini, Martijn P. van den Heuvel, Stefano F. Cappa, Giovanni B. Frisoni
    Nature Reviews Neurology 2014 10 11
  • The forgotten APOE allele: A review of the evidence and suggested mechanisms for the protective effect of APOE ɛ2
    Sana Suri, Verena Heise, Aaron J. Trachtenberg, Clare E. Mackay
    Neuroscience & Biobehavioral Reviews 2013 37 10
  • Gray matter maturation and cognition in children with different APOE ε genotypes
    Linda Chang, Vanessa Douet, Cinnamon Bloss, Kristin Lee, Alexandra Pritchett, Terry L. Jernigan, Natacha Akshoomoff, Sarah S. Murray, Jean Frazier, David N. Kennedy, David G. Amaral, Jeffrey Gruen, Walter E. Kaufmann, B.J. Casey, Elizabeth Sowell, Thomas Ernst, Terry L. Jernigan, Connor McCabe, Linda Chang, Natacha Akshoomoff, Erik Newman, Anders M. Dale, Thomas Ernst, Anders M. Dale, Peter Van Zijl, Joshua Kuperman, Sarah Murray, Cinnamon Bloss, Mark Appelbaum, Anthony Gamst, Wesley Thompson, Brian Keating, David Amaral, Walter Kaufmann, Peter Van Zijl, Stewart Mostofsky, B.J. Casey, Erika J. Ruberry, Alisa Powers, Bruce Rosen, Tal Kenet, Jean Frazier, David Kennedy, Jeffrey Gruen
    Neurology 2016 87 6
  • White matter abnormalities associated with Alzheimer’s disease and mild cognitive impairment: a critical review of MRI studies
    Marcia Radanovic, Fabrício Ramos Silvestre Pereira, Florindo Stella, Ivan Aprahamian, Luiz Kobuti Ferreira, Orestes Vicente Forlenza, Geraldo F Busatto
    Expert Review of Neurotherapeutics 2013 13 5
  • Relationship betweenAPOEGenotype and Structural MRI Measures throughout Adulthood in the Study of Health in Pomerania Population-Based Cohort
    M. Habes, J.B. Toledo, S.M. Resnick, J. Doshi, S. Van der Auwera, G. Erus, D. Janowitz, K. Hegenscheid, G. Homuth, H. Völzke, W. Hoffmann, H.J. Grabe, C. Davatzikos
    American Journal of Neuroradiology 2016 37 9
  • Imaging markers of structural and functional brain changes that precede cognitive symptoms in risk for Alzheimer’s disease
    Alison Burggren, Jesse Brown
    Brain Imaging and Behavior 2014 8 2
  • Longitudinal white matter and cognitive development in pediatric carriers of the apolipoprotein ε4 allele
    Justin Remer, Douglas C. Dean, Kewei Chen, Rebecca A. Reiman, Matthew J. Huentelman, Eric M. Reiman, Sean C.L. Deoni
    NeuroImage 2020 222
  • Apolipoprotein E Genotype e2: Neuroprotection and Its Limits
    Hyun Kim, Davangere P. Devanand, Scott Carlson, Terry E. Goldberg
    Frontiers in Aging Neuroscience 2022 14

More in this TOC Section

  • Statin Therapy Does Not Affect the Radiographic and Clinical Profile of Patients with TIA and Minor Stroke
  • Optimal MRI Sequence for Identifying Occlusion Location in Acute Stroke: Which Value of Time-Resolved Contrast-Enhanced MRA?
  • SWI or T2*: Which MRI Sequence to Use in the Detection of Cerebral Microbleeds? The Karolinska Imaging Dementia Study
Show more Brain

Similar Articles

Advertisement

Indexed Content

  • Current Issue
  • Accepted Manuscripts
  • Article Preview
  • Past Issues
  • Editorials
  • Editors Choice
  • Fellow Journal Club
  • Letters to the Editor

Cases

  • Case Collection
  • Archive - Case of the Week
  • Archive - Case of the Month
  • Archive - Classic Case

Special Collections

  • Special Collections

Resources

  • News and Updates
  • Turn around Times
  • Submit a Manuscript
  • Author Policies
  • Manuscript Submission Guidelines
  • Evidence-Based Medicine Level Guide
  • Publishing Checklists
  • Graphical Abstract Preparation
  • Imaging Protocol Submission
  • Submit a Case
  • Become a Reviewer/Academy of Reviewers
  • Get Peer Review Credit from Publons

Multimedia

  • AJNR Podcast
  • AJNR SCANtastic
  • Video Articles

About Us

  • About AJNR
  • Editorial Board
  • Not an AJNR Subscriber? Join Now
  • Alerts
  • Feedback
  • Advertise with us
  • Librarian Resources
  • Permissions
  • Terms and Conditions

American Society of Neuroradiology

  • Not an ASNR Member? Join Now

© 2025 by the American Society of Neuroradiology All rights, including for text and data mining, AI training, and similar technologies, are reserved.
Print ISSN: 0195-6108 Online ISSN: 1936-959X

Powered by HighWire