Skip to main content
Advertisement

Main menu

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • Video Articles
    • AJNR Case Collection
    • Case of the Week Archive
    • Case of the Month Archive
    • Classic Case Archive
  • Special Collections
    • AJNR Awards
    • Low-Field MRI
    • Alzheimer Disease
    • ASNR Foundation Special Collection
    • Photon-Counting CT
    • View All
  • Multimedia
    • AJNR Podcasts
    • AJNR SCANtastic
    • Trainee Corner
    • MRI Safety Corner
    • Imaging Protocols
  • For Authors
    • Submit a Manuscript
    • Submit a Video Article
    • Submit an eLetter to the Editor/Response
    • Manuscript Submission Guidelines
    • Statistical Tips
    • Fast Publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Imaging Protocol Submission
    • Author Policies
  • About Us
    • About AJNR
    • Editorial Board
    • Editorial Board Alumni
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home

User menu

  • Alerts
  • Log in

Search

  • Advanced search
American Journal of Neuroradiology
American Journal of Neuroradiology

American Journal of Neuroradiology

ASHNR American Society of Functional Neuroradiology ASHNR American Society of Pediatric Neuroradiology ASSR
  • Alerts
  • Log in

Advanced Search

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • Video Articles
    • AJNR Case Collection
    • Case of the Week Archive
    • Case of the Month Archive
    • Classic Case Archive
  • Special Collections
    • AJNR Awards
    • Low-Field MRI
    • Alzheimer Disease
    • ASNR Foundation Special Collection
    • Photon-Counting CT
    • View All
  • Multimedia
    • AJNR Podcasts
    • AJNR SCANtastic
    • Trainee Corner
    • MRI Safety Corner
    • Imaging Protocols
  • For Authors
    • Submit a Manuscript
    • Submit a Video Article
    • Submit an eLetter to the Editor/Response
    • Manuscript Submission Guidelines
    • Statistical Tips
    • Fast Publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Imaging Protocol Submission
    • Author Policies
  • About Us
    • About AJNR
    • Editorial Board
    • Editorial Board Alumni
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home
  • Follow AJNR on Twitter
  • Visit AJNR on Facebook
  • Follow AJNR on Instagram
  • Join AJNR on LinkedIn
  • RSS Feeds

AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates

Research ArticleBrain
Open Access

Neuronavigation-Guided Focused Ultrasound-Induced Blood-Brain Barrier Opening: A Preliminary Study in Swine

K.-C. Wei, H.-C. Tsai, Y.-J. Lu, H.-W. Yang, M.-Y. Hua, M.-F. Wu, P.-Y. Chen, C.-Y. Huang, T.-C. Yen and H.-L. Liu
American Journal of Neuroradiology January 2013, 34 (1) 115-120; DOI: https://doi.org/10.3174/ajnr.A3150
K.-C. Wei
aFrom the Departments of Neurosurgery (K.-C.W., H.-C.T., Y.-J.L., P.-Y.C., C.-Y.H.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
H.-C. Tsai
aFrom the Departments of Neurosurgery (K.-C.W., H.-C.T., Y.-J.L., P.-Y.C., C.-Y.H.)
gGraduate Institute of Clinical Medical Sciences (H.-C.T.), Chang-Gung University and Memorial Hospital, Taoyuan, Taiwan
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Y.-J. Lu
aFrom the Departments of Neurosurgery (K.-C.W., H.-C.T., Y.-J.L., P.-Y.C., C.-Y.H.)
cChemical and Material Engineering (Y.-J.L., H.-W.Y., M.-Y.H., P.-Y.C.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
H.-W. Yang
cChemical and Material Engineering (Y.-J.L., H.-W.Y., M.-Y.H., P.-Y.C.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
M.-Y. Hua
cChemical and Material Engineering (Y.-J.L., H.-W.Y., M.-Y.H., P.-Y.C.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
M.-F. Wu
hAnimal Medicine Center (M.-F.W.), National Taiwan University, Taipei, Taiwan.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
P.-Y. Chen
aFrom the Departments of Neurosurgery (K.-C.W., H.-C.T., Y.-J.L., P.-Y.C., C.-Y.H.)
cChemical and Material Engineering (Y.-J.L., H.-W.Y., M.-Y.H., P.-Y.C.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
C.-Y. Huang
aFrom the Departments of Neurosurgery (K.-C.W., H.-C.T., Y.-J.L., P.-Y.C., C.-Y.H.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
T.-C. Yen
bNuclear Medicine (T.-C.Y.)
eMolecular Imaging Center (T.-C.Y., H.-L.L.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
H.-L. Liu
dElectrical Engineering (H.-L.L.)
eMolecular Imaging Center (T.-C.Y., H.-L.L.)
fHealthy Aging Research Center (H.-L.L.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • Supplemental
  • Info & Metrics
  • Responses
  • References
  • PDF
Loading

References

  1. 1.↵
    1. Brightman MW,
    2. Reese TS
    . Junctions between intimately apposed cell membranes in the vertebrate brain. J Cell Biol 1969;40:648–77
    Abstract/FREE Full Text
  2. 2.↵
    1. Pardridge WM
    . Drug and gene delivery to the brain: the vascular route. Neuron 2002;36:555–58
    CrossRefPubMedWeb of Science
  3. 3.↵
    1. Hynynen K,
    2. McDannold N,
    3. Sheikov NA,
    4. et al
    . Local and reversible blood-brain barrier disruption by noninvasive focused ultrasound at frequencies suitable for trans-skull sonications. Neuroimage 2005;24:12–20
    CrossRefPubMedWeb of Science
  4. 4.↵
    1. Hynynen K,
    2. McDannold N,
    3. Vykhodtseva N,
    4. et al
    . Noninvasive MR imaging-guided focal opening of the blood-brain barrier in rabbits. Radiology 2001;220:640–46
    CrossRefPubMedWeb of Science
  5. 5.↵
    1. Samiotaki G,
    2. Vlachos F,
    3. Tung YS,
    4. et al
    . A quantitative pressure and microbubble-size dependence study of focused ultrasound-induced blood-brain barrier opening reversibility in vivo using MRI. Magn Reson Med 2012;67:769–77
    CrossRefPubMed
  6. 6.↵
    1. Liu HL,
    2. Hsu PH,
    3. Chu PC,
    4. et al
    . Magnetic resonance imaging enhanced by superparamagnetic iron oxide particles: usefulness for distinguishing between focused ultrasound-induced blood-brain barrier disruption and brain hemorrhage. J Magn Reson Imaging 2009;29:31–38
    CrossRefPubMed
  7. 7.↵
    1. Cohen ZR,
    2. Zaubermann J,
    3. Harnof S,
    4. et al
    . Magnetic resonance imaging-guided focused ultrasound for thermal ablation in the brain: a feasibility study in a swine model. Neurosurgery 2007;60:593–600; discussion 600
    PubMed
  8. 8.↵
    1. Jagannathan J,
    2. Sanghvi NT,
    3. Crum LA,
    4. et al
    . High-intensity focused ultrasound surgery of the brain: part 1–A historical perspective with modern applications. Neurosurgery 2009;64:201–10; discussion 210–11
    CrossRefPubMed
  9. 9.↵
    1. McDannold N,
    2. Clement GT,
    3. Black P,
    4. et al
    . Transcranial magnetic resonance imaging-guided focused ultrasound surgery of brain tumors: initial findings in 3 patients. Neurosurgery 2010;66:323–32; discussion 332
    CrossRefPubMed
  10. 10.↵
    1. Hynynen K,
    2. Clement GT,
    3. McDannold N,
    4. et al
    . 500-element ultrasound phased array system for noninvasive focal surgery of the brain: a preliminary rabbit study with ex vivo human skulls. Magn Reson Med 2004;52:100–07
    CrossRefPubMedWeb of Science
  11. 11.↵
    1. Tung YS,
    2. Marquet F,
    3. Teichert T,
    4. et al
    . Feasibility of noninvasive cavitation-guided blood-brain barrier opening using focused ultrasound and microbubbles in nonhuman primates. Appl Phys Lett 2011;98:163704
    CrossRefPubMed
  12. 12.↵
    1. Xie F,
    2. Boska MD,
    3. Lof J,
    4. et al
    . Effects of transcranial ultrasound and intravenous microbubbles on blood brain barrier permeability in a large animal model. Ultrasound Med Biol 2008;34:2028–34
    CrossRefPubMed
  13. 13.↵
    1. Liu HL,
    2. Chen PY,
    3. Yang HW,
    4. et al
    . In vivo MR quantification of superparamagnetic iron oxide nanoparticle leakage during low-frequency-ultrasound-induced blood-brain barrier opening in swine. J Magn Reson Imaging 2011;34:1313–24
    CrossRefPubMed
  14. 14.↵
    1. Willems PW,
    2. van der Sprenkel JW,
    3. Tulleken CA,
    4. et al
    . Neuronavigation and surgery of intracerebral tumours. J Neurol 2006;253:1123–36
    CrossRefPubMedWeb of Science
  15. 15.↵
    1. Liu HL,
    2. Wai YY,
    3. Chen WS,
    4. et al
    . Hemorrhage detection during focused-ultrasound induced blood-brain-barrier opening by using susceptibility-weighted magnetic resonance imaging. Ultrasound Med Biol 2008;34:598–606
    CrossRefPubMed
  16. 16.↵
    1. Li KL,
    2. Zhu XP,
    3. Waterton J,
    4. et al
    . Improved 3D quantitative mapping of blood volume and endothelial permeability in brain tumors. J Magn Reson Imaging 2000;12:347–57
    CrossRefPubMed
  17. 17.↵
    1. Zhu XP,
    2. Li KL,
    3. Kamaly-Asl ID,
    4. et al
    . Quantification of endothelial permeability, leakage space, and blood volume in brain tumors using combined T1 and T2* contrast-enhanced dynamic MR imaging. J Magn Reson Imaging 2000;11:575–85
    CrossRefPubMedWeb of Science
  18. 18.↵
    1. Hynynen K,
    2. McDannold N,
    3. Martin H,
    4. et al
    . The threshold for brain damage in rabbits induced by bursts of ultrasound in the presence of an ultrasound contrast agent (Optison). Ultrasound Med Biol 2003;29:473–81
    CrossRefPubMed
  19. 19.↵
    1. Tung YS,
    2. Vlachos F,
    3. Choi JJ,
    4. et al
    . In vivo transcranial cavitation threshold detection during ultrasound-induced blood-brain barrier opening in mice. Phys Med Biol 2010;55:6141–55
    CrossRefPubMed
  20. 20.↵
    1. Omay SB,
    2. Barnett GH
    . Surgical navigation for meningioma surgery. J Neurooncol 2010;99:357–64
    CrossRefPubMed
  21. 21.↵
    1. Treat LH,
    2. McDannold N,
    3. Vykhodtseva N,
    4. et al
    . Targeted delivery of doxorubicin to the rat brain at therapeutic levels using MRI-guided focused ultrasound. Int J Cancer 2007;121:901–07
    CrossRefPubMedWeb of Science
  22. 22.↵
    1. Kinoshita M,
    2. McDannold N,
    3. Jolesz FA,
    4. et al
    . Noninvasive localized delivery of herceptin to the mouse brain by MRI-guided focused ultrasound-induced blood-brain barrier disruption. Proc Natl Acad Sci U S A 2006;103:11719–23
    Abstract/FREE Full Text
  23. 23.↵
    1. Holodny AI,
    2. Nusbaum AO,
    3. Festa S,
    4. et al
    . Correlation between the degree of contrast enhancement and the volume of peritumoral edema in meningiomas and malignant gliomas. Neuroradiology 1999;41:820–25
    CrossRefPubMed
  24. 24.↵
    1. Tralins KS,
    2. Douglas JG,
    3. Stelzer KJ,
    4. et al
    . Volumetric analysis of 18F-FDG PET in glioblastoma multiforme: prognostic information and possible role in definition of target volumes in radiation dose escalation. J Nucl Med 2002;43:1667–73
    Abstract/FREE Full Text
  25. 25.↵
    1. Kuhn SA,
    2. Romeike B,
    3. Walter J,
    4. et al
    . Multiplanar MRI-CT fusion neuronavigation-guided serial stereotactic biopsy of human brain tumors: proof of a strong correlation between tumor imaging and histopathology by a new technical approach. J Cancer Res Clin Oncol 2009;135:1293–302
    CrossRefPubMedWeb of Science
  26. 26.↵
    1. Yang FY,
    2. Liu SH,
    3. Ho FM,
    4. et al
    . Effect of ultrasound contrast agent dose on the duration of focused-ultrasound-induced blood-brain barrier disruption. J Acoust Soc Am 2009;126:3344–49
    CrossRefPubMed
PreviousNext
Back to top

In this issue

American Journal of Neuroradiology: 34 (1)
American Journal of Neuroradiology
Vol. 34, Issue 1
1 Jan 2013
  • Table of Contents
  • Index by author
Advertisement
Print
Download PDF
Email Article

Thank you for your interest in spreading the word on American Journal of Neuroradiology.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Neuronavigation-Guided Focused Ultrasound-Induced Blood-Brain Barrier Opening: A Preliminary Study in Swine
(Your Name) has sent you a message from American Journal of Neuroradiology
(Your Name) thought you would like to see the American Journal of Neuroradiology web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Cite this article
K.-C. Wei, H.-C. Tsai, Y.-J. Lu, H.-W. Yang, M.-Y. Hua, M.-F. Wu, P.-Y. Chen, C.-Y. Huang, T.-C. Yen, H.-L. Liu
Neuronavigation-Guided Focused Ultrasound-Induced Blood-Brain Barrier Opening: A Preliminary Study in Swine
American Journal of Neuroradiology Jan 2013, 34 (1) 115-120; DOI: 10.3174/ajnr.A3150

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
0 Responses
Respond to this article
Share
Bookmark this article
Neuronavigation-Guided Focused Ultrasound-Induced Blood-Brain Barrier Opening: A Preliminary Study in Swine
K.-C. Wei, H.-C. Tsai, Y.-J. Lu, H.-W. Yang, M.-Y. Hua, M.-F. Wu, P.-Y. Chen, C.-Y. Huang, T.-C. Yen, H.-L. Liu
American Journal of Neuroradiology Jan 2013, 34 (1) 115-120; DOI: 10.3174/ajnr.A3150
del.icio.us logo Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One
Purchase

Jump to section

  • Article
    • Abstract
    • ABBREVIATIONS:
    • Materials and Methods
    • Results
    • Discussion
    • Conclusions
    • Footnotes
    • References
  • Figures & Data
  • Supplemental
  • Info & Metrics
  • Responses
  • References
  • PDF

Related Articles

  • PubMed
  • Google Scholar

Cited By...

  • Neuronavigation-guided focused ultrasound for transcranial blood-brain barrier opening and immunostimulation in brain tumors
  • Crossref
  • Google Scholar

This article has not yet been cited by articles in journals that are participating in Crossref Cited-by Linking.

More in this TOC Section

  • Quiet PROPELLER MRI Techniques Match the Quality of Conventional PROPELLER Brain Imaging Techniques
  • Predictors of Reperfusion in Patients with Acute Ischemic Stroke
  • Enhanced Axonal Metabolism during Early Natalizumab Treatment in Relapsing-Remitting Multiple Sclerosis
Show more Brain

Similar Articles

Advertisement

Indexed Content

  • Current Issue
  • Accepted Manuscripts
  • Article Preview
  • Past Issues
  • Editorials
  • Editor's Choice
  • Fellows' Journal Club
  • Letters to the Editor
  • Video Articles

Cases

  • Case Collection
  • Archive - Case of the Week
  • Archive - Case of the Month
  • Archive - Classic Case

More from AJNR

  • Trainee Corner
  • Imaging Protocols
  • MRI Safety Corner
  • Book Reviews

Multimedia

  • AJNR Podcasts
  • AJNR Scantastics

Resources

  • Turnaround Time
  • Submit a Manuscript
  • Submit a Video Article
  • Submit an eLetter to the Editor/Response
  • Manuscript Submission Guidelines
  • Statistical Tips
  • Fast Publishing of Accepted Manuscripts
  • Graphical Abstract Preparation
  • Imaging Protocol Submission
  • Evidence-Based Medicine Level Guide
  • Publishing Checklists
  • Author Policies
  • Become a Reviewer/Academy of Reviewers
  • News and Updates

About Us

  • About AJNR
  • Editorial Board
  • Editorial Board Alumni
  • Alerts
  • Permissions
  • Not an AJNR Subscriber? Join Now
  • Advertise with Us
  • Librarian Resources
  • Feedback
  • Terms and Conditions
  • AJNR Editorial Board Alumni

American Society of Neuroradiology

  • Not an ASNR Member? Join Now

© 2025 by the American Society of Neuroradiology All rights, including for text and data mining, AI training, and similar technologies, are reserved.
Print ISSN: 0195-6108 Online ISSN: 1936-959X

Powered by HighWire