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Research ArticleFunctional

Role of Semantic Paradigms for Optimization of Language Mapping in Clinical fMRI Studies

D. Zacà, S. Jarso and J.J. Pillai
American Journal of Neuroradiology October 2013, 34 (10) 1966-1971; DOI: https://doi.org/10.3174/ajnr.A3628
D. Zacà
aFrom the Division of Neuroradiology (D.Z., J.J.P.), Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland
bCenter for Mind/Brain Sciences (D.Z.), University of Trento, Trento, Italy
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S. Jarso
cF.M. Kirby Research Center for Functional Brain Imaging (S.J.), The Kennedy-Krieger Institute, Baltimore, Maryland.
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J.J. Pillai
aFrom the Division of Neuroradiology (D.Z., J.J.P.), Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland
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    Fig 1.

    Examples of the stimuli in the control (first and third columns) and active (second and fourth columns) tasks in the 4 visually delivered paradigms used in the study: A, Silent Word Generation; B, Sentence Completion; C, Visual Antonym Pair; D, Noun-Verb Association.

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    Fig 2.

    Regions of interest defined on the MNI-152 atlas, where language localization (PSC) and lateralization (LI) were compared among the 5 language paradigms adopted in this study.

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    Table 1:

    Summary of Wilcoxon test results in PSC for language localization in the 5 ROIs included in the analysis

    IFGMFGSFGMTGSTG
    AAP<NVAAAP<NVAAAP<NVAAAP>NVAAAP>NVA
    LeftLeftLeftRightRight
    SC>AAPAAP>NVAAAP>NVASC>AAPSC>NVA
    LeftRightRightLeftRight
    SC>NVASC>AAPSC>AAPSC>VAPSC>VAP
    LeftLeftLeftRight and LeftRight
    SC>VAPSC>NVASC>VAPSWG<AAPSWG<AAP
    LeftLeftLeftRight and LeftRight and Left
    SWG>AAPSC>VAPSWG>AAPSWG<NVASWG<NVA
    LeftLeftLeftRight and LeftRight and Left
    SWG>NVASWG>AAPSWG>NVASWG<SCSWG<SC
    LeftLeftLeftRight and LeftRight and Left
    SWG>VAPSWG>VAPSWG>VAPSWG<VAPSWG<VAP
    LeftLeftLeftRight and LeftRight and Left
    VAP>AAPSWG<VAPVAP>AAPVAP<AAPVAP<AAP
    LeftRightLeftRightRight and Left
    SC>AAPVAP>AAPVAP<AAPSC>NVA
    LeftLeftRightRight
    • Note:—AAP indicates Auditory Antonym Pair; NVA, Noun-Verb Association; SC, Sentence Completion; SWG, Silent Word Generation; VAP, Visual Antonym Pair.

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    Table 2:

    Summary of Wilcoxon test results in the LI for lateralization analysis

    IFGMFGSFGMTG
    SWG>SCSWG>SCSWG>AAPSWG>AAP
    SWG>AAPSWG> VAPSWG>NVASC>AAP
    NVA>AAPSWG >NVASC>NVAVAP>AAP
    NVA>VAPSWG>AAPNVA>AAP
    NVA>AAP (trend)
    • Note:—AAP indicates Auditory Antonym Pair; NVA, Noun-Verb Association; SC, Sentence Completion; SWG, Silent Word Generation; VAP, Visual Antonym Pair.

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American Journal of Neuroradiology: 34 (10)
American Journal of Neuroradiology
Vol. 34, Issue 10
1 Oct 2013
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Cite this article
D. Zacà, S. Jarso, J.J. Pillai
Role of Semantic Paradigms for Optimization of Language Mapping in Clinical fMRI Studies
American Journal of Neuroradiology Oct 2013, 34 (10) 1966-1971; DOI: 10.3174/ajnr.A3628

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Role of Semantic Paradigms for Optimization of Language Mapping in Clinical fMRI Studies
D. Zacà, S. Jarso, J.J. Pillai
American Journal of Neuroradiology Oct 2013, 34 (10) 1966-1971; DOI: 10.3174/ajnr.A3628
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