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Research ArticleBrain
Open Access

T1 Gadolinium Enhancement of Intracranial Atherosclerotic Plaques Associated with Symptomatic Ischemic Presentations

P. Vakil, J. Vranic, M.C. Hurley, R.A. Bernstein, A.W. Korutz, A. Habib, A. Shaibani, F.H. Dehkordi, T.J. Carroll and S.A. Ansari
American Journal of Neuroradiology December 2013, 34 (12) 2252-2258; DOI: https://doi.org/10.3174/ajnr.A3606
P. Vakil
aFrom the Departments of Radiology (P.V., J.V., M.C.H., A.W.K., A.H., A.S., T.J.C., S.A.A.)
dBiomedical Engineering (P.V., T.J.C.), Northwestern University, Feinberg School of Medicine, Chicago, Illinois
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J. Vranic
aFrom the Departments of Radiology (P.V., J.V., M.C.H., A.W.K., A.H., A.S., T.J.C., S.A.A.)
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M.C. Hurley
aFrom the Departments of Radiology (P.V., J.V., M.C.H., A.W.K., A.H., A.S., T.J.C., S.A.A.)
cNeurosurgery (M.C.H., A.S., S.A.A.)
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R.A. Bernstein
bNeurology (R.A.B., S.A.A.)
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A.W. Korutz
aFrom the Departments of Radiology (P.V., J.V., M.C.H., A.W.K., A.H., A.S., T.J.C., S.A.A.)
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A. Habib
aFrom the Departments of Radiology (P.V., J.V., M.C.H., A.W.K., A.H., A.S., T.J.C., S.A.A.)
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A. Shaibani
aFrom the Departments of Radiology (P.V., J.V., M.C.H., A.W.K., A.H., A.S., T.J.C., S.A.A.)
cNeurosurgery (M.C.H., A.S., S.A.A.)
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F.H. Dehkordi
eDepartment of Economics and Decision Sciences (F.H.D.), Western Illinois University, Macomb, Illinois.
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T.J. Carroll
aFrom the Departments of Radiology (P.V., J.V., M.C.H., A.W.K., A.H., A.S., T.J.C., S.A.A.)
dBiomedical Engineering (P.V., T.J.C.), Northwestern University, Feinberg School of Medicine, Chicago, Illinois
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S.A. Ansari
aFrom the Departments of Radiology (P.V., J.V., M.C.H., A.W.K., A.H., A.S., T.J.C., S.A.A.)
bNeurology (R.A.B., S.A.A.)
cNeurosurgery (M.C.H., A.S., S.A.A.)
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    Fig 1.

    Symptomatic patient with MR DWI (A) demonstrating focal infarcts in the bilateral distributions (white arrows). TOF MR angiography MIP (B) and source images (C) confirm severe stenosis in an A2 azygous ACA segment. Axial T1-weighted-pre (D) and T1-weighted-post contrast (E) images identify enhancing ICAD plaque (inset) involving the azygous A2 ACA segment. Methodology of plaque/wall area measurements are demonstrated (F), with solid black line delineating outer wall boundary and dotted line segmenting the vessel lumen denoted as “L.”

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    Fig 2.

    Asymptomatic patient with history of stroke receiving follow-up imaging. TOF MRA reveals severe basilar stenosis in MIP (A) and source images (B). Axial T1WI precontrast (C) and postcontrast (D) demonstrates nonenhancing ICAD plaque.

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    Table 1:

    Patient demographics, clinical history, and imaging assessment

    Patient CharacteristicsSymptomaticAsymptomatic
    n109
    Age, y66.7 (SD, 11.7; range, 46–83)70.9 (SD, 6.7; range 60–81)
    Sex7 M; 3 F6 M; 3 F
    Active smoker1 (10%)1 (11%)
    History of ischemic stroke6 (60%)0 (0%)
    TIA10 (100%)1 (11%)a
    Diabetes mellitus5 (50%)4 (44%)
    Hypertension10 (100%)7 (78%)
    Hyperlipidemia9 (90%)7 (78%)
    Statin therapy8 (80%)5 (56%)
    Antiplatelet therapy6 (60%)4 (44%)
    Hypertension therapy8 (80%)5 (56%)
    Atrial fibrillation0 (0%)0 (0%)
    Anticoagulant therapy2 (20%)1 (11%)
    IPE7 (70%)1 (11%)
    • ↵a History of TIA.

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American Journal of Neuroradiology: 34 (12)
American Journal of Neuroradiology
Vol. 34, Issue 12
1 Dec 2013
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Cite this article
P. Vakil, J. Vranic, M.C. Hurley, R.A. Bernstein, A.W. Korutz, A. Habib, A. Shaibani, F.H. Dehkordi, T.J. Carroll, S.A. Ansari
T1 Gadolinium Enhancement of Intracranial Atherosclerotic Plaques Associated with Symptomatic Ischemic Presentations
American Journal of Neuroradiology Dec 2013, 34 (12) 2252-2258; DOI: 10.3174/ajnr.A3606

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T1 Gadolinium Enhancement of Intracranial Atherosclerotic Plaques Associated with Symptomatic Ischemic Presentations
P. Vakil, J. Vranic, M.C. Hurley, R.A. Bernstein, A.W. Korutz, A. Habib, A. Shaibani, F.H. Dehkordi, T.J. Carroll, S.A. Ansari
American Journal of Neuroradiology Dec 2013, 34 (12) 2252-2258; DOI: 10.3174/ajnr.A3606
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Cited By...

  • Delayed Enhancement of Intracranial Atherosclerotic Plaque Can Better Differentiate Culprit Lesions: A Multiphase Contrast-Enhanced Vessel Wall MRI Study
  • Effect of Time Elapsed since Gadolinium Administration on Atherosclerotic Plaque Enhancement in Clinical Vessel Wall MR Imaging Studies
  • Perfusion and plaque evaluation to predict recurrent stroke in symptomatic middle cerebral artery stenosis
  • Diagnostic Accuracy of High-Resolution Black-Blood MRI in the Evaluation of Intracranial Large-Vessel Arterial Occlusions
  • Development of a high resolution MRI intracranial atherosclerosis imaging phantom
  • Identification and Quantitative Assessment of Different Components of Intracranial Atherosclerotic Plaque by Ex Vivo 3T High-Resolution Multicontrast MRI
  • Gadolinium Enhancement in Intracranial Atherosclerotic Plaque and Ischemic Stroke: A Systematic Review and Meta-Analysis
  • Multimodal Diagnostic Imaging for Hyperacute Stroke
  • Imaging Intracranial Vessel Wall Pathology With Magnetic Resonance Imaging: Current Prospects and Future Directions
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