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Images from over 500 patients with glioblastoma were used to build location atlases corresponding to genetic and biologic abnormalities as well as prognosis based on age. Most glioblastomas grew into the periventricular regions adjacent to the subventricular zone. MGMT promoter methylated tumors occurred more frequently in the left temporal lobe in young patients, in IDH1 mutant tumors, in those having the proneural gene expression subtype, and in tumors lacking loss of PTEN that occurred most frequently in the frontal lobe. MGMT methylated tumors with IDH1 mutation tended to occur in the left frontal lobe. EGFR amplified and EGFR variant 3-expressing tumors were found most frequently in the left temporal lobe. Tumors in the left temporal lobe were associated with favorable response to radiochemotherapy and increased survival.

To shed light on brain complications occurring after heart surgery, the authors assessed BBB disruption and DWI findings in half of their patients by imaging at 24 hours after surgery and 24–48 hours later. Additionally, postcontrast T1 images were obtained postoperatively at 2–4 days in the other half of the patients. Almost half the patients undergoing cardiac surgery had evidence of BBB abnormalities and three-quarters showed acute lesions on DWI after surgery. BBB disruption is more prevalent in the first 24 hours after surgery. These findings suggest that MR can be used as an imaging biomarker to assess therapies that may protect the BBB in patients undergoing heart surgery.