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AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates

Research ArticleExtracranial Vascular

Cerebral Hemodynamic Benefits after Contralateral Carotid Artery Stenting in Patients with Internal Carotid Artery Occlusion

F. Oka, H. Ishihara, S. Kato, M. Higashi and M. Suzuki
American Journal of Neuroradiology March 2013, 34 (3) 616-621; DOI: https://doi.org/10.3174/ajnr.A3250
F. Oka
aFrom the Department of Neurosurgery, Yamaguchi University School of Medicine, Ube, Japan.
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H. Ishihara
aFrom the Department of Neurosurgery, Yamaguchi University School of Medicine, Ube, Japan.
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S. Kato
aFrom the Department of Neurosurgery, Yamaguchi University School of Medicine, Ube, Japan.
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M. Higashi
aFrom the Department of Neurosurgery, Yamaguchi University School of Medicine, Ube, Japan.
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M. Suzuki
aFrom the Department of Neurosurgery, Yamaguchi University School of Medicine, Ube, Japan.
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    Fig. 1.

    Images obtained in a representative case. A, A preoperative left common carotid artery angiogram shows severe ICA stenosis (anteroposterior view). B, Left CAS was performed and a postoperative angiogram reveals no significant residual stenosis (anteroposterior view). C and D, Preoperative SPECT shows hypoperfusion (C) and low cerebrovascular reactivity (D) in both hemispheres. In the right hemisphere, a steal phenomenon is detected (D). E and F, Postoperative SPECT obtained 3 months after CAS. The examination demonstrates increased resting CBF (E) and cerebrovascular reactivity (F) on both the ipsilateral and the contralateral carotid occluded sides.

Tables

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    Table 1:

    Patient and interventional characteristics

    PatientAge (yr)/SexSymptomDegree of Stenosis (%)Collateral FlowDPStentMaximum Balloon Size (mm)Procedure Timea (Occlusion Timeb) (min)Degree of Stenosis after CAS (%)Clinical Outcome (mRS)
    173/MAsymptomatic86AcomA +CGP5.03150
    PcomA +(8)
    268/MMinor stroke (hemodynamic)83AcomA +CGP4.03250
    PcomA −(12)
    363/FMinor stroke (emboli)80AcomA +AGP4.52901
    PcomA +
    460/MMinor stroke (emboli)80AcomA +CGP5.03001
    PcomA +(11)
    581/MAsymptomatic83AcomA +CGP4.02500
    PcomA −(7)
    669/MTIA (hemodynamic)90AcomA +FWCW4.03200
    PcomA +
    780/MMinor stroke (emboli)70AcomA +FWP5.03150
    PcomA +
    869/MMinor stroke (hemodynamic)80AcomA +FWP4.54000
    PcomA −
    • Note:—AG indicates AngioGuard XP; AcomA, anterior communicating artery; CG, carotid GuardWire; CW, carotid Wallstent; DP, distal protection device; FW, FilterWire EZ; mRS, modified Rankin Scale; P, Precise stent; PcomA, posterior communicating artery.

    • ↵a The period from insertion of a guiding catheter until the end of the procedure.

    • ↵b The period from inflation to deflation of a distal occlusion balloon in cases in which a Carotid GuardWire was used.

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    Table 2:

    Physiologic data before and after carotid artery stenting

    ParameterBefore CASAfter CAS (<2 h)After CAS (<3 mo)
    Hematocrit (%)35.0 ± 3.335.9 ± 3.133.5 ± 5.0
    PaCO2 (mm Hg)36.4 ± 2.738.3 ± 3.637.1 ± 2.9
    Mean arterial pressure (mm Hg)104 ± 986 ± 17.6a89 ± 9.2a
    • ↵a P < .05 vs preoperative data.

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    Table 3:

    Hemodynamic changes in both cerebral hemispheres before, immediately after, and chronically after carotid artery stenting

    PatientSide of CASSide of ICA Occlusion
    Resting CBF (mL/100 g/min)CVR (%)Resting CBF (mL/100 g/min)CVR (%)
    Before CASAfter CAS (<2 h)After CAS (3–6 mo)Before CASAfter CAS (3–6 mo)Before CASAfter CAS (<2 h)After CAS (3–6 mo)Before CASAfter CAS (3–6 mo)
    132.831.040.36.019.631.930.438.5−1.1−1.2
    225.720.727.35.933.124.619.726.2−6.315.8
    327.623.227.830.039.223.419.423.317.832.4
    424.430.929.57.344.419.724.223.310.336.2
    525.325.626.248.454.019.221.523.13.45.0
    627.927.934.526.659.926.027.032.720.018.0
    731.329.332.530.128.232.831.330.616.724.9
    818.517.019.938.051.618.916.920.233.245.2
    Mean26.7 ± 4.125.7 ± 4.829.7 ± 5.7a24.0 ± 15.041.2 ± 12.9a24.6 ± 5.123.8 ± 5.027.2 ± 5.8a11.8 ± 12.022.0 ± 14.7a
    • ↵a P < .05 vs preoperative data.

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American Journal of Neuroradiology: 34 (3)
American Journal of Neuroradiology
Vol. 34, Issue 3
1 Mar 2013
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F. Oka, H. Ishihara, S. Kato, M. Higashi, M. Suzuki
Cerebral Hemodynamic Benefits after Contralateral Carotid Artery Stenting in Patients with Internal Carotid Artery Occlusion
American Journal of Neuroradiology Mar 2013, 34 (3) 616-621; DOI: 10.3174/ajnr.A3250

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Cerebral Hemodynamic Benefits after Contralateral Carotid Artery Stenting in Patients with Internal Carotid Artery Occlusion
F. Oka, H. Ishihara, S. Kato, M. Higashi, M. Suzuki
American Journal of Neuroradiology Mar 2013, 34 (3) 616-621; DOI: 10.3174/ajnr.A3250
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