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AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates

Research ArticlePediatric Neuroimaging
Open Access

Location of Periventricular Nodular Heterotopia Is Related to the Malformation Phenotype on MRI

G. González, L. Vedolin, B. Barry, A. Poduri, C. Walsh and A.J. Barkovich
American Journal of Neuroradiology April 2013, 34 (4) 877-883; DOI: https://doi.org/10.3174/ajnr.A3312
G. González
aFrom the Department of Radiology and Biomedical Imaging (G.G., L.V., A.J.B.), University of California, San Francisco, California
bDepartment of Radiology (G.G.), Hospital San Juan de Dios, Santiago, Chile
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L. Vedolin
aFrom the Department of Radiology and Biomedical Imaging (G.G., L.V., A.J.B.), University of California, San Francisco, California
cNeuroradiology Section (L.V.), Hospital Moinhos de Vento, Porto Alegre, Brazil
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B. Barry
dDivision of Genetics (B.B., C.W.), Manton Center for Orphan Disease Research and Howard Hughes Medical Institute, Boston Children's Hospital, Boston, Massachusetts
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A. Poduri
eDepartment of Neurology (A.P., C.W.), Boston Children's Hospital, Boston, Massachusetts
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C. Walsh
dDivision of Genetics (B.B., C.W.), Manton Center for Orphan Disease Research and Howard Hughes Medical Institute, Boston Children's Hospital, Boston, Massachusetts
eDepartment of Neurology (A.P., C.W.), Boston Children's Hospital, Boston, Massachusetts
fDepartment of Neurology (C.W.), Harvard Medical School, Boston, Massachusetts.
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A.J. Barkovich
aFrom the Department of Radiology and Biomedical Imaging (G.G., L.V., A.J.B.), University of California, San Francisco, California
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    Fig. 1.

    PNH main patterns evaluated with T1 inversion recovery–weighted image. Arrowheads show locations of heterotopia. Axial images show an aPNH pattern with nodules restricted to the frontal horns (A) and bodies (B). Axial images demonstrate a pPNH pattern. Nodules are lining trigones and temporal and occipital horns bilaterally (C), sparing the frontal horns and bodies (D). E and F, Axial images show a dPNH pattern with nodules lining all of the walls of the lateral ventricles.

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    Fig. 2.

    pPNH and malformations of cortical development. Axial T2 FSE images show PNH lining the wall of the right temporal and occipital horns and trigone (arrowheads in A) and a large region of subcortical heterotopia in the right frontoparietal region (asterisks in B). C, Coronal T1 inversion recovery–weighted image demonstrates bilateral PNH in the temporal horns (arrowheads) and bilateral parietal pachygyria (arrows). D, Coronal inversion recovery–weighted image shows right temporal PNH (arrowheads) and bilateral perisylvian polymicrogyria (white arrows). E and F, Axial T1 inversion recovery–weighted images demonstrate bilateral pPNH (arrowheads) and a left occipital schizencephaly (asterisk in E). White arrows in F show the thickness of the WM band measured between the most posteromedial margin of Sylvian fissure and the lateral border of the ventricular trigone. In this case, it was diminished (5 mm).

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    Fig. 3.

    Heterotopia and commissure anomalies. T1 inversion recovery–weighted images in a 12-year-old boy with dPNH on the right cerebral hemisphere. A, Right parasagittal image shows multiple PNH lining the entire margin of the lateral ventricle. B, Sagittal image demonstrates agenesis of the corpus callosum with a thick anterior commissure (arrowhead) and an anteriorly positioned hippocampal commissure (arrow). A vascular structure is running along of the top of the third ventricle (open arrowhead). C, Coronal image shows moderate white matter volume reduction in the right hemisphere. The fornices are properly located at the roof of the third ventricle (arrows). PNH is seen in the margin of the frontal and temporal horns (arrowheads).

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    Fig. 4.

    pPNH and posterior fossa anomalies. A and B, An 11-day-old boy with microcephaly. Small PNH are present in the trigones (black arrowheads in A [axial T2 spin-echo–weighted image]). Other findings include a small pons (p in B [sagittal T1 spin-echo–weighted image]), a hypoplastic and dysmorphic vermis (white arrowheads), and a large inferior cerebellar peduncle (arrow). C and D, A 2-year-old boy with PNH in the trigones (black arrows in C [coronal T1 inversion recovery–weighted image]) and a very small vermis (white arrowheads), dysplastic and small cerebellar hemispheres (black arrowheads), and megacisterna magna (MCM).

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American Journal of Neuroradiology: 34 (4)
American Journal of Neuroradiology
Vol. 34, Issue 4
1 Apr 2013
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Cite this article
G. González, L. Vedolin, B. Barry, A. Poduri, C. Walsh, A.J. Barkovich
Location of Periventricular Nodular Heterotopia Is Related to the Malformation Phenotype on MRI
American Journal of Neuroradiology Apr 2013, 34 (4) 877-883; DOI: 10.3174/ajnr.A3312

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Location of Periventricular Nodular Heterotopia Is Related to the Malformation Phenotype on MRI
G. González, L. Vedolin, B. Barry, A. Poduri, C. Walsh, A.J. Barkovich
American Journal of Neuroradiology Apr 2013, 34 (4) 877-883; DOI: 10.3174/ajnr.A3312
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