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AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates

Research ArticleTechnical Note

Visual Cerebral Microbleed Detection on 7T MR Imaging: Reliability and Effects of Image Processing

J. de Bresser, M. Brundel, M.M. Conijn, J.J. van Dillen, M.I. Geerlings, M.A. Viergever, P.R. Luijten and G.J. Biessels
American Journal of Neuroradiology June 2013, 34 (6) E61-E64; DOI: https://doi.org/10.3174/ajnr.A2960
J. de Bresser
aFrom the Image Sciences Institute (J.d.B., M.A.V., P.R.L.)
bDepartment of Neurology (J.d.B., M.B., J.J.v.D., G.J.B.), Rudolf Magnus Institute of Neuroscience
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M. Brundel
bDepartment of Neurology (J.d.B., M.B., J.J.v.D., G.J.B.), Rudolf Magnus Institute of Neuroscience
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M.M. Conijn
cDepartment of Radiology (M.M.C., P.R.L.)
dJulius Center for Health Sciences and Primary Care (M.M.C., M.I.G.), University Medical Center Utrecht, Utrecht, the Netherlands.
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J.J. van Dillen
bDepartment of Neurology (J.d.B., M.B., J.J.v.D., G.J.B.), Rudolf Magnus Institute of Neuroscience
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M.I. Geerlings
dJulius Center for Health Sciences and Primary Care (M.M.C., M.I.G.), University Medical Center Utrecht, Utrecht, the Netherlands.
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M.A. Viergever
aFrom the Image Sciences Institute (J.d.B., M.A.V., P.R.L.)
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P.R. Luijten
aFrom the Image Sciences Institute (J.d.B., M.A.V., P.R.L.)
cDepartment of Radiology (M.M.C., P.R.L.)
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G.J. Biessels
bDepartment of Neurology (J.d.B., M.B., J.J.v.D., G.J.B.), Rudolf Magnus Institute of Neuroscience
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  • Fig 1.
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    Fig 1.

    Total number of microbleeds for mIP processing with and without an overlap. The left figure shows results of mIP processing without overlap but with differences in section thickness. The right figure shows the results of processing with overlap. The total number of detected microbleeds (possible and definite) is shown for all subjects, expressed as a percentage of maximum detected microbleeds within subjects.

  • Fig 2.
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    Fig 2.

    Examples of microbleeds that are easy or hard to detect. This figure illustrates different microbleeds that were classified as definite microbleeds in the ground truth ratings. A and B, The TE 1 and TE 2 of the T2*-weighted 7T MR scan with a microbleed that was detected by all raters. The microbleed is seen on both the TE 1 and TE 2 images. C and D, A microbleed that was only detected by a few raters. This microbleed was only seen on the TE 2 image.

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  • Visual rating of individual definite microbleed locations compared with the ground truth ratinga

    2/0 mIP Processing4/−2 mIP Processing
    Rater 1Rater 2Rater 3Rater 4Mean of All RatersRater 1Rater 2Rater 3Rater 4Mean of All Raters
    Mean time per subject (min)42182435304216233429
    Lobar (sensitivity/SI)0.61/0.630.23/0.370.61/0.720.71/0.760.54/0.620.65/0.730.42/0.590.52/0.650.81/0.830.60/0.70
    Deep (sensitivity/SI)1.00/0.890.75/0.750.75/0.550.75/0.400.81/0.650.50/0.360.75/0.750.50/0.671.00/0.460.69/0.56
    Total (sensitivity/SI)0.67/0.680.31/0.460.64/0.700.72/0.690.58/0.630.61/0.660.44/0.600.53/0.670.83/0.770.60/0.67
    • ↵a Ratings for each rater, which consisted of individual definite microbleed locations on scans with 2/0 and 4/−2 mIP processing, were compared with the ground truth ratings by sensitivity and SI.

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American Journal of Neuroradiology: 34 (6)
American Journal of Neuroradiology
Vol. 34, Issue 6
1 Jun 2013
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J. de Bresser, M. Brundel, M.M. Conijn, J.J. van Dillen, M.I. Geerlings, M.A. Viergever, P.R. Luijten, G.J. Biessels
Visual Cerebral Microbleed Detection on 7T MR Imaging: Reliability and Effects of Image Processing
American Journal of Neuroradiology Jun 2013, 34 (6) E61-E64; DOI: 10.3174/ajnr.A2960

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Visual Cerebral Microbleed Detection on 7T MR Imaging: Reliability and Effects of Image Processing
J. de Bresser, M. Brundel, M.M. Conijn, J.J. van Dillen, M.I. Geerlings, M.A. Viergever, P.R. Luijten, G.J. Biessels
American Journal of Neuroradiology Jun 2013, 34 (6) E61-E64; DOI: 10.3174/ajnr.A2960
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