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Research ArticleNeurointervention
Open Access

Last-Recorded P2Y12 Reaction Units Value Is Strongly Associated with Thromboembolic and Hemorrhagic Complications Occurring Up to 6 Months after Treatment in Patients with Cerebral Aneurysms Treated with the Pipeline Embolization Device

J.E. Delgado Almandoz, B.M. Crandall, J.M. Scholz, J.L. Fease, R.E. Anderson, Y. Kadkhodayan and D.E. Tubman
American Journal of Neuroradiology January 2014, 35 (1) 128-135; DOI: https://doi.org/10.3174/ajnr.A3621
J.E. Delgado Almandoz
aFrom the Division of Interventional Neuroradiology, Neuroscience Institute, Abbott Northwestern Hospital, Minneapolis, Minnesota.
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B.M. Crandall
aFrom the Division of Interventional Neuroradiology, Neuroscience Institute, Abbott Northwestern Hospital, Minneapolis, Minnesota.
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J.M. Scholz
aFrom the Division of Interventional Neuroradiology, Neuroscience Institute, Abbott Northwestern Hospital, Minneapolis, Minnesota.
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J.L. Fease
aFrom the Division of Interventional Neuroradiology, Neuroscience Institute, Abbott Northwestern Hospital, Minneapolis, Minnesota.
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R.E. Anderson
aFrom the Division of Interventional Neuroradiology, Neuroscience Institute, Abbott Northwestern Hospital, Minneapolis, Minnesota.
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Y. Kadkhodayan
aFrom the Division of Interventional Neuroradiology, Neuroscience Institute, Abbott Northwestern Hospital, Minneapolis, Minnesota.
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D.E. Tubman
aFrom the Division of Interventional Neuroradiology, Neuroscience Institute, Abbott Northwestern Hospital, Minneapolis, Minnesota.
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American Journal of Neuroradiology: 35 (1)
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Last-Recorded P2Y12 Reaction Units Value Is Strongly Associated with Thromboembolic and Hemorrhagic Complications Occurring Up to 6 Months after Treatment in Patients with Cerebral Aneurysms Treated with the Pipeline Embolization Device
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J.E. Delgado Almandoz, B.M. Crandall, J.M. Scholz, J.L. Fease, R.E. Anderson, Y. Kadkhodayan, D.E. Tubman
Last-Recorded P2Y12 Reaction Units Value Is Strongly Associated with Thromboembolic and Hemorrhagic Complications Occurring Up to 6 Months after Treatment in Patients with Cerebral Aneurysms Treated with the Pipeline Embolization Device
American Journal of Neuroradiology Jan 2014, 35 (1) 128-135; DOI: 10.3174/ajnr.A3621

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Last-Recorded P2Y12 Reaction Units Value Is Strongly Associated with Thromboembolic and Hemorrhagic Complications Occurring Up to 6 Months after Treatment in Patients with Cerebral Aneurysms Treated with the Pipeline Embolization Device
J.E. Delgado Almandoz, B.M. Crandall, J.M. Scholz, J.L. Fease, R.E. Anderson, Y. Kadkhodayan, D.E. Tubman
American Journal of Neuroradiology Jan 2014, 35 (1) 128-135; DOI: 10.3174/ajnr.A3621
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  • Optimal duration of dual antiplatelet therapy for stent-assisted coiling or flow diverter placement
  • Excessive platelet inhibition following Pipeline embolization of intracranial aneurysms
  • The utility of platelet inhibition testing in patients undergoing Pipeline embolization of intracranial aneurysms
  • Safety of Oral P2Y12 Inhibitors in Interventional Neuroradiology: Current Status and Perspectives
  • Reduction of thromboembolic complications during the endovascular treatment of unruptured aneurysms by employing a tailored dual antiplatelet regimen using aspirin and prasugrel
  • Active management of the target P2Y12 reaction unit range in patients undergoing stent-assisted coil embolization for unruptured cerebral aneurysms
  • Ticagrelor versus Clopidogrel in the Dual Antiplatelet Regimen for Intracranial Stenting or Flow-Diverter Treatment for Unruptured Cerebral Aneurysms: A Single-Center Cohort Study
  • Effect of bodyweight on VerifyNow Aspirin platelet function test: a retrospective review
  • Dose adjustment of clopidogrel in hyper-responder patients with unruptured intracranial aneurysms treated with stents
  • Diffusion weighted image documented cerebral ischemia in the postprocedural period following pipeline embolization device with shield technology treatment of unruptured intracranial aneurysms: a prospective, single center study
  • Predictive value of platelet reactivity unit (PRU) value for thrombotic and hemorrhagic events during flow diversion procedures: a meta-analysis
  • Procedural complexity independent of P2Y12 reaction unit (PRU) values is associated with acute in situ thrombosis in Pipeline flow diversion of cerebral aneurysms
  • Stent and flow diverter assisted treatment of acutely ruptured brain aneurysms
  • Parent Artery Reconstruction for Large or Giant Cerebral Aneurysms Using the Tubridge Flow Diverter: A Multicenter, Randomized, Controlled Clinical Trial (PARAT)
  • Acute thrombus formation on phosphorilcholine surface modified flow diverters
  • Middle cerebral artery flow velocity increases more in patients with delayed intraparenchymal hemorrhage after Pipeline
  • Early angiographic signs of acute thrombus formation following cerebral aneurysm treatment with the Pipeline embolization device
  • P2Y12 hyporesponse (PRU>200) is not associated with increased thromboembolic complications in anterior circulation Pipeline
  • Efficacy of a two-test protocol for achieving a therapeutic response to clopidogrel prior to elective endovascular intracranial aneurysm treatment and an 'induced postoperative hyper-response
  • Periprocedural outcomes and early safety with the use of the Pipeline Flex Embolization Device with Shield Technology for unruptured intracranial aneurysms: preliminary results from a prospective clinical study
  • Endovascular flow diversion for treatment of anterior communicating artery region cerebral aneurysms: a single-center cohort of 50 cases
  • Use of Platelet Function Testing Before Pipeline Embolization Device Placement: A Multicenter Cohort Study
  • Silent ischemic events after Pipeline embolization device: a prospective evaluation with MR diffusion-weighted imaging
  • Platelet reactivity and hemorrhage risk in neurointerventional procedures under dual antiplatelet therapy
  • Flow diverter device for the treatment of small middle cerebral artery aneurysms
  • Risk Factors for Hemorrhagic Complications following Pipeline Embolization Device Treatment of Intracranial Aneurysms: Results from the International Retrospective Study of the Pipeline Embolization Device
  • Critical assessment of complications associated with use of the Pipeline Embolization Device
  • Thromboembolic complications with Pipeline Embolization Device placement: impact of procedure time, number of stents and pre-procedure P2Y12 reaction unit (PRU) value
  • International Retrospective Study of the Pipeline Embolization Device: A Multicenter Aneurysm Treatment Study
  • Platelet function inhibitors and platelet function testing in neurointerventional procedures
  • Thromboembolic Complications in Patients with Clopidogrel Resistance after Coil Embolization for Unruptured Intracranial Aneurysms
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