Skip to main content
Advertisement

Main menu

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • Video Articles
    • AJNR Case Collection
    • Case of the Week Archive
    • Case of the Month Archive
    • Classic Case Archive
  • Special Collections
    • AJNR Awards
    • Low-Field MRI
    • Alzheimer Disease
    • ASNR Foundation Special Collection
    • Photon-Counting CT
    • View All
  • Multimedia
    • AJNR Podcasts
    • AJNR SCANtastic
    • Trainee Corner
    • MRI Safety Corner
    • Imaging Protocols
  • For Authors
    • Submit a Manuscript
    • Submit a Video Article
    • Submit an eLetter to the Editor/Response
    • Manuscript Submission Guidelines
    • Statistical Tips
    • Fast Publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Imaging Protocol Submission
    • Author Policies
  • About Us
    • About AJNR
    • Editorial Board
    • Editorial Board Alumni
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home

User menu

  • Alerts
  • Log in

Search

  • Advanced search
American Journal of Neuroradiology
American Journal of Neuroradiology

American Journal of Neuroradiology

ASHNR American Society of Functional Neuroradiology ASHNR American Society of Pediatric Neuroradiology ASSR
  • Alerts
  • Log in

Advanced Search

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • Video Articles
    • AJNR Case Collection
    • Case of the Week Archive
    • Case of the Month Archive
    • Classic Case Archive
  • Special Collections
    • AJNR Awards
    • Low-Field MRI
    • Alzheimer Disease
    • ASNR Foundation Special Collection
    • Photon-Counting CT
    • View All
  • Multimedia
    • AJNR Podcasts
    • AJNR SCANtastic
    • Trainee Corner
    • MRI Safety Corner
    • Imaging Protocols
  • For Authors
    • Submit a Manuscript
    • Submit a Video Article
    • Submit an eLetter to the Editor/Response
    • Manuscript Submission Guidelines
    • Statistical Tips
    • Fast Publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Imaging Protocol Submission
    • Author Policies
  • About Us
    • About AJNR
    • Editorial Board
    • Editorial Board Alumni
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home
  • Follow AJNR on Twitter
  • Visit AJNR on Facebook
  • Follow AJNR on Instagram
  • Join AJNR on LinkedIn
  • RSS Feeds

AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates

Research ArticleBrain
Open Access

Phase White Matter Signal Abnormalities in Patients with Clinically Isolated Syndrome and Other Neurologic Disorders

J. Hagemeier, M. Heininen-Brown, T. Gabelic, T. Guttuso, N. Silvestri, D. Lichter, L.E. Fugoso, N. Bergsland, E. Carl, J.J.G. Geurts, B. Weinstock-Guttman and R. Zivadinov
American Journal of Neuroradiology October 2014, 35 (10) 1916-1923; DOI: https://doi.org/10.3174/ajnr.A3969
J. Hagemeier
aFrom the Buffalo Neuroimaging Analysis Center (J.H., M.H.-B., T. Gabelic, N.B., E.C., R.Z.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
M. Heininen-Brown
aFrom the Buffalo Neuroimaging Analysis Center (J.H., M.H.-B., T. Gabelic, N.B., E.C., R.Z.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
T. Gabelic
aFrom the Buffalo Neuroimaging Analysis Center (J.H., M.H.-B., T. Gabelic, N.B., E.C., R.Z.)
cDepartment of Neurology (T. Gabelic), Referral Centre for Demyelinating Disease of the Central Nervous System, University Hospital Centre Zagreb, Zagreb, Croatia
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
T. Guttuso Jr
bBaird MS Center (T. Guttuso, N.S., D.L., L.E.F., B.W.-G., R.Z.), Department of Neurology, University at Buffalo, Buffalo, New York
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
N. Silvestri
bBaird MS Center (T. Guttuso, N.S., D.L., L.E.F., B.W.-G., R.Z.), Department of Neurology, University at Buffalo, Buffalo, New York
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
D. Lichter
bBaird MS Center (T. Guttuso, N.S., D.L., L.E.F., B.W.-G., R.Z.), Department of Neurology, University at Buffalo, Buffalo, New York
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
L.E. Fugoso
bBaird MS Center (T. Guttuso, N.S., D.L., L.E.F., B.W.-G., R.Z.), Department of Neurology, University at Buffalo, Buffalo, New York
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
N. Bergsland
aFrom the Buffalo Neuroimaging Analysis Center (J.H., M.H.-B., T. Gabelic, N.B., E.C., R.Z.)
dIstituto Di Ricovero e Cura a Carattere Scientifico (N.B.), Don Gnocchi Foundation, Milan, Italy
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
E. Carl
aFrom the Buffalo Neuroimaging Analysis Center (J.H., M.H.-B., T. Gabelic, N.B., E.C., R.Z.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
J.J.G. Geurts
eDepartment of Anatomy and Neurosciences (J.J.G.G.), Section of Clinical Neuroscience, VU University Medical Center, Amsterdam, the Netherlands.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
B. Weinstock-Guttman
bBaird MS Center (T. Guttuso, N.S., D.L., L.E.F., B.W.-G., R.Z.), Department of Neurology, University at Buffalo, Buffalo, New York
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
R. Zivadinov
aFrom the Buffalo Neuroimaging Analysis Center (J.H., M.H.-B., T. Gabelic, N.B., E.C., R.Z.)
bBaird MS Center (T. Guttuso, N.S., D.L., L.E.F., B.W.-G., R.Z.), Department of Neurology, University at Buffalo, Buffalo, New York
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • Supplemental
  • Info & Metrics
  • Responses
  • References
  • PDF
Loading

REFERENCES

  1. 1.↵
    1. Poloni G,
    2. Minagar A,
    3. Haacke EM, et al
    . Recent developments in imaging of multiple sclerosis. Neurologist 2011;17:185–204
    CrossRefPubMed
  2. 2.↵
    1. Filippi M,
    2. Rocca MA,
    3. De Stefano N, et al
    . Magnetic resonance techniques in multiple sclerosis: the present and the future. Arch Neurol 2011;68:1514–20
    CrossRefPubMed
  3. 3.↵
    1. Barkhof F
    . The clinico-radiological paradox in multiple sclerosis revisited. Curr Opin Neurol 2002;15:239–45
    CrossRefPubMedWeb of Science
  4. 4.↵
    1. Barkhof F
    . MRI in multiple sclerosis: correlation with Expanded Disability Status Scale (EDSS). Mult Scler 1999;5:283–86
    Abstract/FREE Full Text
  5. 5.↵
    1. Miller DH,
    2. Barkhof F,
    3. Nauta JJ
    . Gadolinium enhancement increases the sensitivity of MRI in detecting disease activity in multiple sclerosis. Brain 1993;116(pt 5):1077–94
    Abstract/FREE Full Text
  6. 6.↵
    1. Rovaris M,
    2. Holtmannspotter M,
    3. Rocca MA, et al
    . Contribution of cervical cord MRI and brain magnetization transfer imaging to the assessment of individual patients with multiple sclerosis: a preliminary study. Mult Scler 2002;8:52–58
    Abstract/FREE Full Text
  7. 7.↵
    1. Polman CH,
    2. Reingold SC,
    3. Banwell B, et al
    . Diagnostic criteria for multiple sclerosis: 2010 revisions to the McDonald criteria. Ann Neurol 2011;69:292–302
    CrossRefPubMedWeb of Science
  8. 8.↵
    1. Govoni M,
    2. Castellino G,
    3. Padovan M, et al
    . Recent advances and future perspective in neuroimaging in neuropsychiatric systemic lupus erythematosus. Lupus 2004;13:149–58
    Abstract/FREE Full Text
  9. 9.↵
    1. Triulzi F,
    2. Scotti G
    . Differential diagnosis of multiple sclerosis: contribution of magnetic resonance techniques. J Neurol Neurosurg Psychiatry 1998;64(suppl 1):S6–14
    CrossRefPubMed
  10. 10.↵
    1. Zivadinov R,
    2. Bergsland N,
    3. Stosic M, et al
    . Use of perfusion- and diffusion-weighted imaging in differential diagnosis of acute and chronic ischemic stroke and multiple sclerosis. Neurol Res 2008;30:816–26
    CrossRefPubMedWeb of Science
  11. 11.↵
    1. Yao B,
    2. Bagnato F,
    3. Matsuura E, et al
    . Chronic multiple sclerosis lesions: characterization with high-field-strength MR imaging. Radiology 2012;262:206–15
    CrossRefPubMedWeb of Science
  12. 12.↵
    1. Hagemeier J,
    2. Heininen-Brown M,
    3. Poloni GU, et al
    . Iron deposition in multiple sclerosis lesions measured by susceptibility-weighted imaging filtered phase: a case control study. J Magn Reson Imaging 2012;36:73–83
    CrossRefPubMed
  13. 13.↵
    1. Bian W,
    2. Harter K,
    3. Hammond-Rosenbluth KE, et al
    . A serial in vivo 7T magnetic resonance phase imaging study of white matter lesions in multiple sclerosis. Mult Scler 2013;19:69–75
    Abstract/FREE Full Text
  14. 14.↵
    1. Haacke EM,
    2. Makki M,
    3. Ge Y, et al
    . Characterizing iron deposition in multiple sclerosis lesions using susceptibility weighted imaging. J Magn Reson Imaging 2009;29:537–44
    CrossRefPubMed
  15. 15.↵
    1. Zivadinov R,
    2. Heininen-Brown M,
    3. Schirda CV, et al
    . Abnormal subcortical deep-gray matter susceptibility-weighted imaging filtered phase measurements in patients with multiple sclerosis: a case-control study. Neuroimage 2012;59:331–39
    CrossRefPubMedWeb of Science
  16. 16.↵
    1. Langkammer C,
    2. Krebs N,
    3. Goessler W, et al
    . Susceptibility induced gray-white matter MRI contrast in the human brain. Neuroimage 2012;59:1413–19
    CrossRefPubMed
  17. 17.↵
    1. Yablonskiy DA,
    2. Luo J,
    3. Sukstanskii AL, et al
    . Biophysical mechanisms of MRI signal frequency contrast in multiple sclerosis. Proc Natl Acad Sci U S A 2012;109:14212–17
    Abstract/FREE Full Text
  18. 18.↵
    1. Schweser F,
    2. Deistung A,
    3. Lehr BW, et al
    . Quantitative imaging of intrinsic magnetic tissue properties using MRI signal phase: an approach to in vivo brain iron metabolism? Neuroimage 2011;54:2789–807
    CrossRefPubMed
  19. 19.↵
    1. Hagemeier J,
    2. Geurts JJ,
    3. Zivadinov R
    . Brain iron accumulation in aging and neurodegenerative disorders. Expert Rev Neurother 2012;12:1467–80
    CrossRefPubMed
  20. 20.↵
    1. Wiggermann V,
    2. Hernandez Torres E,
    3. Vavasour IM, et al
    . Magnetic resonance frequency shifts during acute MS lesion formation. Neurology 2013;81:211–18
    CrossRef
  21. 21.↵
    1. Craelius W,
    2. Migdal MW,
    3. Luessenhop CP, et al
    . Iron deposits surrounding multiple sclerosis plaques. Arch Pathol Lab Med 1982;106:397–99
    PubMedWeb of Science
  22. 22.↵
    1. Ferguson B,
    2. Matyszak MK,
    3. Esiri MM, et al
    . Axonal damage in acute multiple sclerosis lesions. Brain 1997;120(pt 3):393–99
    Abstract/FREE Full Text
  23. 23.↵
    1. Trapp BD,
    2. Ransohoff R,
    3. Rudick R
    . Axonal pathology in multiple sclerosis: relationship to neurologic disability. Curr Opin Neurol 1999;12:295–302
    CrossRefPubMedWeb of Science
  24. 24.↵
    1. Grabner G,
    2. Dal-Bianco A,
    3. Schernthaner M, et al
    . Analysis of multiple sclerosis lesions using a fusion of 3.0 T FLAIR and 7.0 T SWI phase: FLAIR SWI. J Magn Reson Imaging 2011;33:543–49
    CrossRefPubMed
  25. 25.↵
    1. Nathoo N,
    2. Agrawal S,
    3. Wu Y, et al
    . Susceptibility-weighted imaging in the experimental autoimmune encephalomyelitis model of multiple sclerosis indicates elevated deoxyhemoglobin, iron deposition and demyelination. Mult Scler 2013;19:721–31
    Abstract/FREE Full Text
  26. 26.↵
    1. O'Connor K,
    2. Weinstock-Guttman B,
    3. Carl E, et al
    . Patterns of dietary and herbal supplement use by multiple sclerosis patients. J Neurol 2012;259:637–44
    CrossRefPubMed
  27. 27.↵
    1. Foster M,
    2. Zivadinov R,
    3. Weinstock-Guttman B, et al
    . Associations of moderate alcohol consumption with clinical and MRI measures in multiple sclerosis. J Neuroimmunol 2012;243:61–68
    CrossRefPubMedWeb of Science
  28. 28.↵
    1. Jenkinson M,
    2. Smith S
    . A global optimisation method for robust affine registration of brain images. Med Image Anal 2001;5:143–56
    CrossRefPubMedWeb of Science
  29. 29.↵
    1. Zivadinov R,
    2. Rudick RA,
    3. De Masi R, et al
    . Effects of IV methylprednisolone on brain atrophy in relapsing-remitting MS. Neurology 2001;57:1239–47
    CrossRef
  30. 30.↵
    1. Polman CH,
    2. Reingold SC,
    3. Edan G, et al
    . Diagnostic criteria for multiple sclerosis: 2005 revisions to the “McDonald criteria.” Ann Neurol 2005;58:840–46
    CrossRefPubMedWeb of Science
  31. 31.↵
    1. Benjamini Y,
    2. Hochberg Y
    . Controlling the false discovery rate: a practical and powerful approach to multiple testing. Journal of the Royal Statistical Society Series B (Methodological) 1995;57:289–300
    CrossRefWeb of Science
  32. 32.↵
    1. Mehta V,
    2. Pei W,
    3. Yang G, et al
    . Iron is a sensitive biomarker for inflammation in multiple sclerosis lesions. PLoS One 2013;8:e57573
    CrossRefPubMed
  33. 33.↵
    1. Eissa A,
    2. Lebel RM,
    3. Korzan JR, et al
    . Detecting lesions in multiple sclerosis at 4.7 Tesla using phase susceptibility-weighting and T2-weighting. J Magn Reson Imaging 2009;30:737–42
    CrossRefPubMed
  34. 34.↵
    1. Rovaris M,
    2. Filippi M
    . Diffusion tensor MRI in multiple sclerosis. J Neuroimaging 2007;17(suppl 1):27S–30S
    CrossRefPubMedWeb of Science
  35. 35.↵
    1. Richards TL
    . Proton MR spectroscopy in multiple sclerosis: value in establishing diagnosis, monitoring progression, and evaluating therapy. AJR Am J Roentgenol 1991;157:1073–78
    CrossRefPubMedWeb of Science
  36. 36.↵
    1. Tan IL,
    2. van Schijndel RA,
    3. Pouwels PJ, et al
    . MR venography of multiple sclerosis. AJNR Am J Neuroradiol 2000;21:1039–42
    Abstract/FREE Full Text
  37. 37.↵
    1. Tallantyre EC,
    2. Morgan PS,
    3. Dixon JE, et al
    . A comparison of 3T and 7T in the detection of small parenchymal veins within MS lesions. Invest Radiol 2009;44:491–94
    CrossRefPubMed
PreviousNext
Back to top

In this issue

American Journal of Neuroradiology: 35 (10)
American Journal of Neuroradiology
Vol. 35, Issue 10
1 Oct 2014
  • Table of Contents
  • Index by author
  • Complete Issue (PDF)
Advertisement
Print
Download PDF
Email Article

Thank you for your interest in spreading the word on American Journal of Neuroradiology.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Phase White Matter Signal Abnormalities in Patients with Clinically Isolated Syndrome and Other Neurologic Disorders
(Your Name) has sent you a message from American Journal of Neuroradiology
(Your Name) thought you would like to see the American Journal of Neuroradiology web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Cite this article
J. Hagemeier, M. Heininen-Brown, T. Gabelic, T. Guttuso, N. Silvestri, D. Lichter, L.E. Fugoso, N. Bergsland, E. Carl, J.J.G. Geurts, B. Weinstock-Guttman, R. Zivadinov
Phase White Matter Signal Abnormalities in Patients with Clinically Isolated Syndrome and Other Neurologic Disorders
American Journal of Neuroradiology Oct 2014, 35 (10) 1916-1923; DOI: 10.3174/ajnr.A3969

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
0 Responses
Respond to this article
Share
Bookmark this article
Phase White Matter Signal Abnormalities in Patients with Clinically Isolated Syndrome and Other Neurologic Disorders
J. Hagemeier, M. Heininen-Brown, T. Gabelic, T. Guttuso, N. Silvestri, D. Lichter, L.E. Fugoso, N. Bergsland, E. Carl, J.J.G. Geurts, B. Weinstock-Guttman, R. Zivadinov
American Journal of Neuroradiology Oct 2014, 35 (10) 1916-1923; DOI: 10.3174/ajnr.A3969
del.icio.us logo Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One
Purchase

Jump to section

  • Article
    • Abstract
    • ABBREVIATIONS:
    • Materials and Methods
    • Results
    • Discussion
    • Conclusions
    • Footnotes
    • REFERENCES
  • Figures & Data
  • Supplemental
  • Info & Metrics
  • Responses
  • References
  • PDF

Related Articles

  • PubMed
  • Google Scholar

Cited By...

  • MRI phase changes in multiple sclerosis vs neuromyelitis optica lesions at 7T
  • Crossref
  • Google Scholar

This article has not yet been cited by articles in journals that are participating in Crossref Cited-by Linking.

More in this TOC Section

  • Evaluating the Effects of White Matter Multiple Sclerosis Lesions on the Volume Estimation of 6 Brain Tissue Segmentation Methods
  • Quiet PROPELLER MRI Techniques Match the Quality of Conventional PROPELLER Brain Imaging Techniques
  • Predictors of Reperfusion in Patients with Acute Ischemic Stroke
Show more Brain

Similar Articles

Advertisement

Indexed Content

  • Current Issue
  • Accepted Manuscripts
  • Article Preview
  • Past Issues
  • Editorials
  • Editor's Choice
  • Fellows' Journal Club
  • Letters to the Editor
  • Video Articles

Cases

  • Case Collection
  • Archive - Case of the Week
  • Archive - Case of the Month
  • Archive - Classic Case

More from AJNR

  • Trainee Corner
  • Imaging Protocols
  • MRI Safety Corner
  • Book Reviews

Multimedia

  • AJNR Podcasts
  • AJNR Scantastics

Resources

  • Turnaround Time
  • Submit a Manuscript
  • Submit a Video Article
  • Submit an eLetter to the Editor/Response
  • Manuscript Submission Guidelines
  • Statistical Tips
  • Fast Publishing of Accepted Manuscripts
  • Graphical Abstract Preparation
  • Imaging Protocol Submission
  • Evidence-Based Medicine Level Guide
  • Publishing Checklists
  • Author Policies
  • Become a Reviewer/Academy of Reviewers
  • News and Updates

About Us

  • About AJNR
  • Editorial Board
  • Editorial Board Alumni
  • Alerts
  • Permissions
  • Not an AJNR Subscriber? Join Now
  • Advertise with Us
  • Librarian Resources
  • Feedback
  • Terms and Conditions
  • AJNR Editorial Board Alumni

American Society of Neuroradiology

  • Not an ASNR Member? Join Now

© 2025 by the American Society of Neuroradiology All rights, including for text and data mining, AI training, and similar technologies, are reserved.
Print ISSN: 0195-6108 Online ISSN: 1936-959X

Powered by HighWire