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Research ArticleBrain

Prediction of Glioma Recurrence Using Dynamic 18F-Fluoroethyltyrosine PET

T. Pyka, J. Gempt, F. Ringel, S. Hüttinger, S. van Marwick, S. Nekolla, H.-J. Wester, M. Schwaiger and S. Förster
American Journal of Neuroradiology October 2014, 35 (10) 1924-1929; DOI: https://doi.org/10.3174/ajnr.A3980
T. Pyka
aFrom the Departments of Nuclear Medicine (T.P., S.v.M., S.N., M.S., S.F)
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J. Gempt
bNeurosurgery (J.G., F.R.)
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F. Ringel
bNeurosurgery (J.G., F.R.)
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S. Hüttinger
cNeuroradiology (S.H.)
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S. van Marwick
aFrom the Departments of Nuclear Medicine (T.P., S.v.M., S.N., M.S., S.F)
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S. Nekolla
aFrom the Departments of Nuclear Medicine (T.P., S.v.M., S.N., M.S., S.F)
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H.-J. Wester
dPharmaceutical Radiochemistry (H.-J.W.), Technical University Munich, Munich, Germany.
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M. Schwaiger
aFrom the Departments of Nuclear Medicine (T.P., S.v.M., S.N., M.S., S.F)
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S. Förster
aFrom the Departments of Nuclear Medicine (T.P., S.v.M., S.N., M.S., S.F)
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REFERENCES

  1. 1.↵
    1. Viaccoz A,
    2. Lekoubou A,
    3. Ducray F
    . Chemotherapy in low-grade gliomas. Curr Opin Oncol 2012;24:694–701
    CrossRefPubMed
  2. 2.↵
    1. Cloughesy T
    . The impact of recent data on the optimization of standards of care in newly diagnosed glioblastoma. Semin Oncol 2011;38(suppl 4):S11–20
  3. 3.↵
    1. Stupp R,
    2. Mason WP,
    3. van den Bent MJ, et al
    . Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N Engl J Med 2005;352:987–96
    CrossRefPubMedWeb of Science
  4. 4.↵
    1. Louis DN,
    2. Ohgaki H,
    3. Wiestler OD, et al
    . The 2007 WHO classification of tumours of the central nervous system. Acta Neuropathol 2007;114:97–109
    CrossRefPubMedWeb of Science
  5. 5.↵
    1. Chaudhry NS,
    2. Shah AH,
    3. Ferraro N, et al
    . Predictors of long-term survival in patients with glioblastoma multiforme: advancements from the last quarter century. Cancer Invest 2013;31:287–308
    CrossRefPubMedWeb of Science
  6. 6.↵
    1. Weiler M,
    2. Wick W
    . Molecular predictors of outcome in low-grade glioma. Curr Opin Neurol 2012;25:767–73
    CrossRefPubMed
  7. 7.↵
    1. Gutman DA,
    2. Cooper LA,
    3. Hwang SN, et al
    . MR imaging predictors of molecular profile and survival: multi-institutional study of the TCGA glioblastoma data set. Radiology 2013;267:560–69
    CrossRefPubMedWeb of Science
  8. 8.↵
    1. Barker FG 2nd.,
    2. Chang SM,
    3. Huhn SL, et al
    . Age and the risk of anaplasia in magnetic resonance-nonenhancing supratentorial cerebral tumors. Cancer 1997;80:936–41
    CrossRefPubMed
  9. 9.↵
    1. Scott JN,
    2. Brasher PM,
    3. Sevick RJ, et al
    . How often are nonenhancing supratentorial gliomas malignant? A population study. Neurology 2002;59:947–49
    CrossRef
  10. 10.↵
    1. Sanz-Requena R,
    2. Revert-Ventura A,
    3. Martí-Bonmatí L, et al
    . Quantitative MR perfusion parameters related to survival time in high-grade gliomas. Eur Radiol 2013;23:3456–65
    CrossRefPubMed
  11. 11.↵
    1. Zonari P,
    2. Baraldi P,
    3. Crisi G
    . Multimodal MRI in the characterization of glial neoplasms: the combined role of single-voxel MR spectroscopy, diffusion imaging and echo-planar perfusion imaging. Neuroradiology 2007;49:795–803
    CrossRefPubMedWeb of Science
  12. 12.↵
    1. Padma MV,
    2. Said S,
    3. Jacobs M, et al
    . Prediction of pathology and survival by FDG PET in gliomas. J Neurooncol 2003;64:227–37
    CrossRefPubMed
  13. 13.↵
    1. Miyagawa T,
    2. Oku T,
    3. Uehara H, et al
    . “Facilitated” amino acid transport is upregulated in brain tumors. J Cereb Blood Flow Metab 1998;18:500–09
    CrossRefPubMed
  14. 14.↵
    1. Jansen NL,
    2. Graute V,
    3. Armbruster L, et al
    . MRI-suspected low-grade glioma: is there a need to perform dynamic FET PET? Eur J Nucl Med Mol Imaging 2012;39:1021–29
    CrossRefPubMed
  15. 15.↵
    1. Weckesser M,
    2. Langen K,
    3. Rickert C, et al
    . O-(2-[(18)F]fluoroethyl)-L-tyrosine PET in the clinical evaluation of primary brain tumour. Eur J Nucl Med Mol Imaging 2005;32:422–29
    CrossRefPubMedWeb of Science
  16. 16.↵
    1. Niyazi M,
    2. Geisler J,
    3. Siefert A, et al
    . FET-PET for malignant glioma treatment planning. Radiother Oncol 2011;99:44–48
    CrossRefPubMed
  17. 17.↵
    1. Rachinger W,
    2. Goetz C,
    3. Pöpperl G, et al
    . Positron emission tomography with O-(2-[18F]fluoroethyl)-l-tyrosine versus magnetic resonance imaging in the diagnosis of recurrent gliomas. Neurosurgery 2005:57:505–11, discussion 505–11
    CrossRefPubMedWeb of Science
  18. 18.↵
    1. Floeth FW,
    2. Pauleit D,
    3. Sabel M, et al
    . Prognostic value of O-(2–18F-fluoroethyl)-L-tyrosine PET and MRI in low-grade glioma. J Nucl Med 2007;48:519–27
    Abstract/FREE Full Text
  19. 19.↵
    1. Galldiks N,
    2. Stoffels G,
    3. Ruge MI, et al
    . Role of O-(2–18F-fluoroethyl)-L-tyrosine PET as a diagnostic tool for detection of malignant progression in patients with low-grade glioma. J Nucl Med 2013;54:2046–54
    Abstract/FREE Full Text
  20. 20.↵
    1. Pöpperl G,
    2. Kreth FW,
    3. Herms J, et al
    . Analysis of 18F-FET PET for grading of recurrent gliomas: is evaluation of uptake kinetics superior to standard methods? J Nucl Med 2006;47:393–403
    Abstract/FREE Full Text
  21. 21.↵
    1. Pöpperl G,
    2. Kreth FW,
    3. Herms J, et al
    . FET PET for the evaluation of untreated gliomas: correlation of FET uptake and uptake kinetics with tumour grading. Eur J Nucl Med Mol Imaging 2007;34:1933–42
    CrossRefPubMedWeb of Science
  22. 22.↵
    1. van den Bent MJ,
    2. Wefel JS,
    3. Schiff D, et al
    . Response assessment in neuro-oncology (a report of the RANO group): assessment of outcome in trials of diffuse low-grade gliomas. Lancet Oncol 2011;12:583–93
    CrossRefPubMedWeb of Science
  23. 23.↵
    1. Lutz K,
    2. Radbruch A,
    3. Wiestler B, et al
    . Neuroradiological response criteria for high-grade gliomas. Clin Neuroradiol 2011;21:199–205
    CrossRefPubMed
  24. 24.↵
    1. Dunet V,
    2. Rossier C,
    3. Buck A, et al
    . Performance of 18F-fluoro-ethyl-tyrosine (18F-FET) PET for the differential diagnosis of primary brain tumor: a systematic review and metaanalysis. J Nucl Med 2012;53:207–14
    Abstract/FREE Full Text
  25. 25.↵
    1. van Marwick S,
    2. Beer A,
    3. Metz S, et al
    . M3P-anima: a visualization and quantification concept for multimodal, multiparametric imaging. In: Proceedings of the 97th Annual Meeting of the Radiological Society of North America, Chicago, Illinois. November 27–December 4, 2011
  26. 26.↵
    1. Thiele F,
    2. Ehmer J,
    3. Piroth MD, et al
    . The quantification of dynamic FET PET imaging and correlation with the clinical outcome in patients with glioblastoma. Phys Med Biol 2009;54:5525–39
    CrossRefPubMed
  27. 27.↵
    1. Labussiere M,
    2. Wang XW,
    3. Idbaih A, et al
    . Prognostic markers in gliomas. Future Oncol 2010;6:733–39
    CrossRefPubMed
  28. 28.↵
    1. Theeler BJ,
    2. Yung WK,
    3. Fuller GN, et al
    . Moving toward molecular classification of diffuse gliomas in adults. Neurology 2012;79:1917–26
    CrossRef
  29. 29.↵
    1. Little SE,
    2. Popov S,
    3. Jury A, et al
    . Receptor tyrosine kinase genes amplified in glioblastoma exhibit a mutual exclusivity in variable proportions reflective of individual tumor heterogeneity. Cancer Res 2012;72:1614–20
    Abstract/FREE Full Text
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American Journal of Neuroradiology: 35 (10)
American Journal of Neuroradiology
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Cite this article
T. Pyka, J. Gempt, F. Ringel, S. Hüttinger, S. van Marwick, S. Nekolla, H.-J. Wester, M. Schwaiger, S. Förster
Prediction of Glioma Recurrence Using Dynamic 18F-Fluoroethyltyrosine PET
American Journal of Neuroradiology Oct 2014, 35 (10) 1924-1929; DOI: 10.3174/ajnr.A3980

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Prediction of Glioma Recurrence Using Dynamic 18F-Fluoroethyltyrosine PET
T. Pyka, J. Gempt, F. Ringel, S. Hüttinger, S. van Marwick, S. Nekolla, H.-J. Wester, M. Schwaiger, S. Förster
American Journal of Neuroradiology Oct 2014, 35 (10) 1924-1929; DOI: 10.3174/ajnr.A3980
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