Article Figures & Data
Figures
- Fig 1.
Positioning of the pons TSI scan and spectrum data processing. A, T2-weighted images show the placement of volumes of interest in the pons. The left side is sagittal, and the right side is transversal. The TSI was positioned parallel to the frontal cranial fossa. Note that the box is the signal-generating area. B, The upper row of images shows the region-of-interest selection area, and the lower image shows the reconstructed average metabolite ratios of the region of interest.
- Fig 2.
Proton MR spectrum of the pons in subjects of different ages. A, Spectrum of a 1-month-old baby's pons. B, Spectrum of a 5-year-old boy's pons. C, Spectrum of a 63-year-old man's pons. Note the relatively high Cho and low NAA levels in the baby. There is a higher NAA level and a lower Cho level in the 5-year-old child compared with the baby. The Cho level is lower in the 63-year-old man compared with the 5-year-old child.
- Fig 3.
Scatterplot showing the metabolite changes in the pons with age. A, The scatterplot shows that NAA/Cr was low at birth, rose rapidly at 0–5 years, reaching a peak at approximately 10–20 years, and then gradually decreased. B, The Cho/Cr decreased rapidly at 0–5 years, then continued to decline, and was stable after 20 years of age. C, The Cho/NAA decreased rapidly at 0–5 years, then continued to decline, and finally rose after 20 years of age. Note that the curve-fitting model used is locally weighted scatterplot smoothing (LOESS), and the percentage of fitting points is 50%.
Tables
Age Groups (yr) Mean No. P Value 0–5 2.14 ± 0.25 20 .001,a <.001b 6–20 1.90 ± 0.20 15 .468,c .261d 21–50 1.85 ± 0.19 21 .665e Older than 50 1.82 ± 0.20 22 <.001f ↵a Comparison between 0 to 5- and 6 to 20-year-old subjects.
↵b Comparison between 0 to 5- and 21 to 50-year-old subjects.
↵c Comparison between 6 to 20- and 21 to 50-year-old subjects.
↵d Comparison between 6 to 20- and older than 50-year-old subjects.
↵e Comparison between 21 to 50- and older than 50-year-old subjects.
↵f Comparison between 0 to 5- and older than 50-year-old subjects.
Age Groups (yr) Mean No. P Value 0–5 2.14 ± 0.25 20 0.001,a <.001b 6–20 1.90 ± 0.20 15 0.468,c .261d 21–50 1.85 ± 0.19 21 .665e Older than 50 1.82 ± 0.20 22 <.001f ↵a Comparison between 0 to 5- and 6 to 20-year-old subjects.
↵b Comparison between 0 to 5- and 21 to 50-year-old subjects.
↵c Comparison between 6 to 20- and 21 to 50-year-old subjects.
↵d Comparison between 6 to 20- and older than 50-year-old subjects.
↵e Comparison between 21 to 50- and older than 50-year-old subjects.
↵f Comparison between 0 to 5- and older than 50-year-old subjects.
Age Groups (yr) Median/Quartile No. P Value 0–5 1.01/0.84–1.43 20 <.001,a <.001b 6–20 0.63/0.60–0.67 15 .005,c <.001d 21–50 0.70/0.65–0.78 21 .015e Older than 50 0.81/0.72–0.86 22 .001f ↵a Comparison between 0 to 5- and 6 to 20-year-old subjects.
↵b Comparison between 0 to 5- and 21 to 50-year-old subjects.
↵c Comparison between 6 to 20- and 21 to 50-year-old subjects.
↵d Comparison between 6 to 20- and older than 50-year-old subjects.
↵e Comparison between 21 to 50- and older than 50-year-old subjects.
↵f Comparison between 0 to 5- and older than 50-year-old subjects.
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