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Research ArticleNeurointervention

Contrast-Enhanced Time-Resolved MRA for Follow-Up of Intracranial Aneurysms Treated with the Pipeline Embolization Device

S.R. Boddu, F.C. Tong, S. Dehkharghani, J.E. Dion and A.M. Saindane
American Journal of Neuroradiology November 2014, 35 (11) 2112-2118; DOI: https://doi.org/10.3174/ajnr.A4008
S.R. Boddu
aFrom the Departments of Radiology and Imaging Sciences (S.R.B., F.C.T., S.D., J.E.D., A.M.S.)
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F.C. Tong
aFrom the Departments of Radiology and Imaging Sciences (S.R.B., F.C.T., S.D., J.E.D., A.M.S.)
bNeurological Surgery (F.C.T., J.E.D.), Emory University School of Medicine, Atlanta, Georgia.
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S. Dehkharghani
aFrom the Departments of Radiology and Imaging Sciences (S.R.B., F.C.T., S.D., J.E.D., A.M.S.)
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J.E. Dion
aFrom the Departments of Radiology and Imaging Sciences (S.R.B., F.C.T., S.D., J.E.D., A.M.S.)
bNeurological Surgery (F.C.T., J.E.D.), Emory University School of Medicine, Atlanta, Georgia.
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A.M. Saindane
aFrom the Departments of Radiology and Imaging Sciences (S.R.B., F.C.T., S.D., J.E.D., A.M.S.)
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  • Fig 1.
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    Fig 1.

    Stent migration with concordance between CE-TR MRA and DSA. A 56-year-old woman with a right cavernous carotid aneurysm. A, Immediate post-PED of the right cavernous ICA aneurysm with stasis. B, DSA shows the actual position of the PED after embolization (yellow line along stent course). C, Complete opacification of the aneurysm at 6-month DSA with no stasis or thrombus. D, DSA confirms distal migration (yellow line along stent course) resulting in reopening of the aneurysm neck (red line with red arrow). Superior demonstration of complete aneurysm opacification (yellow arrow) on CE-TR MRA (F) over 3D-TOF MRA (E) at 6-month follow-up. The hyperintensity in the aneurysm sac on TOF MRA (E) may represent either thrombus from intact PED or aneurysm refilling from PED migration (yellow arrow).

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    Fig 2.

    Discordance between CE-TR MRA and DSA. A 68-year-old woman with a right paraophthalmic aneurysm. A, Post-Pipeline embolization right paraophthalmic aneurysm. B, No residual neck is demonstrated (yellow arrow) on the 6-month follow-up CE-TR MRA. C, A thin crescentic residual neck measuring 1 mm deep (yellow arrow) is seen on the subsequent DSA.

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    Fig 3.

    Overestimation of in-stent stenosis on MRA techniques. A 63-year-old woman with a left ophthalmic artery aneurysm. A, 3D-TOF MRA shows complete loss of flow-related enhancement in the PED (yellow arrow), suggestive of occlusion. B, Preserved enhancement within the PED with a narrowed lumen (yellow arrow) suggestive of in-stent stenosis. C, DSA demonstrates a normal-caliber ICA with no in-stent stenosis or occlusion.

Tables

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    Table 1:

    Quality of visualization of the reconstructed parent artery with the PED using 3D-TOF MRA and CE-TR MRAa

    TechniqueMeanSD95% CI of MeanComparison with DSA (P Value)Comparison with TR-MRA (P Value)
    3D-TOF MRA2.620.8982.243–2.936.0001.0001
    CE-TR MRA3.810.6943.464–4.162.344NA
    • Note:—NA indicates not applicable.

    • ↵a Five-point grading scale from 0–4 (0, very poor; 1, poor; 2, fair; 3, good; 4, excellent). DSA is considered the reference standard with a score of 4.

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    Table 2:

    Measured luminal diameter of the reconstructed parent artery with the PED using 3D-TOF MRA and CE-TR MRA

    TechniqueMean (mm)SD95% CI of MeanComparison with DSA (P Value)Comparison with TR-MRA (P Value)
    3D-TOF MRA2.1080.9641.718–2.497.0001.0001
    CE-TR MRA3.1370.5462.910–3.351.661NA
    DSA4.0960.6873.819–4.374NA.661
    • Note:—NA indicates not applicable.

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    Table 3:

    Overestimation of luminal stenosis of the reconstructed parent artery with the PED

    TechniqueMean (mm) (%)SD (%)95% CI of Mean
    3D-TOF MRA versus DSA1.992 (71.8)0.998 (52.7)0.036–3.948 (31.6%–175%)
    CE-TR MRA versus DSA0.965 (26.6)0.497 (12.7)0.01–1.941 (1.7%–51.5%)
    3D-TOF MRA versus CE-TR MRA1.027 (50.1)0.776 (58.8)0.495–2.55 (65.1%–165%)
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American Journal of Neuroradiology: 35 (11)
American Journal of Neuroradiology
Vol. 35, Issue 11
1 Nov 2014
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Cite this article
S.R. Boddu, F.C. Tong, S. Dehkharghani, J.E. Dion, A.M. Saindane
Contrast-Enhanced Time-Resolved MRA for Follow-Up of Intracranial Aneurysms Treated with the Pipeline Embolization Device
American Journal of Neuroradiology Nov 2014, 35 (11) 2112-2118; DOI: 10.3174/ajnr.A4008

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Contrast-Enhanced Time-Resolved MRA for Follow-Up of Intracranial Aneurysms Treated with the Pipeline Embolization Device
S.R. Boddu, F.C. Tong, S. Dehkharghani, J.E. Dion, A.M. Saindane
American Journal of Neuroradiology Nov 2014, 35 (11) 2112-2118; DOI: 10.3174/ajnr.A4008
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