Skip to main content
Advertisement

Main menu

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • Video Articles
    • AJNR Case Collection
    • Case of the Week Archive
    • Case of the Month Archive
    • Classic Case Archive
  • Special Collections
    • AJNR Awards
    • Low-Field MRI
    • Alzheimer Disease
    • ASNR Foundation Special Collection
    • Photon-Counting CT
    • View All
  • Multimedia
    • AJNR Podcasts
    • AJNR SCANtastic
    • Trainee Corner
    • MRI Safety Corner
    • Imaging Protocols
  • For Authors
    • Submit a Manuscript
    • Submit a Video Article
    • Submit an eLetter to the Editor/Response
    • Manuscript Submission Guidelines
    • Statistical Tips
    • Fast Publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Imaging Protocol Submission
    • Author Policies
  • About Us
    • About AJNR
    • Editorial Board
    • Editorial Board Alumni
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home

User menu

  • Alerts
  • Log in

Search

  • Advanced search
American Journal of Neuroradiology
American Journal of Neuroradiology

American Journal of Neuroradiology

ASHNR American Society of Functional Neuroradiology ASHNR American Society of Pediatric Neuroradiology ASSR
  • Alerts
  • Log in

Advanced Search

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • Video Articles
    • AJNR Case Collection
    • Case of the Week Archive
    • Case of the Month Archive
    • Classic Case Archive
  • Special Collections
    • AJNR Awards
    • Low-Field MRI
    • Alzheimer Disease
    • ASNR Foundation Special Collection
    • Photon-Counting CT
    • View All
  • Multimedia
    • AJNR Podcasts
    • AJNR SCANtastic
    • Trainee Corner
    • MRI Safety Corner
    • Imaging Protocols
  • For Authors
    • Submit a Manuscript
    • Submit a Video Article
    • Submit an eLetter to the Editor/Response
    • Manuscript Submission Guidelines
    • Statistical Tips
    • Fast Publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Imaging Protocol Submission
    • Author Policies
  • About Us
    • About AJNR
    • Editorial Board
    • Editorial Board Alumni
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home
  • Follow AJNR on Twitter
  • Visit AJNR on Facebook
  • Follow AJNR on Instagram
  • Join AJNR on LinkedIn
  • RSS Feeds

AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates

Review ArticleReview Articles
Open Access

Gadolinium Contrast Agents for CNS Imaging: Current Concepts and Clinical Evidence

E. Kanal, K. Maravilla and H.A. Rowley
American Journal of Neuroradiology December 2014, 35 (12) 2215-2226; DOI: https://doi.org/10.3174/ajnr.A3917
E. Kanal
aFrom Magnetic Resonance Services (E.K.), Department of Radiology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
K. Maravilla
bResearch Laboratory (K.M.), University of Washington, Seattle, Washington
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
H.A. Rowley
cDepartments of Radiology, Neurology, and Neurosurgery (H.A.R.), University of Wisconsin, Madison, Wisconsin.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • Supplemental
  • Info & Metrics
  • Responses
  • References
  • PDF
Loading

References

  1. 1.↵
    Dotarem product label. http://www.accessdata.fda.gov/drugsatfda_docs/label/2013/204781s000lbl.pdf. Accessed May 10, 2013.
  2. 2.↵
    Gadavist product label. http://www.accessdata.fda.gov/drugsatfda_docs/label/2011/201277s000lbl.pdf. Accessed May 10, 2013.
  3. 3.↵
    Magnevist product label. http://www.accessdata.fda.gov/drugsatfda_docs/label/2012/019596s051lbl.pdf. Accessed May 10, 2013.
  4. 4.↵
    MultiHance product label. http://www.accessdata.fda.gov/drugsatfda_docs/label/2010/021357s009lbl.pdf. Accessed May 10, 2013.
  5. 5.↵
    Omniscan product label. http://www.accessdata.fda.gov/drugsatfda_docs/label/2010/020123s037lbl.pdf. Accessed May 10, 2013.
  6. 6.↵
    OptiMARK product label. http://www.accessdata.fda.gov/drugsatfda_docs/label/2010/020937s016lbl.pdf. Accessed 10 May 10, 2013.
  7. 7.↵
    ProHance product label. http://www.accessdata.fda.gov/drugsatfda_docs/label/2010/020131s024lbl.pdf. Accessed May 10, 2013.
  8. 8.↵
    Ablavar product label. http://www.accessdata.fda.gov/drugsatfda_docs/label/2010/021711s003lbl.pdf. Accessed May 10, 2013.
  9. 9.↵
    Eovist product label. http://www.accessdata.fda.gov/drugsatfda_docs/label/2010/022090s004lbl.pdf. Accessed May 10, 2013.
  10. 10.↵
    1. Bellin MF,
    2. Van Der Molen AJ
    . Extracellular gadolinium-based contrast media: an overview. Eur J Radiol 2008;66:160–67
    CrossRefPubMed
  11. 11.↵
    1. Rohrer M,
    2. Bauer H,
    3. Mintorovitch J, et al
    . Comparison of magnetic properties of MRI contrast media solutions at different magnetic field strengths. Invest Radiol 2005;40:715–24
    CrossRefPubMedWeb of Science
  12. 12.↵
    1. Cavagna FM,
    2. Maggioni F,
    3. Castelli PM, et al
    . Gadolinium chelates with weak binding to serum proteins: a new class of high-efficiency, general purpose contrast agents for magnetic resonance imaging. Invest Radiol 1997;32:780–96
    CrossRefPubMed
  13. 13.↵
    1. Giesel FL,
    2. von Tengg-Kobligk H,
    3. Wilkinson ID, et al
    . Influence of human serum albumin on longitudinal and transverse relaxation rates (R1 and R2) of magnetic resonance contrast agents. Invest Radiol 2006;41:222–28
    CrossRefPubMed
  14. 14.↵
    1. Pintaske J,
    2. Martirosian P,
    3. Graf H, et al
    . Relaxivity of gadopentetate dimeglumine (Magnevist), gadobutrol (Gadavist), and gadobenate dimeglumine (MultiHance) in human blood plasma at 0.2, 1.5, and 3 Tesla. Invest Radiol 2006;41:213–21, Erratum in Invest Radiol 2006;41:859
    CrossRefPubMed
  15. 15.↵
    1. Laurent S,
    2. Elst LV,
    3. Muller RN
    . Comparative study of the physicochemical properties of six clinical low molecular weight gadolinium contrast agents. Contrast Media Mol Imaging 2006;1:128–37
    CrossRefPubMedWeb of Science
  16. 16.↵
    1. Yuh WT,
    2. Fisher DJ,
    3. Engelken JD, et al
    . MR evaluation of CNS tumors: dose comparison study with gadopentetate dimeglumine and gadoteridol. Radiology 1991;180:485–91
    CrossRefPubMed
  17. 17.↵
    1. Myhr G,
    2. Rinck PA,
    3. Børseth A
    . Gadodiamide injection and gadopentetate dimeglumine: a double-blind study in MR imaging of the CNS. Acta Radiol 1992;33:405–09
    Abstract/FREE Full Text
  18. 18.↵
    1. Balériaux D,
    2. Matos C,
    3. De Greef D
    . Gadodiamide injection as a contrast medium for MRI of the central nervous system: a comparison with gadolinium-DOTA. Neuroradiology 1993;35:490–94
    CrossRefPubMed
  19. 19.↵
    1. Valk J,
    2. Algra PR,
    3. Hazenberg CJ, et al
    . A double-blind, comparative study of gadodiamide injection and gadopentetate dimeglumine in MRI of the central nervous system. Neuroradiology 1993;35:173–77
    CrossRefPubMed
  20. 20.↵
    1. Brugières P,
    2. Gaston A,
    3. Degryse HR, et al
    . Randomised double blind trial of the safety and efficacy of two gadolinium complexes (Gd-DTPA and Gd-DOTA). Neuroradiology 1994;36:27–30
    CrossRefPubMed
  21. 21.↵
    1. Akeson P,
    2. Jonsson E,
    3. Haugen I, et al
    . Contrast-enhanced MRI of the central nervous system: comparison between gadodiamide injection and gadolinium-DTPA. Neuroradiology 1995;37:229–33
    CrossRefPubMed
  22. 22.↵
    1. Oudkerk M,
    2. Sijens PE,
    3. van Beek EJ, et al
    . Safety and efficacy of Dotarem (Gd-DOTA) versus Magnevist (Gd-DTPA) in magnetic resonance imaging of the central nervous system. Invest Radiol 1995;30:75–78
    CrossRefPubMed
  23. 23.↵
    1. Grossman RI,
    2. Rubin DI,
    3. Hunter G, et al
    . Magnetic resonance imaging in patients with central nervous system pathology: q comparison of OptiMARK (Gd-DTPA-BMEA) and Magnevist (Gd-DTPA). Invest Radiol 2000;35:412–19
    CrossRefPubMed
  24. 24.↵
    1. Runge VM,
    2. Armstrong MR,
    3. Barr RG, et al
    . A clinical comparison of the safety and efficacy of MultiHance (gadobenate dimeglumine) and Omniscan (gadodiamide) in magnetic resonance imaging in patients with central nervous system pathology. Invest Radiol 2001;36:65–71
    CrossRefPubMed
  25. 25.↵
    1. Runge VM,
    2. Parker JR,
    3. Donovan M
    . Double-blind, efficacy evaluation of gadobenate dimeglumine, a gadolinium chelate with enhanced relaxivity, in malignant lesions of the brain. Invest Radiol 2002;37:269–80
    CrossRefPubMed
  26. 26.↵
    1. Greco A,
    2. Parker JR,
    3. Ratcliffe CG, et al
    . Phase III, randomized, double blind, crossover comparison of gadoteridol and gadopentetate dimeglumine in magnetic resonance imaging of patients with intracranial lesions. Australas Radiol 2001;45:457–63
    CrossRefPubMed
  27. 27.↵
    1. Anzalone N,
    2. Gerevini S,
    3. Scotti R, et al
    . Detection of cerebral metastases on magnetic resonance imaging: intraindividual comparison of gadobutrol with gadopentetate dimeglumine. Acta Radiol 2009;50:933–40
    Abstract/FREE Full Text
  28. 28.↵
    1. Kim ES,
    2. Chang JH,
    3. Choi HS, et al
    . Diagnostic yield of double-dose gadobutrol in the detection of brain metastasis: intraindividual comparison with double-dose gadopentetate dimeglumine. AJNR Am J Neuroradiol 2010;31:1055–58
    Abstract/FREE Full Text
  29. 29.↵
    1. Katakami N,
    2. Inaba Y,
    3. Sugata S, et al
    . Magnetic resonance evaluation of brain metastases from systemic malignances with two doses of gadobutrol 1.0M compared with gadoteridol: a multicenter, phase II/III study in patients with known or suspected brain metastases. Invest Radiol 2011;46:411–18
    CrossRefPubMed
  30. 30.↵
    1. Koenig M,
    2. Schulte-Altedorneburg G,
    3. Piontek M, et al
    . Intra-individual, randomised comparison of the MRI contrast agents gadobutrol versus gadoteridol in patients with primary and secondary brain tumours, evaluated in a blinded read. Eur Radiol 2013;23:3287–95
    CrossRefPubMed
  31. 31.↵
    Center for Drug Evaluation and Research. FDA Advisory Committee Briefing Document. New Drug Application 201–277. http://www.fda.gov/downloads/drugs/developmentapprovalprocess/developmentresources/ucm255169.pdf. Accessed February 6, 2014.
  32. 32.↵
    1. Anzalone N,
    2. Scarabino T,
    3. Venturi C, et al
    . Cerebral neoplastic enhancing lesions: multicenter, randomized, crossover intraindividual comparison between gadobutrol (1.0M) and gadoterate meglumine (0.5M) at 0.1 mmol Gd/kg body weight in a clinical setting. Eur J Radiol 2013;82:139–45
    CrossRefPubMed
  33. 33.↵
    1. Colosimo C,
    2. Ruscalleda J,
    3. Korves M, et al
    . Detection of intracranial metastases: a multicenter, intrapatient comparison of gadobenate dimeglumine-enhanced MRI with routinely used contrast agents at equal dosage. Invest Radiol 2001;36:72–81
    CrossRefPubMed
  34. 34.↵
    1. Knopp MV,
    2. Runge VM,
    3. Essig M, et al
    . Primary and secondary brain tumors at MR imaging: bicentric intraindividual crossover comparison of gadobenate dimeglumine and gadopentetate dimeglumine. Radiology 2004;230:55–64
    CrossRefPubMed
  35. 35.↵
    1. Colosimo C,
    2. Knopp MV,
    3. Barreau X, et al
    . A comparison of Gd-BOPTA and Gd-DOTA for contrast-enhanced MRI of intracranial tumours. Neuroradiology 2004;46:655–65
    PubMed
  36. 36.↵
    1. Essig M,
    2. Tartaro A,
    3. Tartaglione T, et al
    . Enhancing lesions of the brain: intra-individual crossover comparison of contrast enhancement after gadobenate dimeglumine versus established gadolinium comparators. Academic Radiology 2006;13:744–51
    CrossRefPubMed
  37. 37.↵
    1. Maravilla KR,
    2. Maldjian JA,
    3. Schmalfuss IM, et al
    . Contrast enhancement of central nervous system lesions: multicenter intraindividual crossover comparative study of two MR contrast agents. Radiology 2006;240:389–400
    CrossRefPubMed
  38. 38.↵
    1. Kuhn MJ,
    2. Picozzi P,
    3. Maldjian JA, et al
    . Evaluation of intraaxial enhancing brain tumors on magnetic resonance imaging: intraindividual crossover comparison of gadobenate dimeglumine and gadopentetate dimeglumine for visualization and assessment, and implications for surgical intervention. J Neurosurg 2007;106:557–66
    CrossRefPubMed
  39. 39.↵
    1. Rowley HA,
    2. Scialfa G,
    3. Gao PY, et al
    . Contrast-enhanced MR imaging of brain lesions: a large-scale intraindividual crossover comparison of gadobenate dimeglumine versus gadodiamide. AJNR Am J Neuroradiol 2008;29:1684–91
    Abstract/FREE Full Text
  40. 40.↵
    1. Rumboldt Z,
    2. Rowley HA,
    3. Steinberg F, et al
    . Multicenter, double-blind, randomized, intra-individual crossover comparison of gadobenate dimeglumine and gadopentetate dimeglumine in MRI of brain tumors at 3 Tesla. J Magn Reson Imaging 2009;29:760–67
    CrossRefPubMed
  41. 41.↵
    1. Seidl Z,
    2. Vymazal J,
    3. Mechl M, et al
    . Does higher gadolinium concentration play a role in the morphologic assessment of brain tumors? Results of a multicenter intraindividual crossover comparison of gadobutrol versus gadobenate dimeglumine (the MERIT Study). AJNR Am J Neuroradiol 2012;33:1050–58
    Abstract/FREE Full Text
  42. 42.↵
    1. Griffiths PD,
    2. Wilkinson ID,
    3. Wels T, et al
    . Brain MR perfusion imaging in humans. Acta Radiol 2001;42:555–59
    FREE Full Text
  43. 43.↵
    1. Griffiths PD,
    2. Pandya H,
    3. Wilkinson ID, et al
    . Sequential dynamic gadolinium magnetic resonance perfusion-weighted imaging: effects on transit time and cerebral blood volume measurements. Acta Radiol 2006;47:1079–84
    FREE Full Text
  44. 44.↵
    1. Giesel FL,
    2. Mehndiratta A,
    3. Risse F, et al
    . Intraindividual comparison between gadopentetate dimeglumine and gadobutrol for magnetic resonance perfusion in normal brain and intracranial tumors at 3 Tesla. Acta Radiol 2009;50:521–30
    Abstract/FREE Full Text
  45. 45.↵
    1. Essig M,
    2. Lodemann KP,
    3. Le-Huu M, et al
    . Intraindividual comparison of gadobenate dimeglumine and gadobutrol for cerebral magnetic resonance perfusion imaging at 1.5 T. Invest Radiol 2006;41:256–63
    CrossRefPubMed
  46. 46.↵
    1. Thilmann O,
    2. Larsson EM,
    3. Björkman-Burtscher IM, et al
    . Comparison of contrast agents with high molarity and with weak protein binding in cerebral perfusion imaging at 3 T. J Magn Reson Imaging 2005;22:597–604
    CrossRefPubMed
  47. 47.↵
    1. Wirestam R,
    2. Thilmann O,
    3. Knutsson L, et al
    . Comparison of quantitative dynamic susceptibility-contrast MRI perfusion estimates obtained using different contrast-agent administration schemes at 3T. Eur J Radiol 2010;75:e86–91
    CrossRefPubMed
  48. 48.↵
    1. Beranek-Chiu J,
    2. Froehlich JM,
    3. Wentz KU, et al
    . Improved vessel delineation in keyhole time-resolved contrast-enhanced MR angiography using a gadolinium doped flush. J Magn Reson Imaging 2009;29:1147–53
    CrossRefPubMed
  49. 49.↵
    1. Pediconi F,
    2. Fraioli F,
    3. Catalano C, et al
    . Gadobenate dimeglumine (Gd-BOPTA) vs gadopentetate dimeglumine (Gd-DTPA) for contrast-enhanced magnetic resonance angiography (MRA): improvement in intravascular signal intensity and contrast to noise ratio. Radiol Med 2003;106:87–93
    PubMed
  50. 50.↵
    1. Li Y,
    2. Li X,
    3. Li D, et al
    . Multicenter, intraindividual comparison of single-dose gadobenate dimeglumine and double-dose gadopentetate dimeglumine for MR angiography of the supra-aortic arteries (the Supra-Aortic Value Study). AJNR Am J Neuroradiol 2013;34:847–54
    Abstract/FREE Full Text
  51. 51.↵
    1. Bültmann E,
    2. Erb G,
    3. Kirchin MA, et al
    . Intra-individual crossover comparison of gadobenate dimeglumine and gadopentetate dimeglumine for contrast-enhanced MR angiography of the supraaortic vessels at 3 Tesla. Invest Radiol 2008;43:695–702
    CrossRefPubMed
  52. 52.↵
    1. Kramer JH,
    2. Arnoldi E,
    3. François CJ, et al
    . Dynamic and static magnetic resonance angiography of the supra-aortic vessels at 3.0 T: intraindividual comparison of gadobutrol, gadobenate dimeglumine, and gadoterate meglumine at equimolar dose. Invest Radiol 2013;48:121–8
    CrossRefPubMed
  53. 53.↵
    1. Pirovano G,
    2. Munley J,
    3. Schultz C, et al
    . Nephrogenic systemic fibrosis: a review of published cases and results from three prospective observational studies. Insights Imaging 2012;3(suppl 1):S293
  54. 54.↵
    1. Idée JM,
    2. Port M,
    3. Robic C, et al
    . Role of thermodynamic and kinetic parameters in gadolinium chelate stability. J Magn Reson Imaging 2009;30:1249–58
    CrossRefPubMedWeb of Science
  55. 55.↵
    1. Bennett CL,
    2. Qureshi ZP,
    3. Sartor AO, et al
    . Gadolinium-induced nephrogenic systemic fibrosis: the rise and fall of an iatrogenic disease. Clin Kidney J 2012;5:82–88
    Abstract/FREE Full Text
  56. 56.↵
    1. Abujudeh HH,
    2. Kosaraju VK,
    3. Kaewlai R
    . Acute adverse reactions to gadopentetate dimeglumine and gadobenate dimeglumine: experience with 21,659 injections. AJR Am J Roentgentol 2010;194:430–34
    CrossRefPubMedWeb of Science
  57. 57.↵
    American College of Radiology. Manual on Contrast Media. Version 9. 2013. http://www.acr.org. Accessed January 4, 2013.
  58. 58.↵
    1. Bruder O,
    2. Schneider S,
    3. Nothnagel D, et al
    . Acute adverse reactions to gadolinium-based contrast agents in CMR: multicenter experience with 17,767 patients from the EuroCMR Registry. JACC Cardiovasc Imaging 2011;4:1171–76
    CrossRefPubMedWeb of Science
  59. 59.↵
    1. Cochran ST,
    2. Bomyea K,
    3. Sayre JW
    . Trends in adverse events after IV administration of contrast media. AJR Am J Roentgenol 2001;176:1385–88
    CrossRefPubMedWeb of Science
  60. 60.↵
    1. Forsting M,
    2. Palkowitsch P
    . Prevalence of acute adverse reactions to gadobutrol: a highly concentrated macrocyclic gadolinium chelate: review of 14,299 patients from observational trials. Eur J Radiol 2010;74:e186–92
    CrossRefPubMed
  61. 61.↵
    1. Murphy KP,
    2. Szopinski KT,
    3. Cohal RH, et al
    . Occurrence of adverse reactions to gadolinium-based contrast material and management of patients at increased risk: a survey of the American Society of Neuroradiology Fellowship Directors. Acad Radiol 1999;6:656–64
    CrossRefPubMedWeb of Science
  62. 62.↵
    1. Li A,
    2. Wong CS,
    3. Wong MK, et al
    . Acute adverse reactions to magnetic resonance contrast media: gadolinium chelates. Br J Radiol 2006;79:368–71
    Abstract/FREE Full Text
  63. 63.↵
    1. Dillman JR,
    2. Ellis JH,
    3. Cohan RH, et al
    . Frequency and severity of acute allergic-like reactions to gadolinium-containing I.V. contrast media in children and adults. AJR Am J Roentgenol 2007;189:1533–38
    CrossRefPubMedWeb of Science
  64. 64.↵
    1. Hunt CH,
    2. Hartman RP,
    3. Hesley GK
    . Frequency and severity of adverse effects of iodinated and gadolinium contrast materials: retrospective review of 456,930 doses. AJR Am J Roentgenol 2009;193:1124–27
    CrossRefPubMedWeb of Science
  65. 65.↵
    1. Prince MR,
    2. Zhang H,
    3. Zou Z, et al
    . Incidence of immediate gadolinium contrast media reactions. AJR Am J Roentgenol 2011;196:W138–43
    CrossRefPubMedWeb of Science
  66. 66.↵
    1. Jung JW,
    2. Kang HR,
    3. Kim MH, et al
    . Immediate hypersensitivity reaction to gadolinium-based MR contrast media. Radiology 2012;264:414–22
    CrossRefPubMed
  67. 67.↵
    1. Vervloet D,
    2. Durham S
    . Adverse reactions to drugs. BMJ 1998;316:1511–14
    FREE Full Text
  68. 68.↵
    1. Hasdenteufel F,
    2. Luyasu S,
    3. Renaudin JM, et al
    . Anaphylactic shock after first exposure to gadoterate meglumine: two case reports documented by positive allergy assessment. J Allergy Clin Immunol 2008;121:527–28
    CrossRefPubMed
  69. 69.↵
    1. Schiavino D,
    2. Murzilli F,
    3. Del Ninno M, et al
    . Demonstration of an IgE-mediated immunological pathogenesis of a severe reaction to gadopentetate dimeglumine. J Invest Allergol Clin Immunol 2003;13:140–42
    PubMed
  70. 70.↵
    European Society on Urogenital Radiology (ESUR). ESUR Guidelines on Contrast Media. Version 8.1. http://www.esur.org/esur-guidelines/. Accessed January 4, 2013.
  71. 71.↵
    United States of America ex rel. Lynch vs. Imagimed LLC, et al. (N.D. N.Y.); as reported on http://www.justice.gov/opa/pr/2013/August/13-civ-958.html. Accessed September 14, 2013.
  72. 72.↵
    1. Runge V
    . Safety of approved MR contrast media for intravenous injection. J Magn Reson Imaging 2000;12:205–13
    CrossRefPubMed
  73. 73.↵
    1. Bleicher AG,
    2. Kanal E
    . Assessment of adverse reaction rates to a newly approved MRI contrast agent: review of 23,553 administrations of gadobenate dimeglumine. AJR Am J Roentgenol 2008;191:W307–11
    CrossRefPubMedWeb of Science
  74. 74.↵
    1. Shellock FG,
    2. Parker JR,
    3. Venetianer C, et al
    . Safety of gadobenate dimeglumine (MultiHance): summary of findings from clinical studies and postmarketing surveillance. Invest Radiol 2006;41:500–09
    CrossRefPubMed
  75. 75.↵
    1. Shellock FG,
    2. Parker JR,
    3. Pirovano G, et al
    . Safety characteristics of gadobenate dimeglumine: clinical experience from intra- and interindividual comparison studies with gadopentetate dimeglumine. J Magn Reson Imaging 2006;24:1378–85, Erratum in J Magn Reson Imaging 2007;26:217
    CrossRefPubMed
  76. 76.↵
    1. Rainsford KD,
    2. Velo GP
    1. Weber JC
    . Epidemiology of adverse reactions to nonsteroidal anti-inflammatory drug. In: Rainsford KD, Velo GP, eds. Side Effects of Antiinflammatory/Analgesic Drugs Advances in Inflammation Research. Vol. 6. New York: Raven Press; 1984:1–7
  77. 77.↵
    1. Lalli AF
    . Urographic contrast media reactions and anxiety. Radiology 1974;112:267–71
    CrossRefPubMed
  78. 78.↵
    1. Semelka RC,
    2. Hernandes Mde A,
    3. Stallings CG, et al
    . Objective evaluation of acute adverse events and image quality of gadolinium-based contrast agents (gadobutrol and gadobenate dimeglumine) by blinded evaluation: pilot study. Magn Reson Imaging 2013;31:96–101
    CrossRefPubMed
  79. 79.↵
    1. Davenport MS,
    2. Dillman JR,
    3. Cohan RH, et al
    . Effect of abrupt substitution of gadobenate dimeglumine for gadopentetate dimeglumine on rate of allergic-like reactions. Radiology 2013;266:773–82
    CrossRefPubMed
  80. 80.↵
    1. van Osch MJ,
    2. Vonken EJ,
    3. Wu O, et al
    . Model of the human vasculature for studying the influence of contrast injection speed on cerebral perfusion MRI. Magn Reson Med 2003;50:614–22
    CrossRefPubMed
  81. 81.↵
    1. Prokop M,
    2. Schneider G,
    3. Vanzulli A, et al
    . Contrast-enhanced MR angiography of the renal arteries: blinded multicenter crossover comparison of gadobenate dimeglumine and gadopentetate dimeglumine. Radiology 2005;234:399–408
    CrossRefPubMed
  82. 82.↵
    1. Gerretsen SC,
    2. le Maire TF,
    3. Miller S, et al
    . Multicenter, double-blind, randomized, intraindividual crossover comparison of gadobenate dimeglumine and gadopentetate dimeglumine for MR angiography of peripheral arteries. Radiology 2010;255:988–1000
    CrossRefPubMed
  83. 83.↵
    1. Knopp MV,
    2. Giesel FL,
    3. von Tengg-Kobligk H, et al
    . Contrast-enhanced MR angiography of the run-off vasculature: intraindividual comparison of gadobenate dimeglumine with gadopentetate dimeglumine. J Magn Reson Imaging 2003;17:694–702
    CrossRefPubMed
  84. 84.↵
    1. Stein PD,
    2. Chenevert TL,
    3. Fowler SE, et al
    . Gadolinium-enhanced magnetic resonance angiography for pulmonary embolism: a multicenter prospective study (PIOPED III). Ann Intern Med 2010;152:434–43, W142–43
    CrossRefPubMedWeb of Science
  85. 85.↵
    1. Woodard PK,
    2. Chenevert TL,
    3. Sostman HD, et al
    . Signal quality of single dose gadobenate dimeglumine pulmonary MRA examinations exceeds quality of MRA performed with double dose gadopentetate dimeglumine. Int J Cardiovasc Imaging 2012;28:295–301
    CrossRefPubMed
  86. 86.↵
    1. Wang J,
    2. Yan F,
    3. Liu J, et al
    . Multicenter, intra-individual comparison of single dose gadobenate dimeglumine and double dose gadopentetate dimeglumine for MR angiography of the peripheral arteries (the peripheral VALUE study). J Magn Reson Imaging 2013;38:926–37
    CrossRefPubMed
PreviousNext
Back to top

In this issue

American Journal of Neuroradiology: 35 (12)
American Journal of Neuroradiology
Vol. 35, Issue 12
1 Dec 2014
  • Table of Contents
  • Index by author
  • Complete Issue (PDF)
Advertisement
Print
Download PDF
Email Article

Thank you for your interest in spreading the word on American Journal of Neuroradiology.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Gadolinium Contrast Agents for CNS Imaging: Current Concepts and Clinical Evidence
(Your Name) has sent you a message from American Journal of Neuroradiology
(Your Name) thought you would like to see the American Journal of Neuroradiology web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Cite this article
E. Kanal, K. Maravilla, H.A. Rowley
Gadolinium Contrast Agents for CNS Imaging: Current Concepts and Clinical Evidence
American Journal of Neuroradiology Dec 2014, 35 (12) 2215-2226; DOI: 10.3174/ajnr.A3917

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
0 Responses
Respond to this article
Share
Bookmark this article
Gadolinium Contrast Agents for CNS Imaging: Current Concepts and Clinical Evidence
E. Kanal, K. Maravilla, H.A. Rowley
American Journal of Neuroradiology Dec 2014, 35 (12) 2215-2226; DOI: 10.3174/ajnr.A3917
del.icio.us logo Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One
Purchase

Jump to section

  • Article
    • Abstract
    • ABBREVIATIONS:
    • GBCAs: What They Are and What They Do
    • Clinical Evidence for the Role of Relaxivity on Diagnostic Performance
    • Safety
    • Discussion
    • Conclusions
    • Footnotes
    • References
  • Figures & Data
  • Supplemental
  • Info & Metrics
  • Responses
  • References
  • PDF

Related Articles

  • PubMed
  • Google Scholar

Cited By...

  • Injection Rates for Vessel Optimization During Magnetic Resonance Angiography
  • Twofold improved tumor-to-brain contrast using a novel T1 relaxation-enhanced steady-state (T1RESS) MRI technique
  • Safety and Diagnostic Efficacy of Gadobenate Dimeglumine in MRI of the Brain and Spine of Neonates and Infants
  • High Signal Intensity in the Dentate Nucleus and Globus Pallidus on Unenhanced T1-Weighted MR Images: Comparison between Gadobutrol and Linear Gadolinium-Based Contrast Agents
  • Deep Brain Nuclei T1 Shortening after Gadobenate Dimeglumine in Children: Influence of Radiation and Chemotherapy
  • The Benefits of High Relaxivity for Brain Tumor Imaging: Results of a Multicenter Intraindividual Crossover Comparison of Gadobenate Dimeglumine with Gadoterate Meglumine (The BENEFIT Study)
  • Are There Differences between Macrocyclic Gadolinium Contrast Agents for Brain Tumor Imaging? Results of a Multicenter Intraindividual Crossover Comparison of Gadobutrol with Gadoteridol (the TRUTH Study)
  • Crossref
  • Google Scholar

This article has not yet been cited by articles in journals that are participating in Crossref Cited-by Linking.

More in this TOC Section

  • An Atlas of Neonatal Neurovascular Imaging Anatomy as Depicted with Microvascular Imaging: The Intracranial Arteries
  • An Atlas of Neonatal Neurovascular Imaging Anatomy as Depicted with Microvascular Imaging: The Intracranial Veins
  • Clinical Translation of Hyperpolarized 13C Metabolic Probes for Glioma Imaging
Show more Review Articles

Similar Articles

Advertisement

Indexed Content

  • Current Issue
  • Accepted Manuscripts
  • Article Preview
  • Past Issues
  • Editorials
  • Editor's Choice
  • Fellows' Journal Club
  • Letters to the Editor
  • Video Articles

Cases

  • Case Collection
  • Archive - Case of the Week
  • Archive - Case of the Month
  • Archive - Classic Case

More from AJNR

  • Trainee Corner
  • Imaging Protocols
  • MRI Safety Corner
  • Book Reviews

Multimedia

  • AJNR Podcasts
  • AJNR Scantastics

Resources

  • Turnaround Time
  • Submit a Manuscript
  • Submit a Video Article
  • Submit an eLetter to the Editor/Response
  • Manuscript Submission Guidelines
  • Statistical Tips
  • Fast Publishing of Accepted Manuscripts
  • Graphical Abstract Preparation
  • Imaging Protocol Submission
  • Evidence-Based Medicine Level Guide
  • Publishing Checklists
  • Author Policies
  • Become a Reviewer/Academy of Reviewers
  • News and Updates

About Us

  • About AJNR
  • Editorial Board
  • Editorial Board Alumni
  • Alerts
  • Permissions
  • Not an AJNR Subscriber? Join Now
  • Advertise with Us
  • Librarian Resources
  • Feedback
  • Terms and Conditions
  • AJNR Editorial Board Alumni

American Society of Neuroradiology

  • Not an ASNR Member? Join Now

© 2025 by the American Society of Neuroradiology All rights, including for text and data mining, AI training, and similar technologies, are reserved.
Print ISSN: 0195-6108 Online ISSN: 1936-959X

Powered by HighWire