Article Figures & Data
Figures
- Fig 1.
Case 21. A 59-year-old woman with GBM in the right temporal lobe (tumor volume, 79.6 cm3). PET images of 62Cu-ATSM (A), FDG (B), and MET (C) are shown; the 62Cu-ATSM–active regions are outlined by red lines (D–F, respectively). 62Cu-ATSM-PET/MR imaging fusion image (D) showing the intratumoral hypoxic region (11.8 cm3), which is less than that of the contrast-enhanced volume (30.9 cm3). FDG-PET/MR imaging fusion image (E) also indicating the intratumoral active region (4.6 cm3), which is heterogeneously distributed compared with the 62Cu-ATSM–active region. MET-PET/MR imaging fusion image (F) showing the more extensive active region (73.1 cm3), which completely covered the 62Cu-ATSM–active regions.
- Fig 2.
Boxplots comparing uptake values between GBM and non-GBM gliomas. The 62Cu-ATSM and MET SUVmax values show significant differences (P = .03 and P = .02); however, FDG SUVmax values are not significantly different (P = .18; A). The 62Cu-ATSM and MET T/B ratios also show significant differences (P = .03 and P = .01), but no significant difference is observed in the FDG T/B ratio (P = .65; B). *P < .05.
Tables
GBM (n=10) Volume (cm3) r P Value Heterogeneous Metabolism (%)a 62Cu-ATSM 8.2 ± 14.0 − − − FDG 11.0 ± 12.0 0.68 .03 5/10 (50%) MET 38.0 ± 19.0 0.87 .03 0/6 (0%) Note:—r indicates correlation coefficient when compared with 62Cu-ATSM.
↵a Heterogeneous metabolism indicates an overlap of ≤50% of the active volume of 62Cu-ATSM with those of FDG and MET.
GBM (n=10) TV (45.4 ± 26.5 cm3)a CEV (21.6 ± 14.3 cm3)b 62Cu-ATSM (8.2 ± 14.0 cm3) P = .002 P = .002 FDG (11.0 ± 12.0 cm3) P = .002 P = .006 MET (38.0 ± 19.0 cm3) P = .56 P = .06 Note:—The mean tumor volume (TV) and contrast-enhanced volume (CEV) were compared with the active volume of 62Cu-ATSM (T/B cutoff threshold ≥1.8), FDG (T/B cutoff threshold of ≥1.5), and MET (T/B cutoff threshold of ≥1.3). P values < .05 were considered to indicate statistical significance.
↵a TV was measured as a completely covered contrast-enhanced region with necrotic and cystic components.
↵b CEV was measured as a contrast-enhanced region without necrotic and cystic components on T1-weighted MRI with Gd-DTPA.
