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Research ArticleBrain
Open Access

Local and Global Fiber Tractography in Patients with Epilepsy

C. Anastasopoulos, M. Reisert, V.G. Kiselev, T. Nguyen-Thanh, A. Schulze-Bonhage, J. Zentner and I. Mader
American Journal of Neuroradiology February 2014, 35 (2) 291-296; DOI: https://doi.org/10.3174/ajnr.A3752
C. Anastasopoulos
aFrom the Clinic of Neuropediatrics and Neuromuscular Diseases (C.A.)
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M. Reisert
bMedical Physics, Department of Radiology (M.R., V.G.K.)
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V.G. Kiselev
bMedical Physics, Department of Radiology (M.R., V.G.K.)
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T. Nguyen-Thanh
fDepartment of Radiology (T.N.-T.), Hue University College of Medicine and Pharmacy, Hué, Vietnam.
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A. Schulze-Bonhage
cEpilepsy Center (A.S.-B.)
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J. Zentner
dDepartments of Neurosurgery (J.Z.)
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I. Mader
eNeuroradiology (I.M.), University Medical Center Freiburg, Freiburg, Germany
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    Fig 1.

    Depiction of the left descending motor pathways on the healthy side in patient 3 and the fan angle measurement performed. FACT (A), probabilistic (B), and global (C and F) tractography show approximately the same route and extent along the internal capsule. Note differences in the reconstruction of fibers arising from the lateral area of face cortical representation. These corticobulbar fibers are best depicted by global tracking, as this method is least susceptible to fiber crossings in the semiovale center (D) (orientation distribution function of the diffusion signal) and (E) (principal direction of the diffusion tensor shown as color-coded map) between the corpus callosum (1), corona radiata (2), and SLF (3). FACT and probabilistic tractography cannot overcome the crossing with the SLF (3, green in F, oriented perpendicular to the plane of the figure), with the results shown in On-Line Fig 2 in mind.

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    Fig 2.

    Assessment of the OR in patient 14 with a right hippocampal sclerosis. Results of probabilistic tractography (A) for the right Meyer loop (arrowhead) and (B) for the main part of the OR are shown. The preoperative OR reconstruction by the probabilistic algorithm is superimposed onto postoperative images (C and D, asterisk = resection area, arrow = anterior extent of Meyer loop). Postoperatively, the patient presented with a partial visual field defect in the left upper quadrant.

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    Fig 3.

    Coronal sections through the OR at the level of the trigone of the lateral ventricle in patient 15 with a perinatal stroke. Scheme drawing (A) of the functional organization of the OR on the healthy side (redrawn26), indicating the course of the posterior (p), anterior (a), and central (c) bundles, carrying fibers of the lower quadrant, upper quadrant, and center of the contralateral visual field, respectively. Preoperative T1WI of the pathologic side (right half, A). Postoperatively, the patient had a lower right quadrant anopia. Preoperative tractography superimposed on the postoperative coronal T1 (B–D). The arrowhead indicates that the posterior bundle of the OR was within the resection area. It is missed by FACT (B) but is depicted by probabilistic (C) and global (D) tractography.

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American Journal of Neuroradiology: 35 (2)
American Journal of Neuroradiology
Vol. 35, Issue 2
1 Feb 2014
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Cite this article
C. Anastasopoulos, M. Reisert, V.G. Kiselev, T. Nguyen-Thanh, A. Schulze-Bonhage, J. Zentner, I. Mader
Local and Global Fiber Tractography in Patients with Epilepsy
American Journal of Neuroradiology Feb 2014, 35 (2) 291-296; DOI: 10.3174/ajnr.A3752

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Local and Global Fiber Tractography in Patients with Epilepsy
C. Anastasopoulos, M. Reisert, V.G. Kiselev, T. Nguyen-Thanh, A. Schulze-Bonhage, J. Zentner, I. Mader
American Journal of Neuroradiology Feb 2014, 35 (2) 291-296; DOI: 10.3174/ajnr.A3752
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