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Research ArticleNeurointervention

Hyperattenuated Intracerebral Lesions after Mechanical Recanalization in Acute Stroke

N. Lummel, G. Schulte-Altedorneburg, C. Bernau, T. Pfefferkorn, M. Patzig, H. Janssen, C. Opherk, H. Brückmann and J. Linn
American Journal of Neuroradiology February 2014, 35 (2) 345-351; DOI: https://doi.org/10.3174/ajnr.A3656
N. Lummel
aFrom the Departments of Neuroradiology (N.L., M.P., H.J., H.B., J.L.)
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G. Schulte-Altedorneburg
dInstitute of Radiology, Neuroradiology, and Nuclear Medicine (G.S.-A.), Klinikum Harlaching, Munich, Germany
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C. Bernau
eInstitute for Medical Information Sciences, Biometry, and Epidemiology (C.B.), Ludwig-Maximilian-University, Munich, Germany.
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T. Pfefferkorn
bNeurology (T.P., C.O.)
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M. Patzig
aFrom the Departments of Neuroradiology (N.L., M.P., H.J., H.B., J.L.)
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H. Janssen
aFrom the Departments of Neuroradiology (N.L., M.P., H.J., H.B., J.L.)
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C. Opherk
bNeurology (T.P., C.O.)
cInstitute for Stroke and Dementia Research (C.O.), Klinikum Grosshadern, Ludwig-Maximilian-University, Munich, Germany
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H. Brückmann
aFrom the Departments of Neuroradiology (N.L., M.P., H.J., H.B., J.L.)
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J. Linn
aFrom the Departments of Neuroradiology (N.L., M.P., H.J., H.B., J.L.)
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    Fig 1.

    Postinterventional CCT of 3 different patients with hyperattenuated lesions in the basal ganglia (A, arrows), cortex (B, arrows), and cortical sulci (C, arrows).

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    Fig 2.

    Flow diagram of patient identification and imaging findings. HCLs indicate hyperattenuating intracerebral lesions; pCCT, postinterventional cranial CT; CE, contrast enhancement; HT, hemorrhagic transformation.

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    Fig 3.

    A 47-year-old man with acute occlusion of the right MCA and mechanical recanalization. Postinterventional CCT (A) shows a hyperattenuated intracerebral lesion in the right putamen (thin arrow) and early signs of ischemic infarction in the right anterior insula (thick arrow). MR imaging (FLAIR in B, and T2* in C) 2 days following the event shows pure ischemic infarction in both localizations (right putamen and anterior insula; thin and thick arrows in B and C). Furthermore, MR imaging shows an intracerebral hematoma (PH1) in the right parieto-occipital lobe (arrowheads on B and C), where no hyperattenuated lesion was evident on postinterventional CCT. Clinical outcome of this patient was good (mRS 1).

Tables

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    Table 1:

    Demographic and clinical characteristics of the study population (N = 101 patients)

    No.aNo. (%)MedianIQR
    Age (yr)1017121.5
    Sex101
        Men38 (37.6%)
        Women63 (62.4%)
    NIHSS score on admission98156
    No. of CVRFs8111
    Etiology of stroke101
        TOAST 117 (16.8%)
        TOAST 263 (62.4%)
        TOAST 35 (5%)
        TOAST 416 (15.8%)
    Clinical outcome9842
        Good (mRS 0–3)34 (33.7%)
            mRS 05 (5%)
            mRS 15 (5%)
            mRS 213 (12.9%)
            mRS 311 (10.9%)
        Poor (mRS 4–6)64 (63.4%)
            mRS 439 (38.6%)
            mRS 514 (13.9%)
            mRS 611 (10.9%)
    • Note:—CVRF indicates cardiovascular risk factors; Trial of Org 10172 in Acute Stroke Treatment (TOAST) 1, large-artery atherosclerosis; 2, cardioemboly; 3, dissection; 4, unknown etiology.

    • ↵a No. indicates number in which the parameter was available in this retrospective study.

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    Table 2:

    Characteristics of hyperattenuated intracerebral lesions regarding Hounsfield units in patients with contrast enhancement versus hemorrhagic lesions on follow-up 1 and patients with final ischemic-versus-hemorrhagic infarction, respectively

    No.HU MeanHU Maximum
    MedianIQRP ValueMedianIQRP Value
    HCL on pCCTa7552159461
    Follow-up 175
        CE294547219.5
    <.001<.001
        HL465813.511359.5
    Final infarction74b
        Ischemic354678027
    <.001<.001
        Hemorrhagic39581110968
    • Note:—HCL indicates hyperattenuated intracerebral lesion; CE, contrast enhancement; HL, hemorrhagic lesion; pCCT, postinterventional cranial CT.

    • ↵a All patients with hyperattenuated intracerebral lesions in the basal ganglia and cortex; patients with pure sulcal hyperattenuating lesions (n = 10) are excluded in this calculation because Hounsfield unit values were not evaluated in these patients.

    • ↵b One case with hyperattenuated lesions on postinterventional CCT had no infarction on follow-up 2 and was therefore excluded.

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American Journal of Neuroradiology: 35 (2)
American Journal of Neuroradiology
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Cite this article
N. Lummel, G. Schulte-Altedorneburg, C. Bernau, T. Pfefferkorn, M. Patzig, H. Janssen, C. Opherk, H. Brückmann, J. Linn
Hyperattenuated Intracerebral Lesions after Mechanical Recanalization in Acute Stroke
American Journal of Neuroradiology Feb 2014, 35 (2) 345-351; DOI: 10.3174/ajnr.A3656

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Hyperattenuated Intracerebral Lesions after Mechanical Recanalization in Acute Stroke
N. Lummel, G. Schulte-Altedorneburg, C. Bernau, T. Pfefferkorn, M. Patzig, H. Janssen, C. Opherk, H. Brückmann, J. Linn
American Journal of Neuroradiology Feb 2014, 35 (2) 345-351; DOI: 10.3174/ajnr.A3656
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