Article Figures & Data
Figures
- Fig 1.
The peritumoral region and corresponding imaging modalities. Tumor cells can extend beyond the bulk tumor into vaguely concentric subdivisions of the peritumoral region, including the transitional zone (1), the region of tumor infiltration (2), the peritumoral edema (3), and even the normal-appearing white matter (4).
- Fig 2.
Schematic illustrating the factors behind the comparable change in peritumoral FA. A, Water content contributing to decreased FA in metastatic lesions. B, Water content and axonal disorganization contributing to decreased FA in high-grade gliomas. Reprinted from Lu et al.20
- Fig 3.
Graph of TII values in meningiomas and metastases compared with TIIs in gliomas. The mean TII of meningiomas and metastases is zero, with a 95% CI between −15 and 15. The mean TII of gliomas is 64, with a 95% CI between 38 and 90. Reprinted with permission from Lu S, Ahn D, Johnson G, et al. Diffusion-tensor MR imaging of intracranial neoplasia and associated peritumoral edema: introduction of the tumor infiltration index. Radiology 2004;232:221–28.24
- Fig 4.
FA and MD results from a patient with glioblastoma. A, Placement of ROIs. Arrangement of images and ROIs as in Fig 1A. B, FA (upper graph) and MD (lower graph) values and SD boxplots in high-grade gliomas. Numbers 1–5 correspond to ROIs as indicated in Fig 3A. Reprinted with permission from Tropine et al.25
Tables
Summary table of DTI studies of the peritumoral region
Article No. Design Measures Tumor types Criterion Standard Conclusiona Deng et al, 201027 20 Prospective cohort study FA, ADC ☒ Primary □ Metastasis □ Extra-axial Tissue Yes Wang et al, 200928 49 Retrospective analysis FA, p, q, L ☒ Primary □ Metastasis □ Extra-axial None Yes Price et al, 200629 20 Prospective cohort study FA, p, q ☒ Primary ☒ Metastasis □ Extra-axial Tissue Yes Sinha et al, 200213 9 Prospective cohort study FA, MD ☒ Primary □ Metastasis □ Extra-axial None No Provenzale et al, 200426 17 Retrospective analysis FA, ADC ☒ Primary □ Metastasis ☒ Extra-axial None Yes Lu et al, 200320 24 Prospective cohort study FA, MD ☒ Primary ☒ Metastasis □ Extra-axial None Yes Lu et al, 200424 40 Retrospective analysis FA, MD, TII ☒ Primary ☒ Metastasis ☒ Extra-axial None Yes Price et al, 200323 20 Prospective cohort study RAI ☒ Primary ☒ Metastasis □ Extra-axial None Yes Sundgren et al, 200621 28 Prospective cohort study FA, ADC ☒ Primary ☒ Metastasis □ Extra-axial Follow-up Yes van Westen et al, 200614 30 Prospective cohort study FA, ADC ☒ Primary ☒ Metastasis ☒ Extra-axial Tissue, cytology No Kinoshita et al, 201030 14 Retrospective analysis FA, ADC, TII ☒ Primary ☒ Metastasis ☒ Extra-axial None No Tropine et al, 200425 12 Prospective cohort study FA, MD ☒ Primary □ Metastasis ☒ Extra-axial None Inconclusive Note:—p indicates pure isotropic vector component; q, pure anisotropic vector component; L, total magnitude of the diffusion tensor; RAI, relative anisotropy index.
↵a Whether the study data suggest that DTI has utility in determining the extent of brain tumor infiltration.
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