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Research ArticleBrain
Open Access

Evaluation of Common Structural Brain Changes in Aging and Alzheimer Disease with the Use of an MRI-Based Brain Atrophy and Lesion Index: A Comparison Between T1WI and T2WI at 1.5T and 3T

H. Guo, X. Song, R. Vandorpe, Y. Zhang, W. Chen, N. Zhang, M.H. Schmidt and K. Rockwood for the Alzheimer's Disease Neuroimaging Initiative
American Journal of Neuroradiology March 2014, 35 (3) 504-512; DOI: https://doi.org/10.3174/ajnr.A3709
H. Guo
aFrom the Neuroimaging Research Laboratory, Biomedical Translational Imaging Center (H.G., X.S., W.C., N.Z.), QEII & IWK Health Centre (former National Research Council Canada Institute for Biodiagnostics–Atlantic), Halifax, Nova Scotia, Canada
bDepartment of Radiology (G.H., Y.Z., W.C., N.Z.), General Hospital of Tianjin Medical University, Tianjin, China
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X. Song
aFrom the Neuroimaging Research Laboratory, Biomedical Translational Imaging Center (H.G., X.S., W.C., N.Z.), QEII & IWK Health Centre (former National Research Council Canada Institute for Biodiagnostics–Atlantic), Halifax, Nova Scotia, Canada
cDepartments of Medicine (X.S., K.R.)
fCentre for Health Care of the Elderly (X.S., K.R.)
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R. Vandorpe
dRadiology (R.V., M.H.S.)
gDepartment of Diagnostic Imaging (R.V., M.H.S.), QEII Health Sciences Centre, Halifax, Nova Scotia, Canada.
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Y. Zhang
bDepartment of Radiology (G.H., Y.Z., W.C., N.Z.), General Hospital of Tianjin Medical University, Tianjin, China
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W. Chen
aFrom the Neuroimaging Research Laboratory, Biomedical Translational Imaging Center (H.G., X.S., W.C., N.Z.), QEII & IWK Health Centre (former National Research Council Canada Institute for Biodiagnostics–Atlantic), Halifax, Nova Scotia, Canada
bDepartment of Radiology (G.H., Y.Z., W.C., N.Z.), General Hospital of Tianjin Medical University, Tianjin, China
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N. Zhang
aFrom the Neuroimaging Research Laboratory, Biomedical Translational Imaging Center (H.G., X.S., W.C., N.Z.), QEII & IWK Health Centre (former National Research Council Canada Institute for Biodiagnostics–Atlantic), Halifax, Nova Scotia, Canada
bDepartment of Radiology (G.H., Y.Z., W.C., N.Z.), General Hospital of Tianjin Medical University, Tianjin, China
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M.H. Schmidt
dRadiology (R.V., M.H.S.)
gDepartment of Diagnostic Imaging (R.V., M.H.S.), QEII Health Sciences Centre, Halifax, Nova Scotia, Canada.
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K. Rockwood
cDepartments of Medicine (X.S., K.R.)
eNeurology (K.R.), Dalhousie University, Halifax, Nova Scotia, Canada
fCentre for Health Care of the Elderly (X.S., K.R.)
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Article Information

vol. 35 no. 3 504-512
DOI 
https://doi.org/10.3174/ajnr.A3709
PubMed 
23988753

Published By 
American Journal of Neuroradiology
Print ISSN 
0195-6108
Online ISSN 
1936-959X
History 
  • Received May 8, 2013
  • Accepted after revision June 20, 2013
  • Published online March 13, 2014.

Copyright & Usage 
© 2014 by American Journal of Neuroradiology Indicates open access to non-subscribers at www.ajnr.org

Author Information

  1. H. Guoa,b,
  2. X. Songa,c,f,
  3. R. Vandorped,g,
  4. Y. Zhangb,
  5. W. Chena,b,
  6. N. Zhanga,b,
  7. M.H. Schmidtd,g and
  8. K. Rockwoodc,e,f
  9. for the Alzheimer's Disease Neuroimaging Initiative
  1. aFrom the Neuroimaging Research Laboratory, Biomedical Translational Imaging Center (H.G., X.S., W.C., N.Z.), QEII & IWK Health Centre (former National Research Council Canada Institute for Biodiagnostics–Atlantic), Halifax, Nova Scotia, Canada
  2. bDepartment of Radiology (G.H., Y.Z., W.C., N.Z.), General Hospital of Tianjin Medical University, Tianjin, China
  3. cDepartments of Medicine (X.S., K.R.)
  4. dRadiology (R.V., M.H.S.)
  5. eNeurology (K.R.), Dalhousie University, Halifax, Nova Scotia, Canada
  6. fCentre for Health Care of the Elderly (X.S., K.R.)
  7. gDepartment of Diagnostic Imaging (R.V., M.H.S.), QEII Health Sciences Centre, Halifax, Nova Scotia, Canada.
  1. Please address correspondence to Xiaowei Song, PhD, MSCS, Neuroimaging Research Laboratory, Dalhousie University, Suite 3900, 1796 Summer St, Halifax, Nova Scotia B3H 3A7, Canada; e-mail: xiaowei.song{at}dal.ca
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H. Guo, X. Song, R. Vandorpe, Y. Zhang, W. Chen, N. Zhang, M.H. Schmidt, K. Rockwood
Evaluation of Common Structural Brain Changes in Aging and Alzheimer Disease with the Use of an MRI-Based Brain Atrophy and Lesion Index: A Comparison Between T1WI and T2WI at 1.5T and 3T
American Journal of Neuroradiology Mar 2014, 35 (3) 504-512; DOI: 10.3174/ajnr.A3709

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Evaluation of Common Structural Brain Changes in Aging and Alzheimer Disease with the Use of an MRI-Based Brain Atrophy and Lesion Index: A Comparison Between T1WI and T2WI at 1.5T and 3T
H. Guo, X. Song, R. Vandorpe, Y. Zhang, W. Chen, N. Zhang, M.H. Schmidt, K. Rockwood
American Journal of Neuroradiology Mar 2014, 35 (3) 504-512; DOI: 10.3174/ajnr.A3709
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This article has been cited by the following articles in journals that are participating in Crossref Cited-by Linking.

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    Elisa Cuadrado-Godia, Pratistha Dwivedi, Sanjiv Sharma, Angel Ois Santiago, Jaume Roquer Gonzalez, Mercedes Balcells, John Laird, Monika Turk, Harman S. Suri, Andrew Nicolaides, Luca Saba, Narendra N. Khanna, Jasjit S. Suri
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  • Recent publications from the Alzheimer's Disease Neuroimaging Initiative: Reviewing progress toward improved AD clinical trials
    Michael W. Weiner, Dallas P. Veitch, Paul S. Aisen, Laurel A. Beckett, Nigel J. Cairns, Robert C. Green, Danielle Harvey, Clifford R. Jack, William Jagust, John C. Morris, Ronald C. Petersen, Andrew J. Saykin, Leslie M. Shaw, Arthur W. Toga, John Q. Trojanowski
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  • Cerebral Small Vessel Disease
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    International Journal of Molecular Sciences 2020 21 24
  • Age-related deficit accumulation and the risk of late-life dementia
    Xiaowei Song, Arnold Mitnitski, Kenneth Rockwood
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  • Correlating Cognitive Decline with White Matter Lesion and Brain Atrophy Magnetic Resonance Imaging Measurements in Alzheimer’s Disease
    Michel Bilello, Jimit Doshi, S. Ali Nabavizadeh, Jon B. Toledo, Guray Erus, Sharon X. Xie, John Q. Trojanowski, Xiaoyan Han, Christos Davatzikos
    Journal of Alzheimer's Disease 2015 48 4
  • MRI-assessed atrophy subtypes in Alzheimer’s disease and the cognitive reserve hypothesis
    Karin Persson, Rannveig Sakshaug Eldholm, Maria Lage Barca, Lena Cavallin, Daniel Ferreira, Anne-Brita Knapskog, Geir Selbæk, Anne Brækhus, Ingvild Saltvedt, Eric Westman, Knut Engedal, Stephen D Ginsberg
    PLOS ONE 2017 12 10
  • MRI-based evaluation of structural degeneration in the ageing brain: Pathophysiology and assessment
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    Ageing Research Reviews 2019 49
  • Association of Cerebral Small Vessel Disease With Gait and Balance Disorders
    Chen Su, Xiaoyu Yang, Shuqi Wei, Renliang Zhao
    Frontiers in Aging Neuroscience 2022 14
  • Potential of dietary polyphenols for protection from age-related decline and neurodegeneration: a role for gut microbiota?
    F. C. Ross, D. E. Mayer, J. Horn, J. F. Cryan, D. Del Rio, E. Randolph, C. I. R. Gill, A. Gupta, R. P. Ross, C. Stanton, E. A. Mayer
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