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Research ArticleExtracranial Vascular

Intraplaque High-Intensity Signal on 3D Time-of-Flight MR Angiography Is Strongly Associated with Symptomatic Carotid Artery Stenosis

A. Gupta, H. Baradaran, H. Kamel, A. Mangla, A. Pandya, V. Fodera, A. Dunning and P.C. Sanelli
American Journal of Neuroradiology March 2014, 35 (3) 557-561; DOI: https://doi.org/10.3174/ajnr.A3732
A. Gupta
aFrom the Departments of Radiology (A.G., H.B., V.F., P.C.S.)
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H. Baradaran
aFrom the Departments of Radiology (A.G., H.B., V.F., P.C.S.)
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H. Kamel
bNeurology (H.K., A.M.)
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A. Mangla
bNeurology (H.K., A.M.)
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A. Pandya
cPublic Health (A.P., A.D., P.C.S.), Weill Cornell Medical College, New York, New York.
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V. Fodera
aFrom the Departments of Radiology (A.G., H.B., V.F., P.C.S.)
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A. Dunning
cPublic Health (A.P., A.D., P.C.S.), Weill Cornell Medical College, New York, New York.
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P.C. Sanelli
aFrom the Departments of Radiology (A.G., H.B., V.F., P.C.S.)
cPublic Health (A.P., A.D., P.C.S.), Weill Cornell Medical College, New York, New York.
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REFERENCES

  1. 1.↵
    Beneficial effect of carotid endarterectomy in symptomatic patients with high-grade carotid stenosis. North American Symptomatic Carotid Endarterectomy Trial Collaborators. N Engl J Med 1991;325:445–53
    CrossRefPubMedWeb of Science
  2. 2.↵
    1. Halliday A,
    2. Harrison M,
    3. Hayter E,
    4. et al
    . 10-year stroke prevention after successful carotid endarterectomy for asymptomatic stenosis (ACST-1): a multicentre randomised trial. Lancet 2010;376:1074–84
    CrossRefPubMedWeb of Science
  3. 3.↵
    Randomised trial of endarterectomy for recently symptomatic carotid stenosis: final results of the MRC European Carotid Surgery Trial (ECST). Lancet 1998;351:1379–87
    CrossRefPubMedWeb of Science
  4. 4.↵
    1. den Hartog AG,
    2. Bovens SM,
    3. Koning W,
    4. et al
    . Current status of clinical magnetic resonance imaging for plaque characterisation in patients with carotid artery stenosis. Eur J Vasc Endovasc Surg 2013;45:7–21
    CrossRefPubMed
  5. 5.↵
    1. Cai JM,
    2. Hatsukami TS,
    3. Ferguson MS,
    4. et al
    . Classification of human carotid atherosclerotic lesions with in vivo multicontrast magnetic resonance imaging. Circulation 2002;106:1368–73
    Abstract/FREE Full Text
  6. 6.↵
    1. Stary HC,
    2. Chandler AB,
    3. Dinsmore RE,
    4. et al
    . A definition of advanced types of atherosclerotic lesions and a histological classification of atherosclerosis. A report from the Committee on Vascular Lesions of the Council on Arteriosclerosis, American Heart Association. Circulation 1995;92:1355–74
    Abstract/FREE Full Text
  7. 7.↵
    1. Millon A,
    2. Mathevet JL,
    3. Boussel L,
    4. et al
    . High-resolution magnetic resonance imaging of carotid atherosclerosis identifies vulnerable carotid plaques. J Vasc Surg 2013;57:1046–51
    CrossRefPubMed
  8. 8.↵
    1. Qiao Y,
    2. Etesami M,
    3. Astor BC,
    4. et al
    . Carotid plaque neovascularization and hemorrhage detected by MR imaging are associated with recent cerebrovascular ischemic events. AJNR Am J Neuroradiol 2012;33:755–60
    Abstract/FREE Full Text
  9. 9.↵
    1. Hosseini AA,
    2. Kandiyil N,
    3. Macsweeney ST,
    4. et al
    . Carotid plaque hemorrhage on MRI strongly predicts recurrent ischemia and stroke. Ann Neurol 2013;73:774–84
    CrossRefPubMed
  10. 10.↵
    1. Altaf N,
    2. Akwei S,
    3. Auer DP,
    4. et al
    . Magnetic resonance detected carotid plaque hemorrhage is associated with inflammatory features in symptomatic carotid plaques. Ann Vasc Surg 2013;27:655–61
    CrossRefPubMed
  11. 11.↵
    1. Singh N,
    2. Moody AR,
    3. Rochon-Terry G,
    4. et al
    . Identifying a high risk cardiovascular phenotype by carotid MRI-depicted intraplaque hemorrhage. Int J Cardiovasc Imaging 2013;29:1477–83
    CrossRefPubMed
  12. 12.↵
    1. Takaya N,
    2. Yuan C,
    3. Chu B,
    4. et al
    . Association between carotid plaque characteristics and subsequent ischemic cerebrovascular events: a prospective assessment with MRI–initial results. Stroke 2006;37:818–23
    Abstract/FREE Full Text
  13. 13.↵
    1. Qiao Y,
    2. Etesami M,
    3. Malhotra S,
    4. et al
    . Identification of intraplaque hemorrhage on MR angiography images: a comparison of contrast-enhanced mask and time-of-flight techniques. AJNR Am J Neuroradiol 2011;32:454–59
    Abstract/FREE Full Text
  14. 14.↵
    1. Yamada K,
    2. Song Y,
    3. Hippe DS,
    4. et al
    . Quantitative evaluation of high intensity signal on MIP images of carotid atherosclerotic plaques from routine TOF-MRA reveals elevated volumes of intraplaque hemorrhage and lipid rich necrotic core. J Cardiovasc Magn Reson 2012;14:81
    CrossRefPubMed
  15. 15.↵
    1. Singh N,
    2. Moody AR,
    3. Gladstone DJ,
    4. et al
    . Moderate carotid artery stenosis: MR imaging-depicted intraplaque hemorrhage predicts risk of cerebrovascular ischemic events in asymptomatic men. Radiology 2009;252:502–08
    CrossRefPubMedWeb of Science
  16. 16.↵
    1. Babiarz LS,
    2. Romero JM,
    3. Murphy EK,
    4. et al
    . Contrast-enhanced MR angiography is not more accurate than unenhanced 2D time-of-flight MR angiography for determining > or = 70% internal carotid artery stenosis. AJNR Am J Neuroradiol 2009;30:761–68
    Abstract/FREE Full Text
  17. 17.↵
    1. Fox AJ
    . How to measure carotid stenosis. Radiology 1993;186:316–18
    PubMedWeb of Science
  18. 18.↵
    1. Easton JD,
    2. Saver JL,
    3. Albers GW,
    4. et al
    . Definition and evaluation of transient ischemic attack: a scientific statement for healthcare professionals from the American Heart Association/American Stroke Association Stroke Council; Council on Cardiovascular Surgery and Anesthesia; Council on Cardiovascular Radiology and Intervention; Council on Cardiovascular Nursing; and the Interdisciplinary Council on Peripheral Vascular Disease. The American Academy of Neurology affirms the value of this statement as an educational tool for neurologists. Stroke 2009;40:2276–93
    Abstract/FREE Full Text
  19. 19.↵
    1. Saam T,
    2. Ferguson MS,
    3. Yarnykh VL,
    4. et al
    . Quantitative evaluation of carotid plaque composition by in vivo MRI. Arterioscler Thromb Vasc Biol 2005;25:234–39
    Abstract/FREE Full Text
  20. 20.↵
    1. Yamada N,
    2. Higashi M,
    3. Otsubo R,
    4. et al
    . Association between signal hyperintensity on T1-weighted MR imaging of carotid plaques and ipsilateral ischemic events. AJNR Am J Neuroradiol 2007;28:287–92
    Abstract/FREE Full Text
  21. 21.↵
    1. Kurosaki Y,
    2. Yoshida K,
    3. Endo H,
    4. et al
    . Association between carotid atherosclerosis plaque with high signal intensity on T1-weighted imaging and subsequent ipsilateral ischemic events. Neurosurgery 2011;68:62–67; discussion 67
    CrossRefPubMed
  22. 22.↵
    1. Kwee RM,
    2. van Oostenbrugge RJ,
    3. Mess WH,
    4. et al
    . MRI of carotid atherosclerosis to identify TIA and stroke patients who are at risk of a recurrence. J Magn Reson Imaging 2013;37:1189–94
    CrossRefPubMed
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American Journal of Neuroradiology: 35 (3)
American Journal of Neuroradiology
Vol. 35, Issue 3
1 Mar 2014
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Cite this article
A. Gupta, H. Baradaran, H. Kamel, A. Mangla, A. Pandya, V. Fodera, A. Dunning, P.C. Sanelli
Intraplaque High-Intensity Signal on 3D Time-of-Flight MR Angiography Is Strongly Associated with Symptomatic Carotid Artery Stenosis
American Journal of Neuroradiology Mar 2014, 35 (3) 557-561; DOI: 10.3174/ajnr.A3732

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Intraplaque High-Intensity Signal on 3D Time-of-Flight MR Angiography Is Strongly Associated with Symptomatic Carotid Artery Stenosis
A. Gupta, H. Baradaran, H. Kamel, A. Mangla, A. Pandya, V. Fodera, A. Dunning, P.C. Sanelli
American Journal of Neuroradiology Mar 2014, 35 (3) 557-561; DOI: 10.3174/ajnr.A3732
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  • Proximal Vertebral Artery Variants and Embryology
  • High-Risk Plaque Features in Carotid MRI
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