DWI Reversal Is Associated with Small Infarct Volume in Patients with TIA and Minor Stroke

Article Figures & Data

Download figure
Open in new tab
Download powerpoint
Fig 1.
Example of focal atrophy on follow-up FLAIR imaging in the region of the original DWI lesion that could mimic DWI reversal. Baseline DWI lesion (A) and baseline FLAIR (B) show the acute ischemic infarct. C, An area of focal atrophy in the region of the baseline DWI lesion.
Download figure
Open in new tab
Download powerpoint
Fig 2.
Example of a patient with DWI reversal. Baseline DWI (A) and baseline FLAIR (B) show the acute ischemic infarct corresponding to the patient's presenting symptoms. C, Complete resolution of the DWI signal on follow-up MR imaging (FLAIR).
Download figure
Open in new tab
Download powerpoint
Fig 3.
The distribution of the modified Rankin Scale at 90 days in patients with follow-up imaging based on DWI persistence or reversal.

Clinical and radiographic characteristics of the DWI-positive patients with or without reversal

Clinical and Radiographic Characteristics	DWI Reversal (n = 11)	No. DWI Reversals (n = 181)	P Value
Age (median) (IQR) (yr)	68.5 (20.7)	68.5 (16.3)	.95
HTN (No., %)	5 (45.5%)	101 (55.8%)	.50
Diabetes (No., %)	1 (9.1%)	24 (13.3%)	.69
Atrial fibrillation (No., %)	1 (9.1%)	18 (9.9%)	.96
Smoking (No., %)	2 (18.2%)	36 (19.9%)	.89
Time from symptom onset to baseline DWI/PWI in hours (IQR)	13.3 (11.4)	11 (8.6)	.15
Time from symptom onset to follow-up FLAIR in days (IQR)	76.5 (46)	79.6 (59.4)	.61
Median DWI lesion volume	0.26 mL (0.58)	1.29 mL (3.6)	.002^a
Concurrent PWI deficit (Tmax +2 seconds) (No., %)	4 (36.4%)	113 (62.4%)	.08
Concurrent penumbra (Tmax +6 seconds), DWI (No., %)	2 (18%)	58 (32%)	.33
Topography			.034^a
Cortical	72.7%	27.6%
Subcortical WM	18.2%	12.2%
Subcortical GM	0%	8.8%
Cortical and subcortical	9.1%	41.4%
Infratentorial	0%	8.3%
Multiterritorial	0%	1.7%
Acute FLAIR hyperintensity	18.2%	23.8%	.67