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Research ArticlePediatrics

Time-Dependent Structural Changes of the Dentatothalamic Pathway in Children Treated for Posterior Fossa Tumor

S. Perreault, R.M. Lober, S. Cheshier, S. Partap, M.S. Edwards and K.W. Yeom
American Journal of Neuroradiology April 2014, 35 (4) 803-807; DOI: https://doi.org/10.3174/ajnr.A3735
S. Perreault
aFrom the Departments of Neurology (S. Perreault, S. Partap)
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R.M. Lober
bNeurosurgery (R.M.L., S.C., M.S.E.)
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S. Cheshier
bNeurosurgery (R.M.L., S.C., M.S.E.)
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S. Partap
aFrom the Departments of Neurology (S. Perreault, S. Partap)
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M.S. Edwards
bNeurosurgery (R.M.L., S.C., M.S.E.)
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K.W. Yeom
cRadiology (K.W.Y.), Lucile Packard Children's Hospital at Stanford, Palo Alto, California.
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References

  1. 1.↵
    1. Arora RS,
    2. Alston RD,
    3. Eden TO,
    4. et al
    . Age-incidence patterns of primary CNS tumors in children, adolescents, and adults in England. Neuro Oncol 2009;11:403–13
    Abstract/FREE Full Text
  2. 2.↵
    1. Rønning C,
    2. Sundet K,
    3. Due-Tonnessen B,
    4. et al
    . Persistent cognitive dysfunction secondary to cerebellar injury in patients treated for posterior fossa tumors in childhood. Pediatr Neurosurg 2005;41:15–21
    CrossRefPubMedWeb of Science
  3. 3.↵
    1. Mabbott DJ,
    2. Penkman L,
    3. Witol A,
    4. et al
    . Core neurocognitive functions in children treated for posterior fossa tumors. Neuropsychology 2008;22:159–68
    CrossRefPubMedWeb of Science
  4. 4.↵
    1. Spiegler BJ,
    2. Bouffet E,
    3. Greenberg ML,
    4. et al
    . Change in neurocognitive functioning after treatment with cranial radiation in childhood. J Clin Oncol 2004;22:706–13
    Abstract/FREE Full Text
  5. 5.↵
    1. Timmann D,
    2. Daum I
    . Cerebellar contributions to cognitive functions: a progress report after two decades of research. Cerebellum 2007;6:159–62
    CrossRefPubMedWeb of Science
  6. 6.↵
    1. Kim SG,
    2. Ugurbil K,
    3. Strick PL
    . Activation of a cerebellar output nucleus during cognitive processing. Science 1994;265:949–51
    Abstract/FREE Full Text
  7. 7.↵
    1. Leiner HC,
    2. Leiner AL,
    3. Dow RS
    . Cognitive and language functions of the human cerebellum. Trends Neurosci 1993;16:444–47
    PubMedWeb of Science
  8. 8.↵
    1. Marx JJ,
    2. Iannetti GD,
    3. Thomke F,
    4. et al
    . Topodiagnostic implications of hemiataxia: an MRI-based brainstem mapping analysis. Neuroimage 2008;39:1625–32
    CrossRefPubMed
  9. 9.↵
    1. Schmahmann JD,
    2. Sherman JC
    . The cerebellar cognitive affective syndrome. Brain 1998;121(pt 4):561–79
    Abstract/FREE Full Text
  10. 10.↵
    1. Müller RA,
    2. Chugani DC,
    3. Behen ME,
    4. et al
    . Impairment of dentato-thalamo-cortical pathway in autistic men: language activation data from positron emission tomography. Neurosci Lett 1998;245:1–4
    CrossRefPubMedWeb of Science
  11. 11.↵
    1. Kwon HG,
    2. Hong JH,
    3. Hong CP,
    4. et al
    . Dentatorubrothalamic tract in human brain: diffusion tensor tractography study. Neuroradiology 2011;53:787–91
    CrossRefPubMedWeb of Science
  12. 12.↵
    1. Law N,
    2. Bouffet E,
    3. Laughlin S,
    4. et al
    . Cerebello-thalamo-cerebral connections in pediatric brain tumor patients: impact on working memory. Neuroimage 2011;56:2238–48
    CrossRefPubMedWeb of Science
  13. 13.↵
    1. Morris EB,
    2. Phillips NS,
    3. Laningham FH,
    4. et al
    . Proximal dentatothalamocortical tract involvement in posterior fossa syndrome. Brain 2009;132:3087–95
    Abstract/FREE Full Text
  14. 14.↵
    1. Robertson PL,
    2. Muraszko KM,
    3. Holmes EJ,
    4. et al
    . Incidence and severity of postoperative cerebellar mutism syndrome in children with medulloblastoma: a prospective study by the Children's Oncology Group. J Neurosurg 2006;105:444–51
    PubMedWeb of Science
  15. 15.↵
    1. Huber JF,
    2. Bradley K,
    3. Spiegler BJ,
    4. et al
    . Long-term effects of transient cerebellar mutism after cerebellar astrocytoma or medulloblastoma tumor resection in childhood. Childs Nerv Syst 2006;22:132–38
    CrossRefPubMedWeb of Science
  16. 16.↵
    1. Law N,
    2. Greenberg M,
    3. Bouffet E,
    4. et al
    . Clinical and neuroanatomical predictors of cerebellar mutism syndrome. Neuro Oncol 2012;14:1294–303
    Abstract/FREE Full Text
  17. 17.↵
    1. Lober RM,
    2. Perreault S,
    3. Partap S,
    4. et al
    . Injury to dentate nuclei and efferent fibers by pediatric posterior fossa tumors. Neuro Oncol 2012;14(suppl 1):132
    Abstract/FREE Full Text
  18. 18.↵
    1. George R,
    2. Griffin JW
    . The proximo-distal spread of axonal degeneration in the dorsal columns of the rat. J Neurocytol 1994;23:657–67
    CrossRefPubMedWeb of Science
  19. 19.↵
    1. George R,
    2. Griffin JW
    . Delayed macrophage responses and myelin clearance during Wallerian degeneration in the central nervous system: the dorsal radiculotomy model. Exp Neurol 1994;129:225–36
    CrossRefPubMedWeb of Science
  20. 20.↵
    1. Kerschensteiner M,
    2. Schwab ME,
    3. Lichtman JW,
    4. et al
    . In vivo imaging of axonal degeneration and regeneration in the injured spinal cord. Nat Med 2005;11:572–77
    CrossRefPubMedWeb of Science
  21. 21.↵
    1. Skare S,
    2. Newbould RD,
    3. Clayton DB,
    4. et al
    . Clinical multishot DW-EPI through parallel imaging with considerations of susceptibility, motion, and noise. Magn Reson Med 2007;57:881–90
    CrossRefPubMed
  22. 22.↵
    1. Du AX,
    2. Cuzzocreo JL,
    3. Landman BA,
    4. et al
    . Diffusion tensor imaging reveals disease-specific deep cerebellar nuclear changes in cerebellar degeneration. J Neurol 2010;257:1406–08
    CrossRefPubMed
  23. 23.↵
    1. Cohen-Adad J,
    2. Leblond H,
    3. Delivet-Mongrain H,
    4. et al
    . Wallerian degeneration after spinal cord lesions in cats detected with diffusion tensor imaging. Neuroimage 2011;57:1068–76
    CrossRefPubMed
  24. 24.↵
    1. Cohen-Adad J,
    2. Benali H,
    3. Hoge RD,
    4. et al
    . In vivo DTI of the healthy and injured cat spinal cord at high spatial and angular resolution. Neuroimage 2008;40:685–97
    CrossRefPubMed
  25. 25.↵
    1. DeBoy CA,
    2. Zhang J,
    3. Dike S,
    4. et al
    . High-resolution diffusion tensor imaging of axonal damage in focal inflammatory and demyelinating lesions in rat spinal cord. Brain 2007;130:2199–210
    Abstract/FREE Full Text
  26. 26.↵
    1. Beirowski B,
    2. Adalbert R,
    3. Wagner D,
    4. et al
    . The progressive nature of Wallerian degeneration in wild-type and slow Wallerian degeneration (WldS) nerves. BMC Neurosci 2005;6:6
    CrossRefPubMed
  27. 27.↵
    1. McMillan HJ,
    2. Keene DL,
    3. Matzinger MA,
    4. et al
    . Brainstem compression: a predictor of postoperative cerebellar mutism. Childs Nerv Syst 2009;25:677–81
    CrossRefPubMed
  28. 28.↵
    1. Ogiwara H,
    2. Dipatri AJ Jr.,
    3. Bowman RM,
    4. et al
    . Diffuse postoperative cerebellar swelling in medulloblastoma: report of two cases. Childs Nerv Syst 2011;27:743–47
    CrossRefPubMed
  29. 29.↵
    1. Rao VK,
    2. Haridas A,
    3. Nguyen TT,
    4. et al
    . Symptomatic cerebral vasospasm following resection of a medulloblastoma in a child. Neurocrit Care 2013;18:84–88
    CrossRefPubMed
  30. 30.↵
    1. Beaulieu C
    . The basis of anisotropic water diffusion in the nervous system: a technical review. NMR Biomed 2002;15:435–55
    CrossRefPubMedWeb of Science
  31. 31.↵
    1. Beaulieu C,
    2. Does MD,
    3. Snyder RE,
    4. et al
    . Changes in water diffusion due to Wallerian degeneration in peripheral nerve. Magn Reson Med 1996;36:627–31
    CrossRefPubMedWeb of Science
  32. 32.↵
    1. Song SK,
    2. Yoshino J,
    3. Le TQ,
    4. et al
    . Demyelination increases radial diffusivity in corpus callosum of mouse brain. Neuroimage 2005;26:132–40
    CrossRefPubMedWeb of Science
  33. 33.↵
    1. Ochs S,
    2. Pourmand R,
    3. Jersild RA Jr.,
    4. et al
    . The origin and nature of beading: a reversible transformation of the shape of nerve fibers. Prog Neurobiol 1997;52:391–426
    CrossRefPubMedWeb of Science
  34. 34.↵
    1. Budde MD,
    2. Kim JH,
    3. Liang HF,
    4. et al
    . Axonal injury detected by in vivo diffusion tensor imaging correlates with neurological disability in a mouse model of multiple sclerosis. NMR Biomed 2008;21:589–97
    CrossRefPubMedWeb of Science
  35. 35.↵
    1. Budde MD,
    2. Xie M,
    3. Cross AH,
    4. et al
    . Axial diffusivity is the primary correlate of axonal injury in the experimental autoimmune encephalomyelitis spinal cord: a quantitative pixelwise analysis. J Neurosci 2009;29:2805–13
    Abstract/FREE Full Text
  36. 36.↵
    1. Kim JH,
    2. Loy DN,
    3. Liang HF,
    4. et al
    . Noninvasive diffusion tensor imaging of evolving white matter pathology in a mouse model of acute spinal cord injury. Magn Reson Med 2007;58:253–60
    CrossRefPubMedWeb of Science
  37. 37.↵
    1. Mac Donald CL,
    2. Dikranian K,
    3. Bayly P,
    4. et al
    . Diffusion tensor imaging reliably detects experimental traumatic axonal injury and indicates approximate time of injury. J Neurosci 2007;27:11869–76
    Abstract/FREE Full Text
  38. 38.↵
    1. Song SK,
    2. Sun SW,
    3. Ramsbottom MJ,
    4. et al
    . Dysmyelination revealed through MRI as increased radial (but unchanged axial) diffusion of water. Neuroimage 2002;17:1429–36
    CrossRefPubMedWeb of Science
  39. 39.↵
    1. Zhang J,
    2. Jones M,
    3. DeBoy CA,
    4. et al
    . Diffusion tensor magnetic resonance imaging of Wallerian degeneration in rat spinal cord after dorsal root axotomy. J Neurosci 2009;29:3160–71
    Abstract/FREE Full Text
  40. 40.↵
    1. Concha L,
    2. Gross DW,
    3. Wheatley BM,
    4. et al
    . Diffusion tensor imaging of time-dependent axonal and myelin degradation after corpus callosotomy in epilepsy patients. Neuroimage 2006;32:1090–99
    CrossRefPubMedWeb of Science
  41. 41.↵
    1. Farrell JA,
    2. Zhang J,
    3. Jones MV,
    4. et al
    . Q-space and conventional diffusion imaging of axon and myelin damage in the rat spinal cord after axotomy. Magn Reson Med 2010;63:1323–35
    CrossRefPubMed
  42. 42.↵
    1. Wieshmann UC,
    2. Symms MR,
    3. Clark CA,
    4. et al
    . Wallerian degeneration in the optic radiation after temporal lobectomy demonstrated in vivo with diffusion tensor imaging. Epilepsia 1999;40:1155–58
    CrossRefPubMedWeb of Science
  43. 43.↵
    1. Werring DJ,
    2. Toosy AT,
    3. Clark CA,
    4. et al
    . Diffusion tensor imaging can detect and quantify corticospinal tract degeneration after stroke. J Neurol Neurosurg Psychiatry 2000;69:269–72
    Abstract/FREE Full Text
  44. 44.↵
    1. Thomalla G,
    2. Glauche V,
    3. Weiller C,
    4. et al
    . Time course of Wallerian degeneration after ischaemic stroke revealed by diffusion tensor imaging. J Neurol Neurosurg Psychiatry 2005;76:266–68
    Abstract/FREE Full Text
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Cite this article
S. Perreault, R.M. Lober, S. Cheshier, S. Partap, M.S. Edwards, K.W. Yeom
Time-Dependent Structural Changes of the Dentatothalamic Pathway in Children Treated for Posterior Fossa Tumor
American Journal of Neuroradiology Apr 2014, 35 (4) 803-807; DOI: 10.3174/ajnr.A3735

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Time-Dependent Structural Changes of the Dentatothalamic Pathway in Children Treated for Posterior Fossa Tumor
S. Perreault, R.M. Lober, S. Cheshier, S. Partap, M.S. Edwards, K.W. Yeom
American Journal of Neuroradiology Apr 2014, 35 (4) 803-807; DOI: 10.3174/ajnr.A3735
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