Article Figures & Data
Figures
- Fig 1.
A, Boxplots of left (white) and right (gray) thalamic volumes in milliliters in healthy controls and patients with PD, CBS, and PSP. Vertical lines illustrate the range in calculated volume for each group, and upper and lower box boundaries correspond to 75th and 25th percentiles for volumes, respectively. Dark horizontal lines represent median values. B–E, Statistical maps of shape difference displayed on the average left (B and D) and right (C and E) thalami. Note relatively the symmetric shape difference in the lateral thalamus, with relative sparing of the medial thalamus. Only white met statistical significance. Yellow indicates areas with trends toward significance (P < .25), seen clustered more extensively around regions in the expected location of the ventral anterior and ventral lateral thalamic nuclei. A similar pattern of difference in shape is observed when the atypical group (CBD+PSP) is compared with the healthy control group (B and C) and patients with PD (D and E).
- Fig 2.
Correspondence between thalamic surface templates and DTI estimates of the location of thalamic nuclei, as viewed from a level superior to the thalami. The right and left thalamic motor nuclear groups, parcellated from the nonmotor regions of the thalamus by using probabilistic DTI tractography, are depicted in red. The contours of the thalami, shaded gray, were delineated automatically from the T1-weighted anatomic images. A indicates anterior; P, posterior.
- Fig 3.
A, Boxplots of left (white) and right (gray) thalamic ADC in mm2/s (×10−3) in control, PD, CBS, and PSP groups. Nonparametric tests of intergroup equivalence demonstrate significant differences in thalamic ADC in the PSP group compared with both healthy controls and patients with PD (see text). B, Boxplots of mean ADC in mm2/s (×10−3) within nonmotor (white) and motor (gray) thalamic nuclei in healthy controls and patients with PD and atypical PD (CBS+PSP).
Tables
Baseline characteristics for study participants
NC PD PSP CBD P Value No. 12 9 5 6 Age (yr) 68.6 ± 5.5 66.3 ± 7.9 69.2 ± 3.0 70.5 ± 4.8 .67 Sex (F/M) 4:8 2:7 3:2 5:1 .09 Disease duration (yr) N/A 8.6 ± 4.2 3.8 ± 1.4 5.5 ± 1.4 .03a Side of main symptoms N/A 5 left; 4 right N/A 3 left; 3 right .24 eTIV (L) 1.59 ± 0.18 1.53 ± 0.10 1.43 ± 0.27 1.58 ± 0.32 .24 Note:—NC indicates healthy control; L, liters; NA, not applicable; eTIV, estimated total intracranial volume.
↵a Statistically significant (P < .05).
