Imaging and Treatment of Patients with Acute Stroke: An Evidence-Based Review

American Journal of Neuroradiology

Table 1:

Classification scheme for the strength of evidence

Strength of Evidence	Criteria Used
Strong	Studies with broad generalizability to most patients suspected of having the disease; include prospective, blinded comparison of a diagnostic test with a well-defined final diagnosis in an unbiased sample when assessing diagnostic accuracy or blinded randomized control trials when assessing therapeutic impact or patient outcomes; also included are well-designed meta-analyses
Moderate	Prospective or retrospective studies with narrower spectrum of generalizability, with only a few flaws that are well-described so that their impact can be assessed but still include a blinded study of diagnostic accuracy on an unbiased sample (well-designed cohort or case-control studies) and randomized trials for therapeutic effects or patient outcomes
Limited	Diagnostic accuracy studies with several flaws in research methods, small sample sizes, incomplete reporting, or nonrandomized comparisons for therapeutic impact or patient outcomes
Insufficient	Studies with multiple flaws in research methods, case series, descriptive studies, or expert opinions without substantiating data