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High WSS or Low WSS? Complex Interactions of Hemodynamics with Intracranial Aneurysm Initiation, Growth, and Rupture: Toward a Unifying Hypothesis

H. Meng, V.M. Tutino, J. Xiang and A. Siddiqui
American Journal of Neuroradiology July 2014, 35 (7) 1254-1262; DOI: https://doi.org/10.3174/ajnr.A3558
H. Meng
aFrom the Toshiba Stroke and Vascular Research Center (H.M., V.M.T., J.X., A.S.)
bDepartments of Mechanical and Aerospace Engineering (H.M.)
cNeurosurgery (H.M., J.X., A.S.)
dBiomedical Engineering (H.M., V.M.T.), University at Buffalo, State University of New York, Buffalo, New York.
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V.M. Tutino
aFrom the Toshiba Stroke and Vascular Research Center (H.M., V.M.T., J.X., A.S.)
dBiomedical Engineering (H.M., V.M.T.), University at Buffalo, State University of New York, Buffalo, New York.
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J. Xiang
aFrom the Toshiba Stroke and Vascular Research Center (H.M., V.M.T., J.X., A.S.)
cNeurosurgery (H.M., J.X., A.S.)
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A. Siddiqui
aFrom the Toshiba Stroke and Vascular Research Center (H.M., V.M.T., J.X., A.S.)
cNeurosurgery (H.M., J.X., A.S.)
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References

  1. 1.↵
    1. Rinkel GJ,
    2. Djibuti M,
    3. Algra A,
    4. et al
    . Prevalence and risk of rupture of intracranial aneurysms: a systematic review. Stroke 1998;29:251–56
    Abstract/FREE Full Text
  2. 2.↵
    1. Connolly ES Jr.,
    2. Rabinstein AA,
    3. Carhuapoma JR,
    4. et al
    . Guidelines for the management of aneurysmal subarachnoid hemorrhage: a guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke 2012;43:1711–37
    Abstract/FREE Full Text
  3. 3.↵
    1. Wiebers DO,
    2. Torner JC,
    3. Meissner I
    . Impact of unruptured intracranial aneurysms on public health in the United States. Stroke 1992;23:1416–19
    Abstract/FREE Full Text
  4. 4.↵
    1. Metaxa E,
    2. Tremmel M,
    3. Natarajan SK,
    4. et al
    . Characterization of critical hemodynamics contributing to aneurysmal remodeling at the basilar terminus in a rabbit model. Stroke 2010;41:1774–82
    Abstract/FREE Full Text
  5. 5.↵
    1. Xiang J,
    2. Natarajan SK,
    3. Tremmel M,
    4. et al
    . Hemodynamic-morphologic discriminants for intracranial aneurysm rupture. Stroke 2011;42:144–52
    Abstract/FREE Full Text
  6. 6.↵
    1. Cebral JR,
    2. Mut F,
    3. Weir J,
    4. et al
    . Quantitative characterization of the hemodynamic environment in ruptured and unruptured brain aneurysms. AJNR Am J Neuroradiol 2011;32:145–51
    Abstract/FREE Full Text
  7. 7.↵
    1. Jou LD,
    2. Lee DH,
    3. Morsi H,
    4. et al
    . Wall shear stress on ruptured and unruptured intracranial aneurysms at the internal carotid artery. AJNR Am J Neuroradiol 2008;29:1761–67
    Abstract/FREE Full Text
  8. 8.↵
    1. Shojima M,
    2. Oshima M,
    3. Takagi K,
    4. et al
    . Magnitude and role of wall shear stress on cerebral aneurysm: computational fluid dynamic study of 20 middle cerebral artery aneurysms. Stroke 2004;35:2500–05
    Abstract/FREE Full Text
  9. 9.↵
    1. Boussel L,
    2. Rayz V,
    3. McCulloch C,
    4. et al
    . Aneurysm growth occurs at region of low wall shear stress: patient-specific correlation of hemodynamics and growth in a longitudinal study. Stroke 2008;39:2997–3002
    Abstract/FREE Full Text
  10. 10.↵
    1. Acevedo-Bolton G,
    2. Jou LD,
    3. Dispensa BP,
    4. et al
    . Estimating the hemodynamic impact of interventional treatments of aneurysms: numerical simulation with experimental validation: technical case report. Neurosurgery 2006;59:E429–30, author reply E429–30
    CrossRefPubMed
  11. 11.↵
    1. Castro MA,
    2. Putman CM,
    3. Sheridan MJ,
    4. et al
    . Hemodynamic patterns of anterior communicating artery aneurysms: a possible association with rupture. AJNR Am J Neuroradiol 2009;30:297–302
    Abstract/FREE Full Text
  12. 12.↵
    1. Qian Y,
    2. Takao H,
    3. Umezu M,
    4. et al
    . Risk analysis of unruptured aneurysms using computational fluid dynamics technology: preliminary results. AJNR Am J Neuroradiol 2011;32:1948–55
    Abstract/FREE Full Text
  13. 13.↵
    1. Sugiyama SI,
    2. Meng H,
    3. Funamoto K,
    4. et al
    . Hemodynamic analysis of growing intracranial aneurysms arising from a posterior inferior cerebellar artery. World Neurosurg 2012;78:462–68
    CrossRefPubMed
  14. 14.↵
    1. Takao H,
    2. Murayama Y,
    3. Otsuka S,
    4. et al
    . Hemodynamic differences between unruptured and ruptured intracranial aneurysms during observation. Stroke 2012;43:1436–39
    Abstract/FREE Full Text
  15. 15.↵
    1. Kallmes DF
    . Point: CFD—computational fluid dynamics or confounding factor dissemination. AJNR Am J Neuroradiol 2012;33:395–96
    FREE Full Text
  16. 16.↵
    1. Cebral JR,
    2. Meng H
    . Counterpoint: realizing the clinical utility of computational fluid dynamics—closing the gap. AJNR Am J Neuroradiol 2012;33:396–98
    FREE Full Text
  17. 17.↵
    1. Robertson AM,
    2. Watton PN
    . Computational fluid dynamics in aneurysm research: critical reflections, future directions. AJNR Am J Neuroradiol 2012;33:992–95
    FREE Full Text
  18. 18.↵
    1. Ujiie H,
    2. Tachibana H,
    3. Hiramatsu O,
    4. et al
    . Effects of size and shape (aspect ratio) on the hemodynamics of saccular aneurysms: a possible index for surgical treatment of intracranial aneurysms. Neurosurgery 1999;45:119–30, discussion 129–30
    CrossRefPubMedWeb of Science
  19. 19.↵
    1. Humphrey JD,
    2. Taylor CA
    . Intracranial and abdominal aortic aneurysms: similarities, differences, and need for a new class of computational models. Annu Rev Biomed Eng 2008;10:221–46
    CrossRefPubMedWeb of Science
  20. 20.↵
    1. Nixon AM,
    2. Gunel M,
    3. Sumpio BE
    . The critical role of hemodynamics in the development of cerebral vascular disease. J Neurosurg 2010;112:1240–53
    CrossRefPubMedWeb of Science
  21. 21.↵
    1. Malek AM,
    2. Alper SL,
    3. Izumo S
    . Hemodynamic shear stress and its role in atherosclerosis. JAMA 1999;282:2035–42
    CrossRefPubMedWeb of Science
  22. 22.↵
    1. Ota R,
    2. Kurihara C,
    3. Tsou TL,
    4. et al
    . Roles of matrix metalloproteinases in flow-induced outward vascular remodeling. J Cereb Blood Flow Metab 2009;29:1547–58
    CrossRefPubMed
  23. 23.↵
    1. Frosen J,
    2. Tulamo R,
    3. Paetau A,
    4. et al
    . Saccular intracranial aneurysm: pathology and mechanisms. Acta Neuropathol 2012;123:773–86
    CrossRefPubMedWeb of Science
  24. 24.↵
    1. Wang Z,
    2. Kolega J,
    3. Hoi Y,
    4. et al
    . Molecular alterations associated with aneurysmal remodeling are localized in the high hemodynamic stress region of a created carotid bifurcation. Neurosurgery 2009;65:169–77, discussion 177–78
    CrossRefPubMedWeb of Science
  25. 25.↵
    1. Kolega J,
    2. Gao L,
    3. Mandelbaum M,
    4. et al
    . Cellular and molecular responses of the basilar terminus to hemodynamics during intracranial aneurysm initiation in a rabbit model. J Vasc Res 2011;48:429–42
    CrossRefPubMed
  26. 26.↵
    1. Findlay JM,
    2. Hao C,
    3. Emery D
    . Non-atherosclerotic fusiform cerebral aneurysms. Can J Neurol Sci 2002;29:41–48
    PubMed
  27. 27.↵
    1. Park SH,
    2. Yim MB,
    3. Lee CY,
    4. et al
    . Intracranial fusiform aneurysms: It's pathogenesis, clinical characteristics and managements. J Korean Neurosurg Soc 2008;44:116–23
    CrossRefPubMed
  28. 28.↵
    1. Yong-Zhong G,
    2. van Alphen HA
    . Pathogenesis and histopathology of saccular aneurysms: review of the literature. Neurol Res 1990;12:249–55
    PubMed
  29. 29.↵
    1. Hashimoto T,
    2. Meng H,
    3. Young WL
    . Intracranial aneurysms: links among inflammation, hemodynamics and vascular remodeling. Neurol Res 2006;28:372–80
    CrossRefPubMed
  30. 30.↵
    1. Stehbens WE
    . Pathology and pathogenesis of intracranial berry aneurysms. Neurol Res 1990;12:29–34
    PubMed
  31. 31.↵
    1. Inci S,
    2. Spetzler RF
    . Intracranial aneurysms and arterial hypertension: a review and hypothesis. Surg Neurol 2000;53:530–40, discussion 540–42
    CrossRefPubMedWeb of Science
  32. 32.↵
    1. Finlay HM,
    2. Whittaker P,
    3. Canham PB
    . Collagen organization in the branching region of human brain arteries. Stroke 1998;29:1595–601
    Abstract/FREE Full Text
  33. 33.↵
    1. Steiger HJ
    . Pathophysiology of development and rupture of cerebral aneurysms. Acta Neurochir Suppl (Wien) 1990;48:1–57
    PubMed
  34. 34.↵
    1. Aoki T,
    2. Kataoka H,
    3. Morimoto M,
    4. et al
    . Macrophage-derived matrix metalloproteinase-2 and -9 promote the progression of cerebral aneurysms in rats. Stroke 2007;38:162–69
    Abstract/FREE Full Text
  35. 35.↵
    1. Hashimoto N,
    2. Handa H,
    3. Nagata I,
    4. et al
    . Animal model of cerebral aneurysms: pathology and pathogenesis of induced cerebral aneurysms in rats. Neurol Res 1984;6:33–40
    PubMed
  36. 36.↵
    1. Meng H,
    2. Metaxa E,
    3. Gao L,
    4. et al
    . Progressive aneurysm development following hemodynamic insult. J Neurosurg 2011;114:1095–103
    CrossRefPubMedWeb of Science
  37. 37.↵
    1. Meng H,
    2. Wang Z,
    3. Hoi Y,
    4. et al
    . Complex hemodynamics at the apex of an arterial bifurcation induces vascular remodeling resembling cerebral aneurysm initiation. Stroke 2007;38:1924–31
    Abstract/FREE Full Text
  38. 38.↵
    1. Cai J,
    2. He C,
    3. Yuan FL,
    4. et al
    . A novel haemodynamic cerebral aneurysm model of rats with normal blood pressure. J Clin Neurosci 2012;19:135–38
    CrossRefPubMed
  39. 39.↵
    1. Meng H,
    2. Xiang J,
    3. Liaw N
    . The role of hemodynamics in intracranial aneurysm initiation. Int Rev Thromb 2012;7:40–57
  40. 40.↵
    1. Juvela S
    . Natural history of unruptured intracranial aneurysms: risks for aneurysm formation, growth, and rupture. Acta Neurochir Suppl 2002;82:27–30
    PubMedWeb of Science
  41. 41.↵
    1. Vega C,
    2. Kwoon JV,
    3. Lavine SD
    . Intracranial aneurysms: current evidence and clinical practice. Am Fam Physician 2002;66:601–08
    PubMed
  42. 42.↵
    1. Cebral JR,
    2. Raschi M
    . Suggested connections between risk factors of intracranial aneurysms: a review. Ann Biomed Eng 2013;41:1366–83
    CrossRefPubMed
  43. 43.↵
    1. Dolan JM,
    2. Kolega J,
    3. Meng H
    . High wall shear stress and spatial gradients in vascular pathology: a review. Ann Biomed Eng 2013;41:1411–27
    CrossRefPubMed
  44. 44.↵
    1. Aoki T,
    2. Kataoka H,
    3. Shimamura M,
    4. et al
    . Nf-kappaB is a key mediator of cerebral aneurysm formation. Circulation 2007;116:2830–40
    Abstract/FREE Full Text
  45. 45.↵
    1. Jamous MA,
    2. Nagahiro S,
    3. Kitazato KT,
    4. et al
    . Vascular corrosion casts mirroring early morphological changes that lead to the formation of saccular cerebral aneurysm: an experimental study in rats. J Neurosurg 2005;102:532–35
    CrossRefPubMed
  46. 46.↵
    1. Chalouhi N,
    2. Ali MS,
    3. Jabbour PM,
    4. et al
    . Biology of intracranial aneurysms: role of inflammation. J Cereb Blood Flow Metab 2012;32:1659–76
    CrossRefPubMed
  47. 47.↵
    1. Asari S,
    2. Ohmoto T
    . Long-term outcome of surgically treated unruptured cerebral aneurysms. Clin Neurol Neurosurg 1994;96:230–35
    CrossRefPubMed
  48. 48.↵
    1. Inagawa T,
    2. Hirano A
    . Autopsy study of unruptured incidental intracranial aneurysms. Surg Neurol 1990;34:361–65
    CrossRefPubMedWeb of Science
  49. 49.↵
    1. Mizoi K,
    2. Yoshimoto T,
    3. Nagamine Y
    . Types of unruptured cerebral aneurysms reviewed from operation video-recordings. Acta Neurochir 1996;138:965–69
    CrossRefPubMedWeb of Science
  50. 50.↵
    1. Kadasi LM,
    2. Dent WC,
    3. Malek AM
    . Cerebral aneurysm wall thickness analysis using intraoperative microscopy: effect of size and gender on thin translucent regions. J Neurointerv Surg 2013;5:201–06
    Abstract/FREE Full Text
  51. 51.↵
    1. Chyatte D,
    2. Bruno G,
    3. Desai S,
    4. et al
    . Inflammation and intracranial aneurysms. Neurosurgery 1999;45:1137–46, discussion 1146–47
    CrossRefPubMedWeb of Science
  52. 52.↵
    1. Frösen J,
    2. Piippo A,
    3. Paetau A,
    4. et al
    . Remodeling of saccular cerebral artery aneurysm wall is associated with rupture: histological analysis of 24 unruptured and 42 ruptured cases. Stroke 2004;35:2287–93
    Abstract/FREE Full Text
  53. 53.↵
    1. Kataoka K,
    2. Taneda M,
    3. Asai T,
    4. et al
    . Structural fragility and inflammatory response of ruptured cerebral aneurysms: a comparative study between ruptured and unruptured cerebral aneurysms. Stroke 1999;30:1396–401
    Abstract/FREE Full Text
  54. 54.↵
    1. Kataoka K,
    2. Taneda M,
    3. Asai T,
    4. et al
    . Difference in nature of ruptured and unruptured cerebral aneurysms. Lancet 2000;355:203–03
    PubMed
  55. 55.↵
    1. Reynolds MR,
    2. Willie JT,
    3. Zipfel GJ,
    4. et al
    . Sexual intercourse and cerebral aneurysmal rupture: potential mechanisms and precipitants. J Neurosurg 2011;114:969–77
    CrossRefPubMedWeb of Science
  56. 56.↵
    1. Jiang J,
    2. Strother C
    . Computational fluid dynamics simulations of intracranial aneurysms at varying heart rates: a “patient-specific” study. J Biomech Eng 2009;131:091001
  57. 57.↵
    1. Foutrakis GN,
    2. Yonas H,
    3. Sclabassi RJ
    . Saccular aneurysm formation in curved and bifurcating arteries. AJNR Am J Neuroradiol 1999;20:1309–17
    Abstract/FREE Full Text
  58. 58.↵
    1. Tremmel M,
    2. Dhar S,
    3. Levy EI,
    4. et al
    . Influence of intracranial aneurysm-to-parent vessel size ratio on hemodynamics and implication for rupture: results from a virtual experimental study. Neurosurgery 2009;64:622–30, discussion 630–31
    CrossRefPubMedWeb of Science
  59. 59.↵
    1. Bian C,
    2. Xu G,
    3. Wang JA,
    4. et al
    . Hypercholesterolaemic serum increases the permeability of endothelial cells through zonula occludens-1 with phosphatidylinositol 3-kinase signaling pathway. J Biomed Biotechnol 2009;2009:814979
    PubMed
  60. 60.↵
    1. Ross R,
    2. Glomset JA
    . The pathogenesis of atherosclerosis (first of two parts). N Engl J Med 1976;295:369–77
    CrossRefPubMedWeb of Science
  61. 61.↵
    1. Galis ZS,
    2. Sukhova GK,
    3. Lark MW,
    4. et al
    . Increased expression of matrix metalloproteinases and matrix degrading activity in vulnerable regions of human atherosclerotic plaques. J Clin Invest 1994;94:2493–503
    CrossRefPubMedWeb of Science
  62. 62.↵
    1. Chiu JJ,
    2. Chien S
    . Effects of disturbed flow on vascular endothelium: pathophysiological basis and clinical perspectives. Physiol Rev 2011;91:327–87
    Abstract/FREE Full Text
  63. 63.↵
    1. Ross R
    . Mechanisms of disease: atherosclerosis—an inflammatory disease. N Engl J Med 1999;340:115–26
    CrossRefPubMedWeb of Science
  64. 64.↵
    1. Meng H,
    2. Wang Z,
    3. Kim M,
    4. et al
    . Saccular aneurysms on straight and curved vessels are subject to different hemodynamics: implications of intravascular stenting. AJNR Am J Neuroradiol 2006;27:1861–65
    Abstract/FREE Full Text
  65. 65.↵
    1. Dhar S,
    2. Tremmel M,
    3. Mocco J,
    4. et al
    . Morphology parameters for intracranial aneurysm rupture risk assessment. Neurosurgery 2008;63:185–96, discussion 196–97
    CrossRefPubMedWeb of Science
  66. 66.↵
    1. Baharoglu MI,
    2. Schirmer CM,
    3. Hoit DA,
    4. et al
    . Aneurysm inflow-angle as a discriminant for rupture in sidewall cerebral aneurysms: morphometric and computational fluid dynamic analysis. Stroke 2010;41:1423–30
    Abstract/FREE Full Text
  67. 67.↵
    1. Honda HM,
    2. Hsiai T,
    3. Wortham CM,
    4. et al
    . A complex flow pattern of low shear stress and flow reversal promotes monocyte binding to endothelial cells. Atherosclerosis 2001;158:385–90
    CrossRefPubMedWeb of Science
  68. 68.↵
    1. Horie N,
    2. Morikawa M,
    3. Fukuda S,
    4. et al
    . Detection of blood blister-like aneurysm and intramural hematoma with high-resolution magnetic resonance imaging. J Neurosurg 2011;115:1206–09
    CrossRefPubMed
  69. 69.↵
    1. Michel JB
    . Anoikis in the cardiovascular system: known and unknown extracellular mediators. Arterioscler Thromb Vasc Biol 2003;23:2146–54
    Abstract/FREE Full Text
  70. 70.↵
    1. Gui T,
    2. Shimokado A,
    3. Sun Y,
    4. et al
    . Diverse roles of macrophages in atherosclerosis: from inflammatory biology to biomarker discovery. Mediators Inflamm 2012;2012:693083
    PubMed
  71. 71.↵
    1. Zeng Z,
    2. Kallmes DF,
    3. Durka MJ,
    4. et al
    . Sensitivity of CFD based hemodynamic results in rabbit aneurysm models to idealizations in surrounding vasculature. J Biomech Eng 2010;132:091009
  72. 72.
    1. Dolan JM,
    2. Meng H,
    3. Sim FJ,
    4. et al
    . Endothelial cells express a unique transcriptional profile under very high wall shear stress known to induce expansive arterial remodeling. Am J Physiol Cell Physiol 2012;302:C1109–18
    Abstract/FREE Full Text
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American Journal of Neuroradiology: 35 (7)
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H. Meng, V.M. Tutino, J. Xiang, A. Siddiqui
High WSS or Low WSS? Complex Interactions of Hemodynamics with Intracranial Aneurysm Initiation, Growth, and Rupture: Toward a Unifying Hypothesis
American Journal of Neuroradiology Jul 2014, 35 (7) 1254-1262; DOI: 10.3174/ajnr.A3558

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High WSS or Low WSS? Complex Interactions of Hemodynamics with Intracranial Aneurysm Initiation, Growth, and Rupture: Toward a Unifying Hypothesis
H. Meng, V.M. Tutino, J. Xiang, A. Siddiqui
American Journal of Neuroradiology Jul 2014, 35 (7) 1254-1262; DOI: 10.3174/ajnr.A3558
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