Impact of Age and Baseline NIHSS Scores on Clinical Outcomes in the Mechanical Thrombectomy Using Solitaire FR in Acute Ischemic Stroke Study

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Fig 1.
Ninety-day modified Rankin Scale scores. The distribution of 90-day modified Rankin Scale scores among patients according to the SPAN-100 index. The lines indicate the mRS category (mRS 0–2 and mRS 5–6) between SPAN-100 groups. P value refers to the significance level of the χ² test for proportion comparison.

Table 1:

Outcome measures

Outcome	Entire Cohort (N = 202)	SPAN-100-Positive (n = 15)	SPAN-100-Negative (n = 181)
Median time from stroke onset to groin puncture (min) (range)	238 (72–714)	280 (140–450)	235 (72–714)
Successful recanalization (after rescue therapy) as per core lab^{^a}	88% (171/194)	93% (14/15)	87% (151/173)
Median time from stroke onset to TICI 2b or 3 (or final DSA run) (min) (range)	282 (100–800)	322 (188–483)	282 (100–800)
Stroke onset to successful revascularization categories
0–4.5 hr	46% (92/201)	20% (3/15)	47% (84/180)
4.5–8 hr	50% (101/201)	73% (11/15)	49% (89/180)
≥8 hr	4% (8/201)	7% (1/15)	4% (7/180)
Device- or procedure-related serious adverse events	7% (15/202)	7% (1/15)	8% (14/181)
Any intracranial hemorrhage	19% (38/202)	27% (4/15)	19% (34/181)
Symptomatic intracranial hemorrhage	1% (3/202)	0% (0/15)	2% (3/181)
90-Day clinical outcomes
Death from any cause	7% (14/202)	27% (4/15)	6% (10/181)
Good functional recovery (modified Rankin Scale score 0–2)	58% (117/202)	27% (4/15)	61% (110/181)

Table 2:

Univariable and multivariable logistic regressions of favorable clinical outcome (mRS ≤2)

Variable	Univariable			Multivariable
Variable	Odds Ratio	95% CI	P Value	Odds Ratio	95% CI	P Value
SPAN-100-positive	0.23	(0.07–0.77)	.02	0.25	(0.07–0.91)	.04
Baseline ASPECTS	1.32	(1.10–1.59)	.003	1.28	(1.04–1.58)	.02
Time from stroke onset to TICI 2b or 3 (or final DSA run, hr)	0.70	(0.58–0.84)	<.001	0.68	(0.55–0.84)	<.001
Primary end point success	1.81	(0.82–3.96)	.14	1.73	(0.74–4.03)	.21
IV-tPA administered (vs contraindicated or bridging)	1.05	(0.59–1.87)	.87	1.27	(0.64–2.52)	.49