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Research ArticleInterventional

Flow Diversion versus Traditional Endovascular Coiling Therapy: Design of the Prospective LARGE Aneurysm Randomized Trial

A.S. Turk, R.H. Martin, D. Fiorella, J. Mocco, A. Siddiqui and A. Bonafe
American Journal of Neuroradiology July 2014, 35 (7) 1341-1345; DOI: https://doi.org/10.3174/ajnr.A3968
A.S. Turk III
aFrom the Department of Radiology (A.S.T., R.H.M.), Medical University of South Carolina, Charleston, South Carolina
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R.H. Martin
aFrom the Department of Radiology (A.S.T., R.H.M.), Medical University of South Carolina, Charleston, South Carolina
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D. Fiorella
bDepartment of Neurological Surgery (D.F.), Stony Brook Medicine, Stony Brook, New York
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J. Mocco
cDepartment of Neurological Surgery (J.M.), Vanderbilt University Medical Center, Nashville, Tennessee
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A. Siddiqui
dDepartment of Neurosurgery (A.S.), University of Buffalo, Buffalo, New York
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A. Bonafe
eDepartment of Neurosurgery (A.B.), Hospital Gui de Chauliac, Centre Hospitalier Universitaire de Montpellier, Montpellier, France.
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References

  1. 1.↵
    1. Caranci F,
    2. Briganti F,
    3. Cirillo L,
    4. et al
    . Epidemiology and genetics of intracranial aneurysms. Eur J Radiol. 2013;82:1598–605
    CrossRefPubMed
  2. 2.↵
    1. Molyneux A,
    2. Kerr R,
    3. Stratton I,
    4. et al
    . International subarachnoid aneurysm trial (ISAT) of neurosurgical clipping versus endovascular coiling in 2143 patients with ruptured intracranial aneurysms: a randomized trial. Lancet 2002;360:1267–74
    CrossRefPubMedWeb of Science
  3. 3.↵
    1. Molyneux AJ,
    2. Kerr RS,
    3. Yu LM,
    4. et al
    . International subarachnoid aneurysm trial (ISAT) of neurosurgical clipping versus endovascular coiling in 2143 patients with ruptured intracranial aneurysms: a randomized comparison of effects on survival, dependency, seizures, rebleeding, subgroups, and aneurysm occlusion. Lancet 2005;366:809–17
    CrossRefPubMedWeb of Science
  4. 4.↵
    1. Administration FaD
    FDA. Summary FE. P100018: Chestnut medical Pipeline embolization device. In: Administration FaD , ed. FDA, Washington, DC: Executive Summary; 2011:72
  5. 5.↵
    International Study of Unruptured Intracranial Aneurysms Investigators. Unruptured intracranial aneurysms—risk of rupture and risks of surgical intervention. N Engl J Med 1998;339:1725–33
    CrossRefPubMedWeb of Science
  6. 6.↵
    1. Gonzalez N,
    2. Sedrak M,
    3. Martin N,
    4. et al
    . Impact of anatomic features in the endovascular embolization of 181 anterior communicating artery aneurysms. Stroke 2008;39:2776–82
    Abstract/FREE Full Text
  7. 7.↵
    1. Byrne JV,
    2. Sohn MJ,
    3. Molyneux AJ,
    4. et al
    . Five-year experience in using coil embolization for ruptured intracranial aneurysms: outcomes and incidence of late rebleeding. J Neurosurg 1999;90:656–63
    CrossRefPubMedWeb of Science
  8. 8.↵
    1. Hayakawa M,
    2. Murayama Y,
    3. Duckwiler GR,
    4. et al
    . Natural history of the neck remnant of a cerebral aneurysm treated with the Guglielmi detachable coil system. J Neurosurg 2000;93:561–68
    CrossRefPubMedWeb of Science
  9. 9.↵
    1. Clarencon F,
    2. Bonneville F,
    3. Boch AL,
    4. et al
    . Parent artery occlusion is not obsolete in giant aneurysms of the ICA. Experience with very-long-term follow-up. Neuroradiology 2011;53:973–82
    CrossRefPubMed
  10. 10.↵
    1. Higashida RT,
    2. Halbach VV,
    3. Dowd C,
    4. et al
    . Endovascular detachable balloon embolization therapy of cavernous carotid artery aneurysms: results in 87 cases. J Neurosurg 1990;72:857–63
    CrossRefPubMedWeb of Science
  11. 11.↵
    1. Linskey ME,
    2. Sekhar LN,
    3. Hirsch W Jr.,
    4. et al
    . Aneurysms of the intracavernous carotid artery: clinical presentation, radiographic features, and pathogenesis. Neurosurgery 1990;26:71–79
    CrossRefPubMedWeb of Science
  12. 12.↵
    1. Larson JJ,
    2. Tew JM Jr.,
    3. Tomsick TA,
    4. et al
    . Treatment of aneurysms of the internal carotid artery by intravascular balloon occlusion: long-term follow-up of 58 patients. Neurosurgery 1995;36:26–30
    PubMed
  13. 13.↵
    1. Wong GK,
    2. Poon WS,
    3. Chun H,
    4. et al
    . Balloon test occlusion with hypotensive challenge for main trunk occlusion of internal carotid artery aneurysms and pseudoaneurysms. Br J Neurosurg 2010;24:648–52
    CrossRefPubMed
  14. 14.↵
    1. Gallas S,
    2. Pasco A,
    3. Cottier JP,
    4. et al
    . A multicenter study of 705 ruptured intracranial aneurysms treated with Guglielmi detachable coils. AJNR Am J Neuroradiol 2005;26:1723–31
    Abstract/FREE Full Text
  15. 15.↵
    1. Murayama Y,
    2. Nien YL,
    3. Duckwiler G,
    4. et al
    . Guglielmi detachable coil embolization of cerebral aneurysms: 11 years' experience. J Neurosurg 2003;98:959–66
    CrossRefPubMedWeb of Science
  16. 16.↵
    1. Vinuela F,
    2. Duckwiler G,
    3. Mawad M
    . Guglielmi detachable coil embolization of acute intracranial aneurysm: perioperative anatomical and clinical outcome in 403 patients. J Neurosurg 1997;86:475–82
    CrossRefPubMedWeb of Science
  17. 17.↵
    1. Fernandez Zubillaga A,
    2. Guglielmi G,
    3. Vinuela F,
    4. et al
    . Endovascular occlusion of intracranial aneurysms with electrically detachable coils: correlation of aneurysm neck size and treatment results. AJNR Am J Neuroradiol 1994;15:815–20
    Abstract/FREE Full Text
  18. 18.↵
    1. Raymond J,
    2. Guilbert F,
    3. Weill A,
    4. et al
    . Long-term angiographic recurrences after selective endovascular treatment of aneurysms with detachable coils. Stroke 2003;34:1398–403
    Abstract/FREE Full Text
  19. 19.↵
    1. Ortiz R,
    2. Song J,
    3. Niimi Y,
    4. et al
    . Rate of recanalization and safety of endovascular embolization of intracranial saccular aneurysms framed with GDC 360 coils. Interv Neuroradiol 2008;14:397–401
    PubMed
  20. 20.↵
    1. Fiorella D,
    2. Hsu D,
    3. Woo HH,
    4. et al
    . Very late thrombosis of a Pipeline embolization device construct: case report. Neurosurgery 2010;onsE313–314; discussion onsE314
  21. 21.↵
    1. Fiorella D,
    2. Lylyk P,
    3. Szikora I,
    4. et al
    . Curative cerebrovascular reconstruction with the Pipeline embolization device: the emergence of definitive endovascular therapy for intracranial aneurysms. J Neurointerv Surg 2009;1:56–65
    Abstract/FREE Full Text
  22. 22.↵
    1. Becske T,
    2. Kallmes DF,
    3. Saatci I,
    4. et al
    . Pipeline for uncoilable or failed aneurysms: results from a multicenter clinical trial. Radiology 2013;267:858–68
    CrossRefPubMedWeb of Science
  23. 23.↵
    1. Kawanabe Y,
    2. Sadato A,
    3. Taki W,
    4. et al
    . Endovascular occlusion of intracranial aneurysms with Guglielmi detachable coils: correlation between coil packing density and coil compaction. Acta Neurochir (Wien) 2001;143:451–55
    CrossRefPubMedWeb of Science
  24. 24.↵
    1. Reul J,
    2. Spetzger U,
    3. Weis J,
    4. et al
    . Endovascular occlusion of experimental aneurysms with detachable coils: influence of packing density and perioperative anticoagulation. Neurosurgery 1997;41:1160–65; discussion 1165–68
    CrossRefPubMedWeb of Science
  25. 25.↵
    1. Tamatani S,
    2. Ito Y,
    3. Abe H,
    4. et al
    . Evaluation of the stability of aneurysms after embolization using detachable coils: correlation between stability of aneurysms and embolized volume of aneurysms. AJNR Am J Neuroradiol 2002;23:762–67
    Abstract/FREE Full Text
  26. 26.↵
    1. O'Brien PC,
    2. Fleming TR
    . A multiple testing procedure for clinical trials. Biometrics 1979;35:549–56
    CrossRefPubMedWeb of Science
  27. 27.↵
    1. Pampallona STA,
    2. Kim KM
    . Interim monitoring of group sequential trials using spending functions for the Type I and Type II error probabilities. Drug Inf J 2001;35:1113–21
    CrossRef
  28. 28.↵
    1. Pocock SJ
    . Statistical and ethical issues in monitoring clinical trials. Stat Med 1993;12:1459–69; discussion 1471–55
    CrossRefPubMedWeb of Science
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American Journal of Neuroradiology: 35 (7)
American Journal of Neuroradiology
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A.S. Turk, R.H. Martin, D. Fiorella, J. Mocco, A. Siddiqui, A. Bonafe
Flow Diversion versus Traditional Endovascular Coiling Therapy: Design of the Prospective LARGE Aneurysm Randomized Trial
American Journal of Neuroradiology Jul 2014, 35 (7) 1341-1345; DOI: 10.3174/ajnr.A3968

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Flow Diversion versus Traditional Endovascular Coiling Therapy: Design of the Prospective LARGE Aneurysm Randomized Trial
A.S. Turk, R.H. Martin, D. Fiorella, J. Mocco, A. Siddiqui, A. Bonafe
American Journal of Neuroradiology Jul 2014, 35 (7) 1341-1345; DOI: 10.3174/ajnr.A3968
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