Article Figures & Data
Figures
- Fig 1.
Boxplots of microvascular permeability parameters in primary CNS lymphoma and glioblastoma, including the volume transfer constant (minute−1), the volume of extravascular extracellular space per volume unit of tissue, and the flux rate constant between extravascular extracellular space and plasma (minute−1). The solid line inside the box represents the median value, while the edges represent the 25th and 75th percentiles. The straight line (bar) on each box indicates the range of data distribution. Circles represent outliers (values >1.5 box length from the 75th and 25th percentile).
- Fig 2.
Tissue concentration of contrast agent after bolus injection of 0.1 mmol/g of gadoterate meglumine (left column) in primary CNS lymphoma (upper row) and glioblastoma (lower row). Note the differences in the relative enhancement curve within the region of interest, encompassing the tumor (red square), which peaks at 0.53 in PCNSL and at 0.34 in GB. Perfusion parameters from kinetic modeling parameter maps (right column) were measured by using freehand region-of-interest placement within the solid part of the entire contrast-enhancing tumor (dashed red line within the zoomed kinetic maps; only 1 section is shown here). In these samples, median Ktrans values were 0.147 ± 0.031 for PCNSL and 0.045 ± 0.014 for GB.
- Fig 3.
Histopathologic assessment of vascular integrity from those patients shown in Fig 2 (original magnification ×200 for all stains): Immunohistochemistry for CD31 (left column) highlights endothelium in primary CNS lymphoma (PCNSL) (upper row) and glioblastoma (GB) tissue (lower row). Black arrows point to the endothelium and indicate the actual lumen of the vessel in PCNSL tissue. In contrast, white arrows in the reticulin staining of the PCNSL tissue (upper row, right) illustrate the outer border of the vessel wall, which is infiltrated by tumor cells, destroyed, and detached from the inner endothelial membrane and thus contributing to decreased vascular integrity. White arrows in the reticulin staining of the GB tissue (lower row, right) underline the integer basal membrane of vessels despite endothelial proliferation.
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