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Figures
- Fig 1.
A, A silicone replica of a rabbit elastase–induced aneurysm of the right common carotid artery (arrows) was built and subjected to MR imaging (axial projections along a line in A; the inset is rotational angiography data on which the model was built). Double inversion recovery black-blood (B) and small FOV quadrature recovery (C) suppressed the flow signal in the adjacent arteries but not within the aneurysm dome (arrows). The MSDE sequence combined with SPIR to suppress the surrounding fat with a VENC of 2 cm/s had persistent flow signal in the aneurysm dome (D, arrow), which was eliminated with a VENC of 1 cm/s (E). With a VENC of 1 cm/s and SPIR for fat suppression, we were able to image a realistic Gd-DTPA contrast agent concentration (150 μmol/L) contained within a capsule implanted in the aneurysm (F, frontal projection). Horizontal scale bars represent 3 mm.
- Fig 2.
Schematic of the TSE-based MSDE pulse sequence optimized in the in vitro study (A), subsequently modified for in vivo rabbit aneurysm imaging (B).
- Fig 3.
Model of a saccular aneurysm (arrows) in the rabbit (A, axial projection, turbo spin-echo with SPIR, inset rotational angiogram in frontal oblique projection). MSDE images before receiving the MPO-specific contrast agent (B) and after IV administration of bis-5HT-DTPA(Gd) in the naïve (C) and inflamed (D) aneurysms (0.1-mmol Gd/kg).
- Fig 4.
A, Signal-to-noise ratio change of the inflamed aneurysm was highly significant by using the MSDE sequence and was negligible in the naïve aneurysm as well at the left common carotid artery, suggesting adequate flow suppression. B, SNR change calculated from the T1–fast-field echo axial sections shows a significant increase between the inflamed and naïve aneurysm model, but no differences between the inflamed aneurysm and the left common carotid artery either before or after LPS administration, suggesting flow dependence. The asterisk indicates P < .05; triple asterisks, P < .0001, contrast agent: bis-5HT-DTPA(Gd).
- Fig 5.
Histology of the aneurysm wall in the animal model without (A and B) and with (C and D) perivascular injection with LPS. The naïve aneurysm has limited macrophage infiltration (A) and no MPO (B). The modification with LPS induces significant macrophage (C) infiltration and has prominent distribution of MPO (D). All images are at ×20 magnification.
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