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Research ArticleAdult Brain

Hyperintense Dentate Nuclei on T1-Weighted MRI: Relation to Repeat Gadolinium Administration

M.E. Adin, L. Kleinberg, D. Vaidya, E. Zan, S. Mirbagheri and D.M. Yousem
American Journal of Neuroradiology October 2015, 36 (10) 1859-1865; DOI: https://doi.org/10.3174/ajnr.A4378
M.E. Adin
aFrom the Division of Neuroradiology (M.E.A., E.Z., S.M., D.M.Y.), The Russell H. Morgan Department of Radiology and Radiological Science
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L. Kleinberg
bDepartment of Radiation Oncology and Radiation Molecular Sciences (L.K.)
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D. Vaidya
cJohns Hopkins Bloomberg School of Public Health (D.V.), The Johns Hopkins Medical Institutions, Baltimore, Maryland.
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E. Zan
aFrom the Division of Neuroradiology (M.E.A., E.Z., S.M., D.M.Y.), The Russell H. Morgan Department of Radiology and Radiological Science
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S. Mirbagheri
aFrom the Division of Neuroradiology (M.E.A., E.Z., S.M., D.M.Y.), The Russell H. Morgan Department of Radiology and Radiological Science
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D.M. Yousem
aFrom the Division of Neuroradiology (M.E.A., E.Z., S.M., D.M.Y.), The Russell H. Morgan Department of Radiology and Radiological Science
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REFERENCES

  1. 1.↵
    1. Jain R,
    2. Robertson PL,
    3. Gandhi D, et al
    . Radiation-induced cavernomas of the brain. AJNR Am J Neuroradiol 2005;26:1158–62
    Abstract/FREE Full Text
  2. 2.↵
    1. Lee KF,
    2. Suh JH
    . CT evidence of grey matter calcification secondary to radiation therapy. Comput Tomogr 1977;1:103–10
    CrossRefPubMed
  3. 3.↵
    1. Valk PE,
    2. Dillon WP
    . Radiation injury of the brain. AJNR Am J Neuroradiol 1991;12:45–62
    Abstract/FREE Full Text
  4. 4.↵
    1. Perreault S,
    2. Lober RM,
    3. Cheshier S, et al
    . Time-dependent structural changes of the dentatothalamic pathway in children treated for posterior fossa tumor. AJNR Am J Neuroradiol 2014;35:803–07
    Abstract/FREE Full Text
  5. 5.↵
    1. Errante Y,
    2. Cirimele V,
    3. Mallio CA, et al
    . Progressive increase of T1 signal intensity of the dentate nucleus on unenhanced magnetic resonance images is associated with cumulative doses of intravenously administered gadodiamide in patients with normal renal function, suggesting dechelation. Invest Radiol 2014;49:685–90
    CrossRefPubMed
  6. 6.↵
    1. Kanda T,
    2. Ishii K,
    3. Kawaguchi H, et al
    . High signal intensity in the dentate nucleus and globus pallidus on unenhanced T1-weighted MR images: relationship with increasing cumulative dose of a gadolinium-based contrast material. Radiology 2014;270:834–41
    CrossRefPubMed
  7. 7.↵
    1. Kasahara S,
    2. Miki Y,
    3. Kanagaki M, et al
    . Hyperintense dentate nucleus on unenhanced T1-weighted MR images is associated with a history of brain irradiation. Radiology 2011;258:222–28
    CrossRefPubMed
  8. 8.↵
    1. Roccatagliata L,
    2. Vuolo L,
    3. Bonzano L, et al
    . Multiple sclerosis: hyperintense dentate nucleus on unenhanced T1-weighted MR images is associated with the secondary progressive subtype. Radiology 2009;251:503–10
    CrossRefPubMed
  9. 9.↵
    1. Zhao J,
    2. Zhou ZQ,
    3. Jin JC, et al
    . Mitochondrial dysfunction induced by different concentrations of gadolinium ion. Chemosphere 2014;100:194–99
    CrossRefPubMed
  10. 10.↵
    1. Ray DE,
    2. Cavanagh JB,
    3. Nolan CC, et al
    . Neurotoxic effects of gadopentetate dimeglumine: behavioral disturbance and morphology after intracerebroventricular injection in rats. AJNR Am J Neuroradiol 1996;17:365–73
    Abstract
  11. 11.↵
    1. Abraham JL,
    2. Thakral C
    . Tissue distribution and kinetics of gadolinium and nephrogenic systemic fibrosis. Eur J Radiol 2008;66:200–07
    CrossRefPubMedWeb of Science
  12. 12.↵
    1. Thakral C,
    2. Abraham JL
    . Nephrogenic systemic fibrosis: histology and gadolinium detection. Radiol Clin North Am 2009;47:841–53, vi–vii
    CrossRefPubMed
  13. 13.↵
    1. Thakral C,
    2. Alhariri J,
    3. Abraham JL
    . Long-term retention of gadolinium in tissues from nephrogenic systemic fibrosis patient after multiple gadolinium-enhanced MRI scans: case report and implications. Contrast Media Mol Imaging 2007;2:199–205
    CrossRefPubMed
  14. 14.↵
    1. Sieber MA,
    2. Lengsfeld P,
    3. Frenzel T, et al
    . Preclinical investigation to compare different gadolinium-based contrast agents regarding their propensity to release gadolinium in vivo and to trigger nephrogenic systemic fibrosis-like lesions. Eur Radiol 2008;18:2164–73
    CrossRefPubMed
  15. 15.↵
    1. Boyko OB,
    2. Burger PC,
    3. Shelburne JD, et al
    . Non-heme mechanisms for T1 shortening: pathologic, CT, and MR elucidation. AJNR Am J Neuroradiol 1992;13:1439–45
    Abstract/FREE Full Text
  16. 16.↵
    1. Mirowitz SA,
    2. Sartor K,
    3. Gado M
    . High-intensity basal ganglia lesions on T1-weighted MR images in neurofibromatosis. AJR Am J Roentgenol 1990;154:369–73
    CrossRefPubMed
  17. 17.↵
    1. Moore DF,
    2. Ye F,
    3. Schiffmann R, et al
    . Increased signal intensity in the pulvinar on T1-weighted images: a pathognomonic MR imaging sign of Fabry disease. AJNR Am J Neuroradiol 2003;24:1096–101
    Abstract/FREE Full Text
  18. 18.↵
    1. Inoue E,
    2. Hori S,
    3. Narumi Y, et al
    . Portal-systemic encephalopathy: presence of basal ganglia lesions with high signal intensity on MR images. Radiology 1991;179:551–55
    CrossRefPubMedWeb of Science
  19. 19.↵
    1. Vymazal J,
    2. Righini A,
    3. Brooks RA, et al
    . T1 and T2 in the brain of healthy subjects, patients with Parkinson disease, and patients with multiple system atrophy: relation to iron content. Radiology 1999;211:489–95
    CrossRefPubMedWeb of Science
  20. 20.↵
    1. Suzuki S,
    2. Nishio S,
    3. Takata K, et al
    . Radiation-induced brain calcification: paradoxical high signal intensity in T1-weighted MR images. Acta Neurochir (Wien) 2000;142:801–04
    CrossRefPubMed
  21. 21.↵
    1. Fushimi Y,
    2. Miki Y,
    3. Urayama S, et al
    . Gray matter-white matter contrast on spin-echo T1-weighted images at 3 T and 1.5 T: a quantitative comparison study. Eur Radiol 2007;17:2921–25
    CrossRefPubMed
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American Journal of Neuroradiology: 36 (10)
American Journal of Neuroradiology
Vol. 36, Issue 10
1 Oct 2015
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M.E. Adin, L. Kleinberg, D. Vaidya, E. Zan, S. Mirbagheri, D.M. Yousem
Hyperintense Dentate Nuclei on T1-Weighted MRI: Relation to Repeat Gadolinium Administration
American Journal of Neuroradiology Oct 2015, 36 (10) 1859-1865; DOI: 10.3174/ajnr.A4378

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Hyperintense Dentate Nuclei on T1-Weighted MRI: Relation to Repeat Gadolinium Administration
M.E. Adin, L. Kleinberg, D. Vaidya, E. Zan, S. Mirbagheri, D.M. Yousem
American Journal of Neuroradiology Oct 2015, 36 (10) 1859-1865; DOI: 10.3174/ajnr.A4378
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  • Does Gadolinium Deposition Lead to Metabolite Alteration in the Dentate Nucleus? An MRS Study in Patients with MS
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  • Chemokine receptor 4 targeted protein MRI contrast agent for early detection of liver metastases
  • Effect of Gadolinium on the Estimation of Myelin and Brain Tissue Volumes Based on Quantitative Synthetic MRI
  • Gadolinium use for interventional pain procedures: where we are and where we are heading
  • Gadolinium Deposition within the Pediatric Brain: No Increased Intrinsic T1-Weighted Signal Intensity within the Dentate Nucleus following the Administration of a Minimum of 4 Doses of the Macrocyclic Agent Gadoteridol
  • Gadolinium Deposition in Deep Brain Structures: Relationship with Dose and Ionization of Linear Gadolinium-Based Contrast Agents
  • Deep Brain Nuclei T1 Shortening after Gadobenate Dimeglumine in Children: Influence of Radiation and Chemotherapy
  • Cardiovascular Magnetic Resonance Relaxometry Predicts Regional Functional Outcome After Experimental Myocardial Infarction
  • Intracranial Arteriovenous Shunting: Detection with Arterial Spin-Labeling and Susceptibility-Weighted Imaging Combined
  • T1 Signal-Intensity Increase in the Dentate Nucleus after Multiple Exposures to Gadodiamide: Intraindividual Comparison between 2 Commonly Used Sequences
  • Gadolinium-Based Contrast Agent Accumulation and Toxicity: An Update
  • Recent Advances in Understanding Gadolinium Retention in the Brain
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