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Research ArticleAdult Brain
Open Access

Cytotoxic Edema in Posterior Reversible Encephalopathy Syndrome: Correlation of MRI Features with Serum Albumin Levels

B. Gao, B.X. Yu, R.S. Li, G. Zhang, H.Z. Xie, F.L. Liu and C. Lv
American Journal of Neuroradiology October 2015, 36 (10) 1884-1889; DOI: https://doi.org/10.3174/ajnr.A4379
B. Gao
aFrom the Department of Radiology (B.G., B.X.Y., R.S.L., G.Z., H.Z.X., F.L.L.), Yantai Yuhuangding Hospital, Qingdao University, Shandong Province, China
bDepartment of Radiology (B.G.), Zhongda Hospital, Southeast University, Nanjing, China
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B.X. Yu
aFrom the Department of Radiology (B.G., B.X.Y., R.S.L., G.Z., H.Z.X., F.L.L.), Yantai Yuhuangding Hospital, Qingdao University, Shandong Province, China
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R.S. Li
aFrom the Department of Radiology (B.G., B.X.Y., R.S.L., G.Z., H.Z.X., F.L.L.), Yantai Yuhuangding Hospital, Qingdao University, Shandong Province, China
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G. Zhang
aFrom the Department of Radiology (B.G., B.X.Y., R.S.L., G.Z., H.Z.X., F.L.L.), Yantai Yuhuangding Hospital, Qingdao University, Shandong Province, China
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H.Z. Xie
aFrom the Department of Radiology (B.G., B.X.Y., R.S.L., G.Z., H.Z.X., F.L.L.), Yantai Yuhuangding Hospital, Qingdao University, Shandong Province, China
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F.L. Liu
aFrom the Department of Radiology (B.G., B.X.Y., R.S.L., G.Z., H.Z.X., F.L.L.), Yantai Yuhuangding Hospital, Qingdao University, Shandong Province, China
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C. Lv
cDepartment of Neurology (C.L.), Yantai City Yantaishan Hospital and Yantai Sino-France Friendship Hospital, Shandong Province, China.
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REFERENCES

  1. 1.↵
    1. Hinchey J,
    2. Chaves C,
    3. Appignani B, et al
    . A reversible posterior leukoencephalopathy syndrome. N Engl J Med 1996;334:494–500
    CrossRefPubMedWeb of Science
  2. 2.↵
    1. Bartynski WS
    . Posterior reversible encephalopathy syndrome, Part 1: fundamental imaging and clinical features. AJNR Am J Neuroradiol 2008;29:1036–42
    Abstract/FREE Full Text
  3. 3.↵
    1. McKinney AM,
    2. Short J,
    3. Truwit CL, et al
    . Posterior reversible encephalopathy syndrome: incidence of atypical regions of involvement and imaging findings. AJR Am J Roentgenol 2007;189:904–12
    CrossRefPubMedWeb of Science
  4. 4.↵
    1. Fugate JE,
    2. Claassen DO,
    3. Cloft HJ, et al
    . Posterior reversible encephalopathy syndrome: associated clinical and radiologic findings. Mayo Clin Proc 2010;85:427–32
    CrossRefPubMedWeb of Science
  5. 5.↵
    1. Rykken JB,
    2. McKinney AM
    . Posterior reversible encephalopathy syndrome. Semin Ultrasound CT MR 2014;35:118–35
    CrossRefPubMed
  6. 6.↵
    1. Ay H,
    2. Buonanno FS,
    3. Schaefer PW, et al
    . Posterior leukoencephalopathy without severe hypertension: utility of diffusion-weighted MRI. Neurology 1998;51:1369–76
    Abstract/FREE Full Text
  7. 7.↵
    1. Covarrubias DJ,
    2. Luetmer PH,
    3. Campeau NG
    . Posterior reversible encephalopathy syndrome: prognostic utility of quantitative diffusion-weighted MR images. AJNR Am J Neuroradiol 2002;23:1038–48
    Abstract/FREE Full Text
  8. 8.↵
    1. Henderson RD,
    2. Rajah T,
    3. Nicol AJ,
    4. Read SJ
    . Posterior leukoencephalopathy following intrathecal chemotherapy with MRA-documented vasospasm. Neurology 2003;60:326–28
    Abstract/FREE Full Text
  9. 9.↵
    1. Bartynski WS,
    2. Boardman JF
    . Catheter angiography, MR angiography, and MR perfusion in posterior reversible encephalopathy syndrome. AJNR Am J Neuroradiol 2008;29:447–55
    Abstract/FREE Full Text
  10. 10.↵
    1. Pirker A,
    2. Kramer L,
    3. Voller B, et al
    . Type of edema in posterior reversible encephalopathy syndrome depends on serum albumin levels: an MR imaging study in 28 patients. AJNR Am J Neuroradiol 2011;32:527–31
    Abstract/FREE Full Text
  11. 11.↵
    1. Quinlan G,
    2. Martin GS,
    3. Evans TW
    . Albumin: biochemical properties and therapeutic potential. Hepatology 2005;41:1211–19
    CrossRefPubMedWeb of Science
  12. 12.↵
    1. Blunt MC,
    2. Nicholson JP,
    3. Park GR
    . Serum albumin and colloid osmotic pressure in survivors and nonsurvivors of prolonged critical illness. Anaesthesia 1998;53:755–61
    CrossRefPubMedWeb of Science
  13. 13.↵
    1. Drummond JC
    . Colloid osmotic pressure and the formation of posttraumatic cerebral edema. Anesthesiology 2010;112:1079–81
    CrossRefPubMed
  14. 14.↵
    1. Pulimood TB,
    2. Park GR
    . Debate: albumin administration should be avoided in the critically ill. Crit Care 2000;4:151–55
    CrossRefPubMedWeb of Science
  15. 15.↵
    1. Bartynski WS
    . Posterior reversible encephalopathy syndrome, Part 2: controversies surrounding pathophysiology of vasogenic edema. AJNR Am J Neuroradiol 2008;29:1043–49
    Abstract/FREE Full Text
  16. 16.↵
    1. Marra A,
    2. Vargas M,
    3. Striano P, et al
    . Posterior reversible encephalopathy syndrome: the endothelial hypotheses. Med Hypotheses 2014;82:619–22
    CrossRefPubMed
  17. 17.↵
    1. Donmez FY,
    2. Guleryuz P,
    3. Agildere M
    . MRI findings in childhood PRES: what is different than the adults? Clin Neuroradiol 2014 Oct 8. [Epub ahead of print]
  18. 18.↵
    1. Ozkan E,
    2. Gocmen R,
    3. Topcuoglu MA, et al
    . Blood-retina-barrier disruption accompanying blood-brain-barrier dysfunction in posterior reversible encephalopathy syndrome. J Neurol Sci 2014;346:315–17
    CrossRefPubMed
  19. 19.↵
    1. Decker DA,
    2. Falchook AD,
    3. Yachnis AT, et al
    . Radiographic and pathologic findings in an atypical brainstem variant of reversible posterior leukoencephalopathy syndrome. Neurologist 2009;15:364–66
    CrossRefPubMed
  20. 20.↵
    1. Jacquot C,
    2. Glastonbury CM,
    3. Tihan T
    . Is posterior reversible encephalopathy syndrome really reversible? Autopsy findings 4.5 years after radiographic resolution. Clin Neuropathol 2015;34:26–33
    CrossRefPubMed
  21. 21.↵
    1. Kastrup O,
    2. Schlamann M,
    3. Moenninghoff C, et al
    . Posterior reversible encephalopathy syndrome: the spectrum of MR imaging patterns. Clin Neuroradiol 2015;25:161–71
    CrossRefPubMed
  22. 22.↵
    1. Gao B,
    2. Lv C
    . Posterior reversible encephalopathy syndrome in 46 of 47 patients with eclampsia: beyond it. Am J Obstet Gynecol 2014;211:83–84
  23. 23.↵
    1. McKinney AM,
    2. Sarakiya B,
    3. Gustafson C, et al
    . Detection of microhemorrhage in posterior reversible encephalopathy syndrome using susceptibility-weighted imaging. AJNR Am J Neuroradiol 2012;33:896–903
    Abstract/FREE Full Text
  24. 24.↵
    1. Lv C,
    2. Gao B
    . Can clinical and MRI findings predict the prognosis of variant and classical type of posterior reversible encephalopathy syndrome (PRES)? Still a challenge. Acta Radiol 2015;56:NP3–4
    FREE Full Text
  25. 25.↵
    1. Hinchey JA
    . Reversible posterior leukoencephalopathy syndrome: what have we learned in the last 10 years? Arch Neurol 2008;65:175–76
    CrossRefPubMedWeb of Science
  26. 26.↵
    1. Li Y,
    2. Gor D,
    3. Walicki D, et al
    . Spectrum and potential pathogenesis of reversible posterior leukoencephalopathy syndrome. J Stroke Cerebrovasc Dis 2012;21:873–82
    CrossRefPubMed
  27. 27.↵
    1. Williams KP,
    2. Wilson S
    . Persistence of cerebral hemodynamic changes in patients with eclampsia: a report of three cases. Am J Obstet Gynecol 1999;181:1162–65
    CrossRefPubMedWeb of Science
  28. 28.↵
    1. Tamaki K,
    2. Sadoshima S,
    3. Baumbach GL, et al
    . Evidence that disruption of the blood-brain barrier precedes reduction in cerebral blood flow in hypertensive encephalopathy. Hypertension 1984;6(2 pt 2):I75–81
    CrossRef
  29. 29.↵
    1. Cipolla MJ,
    2. Bishop N,
    3. Chan SL
    . Effect of pregnancy on autoregulation of cerebral blood flow in anterior versus posterior cerebrum. Hypertension 2012;60:705–11
    CrossRef
  30. 30.↵
    1. Porcello Marrone LC,
    2. Gadonski G,
    3. de Oliveira Laguna G, et al
    . Blood-brain barrier breakdown in reduced uterine perfusion pressure: a possible model of posterior reversible encephalopathy syndrome. J Stroke Cerebrovasc Dis 2014;23:2075–79
    CrossRefPubMed
  31. 31.↵
    1. Ishikura K,
    2. Ikeda M,
    3. Hamasaki Y, et al
    . Posterior reversible encephalopathy syndrome in children: its high prevalence and more extensive imaging findings. Am J Kidney Dis 2006;48:231–38
    CrossRefPubMedWeb of Science
  32. 32.↵
    1. McKinney AM,
    2. Kieffer SA,
    3. Paylor RT, et al
    . Acute toxic leukoencephalopathy: potential for reversibility clinically and on MRI with diffusion-weighted and FLAIR imaging. AJR Am J Roentgenol 2009;193:192–206
    CrossRefPubMedWeb of Science
  33. 33.↵
    1. Alhilali LM,
    2. Reynolds AR,
    3. Fakhran S
    . A multi-disciplinary model of risk factors for fatal outcome in posterior reversible encephalopathy syndrome. J Neurol Sci 2014;347:59–65
    CrossRefPubMed
  34. 34.↵
    1. Gao B,
    2. Liu FL,
    3. Zhao B
    . Association of degree and type of edema in posterior reversible encephalopathy syndrome with serum lactate dehydrogenase level: initial experience. Eur J Radiol 2012;81:2844–47
    CrossRefPubMed
  35. 35.↵
    1. Lv C,
    2. Gao B
    . Serum lactate dehydrogenase as a predictor of outcome in posterior reversible encephalopathy syndrome: imperative to unify. AJNR Am J Neuroradiol 2015;36:E29–30
    FREE Full Text
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B. Gao, B.X. Yu, R.S. Li, G. Zhang, H.Z. Xie, F.L. Liu, C. Lv
Cytotoxic Edema in Posterior Reversible Encephalopathy Syndrome: Correlation of MRI Features with Serum Albumin Levels
American Journal of Neuroradiology Oct 2015, 36 (10) 1884-1889; DOI: 10.3174/ajnr.A4379

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Cytotoxic Edema in Posterior Reversible Encephalopathy Syndrome: Correlation of MRI Features with Serum Albumin Levels
B. Gao, B.X. Yu, R.S. Li, G. Zhang, H.Z. Xie, F.L. Liu, C. Lv
American Journal of Neuroradiology Oct 2015, 36 (10) 1884-1889; DOI: 10.3174/ajnr.A4379
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