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Research ArticleNeurointervention

Progressive versus Nonprogressive Intracranial Dural Arteriovenous Fistulas: Characteristics and Outcomes

S.W. Hetts, T. Tsai, D.L. Cooke, M.R. Amans, F. Settecase, P. Moftakhar, C.F. Dowd, R.T. Higashida, M.T. Lawton and V.V. Halbach
American Journal of Neuroradiology October 2015, 36 (10) 1912-1919; DOI: https://doi.org/10.3174/ajnr.A4391
S.W. Hetts
aFrom the Departments of Radiology and Biomedical Imaging (S.W.H., T.T., D.L.C., M.R.A., F.S., P.M., C.F.D., R.T.H., V.V.H.)
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T. Tsai
aFrom the Departments of Radiology and Biomedical Imaging (S.W.H., T.T., D.L.C., M.R.A., F.S., P.M., C.F.D., R.T.H., V.V.H.)
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D.L. Cooke
aFrom the Departments of Radiology and Biomedical Imaging (S.W.H., T.T., D.L.C., M.R.A., F.S., P.M., C.F.D., R.T.H., V.V.H.)
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M.R. Amans
aFrom the Departments of Radiology and Biomedical Imaging (S.W.H., T.T., D.L.C., M.R.A., F.S., P.M., C.F.D., R.T.H., V.V.H.)
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F. Settecase
aFrom the Departments of Radiology and Biomedical Imaging (S.W.H., T.T., D.L.C., M.R.A., F.S., P.M., C.F.D., R.T.H., V.V.H.)
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P. Moftakhar
aFrom the Departments of Radiology and Biomedical Imaging (S.W.H., T.T., D.L.C., M.R.A., F.S., P.M., C.F.D., R.T.H., V.V.H.)
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C.F. Dowd
aFrom the Departments of Radiology and Biomedical Imaging (S.W.H., T.T., D.L.C., M.R.A., F.S., P.M., C.F.D., R.T.H., V.V.H.)
bNeurological Surgery (C.F.D., R.T.H., M.T.L., V.V.H.)
cNeurology (C.F.D., R.T.H., V.V.H.)
dAnesthesia and Perioperative Care (C.F.D., R.T.H., V.V.H.), University of California, San Francisco, San Francisco, California.
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R.T. Higashida
aFrom the Departments of Radiology and Biomedical Imaging (S.W.H., T.T., D.L.C., M.R.A., F.S., P.M., C.F.D., R.T.H., V.V.H.)
bNeurological Surgery (C.F.D., R.T.H., M.T.L., V.V.H.)
cNeurology (C.F.D., R.T.H., V.V.H.)
dAnesthesia and Perioperative Care (C.F.D., R.T.H., V.V.H.), University of California, San Francisco, San Francisco, California.
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M.T. Lawton
bNeurological Surgery (C.F.D., R.T.H., M.T.L., V.V.H.)
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V.V. Halbach
aFrom the Departments of Radiology and Biomedical Imaging (S.W.H., T.T., D.L.C., M.R.A., F.S., P.M., C.F.D., R.T.H., V.V.H.)
bNeurological Surgery (C.F.D., R.T.H., M.T.L., V.V.H.)
cNeurology (C.F.D., R.T.H., V.V.H.)
dAnesthesia and Perioperative Care (C.F.D., R.T.H., V.V.H.), University of California, San Francisco, San Francisco, California.
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    Fig 1.

    Cohort selection.

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    Fig 2.

    Age of diagnosis for patients with progressive-versus-nonprogressive fistulas.

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    Fig 3.

    Multiple and progressive DAVFs. A 25-year-old female patient with large skull base DAVFs refractory to multiple endovascular treatments. She was initially diagnosed at 18 years of age and died of intracranial hemorrhage 6 years later in the setting of intractable intracranial venous hypertension. CTA images demonstrate an extensive skull base vascular abnormality with dilated cortical veins suggestive of intracranial venous hypertension.

  • Fig 4.
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    Fig 4.

    Multiple and progressive DAVFs. Same patient as in Fig 3. DSA images before treatment at our institution but 4 years after initial proximal coil embolization of external carotid artery feeders below the skull base at an outside institution demonstrate multiple skull base fistulas associated with venous hypertension, cortical venous reflux, venous sinus dilation, and a jugular bulb outflow stenosis (between white arrows). (Upper row: right vertebral artery lateral, right vertebral artery lateral, left vertebral artery anteroposterior; lower row: left ICA anteroposterior, left external carotid artery anteroposterior, left external carotid artery lateral). A middle meningeal artery to the torcular fistula indicated by the white arrows is shown in greater detail in Fig 5.

  • Fig 5.
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    Fig 5.

    Multiple and progressive DAVFs. Same patient as in Figs 3 and 4. DSA demonstrates progression of a left middle meningeal artery to a torcular DAVF with interval enlargement of a feeding artery (arrow in upper left panel versus arrow in upper right panel) during 7 months. Lateral CT scanograms obtained at the same time as DSA provide an overview of treatment with interval deposition of embolic coils and n-BCA glue (lower left versus lower right panel).

Tables

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    Table 1:

    UCSF intracranial dural arteriovenous fistula cohort with single fistulas versus subset with confirmed enlarging, de novo, multiple, or recurrent fistulas

    Enlarging, De Novo, Multiple, or Recurrent Fistulas (n = 34)Remainder of UCSF Intracranial DAVFs (n = 545)P Valuea
    Mean age at dx ± SD45 ± 23 y53 ± 20 y.11b
    Median age (range)52.5 y (0.2–77 y)56 y (0–87 y)
    Male35%49%.16c
    • Note:—UCSF indicates University of California at San Francisco; dx, diagnosis.

    • ↵a Enlarging, de novo, multiple, or recurrent vs remainder of UCSF cohort.

    • ↵b Two-tailed t test.

    • ↵c Two-sided Fisher exact test.

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    Table 2:

    Treatments and outcomes stratified by fistula progression

    All Subjects (n = 34)Progressive (n = 19)Nonprogressive (n = 15)P Value
    Treatments
        Median treatment procedures (25%, 75%)5 (3, 9)3 (2, 4).0068a
        Range treatment procedures2–192–7
        Any surgical treatment63%33%.17b
        Transarterial embolization100%80%.076b
        Transvenous embolization74%67%.72b
        Ethanol embolization84%67%.42b
        Coil embolization89%80%.63b
        PVA embolization74%53%.29b
        Glue embolization42%13%.13b
        Onyx embolizationc11%20%.63b
    Outcomes at last follow-up
        Mean follow-up duration4.6 y5.1 y4.0 y.70
        Median (range) follow-up duration2.5 y (56 d to 23 y)3.9 y (58 d to 17 y)1.4 y (56 d to 23 y).37a
        Death16%0%.24b
        Median outcome (normal = 0, deficits/residual fistula = 1, death = 2)1 (0, 1)1 (0, 1).31a
        Median last mRS (25%, 75%)1 (0, 3)1 (0, 3).39a
        Range last mRS0–60–3
        Good outcome (last mRS 0–2)74%73%1.0
        Median change in mRS (25%, 75%)−0.5 (−1, 0)−1 (−1, 0).83a
        Range change mRS−3 to 1−4 to 2
    • Note:—PVA indicates polyvinyl alcohol.

    • ↵a Wilcoxon rank sum (Mann-Whitney) test.

    • ↵b Two-sided Fisher exact test.

    • ↵c Covidien, Irvine, California.

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American Journal of Neuroradiology: 36 (10)
American Journal of Neuroradiology
Vol. 36, Issue 10
1 Oct 2015
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S.W. Hetts, T. Tsai, D.L. Cooke, M.R. Amans, F. Settecase, P. Moftakhar, C.F. Dowd, R.T. Higashida, M.T. Lawton, V.V. Halbach
Progressive versus Nonprogressive Intracranial Dural Arteriovenous Fistulas: Characteristics and Outcomes
American Journal of Neuroradiology Oct 2015, 36 (10) 1912-1919; DOI: 10.3174/ajnr.A4391

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Progressive versus Nonprogressive Intracranial Dural Arteriovenous Fistulas: Characteristics and Outcomes
S.W. Hetts, T. Tsai, D.L. Cooke, M.R. Amans, F. Settecase, P. Moftakhar, C.F. Dowd, R.T. Higashida, M.T. Lawton, V.V. Halbach
American Journal of Neuroradiology Oct 2015, 36 (10) 1912-1919; DOI: 10.3174/ajnr.A4391
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