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Research ArticleNeurointervention
Open Access

Hemodynamic Differences in Intracranial Aneurysms before and after Rupture

B.M.W. Cornelissen, J.J. Schneiders, W.V. Potters, R. van den Berg, B.K. Velthuis, G.J.E. Rinkel, C.H. Slump, E. VanBavel, C.B.L.M. Majoie and H.A. Marquering
American Journal of Neuroradiology October 2015, 36 (10) 1927-1933; DOI: https://doi.org/10.3174/ajnr.A4385
B.M.W. Cornelissen
aFrom the MIRA Institute for Biomedical Engineering and Technical Medicine (B.M.W.C., C.H.S.), University of Twente, Enschede, the Netherlands
bDepartments of Radiology (B.M.W.C., J.J.S., W.V.P., R.v.d.B., C.B.L.M.M., H.A.M.)
cBiomedical Engineering and Physics (B.M.W.C, E.V., H.A.M.), Academic Medical Center, Amsterdam, the Netherlands
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J.J. Schneiders
bDepartments of Radiology (B.M.W.C., J.J.S., W.V.P., R.v.d.B., C.B.L.M.M., H.A.M.)
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W.V. Potters
bDepartments of Radiology (B.M.W.C., J.J.S., W.V.P., R.v.d.B., C.B.L.M.M., H.A.M.)
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R. van den Berg
bDepartments of Radiology (B.M.W.C., J.J.S., W.V.P., R.v.d.B., C.B.L.M.M., H.A.M.)
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B.K. Velthuis
dDepartments of Radiology (B.K.V.)
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G.J.E. Rinkel
eNeurology and Neurosurgery, Brain Center Rudolf Magnus (G.J.E.R.), University Medical Center Utrecht, Utrecht, the Netherlands.
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C.H. Slump
aFrom the MIRA Institute for Biomedical Engineering and Technical Medicine (B.M.W.C., C.H.S.), University of Twente, Enschede, the Netherlands
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E. VanBavel
cBiomedical Engineering and Physics (B.M.W.C, E.V., H.A.M.), Academic Medical Center, Amsterdam, the Netherlands
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C.B.L.M. Majoie
bDepartments of Radiology (B.M.W.C., J.J.S., W.V.P., R.v.d.B., C.B.L.M.M., H.A.M.)
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H.A. Marquering
bDepartments of Radiology (B.M.W.C., J.J.S., W.V.P., R.v.d.B., C.B.L.M.M., H.A.M.)
cBiomedical Engineering and Physics (B.M.W.C, E.V., H.A.M.), Academic Medical Center, Amsterdam, the Netherlands
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  • Fig 1.
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    Fig 1.

    Velocity magnitude (m/s) waveforms for the basilar artery (BA), internal carotid artery, middle cerebral artery, and the anterior cerebral artery (ACA).

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    Fig 2.

    Flow-velocity streamlines (m/s) for all 9 aneurysms before and after rupture. For each aneurysm, the time-step with the peak velocity–magnitude of the inflow artery is shown.

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    Fig 3.

    Heart cycle–averaged WSS (Pascal) distributions for all 9 aneurysms before and after rupture.

Tables

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    Table 1:

    Imaging modalities for all 9 patients before and after rupture, with the time between imaging before and after rupture and the days between hemorrhage and imaging after rupturea

    PtImaging Modality before RuptureResolution (mm)Imaging Modality after RuptureResolution (mm)Time between Imaging before and after RuptureDays between Hemorrhage and Imaging after Rupture
    13D TOF MRA0.49 × 0.49 × 1.23DRA0.22 × 0.22 × 0.220 yr, 183 days1
    23D TOF MRA0.31 × 0.31 × 1.0CTA0.31 × 0.31 × 0.450 yr, 72 days1
    3CTA0.33 × 0.33 × 1.0CTA0.35 × 0.35 × 0.332 yr, 323 days2
    43D PC MRA0.78 × 0.78 × 1.03DRA0.25 × 0.25 × 0.250 yr, 151 days0
    53D TOF MRA0.45 × 0.45 × 1.03DRA0.39 × 0.39 × 0.393 yr, 148 days0
    6CTA0.43 × 0.43 × 0.93DRA0.22 × 0.22 × 0.220 yr, 34 days0
    73D TOF MRA0.20 × 0.20 × 1.03DRA0.17 × 0.17 × 0.174 yr, 1 day3
    83D TOF MRA0.35 × 0.35 × 1.43DRA0.17 × 0.17 × 0.170 yr, 14 days9
    9CTA0.33 × 0.33 × 1.33DRA0.09 × 0.09 × 0.090 yr, 302 days2
    • Note:—Pt indicates patient; PC, phase-contrast.

    • ↵a Table adapted from Schneiders et al.14

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    Table 2:

    Hemodynamic characteristics of the aneurysm models before and after rupturea

    PtLocationFlow ComplexityFlow StabilityInflow ConcentrationFlow ImpingementGeometric Changes
    RegionSize
    1BasilarC-CU-UC-CD-DS-SNoneb
    2AcomAC-CU-UC-CD-BcS-SAneurysm displacement (8.9 mm)
    3PcomAS-CcS-UcD-DN-NS-SGrowth (79%); 1 new lobulation
    4MCAC-CU-UC-CND-NDS-SAneurysm displacement (5.8 mm)
    5MCAC-CS-SD-CcND-NDS-SGrowth (176%)
    6BasilarC-CU-UD-DD-DL-LNoneb
    7PcomAS-CcU-UC-DcN-NBcS-SGrowth (832%); 1 new lobulation
    8Anterior choroidalC-CS-UcC-CNB-NcS-SGrowth (70%)
    9BasilarS-CcS-UcC-CBD-BDL-L1 New lobulation
    • Note:—AcomA indicates anterior communicating artery; PcomA, posterior communicating artery.

    • ↵a Flow complexity was characterized as simple (S) or complex (C); flow stability, as stable (S) or unstable (U); inflow concentration as diffuse (D) or concentrated (C); region of flow impingement, as dome (D), body (B), or neck (N); and size of the impingement zone, as small (S) or large (L).

    • ↵b Aneurysm displacement of ≤0.6 mm or not related to mass effect from hematoma; aneurysm growth of ≤40%.

    • ↵c Changed after rupture.

    • View popup
    Table 3:

    Mean and maximum oscillatory shear index for all 9 aneurysms before and after rupture

    PtMean OSIMaximum OSI
    BeforeAfterΔBeforeAfterΔ
    10.0420.049+0.007 (17%)0.4870.484−0.003 (0.6%)
    20.0740.044−0.029 (40%)0.4860.479−0.007 (1.4%)
    30.0250.049+0.024 (95%)0.4230.482+0.059 (13.9%)
    40.0310.044+0.013 (42%)0.4710.483+0.012 (2.5%)
    50.0070.040+0.034 (520%)0.3500.469+0.119 (34.1%)
    60.0650.028−0.037 (57%)0.4890.459−0.030 (6.1%)
    70.0610.031−0.029 (48%)0.4710.476+0.005 (1.1%)
    80.0210.018−0.003 (16%)0.4750.452−0.023 (4.8%)
    90.0250.058+0.034 (137%)0.4730.485+0.011 (2.4%)
    Mean0.039 ± 0.0230.040 ± 0.0130.458 ± 0.0450.474 ± 0.012
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B.M.W. Cornelissen, J.J. Schneiders, W.V. Potters, R. van den Berg, B.K. Velthuis, G.J.E. Rinkel, C.H. Slump, E. VanBavel, C.B.L.M. Majoie, H.A. Marquering
Hemodynamic Differences in Intracranial Aneurysms before and after Rupture
American Journal of Neuroradiology Oct 2015, 36 (10) 1927-1933; DOI: 10.3174/ajnr.A4385

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Hemodynamic Differences in Intracranial Aneurysms before and after Rupture
B.M.W. Cornelissen, J.J. Schneiders, W.V. Potters, R. van den Berg, B.K. Velthuis, G.J.E. Rinkel, C.H. Slump, E. VanBavel, C.B.L.M. Majoie, H.A. Marquering
American Journal of Neuroradiology Oct 2015, 36 (10) 1927-1933; DOI: 10.3174/ajnr.A4385
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