Recognizing Autoimmune-Mediated Encephalitis in the Differential Diagnosis of Limbic Disorders

REFERENCES

1. 1.↵
   2. Brierley JB,
   3. Corsellis JA,
   4. Hierons R, et al

   . Subacute encephalitis of later adult life mainly affecting the limbic areas. Brain 1960;83:357–68 doi:10.1093/brain/83.3.357

   FREE Full Text
2. 2.↵
   2. Vernino S,
   3. Geschwind M,
   4. Boeve B

   . Autoimmune encephalopathies. Neurologist 2007;13:140–47 doi:10.1097/01.nrl.0000259483.70041.55 pmid:17495758

   CrossRefPubMedWeb of Science
3. 3.↵
   2. Tüzun E,
   3. Dalmau J

   . Limbic encephalitis and variants: classification, diagnosis and treatment. Neurologist 2007;13:261–71 doi:10.1097/NRL.0b013e31813e34a5 pmid:17848866

   CrossRefPubMedWeb of Science
4. 4.↵
   2. Gultekin SH,
   3. Rosenfeld MR,
   4. Voltz R, et al

   . Paraneoplastic limbic encephalitis: neurological symptoms, immunological findings and tumour association in 50 patients. Brain 2000;123(pt 7):1481–94 doi:10.1093/brain/123.7.1481 pmid:10869059

   Abstract/FREE Full Text
5. 5.↵
   2. Vieira Santos A,
   3. Matias S,
   4. Saraiva P, et al

   . Differential diagnosis of mesiotemporal lesions: case report of neurosyphilis. Neuroradiology 2005;47:664–67 doi:10.1007/s00234-005-1414-4 pmid:16021441

   CrossRefPubMedWeb of Science
6. 6.↵
   2. Kararizou E,
   3. Markou I,
   4. Zalonis I, et al

   . Paraneoplastic limbic encephalitis presenting as acute viral encephalitis. J Neurooncol 2005;75:229–32 doi:10.1007/s11060-005-3671-9 pmid:16283448

   CrossRefPubMed
7. 7.↵
   2. Tyler KL

   . Emerging viral infections of the central nervous system: part 1. Arch Neurol 2009;66:939–48 doi:10.1001/archneurol.2009.153 pmid:19667214

   CrossRefPubMedWeb of Science
8. 8.↵
   2. Nagata R,
   3. Ikeda K,
   4. Nakamura Y, et al

   . A case of gliomatosis cerebri mimicking limbic encephalitis: malignant transformation to glioblastoma. Int Med 2010;49:1307–10 doi:10.2169/internalmedicine.49.3278 pmid:20606365

   CrossRefPubMed
9. 9.↵
   2. Förster A,
   3. Griebe M,
   4. Gass A, et al

   . Diffusion-weighted imaging for the differential diagnosis of disorders affecting the hippocampus. Cerebrovasc Dis 2012;33:104–15 doi:10.1159/000332036 pmid:22179485

   CrossRefPubMed
10. 10.↵
    2. Armangue T,
    3. Leypoldt F,
    4. Dalmau J

    . Autoimmune encephalitis as differential diagnosis of infectious encephalitis. Curr Opin Neurol 2014;27:361–68 doi:10.1097/WCO.0000000000000087 pmid:24792345

    CrossRefPubMed
11. 11.↵
    2. Kotsenas AL,
    3. Watson RE,
    4. Pittock SJ, et al

    . MRI findings in autoimmune voltage-gated potassium channel complex encephalitis with seizures: one potential etiology for mesial temporal sclerosis. AJNR Am J Neuroradiol 2014;35:84–89 doi:10.3174/ajnr.A3633 pmid:23868165

    Abstract/FREE Full Text
12. 12.↵
    2. Oyanguren B,
    3. Sánchez V,
    4. González FJ, et al

    . Limbic encephalitis: a clinical-radiological comparison between herpetic and autoimmune etiologies. Eur J Neurol 2013;20:1566–70 doi:10.1111/ene.12249 pmid:23941332

    CrossRefPubMed
13. 13.↵
    2. Dalmau J,
    3. Bataller L

    . Clinical and immunological diversity of limbic encephalitis: a model for paraneoplastic neurologic disorders. Hematol Oncol Clin North Am 2006;20:1319–35 doi:10.1016/j.hoc.2006.09.011 pmid:17113466

    CrossRefPubMedWeb of Science
14. 14.↵
    2. Demaerel P,
    3. Van Dessel W,
    4. Van Paesschen W, et al

    . Autoimmune-mediated encephalitis. Neuroradiology 2011;53:837–51 doi:10.1007/s00234-010-0832-0 pmid:21271243

    CrossRefPubMed
15. 15.↵
    2. Darnell RB,
    3. Posner JB

    . Paraneoplastic syndromes involving the nervous system. N Engl J Med 2003;349:1543–54 doi:10.1056/NEJMra023009 pmid:14561798

    CrossRefPubMedWeb of Science
16. 16.↵
    2. Dalmau J,
    3. Rosenfeld MR

    . Autoimmune encephalitis update. Neuro Oncol 2014;16:771–78 doi:10.1093/neuonc/nou030 pmid:24637228

    Abstract/FREE Full Text
17. 17.↵
    2. Graus F,
    3. Ariño H,
    4. Dalmau J

    . Paraneoplastic neurological syndromes in Hodgkin and non-Hodgkin lymphomas. Blood 2014;123:3230–38 doi:10.1182/blood-2014-03-537506 pmid:24705493

    Abstract/FREE Full Text
18. 18.↵
    2. Graus F,
    3. Keime-Guibert F,
    4. Reñe R, et al

    . Anti-Hu-associated paraneoplastic encephalomyelitis: analysis of 200 patients. Brain 2001;124(pt 6):1138–48 doi:10.1093/brain/124.6.1138 pmid:11353730

    Abstract/FREE Full Text
19. 19.↵
    2. Shavit YB,
    3. Graus F,
    4. Probst A, et al

    . Epilepsia partialis continua: a new manifestation of anti-Hu-associated paraneoplastic encephalomyelitis. Ann Neurol 1999;45:255–58 doi:10.1002/1531-8249(199902)45:23.0.CO;2-N pmid:9989630

    CrossRefPubMedWeb of Science
20. 20.↵
    2. Keime-Guibert F,
    3. Graus F,
    4. Fleury A, et al

    . Treatment of paraneoplastic neurological syndromes with antineuronal antibodies (Anti-Hu, anti-Yo) with a combination of immunoglobulins, cyclophosphamide, and methylprednisolone. J Neurol Neurosurg Psychiatry 2000;68:479–82 doi:10.1136/jnnp.68.4.479 pmid:10727484

    Abstract/FREE Full Text
21. 21.↵
    2. Rosenfeld MR,
    3. Eichen JG,
    4. Wade DF, et al

    . Molecular and clinical diversity in paraneoplastic immunity to Ma proteins. Ann Neurol 2001;50:339–48 doi:10.1002/ana.1288 pmid:11558790

    CrossRefPubMedWeb of Science
22. 22.↵
    2. Dalmau J,
    3. Graus F,
    4. Villarejo A, et al

    . Clinical analysis of anti-Ma2-associated encephalitis. Brain 2004;127(pt 8):1831–44 doi:10.1093/brain/awh203 pmid:15215214

    Abstract/FREE Full Text
23. 23.↵
    2. Dalmau J,
    3. Gultekin SH,
    4. Voltz R, et al

    . Ma1, a novel neuron- and testis-specific protein, is recognized by the serum of patients with paraneoplastic neurological disorders. Brain 1999;122(pt 1):27–39 doi:10.1093/brain/122.1.27 pmid:10050892

    Abstract/FREE Full Text
24. 24.↵
    2. Honnorat J,
    3. Cartalat-Carel S,
    4. Ricard D, et al

    . Onco-neural antibodies and tumour type determine survival and neurological symptoms in paraneoplastic neurological syndromes with Hu or CV2/CRMP5 antibodies. J Neurol Neurosurg Psychiatry 2009;80:412–16 doi:10.1136/jnnp.2007.138016 pmid:18931014

    Abstract/FREE Full Text
25. 25.↵
    2. Vernino S,
    3. Tuite P,
    4. Adler CH, et al

    . Paraneoplastic chorea associated with CRMP-5 neuronal antibody and lung carcinoma. Ann Neurol 2002;51:625–30 doi:10.1002/ana.10178 pmid:12112110

    CrossRefPubMedWeb of Science
26. 26.↵
    2. Gable MS,
    3. Sheriff H,
    4. Dalmau J, et al

    . The frequency of autoimmune N-methyl-D-aspartate receptor encephalitis surpasses that of individual viral etiologies in young individuals enrolled in the California Encephalitis Project. Clin Infect Dis 2012;54:899–904 doi:10.1093/cid/cir1038 pmid:22281844

    Abstract/FREE Full Text
27. 27.↵
    2. Titulaer MJ,
    3. McCracken L,
    4. Gabilondo I, et al

    . Treatment and prognostic factors for long-term outcome in patients with anti-NMDA receptor encephalitis: an observational cohort study. Lancet Neurol 2013;12:157–65 doi:10.1016/S1474-4422(12)70310-1 pmid:23290630

    CrossRefPubMedWeb of Science
28. 28.↵
    2. Irani SR,
    3. Bera K,
    4. Waters P, et al

    . N-methyl-D-aspartate antibody encephalitis: temporal progression of clinical and paraclinical observations in a predominantly non-paraneoplastic disorder of both sexes. Brain 2010;133(pt 6):1655–67 doi:10.1093/brain/awq113 pmid:20511282

    Abstract/FREE Full Text
29. 29.↵
    2. Kayser MS,
    3. Titulaer MJ,
    4. Gresa-Arribas N, et al

    . Frequency and characteristics of isolated psychiatric episodes in anti–N-methyl-d-aspartate receptor encephalitis. JAMA Neurol 2013;70:1133–39 doi:10.1001/jamaneurol.2013.3216 pmid:23877059

    CrossRefPubMed
30. 30.↵
    2. Dalmau J,
    3. Gleichman AJ,
    4. Hughes EG, et al

    . Anti-NMDA-receptor encephalitis: case series and analysis of the effects of antibodies. Lancet Neurol 2008;7:1091–98 doi:10.1016/S1474-4422(08)70224-2 pmid:18851928

    CrossRefPubMedWeb of Science
31. 31.↵
    2. Dalmau J,
    3. Tüzün E,
    4. Wu HY, et al

    . Paraneoplastic anti-N-methyl-D-aspartate receptor encephalitis associated with ovarian teratoma. Ann Neurol 2007;61:25–36 doi:10.1002/ana.21050 pmid:17262855

    CrossRefPubMedWeb of Science
32. 32.↵
    2. Titulaer MJ,
    3. McCracken L,
    4. Gabilondo I, et al

    . Late-onset anti-NMDA receptor encephalitis. Neurology 2013;81:1058–63 doi:10.1212/WNL.0b013e3182a4a49c pmid:23946310

    Abstract/FREE Full Text
33. 33.↵
    2. Johnson N,
    3. Henry C,
    4. Fessler AJ, et al

    . Anti-NMDA receptor encephalitis causing prolonged nonconvulsive status epilepticus. Neurology 2010;75:1480–82 doi:10.1212/WNL.0b013e3181f8831a pmid:20826712

    FREE Full Text
34. 34.↵
    2. Lancaster E,
    3. Lai M,
    4. Peng X, et al

    . Antibodies to the GABA(B) receptor in limbic encephalitis with seizures: case series and characterisation of the antigen. Lancet Neurol 2010;9:67–76 doi:10.1016/S1474-4422(09)70324-2 pmid:19962348

    CrossRefPubMedWeb of Science
35. 35.↵
    2. Höftberger R,
    3. Titulaer MJ,
    4. Sabater L, et al

    . Encephalitis and GABAB receptor antibodies: novel findings in a new case series of 20 patients. Neurology 2013;81:1500–06 doi:10.1212/WNL.0b013e3182a9585f pmid:24068784

    Abstract/FREE Full Text
36. 36.↵
    2. Boronat A,
    3. Sabater L,
    4. Saiz A, et al

    . GABA(B) receptor antibodies in limbic encephalitis and anti-GAD-associated neurologic disorders. Neurology 2011;76:795–800 doi:10.1212/WNL.0b013e31820e7b8d pmid:21357831

    Abstract/FREE Full Text
37. 37.↵
    2. Petit-Pedrol M,
    3. Armangue T,
    4. Peng X, et al

    . Encephalitis with refractory seizures, status epilepticus, and antibodies to the GABAA receptor: a case series, characterisation of the antigen, and analysis of the effects of antibodies. Lancet Neurol 2014;13:276–86 doi:10.1016/S1474-4422(13)70299-0 pmid:24462240

    CrossRefPubMedWeb of Science
38. 38.↵
    2. Graus F,
    3. Boronat A,
    4. Xifró X, et al

    . The expanding clinical profile of anti-AMPA receptor encephalitis. Neurology 2010;74:857–59 doi:10.1212/WNL.0b013e3181d3e404 pmid:20211911

    FREE Full Text
39. 39.↵
    2. Carr I

    . The Ophelia syndrome: memory loss in Hodgkin's disease. Lancet 1982;1:844–45 pmid:6122069

    CrossRefPubMedWeb of Science
40. 40.↵
    2. Mat A,
    3. Adler H,
    4. Merwick A, et al

    . Ophelia syndrome with metabotropic glutamate receptor 5 antibodies in CSF. Neurology 2013;80:1349–50 doi:10.1212/WNL.0b013e31828ab325 pmid:23486886

    Abstract/FREE Full Text
41. 41.↵
    2. Malter MP,
    3. Helmstaedter C,
    4. Urbach H, et al

    . Antibodies to glutamic acid decarboxylase define a form of limbic encephalitis. Ann Neurol 2010;67:470–78 doi:10.1002/ana.21917 pmid:20437582

    CrossRefPubMedWeb of Science
42. 42.↵
    2. Grau-Rivera O,
    3. Sánchez-Valle R,
    4. Saiz A, et al

    . Determination of neuronal antibodies in suspected and definite Creutzfeldt-Jakob disease. JAMA Neurol 2014;71:74–78 doi:10.1001/jamaneurol.2013.4857 pmid:24248099

    CrossRefPubMedWeb of Science
43. 43.↵
    2. Paterson RW,
    3. Zandi MS,
    4. Armstrong R, et al

    . Clinical relevance of positive voltage-gated potassium channel (VGKC)-complex antibodies: experience from a tertiary referral centre. J Neurol Neurosurg Psychiatry 2014;85:625–30 doi:10.1136/jnnp-2013-305218 pmid:23757422

    Abstract/FREE Full Text
44. 44.↵
    2. Irani SR,
    3. Michell AW,
    4. Lang B, et al

    . Faciobrachial dystonic seizures precede Lgi1 antibody limbic encephalitis. Ann Neurol 2011;69:892–900 doi:10.1002/ana.22307 pmid:21416487

    CrossRefPubMedWeb of Science
45. 45.↵
    2. Hiraga A,
    3. Kuwabara S,
    4. Hayakawa S, et al

    . Voltage-gated potassium channel antibody-associated encephalitis with basal ganglia lesions. Neurology 2006;66:1780–81 doi:10.1212/01.wnl.0000218157.53333.79 pmid:16769968

    FREE Full Text
46. 46.↵
    2. Majoie HJ,
    3. de Baets M,
    4. Renier W, et al

    . Antibodies to voltage-gated potassium and calcium channels in epilepsy. Epilepsy Res 2006;71:135–41 doi:10.1016/j.eplepsyres.2006.06.003 pmid:16870397

    CrossRefPubMedWeb of Science
47. 47.↵
    2. Vincent A,
    3. Buckley C,
    4. Schott JM, et al

    . Potassium channel antibody-associated encephalopathy: a potentially immunotherapy-responsive form of limbic encephalitis. Brain 2004;127(pt 3):701–12 doi:10.1093/brain/awh077 pmid:14960497

    Abstract/FREE Full Text
48. 48.↵
    2. Lancaster E,
    3. Huijbers MG,
    4. Bar V, et al

    . Investigations of caspr2, an autoantigen of encephalitis and neuromyotonia. Ann Neurol 2011;69:303–11 doi:10.1002/ana.22297 pmid:21387375

    CrossRefPubMedWeb of Science
49. 49.↵
    2. Blanc F,
    3. Ben Abdelghani K,
    4. Schramm F, et al

    . Whipple limbic encephalitis. Arch Neurol 2011;68:1471–73 doi:10.1001/archneurol.2011.532 pmid:22084133

    CrossRefPubMed
50. 50.↵
    2. Badruddin A,
    3. Menon RS,
    4. Reder AT

    . 4-Aminopyridine toxicity mimics autoimmune-mediated limbic encephalitis. Neurology 2009;72:1100–01 doi:10.1212/01.wnl.0000345063.17185.13 pmid:19307545

    FREE Full Text
51. 51.↵
    2. Boeve BF,
    3. Bell DG,
    4. Noseworthy JH

    . Bilateral temporal lobe MRI changes in uncomplicated hypoglycemic coma. Can J Neurol Sci 1995;22:56–8 pmid:7750077

    PubMed
52. 52.↵
    2. Baringer JR

    . Herpes simplex infections of the nervous system. Neurol Clin 2008;26:657–74, viii doi:10.1016/j.ncl.2008.03.005 pmid:18657720

    CrossRefPubMedWeb of Science
53. 53.↵
    2. Armangue T,
    3. Leypoldt F,
    4. Málaga I, et al

    . Herpes simplex virus encephalitis is a trigger of brain autoimmunity. Ann Neurol 2014;75:317–23 doi:10.1002/ana.24083 pmid:24318406

    CrossRefPubMed
54. 54.↵
    2. Schäbitz WR,
    3. Rogalewski A,
    4. Hagemeister C, et al

    . VZV brainstem encephalitis triggers NMDA receptor immunoreaction. Neurology 2014;83:2309–11 doi:10.1212/WNL.0000000000001072 pmid:25378669

    Abstract/FREE Full Text
55. 55.↵
    2. Höftberger R,
    3. Armangue T,
    4. Leypoldt F, et al

    . Clinical neuropathology practice guide 4–2013: post-herpes simplex encephalitis: N-methyl-Daspartate receptor antibodies are part of the problem. Clin Neuropathol 2013;32:251–54 doi:10.5414/NP300666 pmid:23806220

    CrossRefPubMed
56. 56.↵
    2. Karsan N,
    3. Barker R,
    4. O'Dwyer JP

    . Clinical reasoning: the “great imitator.” Neurology 2014;83:e188–96 doi:10.1212/WNL.0000000000001033 pmid:25422404

    Abstract/FREE Full Text
57. 57.↵
    2. Vates GE,
    3. Chang S,
    4. Lamborn KR, et al

    . Gliomatosis cerebri: a review of 22 cases. Neurosurgery 2003;53:261–71, discussion 271 doi:10.1227/01.NEU.0000073527.20655.E6 pmid:12925240

    CrossRefPubMed
58. 58.↵
    2. Maia AC Jr.,
    3. Malheiros SM,
    4. da Rocha AJ, et al

    . Stereotactic biopsy guidance in adults with supratentorial nonenhancing gliomas: role of perfusion-weighted magnetic resonance imaging. J Neurosurg 2004;101:970–76 doi:10.3171/jns.2004.101.6.0970 pmid:15597757

    CrossRefPubMed
59. 59.↵
    2. Sedlaczek O,
    3. Hirsch JG,
    4. Grips E, et al

    . Detection of delayed focal MR changes in the lateral hippocampus in transient global amnesia. Neurology 2004;62:2165–70 doi:10.1212/01.WNL.0000130504.88404.C9 pmid:15210876

    Abstract/FREE Full Text
60. 60.↵
    2. Cendes F

    . Febrile seizures and mesial temporal sclerosis. Curr Opin Neurol 2004;17:161–64 doi:10.1097/00019052-200404000-00013 pmid:15021243

    CrossRefPubMedWeb of Science
61. 61.↵
    2. Kim JA,
    3. Chung JI,
    4. Yoon PH, et al

    . Transient MR signal changes in patients with generalized tonicoclonic seizure or status epilepticus: periictal diffusion-weighted imaging. AJNR Am J Neuroradiol 2001;22:1149–60 pmid:11415912

    Abstract/FREE Full Text
62. 62.↵
    2. Cox JE,
    3. Mathews VP,
    4. Santos CC, et al

    . Seizure-induced transient hippocampal abnormalities on MR: correlation with positron emission tomography and electroencephalography. AJNR Am J Neuroradiol 1995;16:1736–38 pmid:7502985

    Abstract
63. 63.↵
    2. Hatanpaa KJ,
    3. Blass DM,
    4. Pletnikova O, et al

    . Most cases of dementia with hippocampal sclerosis may represent frontotemporal dementia. Neurology 2004;63:538–42 doi:10.1212/01.WNL.0000129543.46734.C0 pmid:15304590

    Abstract/FREE Full Text
64. 64.↵
    2. Caraballo RH,
    3. Reyes G,
    4. Avaria MF, et al

    . Febrile infection-related epilepsy syndrome: a study of 12 patients. Seizure 2013;22:553–59 doi:10.1016/j.seizure.2013.04.005 pmid:23643626

    CrossRefPubMedWeb of Science
65. 65.↵
    2. van Baalen A,
    3. Häusler M,
    4. Boor R, et al

    . Febrile infection-related epilepsy syndrome (FIRES): a nonencephalitic encephalopathy in childhood. Epilepsia 2010;51:1323–28 doi:10.1111/j.1528-1167.2010.02535.x pmid:20345937

    CrossRefPubMedWeb of Science
66. 66.↵
    2. Venkatesan A,
    3. Benavides DR

    . Autoimmune encephalitis and its relation to infection. Curr Neurol Neurosci Rep 2015;15:3 doi:10.1007/s11910-015-0529 pmid:25637289

    CrossRefPubMed
67. 67.↵
    2. Castillo P,
    3. Woodruff B,
    4. Caselli R, et al

    . Steroid-responsive encephalopathy associated with autoimmune thyroiditis. Arch Neurol 2006;63:197–202 doi:10.1001/archneur.63.2.197 pmid:16476807

    CrossRefPubMedWeb of Science
68. 68.↵
    2. Hollowell JG,
    3. Staehling NW,
    4. Flanders WD, et al

    . Serum TSH, T(4), and thyroid antibodies in the United States population (1988 to 1994): National Health and Nutrition Examination Survey (NHANES III). J Clin Endocrinol Metab 2002;87:489–99 doi:10.1210/jcem.87.2.8182 pmid:11836274

    CrossRefPubMedWeb of Science
69. 69.↵
    2. Ferracci F,
    3. Carnevale A

    . The neurological disorder associated with thyroid autoimmunity. J Neurol 2006;253:975–84 doi:10.1007/s00415-006-0170-7 pmid:16786216

    CrossRefPubMedWeb of Science
70. 70.↵
    2. Song YM,
    3. Seo DW,
    4. Chang GY

    . MR findings in Hashimoto encephalopathy. AJNR Am J Neuroradiol 2004;25:807–08 pmid:15140725

    Abstract/FREE Full Text
71. 71.↵
    2. Fujiki F,
    3. Tsuboi Y,
    4. Hashimoto K, et al

    . Non-herpetic limbic encephalitis associated with relapsing polychondritis. J Neurol Neurosurg Psychiatry 2004;75:1646–47 doi:10.1136/jnnp.2003.035170 pmid:15489409

    FREE Full Text
72. 72.↵
    2. Kumar N,
    3. Leep Hunderfund AN,
    4. Kutzbach BR, et al

    . A limbic encephalitis MR imaging in a patient with Behcet disease and relapsing polychondritis. AJNR Am J Neuroradiol 2009;30:E96 doi:10.3174/ajnr.A1631 pmid:19386730

    FREE Full Text
73. 73.↵
    2. Foidart JM,
    3. Abe S,
    4. Martin GR, et al

    . Antibodies to type II collagen in relapsing polychondritis. N Engl J Med 1978;299:1203–07 doi:10.1056/NEJM197811302992202 pmid:714080

    CrossRefPubMedWeb of Science