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AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates

Review ArticleAdult Brain
Open Access

Multimodal Diagnostic Imaging for Hyperacute Stroke

K.D. Vo, A.J. Yoo, A. Gupta, Y. Qiao, A.S. Vagal, J.A. Hirsch, D.M. Yousem and C. Lum
American Journal of Neuroradiology December 2015, 36 (12) 2206-2213; DOI: https://doi.org/10.3174/ajnr.A4530
K.D. Vo
aFrom the Mallinckrodt Institute of Radiology (K.D.V.), Washington University School of Medicine, St. Louis, Missouri
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A.J. Yoo
bDivision of Neurointervention (A.J.Y.), Texas Stroke Institute, Plano, Texas
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A. Gupta
cDepartment of Radiology and Feil Family Brain and Mind Research Institute (A.G.), Weill Cornell Medical College, New York, New York
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Y. Qiao
dDepartment of Radiology (Y.Q.), Johns Hopkins School of Medicine, Baltimore, Maryland
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A.S. Vagal
eDepartment of Radiology (A.S.V.), University of Cincinnati Medical Center, Cincinnati, Ohio
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J.A. Hirsch
fNeuroInterventional Radiology (J.A.H.), Massachusetts General Hospital, Boston, Massachusetts
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D.M. Yousem
gDepartment of Radiology (D.M.Y.), Johns Hopkins Medical Institution, Baltimore, Maryland
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C. Lum
hInterventional Neuroradiology (C.L.), Ottawa Hospital Research Institute, University of Ottawa, Ottawa, Ontaria, Canada.
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    Figure.

    ASPECTS21 scoring on an NCCT of a 52-year-old woman 2.5 hours after the onset of a left hemiparesis. Ten defined regions of the MCA distribution are identified on a normal left cerebral hemisphere at ganglionic (A) and supraganglionic (B) levels: the caudate nucleus (C), the lentiform nucleus (L), the internal capsule (IC), the insular cortex (I), and M1, M2, M3, M4, M5, and M6. The outlined areas in the right hemisphere show hypoattenuation in 8 regions given an ASPECTS score of 2.

Tables

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  • Efficacious acute stroke randomized controlled trials

    TrialTime Window (hr)TreatmentScreening Imaging Modality
    NINDS10–3IV-tPANCCT
    ECASS III23–4.5IV-tPANCCT
    TNK250–6IV tenecteplaseNCCT+CTA+CTP
    MR CLEAN30–6IA thrombectomyNCCT+CTA/MRA/DSA
    ESCAPE40–12IA thrombectomyNCCT+multiphase CTA
    EXTEND-IA50–6IA thrombectomyNCCT+CTA+CTP
    SWIFT-PRIME60–6IA thrombectomyNCCT+CTA/MRA±CTP/MRP
    • Note:—NINDS indicates National Institute of Neurological Disorders and Stroke; ECASS, European Cooperative Acute Stroke Study; TNK, tenecteplase; MR CLEAN, Multicenter Randomized Clinical Trial of Endovascular Treatment for Acute Ischemic Stroke in the Netherlands; IA, intra-arterial; MRP, MR perfusion.

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American Journal of Neuroradiology: 36 (12)
American Journal of Neuroradiology
Vol. 36, Issue 12
1 Dec 2015
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Cite this article
K.D. Vo, A.J. Yoo, A. Gupta, Y. Qiao, A.S. Vagal, J.A. Hirsch, D.M. Yousem, C. Lum
Multimodal Diagnostic Imaging for Hyperacute Stroke
American Journal of Neuroradiology Dec 2015, 36 (12) 2206-2213; DOI: 10.3174/ajnr.A4530

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Multimodal Diagnostic Imaging for Hyperacute Stroke
K.D. Vo, A.J. Yoo, A. Gupta, Y. Qiao, A.S. Vagal, J.A. Hirsch, D.M. Yousem, C. Lum
American Journal of Neuroradiology Dec 2015, 36 (12) 2206-2213; DOI: 10.3174/ajnr.A4530
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